Details of the Target

General Information of Target

Target ID LDTP04572
Target Name Dipeptidyl peptidase 1 (CTSC)
Gene Name CTSC
Gene ID 1075
Synonyms
CPPI; Dipeptidyl peptidase 1; EC 3.4.14.1; Cathepsin C; Cathepsin J; Dipeptidyl peptidase I; DPP-I; DPPI; Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain; Dipeptidyl peptidase I exclusion domain chain; Dipeptidyl peptidase 1 heavy chain; Dipeptidyl peptidase I heavy chain; Dipeptidyl peptidase 1 light chain; Dipeptidyl peptidase I light chain)]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Peptidase C1 family
Subcellular location
Lysosome
Function
Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B.
TTD ID
T70490
Uniprot ID
P53634
DrugMap ID
TTQ9J6R
Ensemble ID
ENST00000227266.10
HGNC ID
HGNC:2528
ChEMBL ID
CHEMBL2252

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.G4V; p.P5S; p.M57T .
NB1 SNV: p.A11T .
NCIH716 SNV: p.S257R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y107(20.00)  LDD0260  [1]
STPyne
 Probe Info  		K63(1.75)  LDD2217  [2]
Probe 1
 Probe Info  		Y67(16.30)  LDD3495  [3]
P11
 Probe Info  		15.65  LDD0201  [4]
Alkylaryl probe 1
 Probe Info  		3.00  LDD0386  [5]
Alkylaryl probe 2
 Probe Info  		3.00  LDD0390  [5]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [6]
BTD
 Probe Info  		C136(0.59)  LDD2117  [7]
FBPP2
 Probe Info  		2.24  LDD0054  [8]
AHL-Pu-1
 Probe Info  		C136(2.60)  LDD0170  [9]
DBIA
 Probe Info  		C258(1.11); C255(1.05); C136(1.03); C321(1.00)  LDD0078  [10]
5E-2FA
 Probe Info  		N.A.  LDD2235  [11]
ATP probe
 Probe Info  		K140(0.00); K141(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C448(0.00); C337(0.00); C136(0.00); C355(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C355(0.00); C321(0.00)  LDD0032  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C337(0.00); C136(0.00); C355(0.00)  LDD0037  [13]
IPM
 Probe Info  		C255(0.00); C448(0.00); C258(0.00)  LDD0025  [16]
JW-RF-010
 Probe Info  		C448(0.00); C258(0.00); C255(0.00)  LDD0026  [16]
TFBX
 Probe Info  		C255(0.00); C258(0.00); C448(0.00)  LDD0027  [16]
SF
 Probe Info  		Y107(0.00); K108(0.00)  LDD0028  [17]
Phosphinate-6
 Probe Info  		C255(0.00); C136(0.00); C258(0.00)  LDD0018  [18]
Acrolein
 Probe Info  		C448(0.00); H241(0.00); C355(0.00); C337(0.00)  LDD0217  [19]
Crotonaldehyde
 Probe Info  		C448(0.00); H241(0.00); C136(0.00); C337(0.00)  LDD0219  [19]
Methacrolein
 Probe Info  		C448(0.00); C337(0.00)  LDD0218  [19]
W1
 Probe Info  		N239(0.00); N244(0.00); H241(0.00)  LDD0236  [20]
AOyne
 Probe Info  		15.00  LDD0443  [21]
MPP-AC
 Probe Info  		N.A.  LDD0428  [22]
NAIA_5
 Probe Info  		N.A.  LDD2223  [23]
TER-AC
 Probe Info  		N.A.  LDD0426  [22]
TPP-AC
 Probe Info  		N.A.  LDD0427  [22]
HHS-482
 Probe Info  		Y107(0.76)  LDD2239  [24]
PAL-AfBPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C045
 Probe Info  		9.06  LDD1744  [25]
C070
 Probe Info  		8.46  LDD1766  [25]
C073
 Probe Info  		5.06  LDD1769  [25]
C087
 Probe Info  		11.00  LDD1779  [25]
C115
 Probe Info  		7.11  LDD1802  [25]
C149
 Probe Info  		6.68  LDD1830  [25]
C170
 Probe Info  		32.45  LDD1850  [25]
C171
 Probe Info  		9.78  LDD1851  [25]
C186
 Probe Info  		11.88  LDD1864  [25]
C197
 Probe Info  		7.84  LDD1873  [25]
C198
 Probe Info  		9.58  LDD1874  [25]
C208
 Probe Info  		5.98  LDD1883  [25]
C221
 Probe Info  		9.65  LDD1895  [25]
C223
 Probe Info  		13.45  LDD1897  [25]
C237
 Probe Info  		6.54  LDD1910  [25]
C281
 Probe Info  		6.77  LDD1951  [25]
C302
 Probe Info  		6.28  LDD1971  [25]
C305
 Probe Info  		9.85  LDD1974  [25]
C310
 Probe Info  		14.52  LDD1977  [25]
C346
 Probe Info  		15.03  LDD2007  [25]
C348
 Probe Info  		20.97  LDD2009  [25]
C425
 Probe Info  		10.48  LDD2080  [25]
FFF probe12
 Probe Info  		20.00  LDD0473  [26]
FFF probe13
 Probe Info  		20.00  LDD0475  [26]
FFF probe14
 Probe Info  		16.80  LDD0477  [26]
FFF probe15
 Probe Info  		8.48  LDD0478  [26]
FFF probe3
 Probe Info  		13.48  LDD0464  [26]
FFF probe9
 Probe Info  		20.00  LDD0470  [26]
JN0003
 Probe Info  		20.00  LDD0469  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C136(0.59)  LDD2117  [7]
 LDCM0025  4SU-RNA DM93 C136(2.60)  LDD0170  [9]
 LDCM0026  4SU-RNA+native RNA DM93 C136(4.67)  LDD0171  [9]
 LDCM0214  AC1 HCT 116 C258(0.83); C136(0.74); C255(0.78)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C258(0.71); C136(0.84)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C258(1.03); C136(1.02); C255(0.87)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C258(1.06); C136(1.11); C255(0.95)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C258(0.78); C136(1.05); C255(0.96)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C258(1.10); C136(1.03); C255(1.04)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C258(1.03); C136(0.95); C255(0.94)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C258(1.14); C136(1.01); C255(1.10)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C258(1.07); C136(0.98); C255(0.81)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C258(0.88); C136(0.88); C255(0.96)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C258(1.00); C136(0.84); C255(0.77)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C258(1.01); C136(0.81); C255(0.82)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C258(0.81); C136(1.09)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C258(0.98); C136(0.94); C255(0.92)