Details of the Probe

General Information of Probe

Probe ID
LDPC0411
Probe Name
C171
Synonyms
Z4282859626
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 290.4
Lipid-water partition coefficient (xlogp) 2.1
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C16H26N4O
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-N-(1-ethyl-4,4-dimethylpyrrolidin-3-yl)propanamide
Canonical SMILES
CCN1CC(C(C1)(C)C)NC(=O)CCC2(N=N2)CCC#C
InChI
InChI=1S/C16H26N4O/c1-5-7-9-16(18-19-16)10-8-14(21)17-13-11-20(6-2)12-15(13,3)4/h1,13H,6-12H2,2-4H3,(H,17,21)
InChIKey
GQZQKFZKBPDIBN-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

94 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
5'-3' exonuclease PLD3 (PLD3) LDTP08476 7.57  LDD1851 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 7.57  LDD1851 
7-dehydrocholesterol reductase (DHCR7) LDTP13131 8.63  LDD1851 
7-dehydrocholesterol reductase (DHCR7) LDTP13131 8.63  LDD1851 
Acid ceramidase (ASAH1) LDTP05905 8.51  LDD1851 
Acid ceramidase (ASAH1) LDTP05905 8.51  LDD1851 
Acid sphingomyelinase-like phosphodiesterase 3b (SMPDL3B) LDTP09764 6.28  LDD1851 
Acid sphingomyelinase-like phosphodiesterase 3b (SMPDL3B) LDTP09764 6.28  LDD1851 
Alpha-galactosidase A (GLA) LDTP02141 8.82  LDD1851 
Alpha-galactosidase A (GLA) LDTP02141 8.82  LDD1851 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 8.57  LDD1851 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 8.57  LDD1851 
Arylsulfatase A (ARSA) LDTP02776 6.50  LDD1851 
Arylsulfatase A (ARSA) LDTP02776 6.50  LDD1851 
Beta-galactosidase (GLB1) LDTP02837 6.02  LDD1851 
Beta-galactosidase (GLB1) LDTP02837 6.02  LDD1851 
Beta-glucuronidase (GUSB) LDTP02260 8.46  LDD1851 
Beta-glucuronidase (GUSB) LDTP02260 8.46  LDD1851 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 8.11  LDD1851 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 8.11  LDD1851 
Beta-hexosaminidase subunit beta (HEXB) LDTP02216 5.58  LDD1851 
Beta-hexosaminidase subunit beta (HEXB) LDTP02216 5.58  LDD1851 
Beta-mannosidase (MANBA) LDTP00282 8.57  LDD1851 
Beta-mannosidase (MANBA) LDTP00282 8.57  LDD1851 
Bis(5'-adenosyl)-triphosphatase ENPP4 (ENPP4) LDTP14305 6.32  LDD1851 
Bis(5'-adenosyl)-triphosphatase ENPP4 (ENPP4) LDTP14305 6.32  LDD1851 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 9.92  LDD1851 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 9.92  LDD1851 
Cathepsin B (CTSB) LDTP02223 13.64  LDD1851 
Cathepsin B (CTSB) LDTP02223 13.64  LDD1851 
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) LDTP08933 5.10  LDD1851 
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) LDTP08933 5.10  LDD1851 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 8.11  LDD1851 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 8.11  LDD1851 
Delta(24)-sterol reductase (DHCR24) LDTP06375 27.67  LDD1851 
Delta(24)-sterol reductase (DHCR24) LDTP06375 27.67  LDD1851 
Deoxyribonuclease-2-alpha (DNASE2) LDTP00185 12.82  LDD1851 
Deoxyribonuclease-2-alpha (DNASE2) LDTP00185 12.82  LDD1851 
Di-N-acetylchitobiase (CTBS) LDTP14801 8.94  LDD1851 
Di-N-acetylchitobiase (CTBS) LDTP14801 8.94  LDD1851 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 9.78  LDD1851 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 9.78  LDD1851 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 6.06  LDD1851 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 6.06  LDD1851 
Gamma-glutamyl hydrolase (GGH) LDTP09886 6.59  LDD1851 
Gamma-glutamyl hydrolase (GGH) LDTP09886 6.59  LDD1851 
Histone-lysine N-methyltransferase SMYD3 (SMYD3) LDTP12020 6.82  LDD1851 
Histone-lysine N-methyltransferase SMYD3 (SMYD3) LDTP12020 6.82  LDD1851 
Legumain (LGMN) LDTP10888 9.45  LDD1851 
Legumain (LGMN) LDTP10888 9.45  LDD1851 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 8.82  LDD1851 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 8.82  LDD1851 
Lysosomal acid phosphatase (ACP2) LDTP02539 8.88  LDD1851 
Lysosomal acid phosphatase (ACP2) LDTP02539 8.88  LDD1851 
Lysosomal alpha-glucosidase (GAA) LDTP02486 8.06  LDD1851 
Lysosomal alpha-glucosidase (GAA) LDTP02486 8.06  LDD1851 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 7.41  LDD1851 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 7.41  LDD1851 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 8.82  LDD1851 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 8.82  LDD1851 
Lysosomal protective protein (CTSA) LDTP02505 6.77  LDD1851 
