Details of the Target

General Information of Target

Target ID LDTP00779
Target Name Trans-Golgi network integral membrane protein 2 (TGOLN2)
Gene Name TGOLN2
Gene ID 10618
Synonyms
TGN46; TGN51; Trans-Golgi network integral membrane protein 2; Trans-Golgi network glycoprotein 46; TGN38 homolog; hTGN46; Trans-Golgi network glycoprotein 48; hTGN48; Trans-Golgi network glycoprotein 51; hTGN51; Trans-Golgi network protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRFVVALVLLNVAAAGAVPLLATESVKQEEAGVRPSAGNVSTHPSLSQRPGGSTKSHPEP
QTPKDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTK
DSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPN
KSGADGQTPKDGSSKSGAEDQTPKDVPNKSGAEKQTPKDGSNKSGAEEQGPIDGPSKSGA
EEQTSKDSPNKVVPEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGE
ETDLISPPQEEVKSSEPTEDVEPKEAEDDDTGPEEGSPPKEEKEKMSGSASSENREGTLS
DSTGSEKDDLYPNGSGNGSAESSHFFAYLVTAAILVAVLYIAHHNKRKIIAFVLEGKRSK
VTRRPKASDYQRLDQKS
Target Bioclass
Other
Subcellular location
Cell membrane
Function May be involved in regulating membrane traffic to and from trans-Golgi network.
Uniprot ID
O43493
Ensemble ID
ENST00000377386.8
HGNC ID
HGNC:15450

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TG42
 Probe Info  		8.00  LDD0326  [2]
STPyne
 Probe Info  		K417(1.96); K426(1.65)  LDD0277  [3]
FBPP2
 Probe Info  		2.59  LDD0054  [4]
YN-1
 Probe Info  		N.A.  LDD0447  [5]
PAL-AfBPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C045
 Probe Info  		9.32  LDD1744  [6]
C056
 Probe Info  		25.46  LDD1753  [6]
C063
 Probe Info  		13.36  LDD1760  [6]
C085
 Probe Info  		5.03  LDD1777  [6]
C087
 Probe Info  		8.06  LDD1779  [6]
C106
 Probe Info  		37.27  LDD1793  [6]
C107
 Probe Info  		11.79  LDD1794  [6]
C108
 Probe Info  		13.27  LDD1795  [6]
C112
 Probe Info  		28.05  LDD1799  [6]
C115
 Probe Info  		8.46  LDD1802  [6]
C134
 Probe Info  		27.67  LDD1816  [6]
C135
 Probe Info  		10.63  LDD1817  [6]
C141
 Probe Info  		11.96  LDD1823  [6]
C143
 Probe Info  		25.11  LDD1825  [6]
C147
 Probe Info  		7.01  LDD1829  [6]
C149
 Probe Info  		16.00  LDD1830  [6]
C153
 Probe Info  		14.62  LDD1834  [6]
C159
 Probe Info  		10.34  LDD1839  [6]
C160
 Probe Info  		11.71  LDD1840  [6]
C161
 Probe Info  		18.90  LDD1841  [6]
C170
 Probe Info  		20.11  LDD1850  [6]
C171
 Probe Info  		5.06  LDD1851  [6]
C186
 Probe Info  		22.47  LDD1864  [6]
C201
 Probe Info  		36.50  LDD1877  [6]
C208
 Probe Info  		14.42  LDD1883  [6]
C221
 Probe Info  		8.46  LDD1895  [6]
C237
 Probe Info  		17.03  LDD1910  [6]
C243
 Probe Info  		11.08  LDD1916  [6]
C246
 Probe Info  		13.64  LDD1919  [6]
C261
 Probe Info  		7.21  LDD1933  [6]
C281
 Probe Info  		8.51  LDD1951  [6]
C310
 Probe Info  		64.45  LDD1977  [6]
C322
 Probe Info  		11.39  LDD1988  [6]
C326
 Probe Info  		10.78  LDD1990  [6]
C362
 Probe Info  		35.26  LDD2023  [6]
C390
 Probe Info  		29.24  LDD2049  [6]
C425
 Probe Info  		11.16  LDD2080  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0008  Tranylcypromine SH-SY5Y 2.59  LDD0054  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipoprotein lipase (LPL) Lipase family P06858
Plasma kallikrein (KLKB1) Peptidase S1 family P03952
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Angiotensinogen (AGT) Serpin family P01019
T-complex protein 1 subunit beta (CCT2) TCP-1 chaperonin family P78371
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587