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C258(1.03); C136(0.94); C255(1.15)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C258(0.87); C136(0.95); C255(1.20)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C258(0.93); C136(0.94); C255(0.88)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C258(0.87); C136(0.89); C255(0.86)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C258(0.91); C136(0.92); C255(0.84)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C258(1.05); C136(1.06); C255(1.04)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C258(1.09); C136(1.23); C255(1.15)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C258(1.05); C136(0.82); C255(0.98)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C258(0.97); C136(0.92); C255(0.94)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C258(0.78); C136(1.07)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C258(1.32); C136(1.16); C255(1.07)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C258(0.97); C136(1.30); C255(1.22)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C258(1.06); C136(0.91); C255(0.86)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C258(0.74); C136(1.19); C255(0.80)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C258(0.93); C136(0.89); C255(0.97)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C258(0.99); C136(0.88); C255(0.83)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C258(0.92); C136(1.11); C255(0.79)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C258(0.99); C136(0.88); C255(0.89)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C258(1.34); C136(1.13)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C258(1.20); C136(1.03)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C258(1.71); C136(1.07)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C258(1.40); C136(1.22)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C258(1.60); C136(1.11)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C258(1.39); C136(1.12)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C258(1.80); C136(1.21)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C258(1.42); C136(1.18)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C258(1.70); C136(1.01)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C258(1.43); C136(0.89)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C258(1.99); C136(0.96)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C258(1.77); C136(1.17)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C258(1.15); C136(1.33)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C258(2.14); C136(1.20)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C258(2.23); C136(1.14)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C258(1.37); C136(1.00)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C258(0.96); C136(0.89); C255(1.23)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C258(0.94); C136(1.00); C255(3.14)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C258(0.71); C136(1.08); C255(2.54)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C258(1.03); C136(1.06); C255(2.80)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C258(0.73); C136(0.94); C255(1.67)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C258(0.74); C136(0.94); C255(3.68)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C258(0.86); C136(0.98); C255(3.25)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C258(1.01); C136(1.32)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C258(0.75); C136(0.91); C255(1.76)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C136(0.91); C258(0.97); C255(2.03)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C136(0.97); C258(0.98); C255(1.94)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C258(0.79); C136(1.58); C255(2.87)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C258(0.80); C136(0.92); C255(2.17)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C258(0.89); C136(1.18); C255(1.29)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C258(0.86); C136(1.00); C255(1.36)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C258(0.88); C136(1.12); C255(2.87)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C136(0.99); C258(1.04); C255(1.38)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C255(1.11); C136(1.12); C258(1.14)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C136(0.97); C258(1.12); C255(1.22)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C255(0.72); C136(0.82); C258(1.15)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C258(1.04); C255(1.13); C136(1.53)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C255(0.85); C258(1.01); C136(1.11)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C136(1.07); C258(1.15); C255(1.16)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C136(1.07); C255(1.32); C258(1.38)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C255(1.13); C258(1.25); C136(1.37)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C258(0.76); C136(1.04); C255(1.10)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C258(1.04); C136(1.08); C255(1.12)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C258(1.05); C255(1.08); C136(1.16)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C258(0.91); C136(0.99); C255(1.10)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C255(1.07); C136(1.20); C258(1.44)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C136(0.71); C255(0.77); C258(0.95