Lysosomal protective protein (CTSA) LDTP02505 6.77  LDD1851 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 18.38  LDD1851 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 18.38  LDD1851 
N-acetylgalactosamine-6-sulfatase (GALNS) LDTP03683 5.24  LDD1851 
N-acetylgalactosamine-6-sulfatase (GALNS) LDTP03683 5.24  LDD1851 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 18.00  LDD1851 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 18.00  LDD1851 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 8.34  LDD1851 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 8.34  LDD1851 
Peptidyl-glycine alpha-amidating monooxygenase (PAM) LDTP02976 6.92  LDD1851 
Peptidyl-glycine alpha-amidating monooxygenase (PAM) LDTP02976 6.92  LDD1851 
Phospholipase A2 group XV (PLA2G15) LDTP09088 7.26  LDD1851 
Phospholipase A2 group XV (PLA2G15) LDTP09088 7.26  LDD1851 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 7.57  LDD1851 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 7.57  LDD1851 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 7.26  LDD1851 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 7.26  LDD1851 
Procathepsin L (CTSL) LDTP02217 15.56  LDD1851 
Procathepsin L (CTSL) LDTP02217 15.56  LDD1851 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 12.47  LDD1851 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 12.47  LDD1851 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 16.34  LDD1851 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 16.34  LDD1851 
Ribonuclease T2 (RNASET2) LDTP00316 10.56  LDD1851 
Ribonuclease T2 (RNASET2) LDTP00316 10.56  LDD1851 
Sialate O-acetylesterase (SIAE) LDTP12135 8.57  LDD1851 
Sialate O-acetylesterase (SIAE) LDTP12135 8.57  LDD1851 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 7.16  LDD1851 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 7.16  LDD1851 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 25.99  LDD1851 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 25.99  LDD1851 
Uracil-DNA glycosylase (UNG) LDTP02643 5.21  LDD1851 
Uracil-DNA glycosylase (UNG) LDTP02643 5.21  LDD1851 
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⏷ Show the Full List of 94 Enzyme
44 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid-beta precursor protein (APP) LDTP02071 11.71  LDD1851 
Amyloid-beta precursor protein (APP) LDTP02071 11.71  LDD1851 
Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 5.98  LDD1851 
Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 5.98  LDD1851 
Integral membrane protein 2B (ITM2B) LDTP13833 6.45  LDD1851 
Integral membrane protein 2B (ITM2B) LDTP13833 6.45  LDD1851 
Low-density lipoprotein receptor (LDLR) LDTP01829 6.32  LDD1851 
Low-density lipoprotein receptor (LDLR) LDTP01829 6.32  LDD1851 
Low-density lipoprotein receptor-related protein 2 (LRP2) LDTP05218 8.82  LDD1851 
Low-density lipoprotein receptor-related protein 2 (LRP2) LDTP05218 8.82  LDD1851 
Lysosome membrane protein 2 (SCARB2) LDTP06034 9.92  LDD1851 
Lysosome membrane protein 2 (SCARB2) LDTP06034 9.92  LDD1851 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 6.06  LDD1851 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 6.06  LDD1851 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 11.08  LDD1851 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 11.08  LDD1851 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 17.63  LDD1851 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 17.63  LDD1851 
Osteopetrosis-associated transmembrane protein 1 (OSTM1) LDTP08327 7.26  LDD1851 
Osteopetrosis-associated transmembrane protein 1 (OSTM1) LDTP08327 7.26  LDD1851 
Podocalyxin (PODXL) LDTP00321 7.06  LDD1851 
Podocalyxin (PODXL) LDTP00321 7.06  LDD1851 
Prosaposin (PSAP) LDTP02215 13.93  LDD1851 
Prosaposin (PSAP) LDTP02215 13.93  LDD1851 
Protein tweety homolog 3 (TTYH3) LDTP11615 10.06  LDD1851 
Protein tweety homolog 3 (TTYH3) LDTP11615 10.06  LDD1851 
Proton-activated chloride channel (PACC1) LDTP12042 14.83  LDD1851 
Proton-activated chloride channel (PACC1) LDTP12042 14.83  LDD1851 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 5.66  LDD1851 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 5.66  LDD1851 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 6.59  LDD1851 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 6.59  LDD1851 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 5.13  LDD1851 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 5.13  LDD1851 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 9.06  LDD1851 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 9.06  LDD1851 