)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C255(1.04); C136(1.28); C258(1.63)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C258(0.99); C255(1.03); C136(1.16)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C258(1.21); C136(1.27); C255(1.67)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C258(1.01); C136(1.24); C255(1.46)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C258(1.21); C255(1.23); C136(1.41)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C258(0.66); C255(0.80); C136(0.80)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C258(0.81); C136(0.82); C255(0.89)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C255(0.75); C258(0.81); C136(0.87)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C255(0.69); C258(0.77); C136(0.89)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C255(0.75); C258(0.81); C136(0.84)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C136(0.77); C258(0.85); C255(0.90)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C255(0.79); C258(0.89); C136(0.94)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C258(0.81); C255(0.90); C136(0.93)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C258(0.76); C255(0.91); C136(0.92)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C255(0.77); C258(0.86); C136(0.98)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C255(0.98); C136(0.99); C258(1.23)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C255(0.76); C258(0.96); C136(1.05)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C136(1.00); C258(1.11); C255(1.66)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C258(0.98); C136(1.10); C255(1.35)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C258(1.07); C136(1.12); C255(2.01)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C255(1.07); C258(1.17); C136(1.68)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C136(0.70); C258(0.84); C255(0.88)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C258(1.19); C136(1.32); C255(1.39)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C136(1.21); C258(1.30); C255(2.30)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C258(0.98); C136(1.11); C255(1.24)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C136(1.18); C255(1.38); C258(1.44)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C255(0.88); C258(0.98); C136(1.31)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C136(0.87); C258(0.93); C255(1.06)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C255(0.80); C258(0.84); C136(0.92)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C255(0.99); C258(1.03); C136(1.05)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C255(1.11); C258(1.11); C136(1.18)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C136(0.95); C255(1.01); C258(1.02)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C258(0.90); C136(1.02)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C136(0.99); C255(1.20); C258(1.23)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C136(1.02); C255(1.23); C258(1.26)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C255(1.05); C258(1.08); C136(1.11)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C136(1.07); C255(1.15); C258(1.18)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C136(0.99); C258(1.12); C255(1.15)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C136(1.04); C258(1.06); C255(1.07)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C255(1.06); C258(1.11); C136(1.21)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C255(0.75); C258(0.78); C136(0.97)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C258(0.95); C136(0.98); C255(1.06)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C258(0.76); C255(0.94); C136(1.08)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C258(0.88); C136(1.09)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C258(0.88); C136(0.95); C255(0.99)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C136(0.85); C258(0.92); C255(1.09)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C136(0.93); C258(0.95); C255(1.04)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C258(0.90); C255(0.92); C136(0.94)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C258(0.85); C136(0.93); C255(1.05)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C258(0.66); C255(0.78); C136(1.04)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C258(0.85); C255(0.97); C136(1.04)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C136(1.10); C258(1.27); C255(1.40)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C258(0.87); C136(0.99); C255(1.00)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C136(0.83); C258(0.93); C255(1.01)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C258(0.89); C136(1.09)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C136(0.93); C258(1.07); C255(1.26)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C258(0.72); C255(0.85); C136(0.99)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C258(0.56); C255(0.75); C136(0.92)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C255(0.47); C136(0.90); C258(1.24)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C255(0.57); C136(1.31); C258(1.38)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C255(0.53); C136(0.97); C258(1.11)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C255(0.69); C136(1.14); C258(1.46)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C255(0.49