Sortilin-related receptor (SORL1) LDTP09838 8.69  LDD1851 
Sortilin-related receptor (SORL1) LDTP09838 8.69  LDD1851 
Tetraspanin-3 (TSPAN3) LDTP16813 7.67  LDD1851 
Tetraspanin-3 (TSPAN3) LDTP16813 7.67  LDD1851 
Transferrin receptor protein 1 (TFRC) LDTP01969 5.50  LDD1851 
Transferrin receptor protein 1 (TFRC) LDTP01969 5.50  LDD1851 
Transmembrane protein 59 (TMEM59) LDTP11406 16.80  LDD1851 
Transmembrane protein 59 (TMEM59) LDTP11406 16.80  LDD1851 
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⏷ Show the Full List of 44 Transporter and channel
2 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
IgG receptor FcRn large subunit p51 (FCGRT) LDTP04720 7.89  LDD1851 
IgG receptor FcRn large subunit p51 (FCGRT) LDTP04720 7.89  LDD1851 
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2 Cytokine and receptor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Interferon gamma receptor 1 (IFNGR1) LDTP02775 8.51  LDD1851 
Interferon gamma receptor 1 (IFNGR1) LDTP02775 8.51  LDD1851 
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50 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid beta precursor like protein 2 (APLP2) LDTP05491 9.32  LDD1851 
Amyloid beta precursor like protein 2 (APLP2) LDTP05491 9.32  LDD1851 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 5.39  LDD1851 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 5.39  LDD1851 
C-type mannose receptor 2 (MRC2) LDTP13114 6.36  LDD1851 
C-type mannose receptor 2 (MRC2) LDTP13114 6.36  LDD1851 
Calsyntenin-3 (CLSTN3) LDTP11096 8.00  LDD1851 
Calsyntenin-3 (CLSTN3) LDTP11096 8.00  LDD1851 
CD109 antigen (CD109) LDTP07760 5.62  LDD1851 
CD109 antigen (CD109) LDTP07760 5.62  LDD1851 
CD320 antigen (CD320) LDTP12352 7.89  LDD1851 
CD320 antigen (CD320) LDTP12352 7.89  LDD1851 
Collectin-12 (COLEC12) LDTP07031 11.96  LDD1851 
Collectin-12 (COLEC12) LDTP07031 11.96  LDD1851 
Desmocollin-3 (DSC3) LDTP06154 5.17  LDD1851 
Desmocollin-3 (DSC3) LDTP06154 5.17  LDD1851 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 5.90  LDD1851 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 5.90  LDD1851 
Endothelial protein C receptor (PROCR) LDTP13669 5.35  LDD1851 
Endothelial protein C receptor (PROCR) LDTP13669 5.35  LDD1851 
Galectin-3-binding protein (LGALS3BP) LDTP05558 9.25  LDD1851 
Galectin-3-binding protein (LGALS3BP) LDTP05558 9.25  LDD1851 
Ganglioside GM2 activator (GM2A) LDTP02927 9.58  LDD1851 
Ganglioside GM2 activator (GM2A) LDTP02927 9.58  LDD1851 
Golgi apparatus protein 1 (GLG1) LDTP09920 5.31  LDD1851 
Golgi apparatus protein 1 (GLG1) LDTP09920 5.31  LDD1851 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 12.38  LDD1851 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 12.38  LDD1851 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 18.51  LDD1851 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 18.51  LDD1851 
Nidogen-1 (NID1) LDTP02728 5.70  LDD1851 
Nidogen-1 (NID1) LDTP02728 5.70  LDD1851 
Protein CREG1 (CREG1) LDTP01279 19.29  LDD1851 
Protein CREG1 (CREG1) LDTP01279 19.29  LDD1851 
Protein CutA (CUTA) LDTP01075 4.96  LDD1851 
Protein CutA (CUTA) LDTP01075 4.96  LDD1851 
Protein unc-119 homolog B (UNC119B) LDTP00105 13.55  LDD1851 
Protein unc-119 homolog B (UNC119B) LDTP00105 13.55  LDD1851 
Seizure 6-like protein 2 (SEZ6L2) LDTP07703 8.82  LDD1851 
Seizure 6-like protein 2 (SEZ6L2) LDTP07703 8.82  LDD1851 
Synaptic vesicle glycoprotein 2A (SV2A) LDTP07934 5.70  LDD1851 
Synaptic vesicle glycoprotein 2A (SV2A) LDTP07934 5.70  LDD1851 
Tetraspanin-6 (TSPAN6) LDTP14458 6.36  LDD1851 
Tetraspanin-6 (TSPAN6) LDTP14458 6.36  LDD1851 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 5.06  LDD1851 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 5.06  LDD1851 
UPF0606 protein KIAA1549 (KIAA1549) LDTP12256 7.26  LDD1851 
UPF0606 protein KIAA1549 (KIAA1549) LDTP12256 7.26  LDD1851 
Very low-density lipoprotein receptor (VLDLR) LDTP05215 8.88  LDD1851 
Very low-density lipoprotein receptor (VLDLR) LDTP05215 8.88  LDD1851 
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⏷ Show the Full List of 50 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1851 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587