); C136(0.95); C258(1.06)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C255(0.43); C136(0.90); C258(0.92)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C255(0.44); C136(0.86); C258(1.06)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C255(0.38); C136(0.76); C258(0.98)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C255(0.46); C136(0.66); C258(1.26)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C255(0.36); C136(0.72); C258(0.96)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C255(0.46); C136(0.60); C258(0.97)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C255(0.39); C136(0.50); C258(1.16)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C255(0.48); C136(0.56); C258(1.12)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C255(0.38); C136(0.51); C258(0.99)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C255(0.40); C136(0.61); C258(1.27)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C258(0.93); C136(1.02); C255(1.26)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C255(0.87); C136(1.00); C258(1.00)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C258(0.77); C136(1.01)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C258(0.91); C136(1.00)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C258(0.96); C136(1.21)  LDD0592  [10]
 LDCM0020  ARS-1620 HCC44 C258(1.11); C255(1.05); C136(1.03); C321(1.00)  LDD0078  [10]
 LDCM0088  C45 HEK-293T 15.65  LDD0201  [4]
 LDCM0108  Chloroacetamide HeLa C355(0.00); C448(0.00); H241(0.00); C321(0.00)  LDD0222  [19]
 LDCM0367  CL1 HCT 116 C136(0.88); C255(1.03); C258(1.28)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C136(0.88); C255(1.21); C258(2.08)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C255(0.88); C136(0.92); C258(1.01)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C258(1.17); C136(1.43)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C136(1.03); C258(1.13)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C136(1.01); C258(1.23)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C136(0.99); C258(1.29)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C258(0.80); C136(0.95); C255(1.09)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C258(0.68); C136(0.97); C255(1.02)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C258(0.88); C136(0.98); C255(1.13)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C258(0.82); C136(0.97); C255(1.16)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C258(1.03); C136(1.03); C255(1.18)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C136(0.93); C255(0.94); C258(1.11)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C258(1.00); C136(1.02); C255(1.16)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C255(0.83); C258(1.08); C136(1.13)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C255(0.86); C136(0.98); C258(0.98)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C258(1.18); C136(1.27); C255(1.59)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C136(1.20); C255(1.26); C258(1.64)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C136(1.08); C255(1.48); C258(1.62)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C258(0.93); C136(1.01); C255(1.29)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C255(0.88); C258(0.92); C136(1.12)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C136(0.85); C255(0.96); C258(1.04)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C258(0.73); C255(0.93); C136(0.97)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C255(1.05); C136(1.09); C258(1.31)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C258(0.73); C255(0.81); C136(0.85)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C258(0.93); C255(1.19); C136(1.20)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C136(0.86); C258(1.29); C255(1.34)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C136(1.00); C258(1.48); C255(1.87)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C258(0.94); C255(1.05); C136(1.36)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C258(0.94); C255(0.96); C136(0.99)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C136(1.15); C255(1.37); C258(1.43)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C136(1.07); C255(1.10); C258(1.13)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C255(0.95); C136(1.00); C258(1.01)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C136(0.99); C258(1.06); C255(1.21)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C255(1.08); C258(1.09); C136(1.19)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C136(0.96); C258(1.34); C255(1.55)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C136(0.88); C258(1.42)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C136(1.07); C258(1.20)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C136(0.99); C258(1.66)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C136(0.98); C258(1.63)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C136(0.98); C258(1.00); C255(1.12)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C136(1.06); C258(2.61)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C136(0.91); C258(1.53)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C136(1.30); C258(2.77)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C136(1.06); C258(1.52)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C136(0.95); C258(1.54)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C258(1.43); C136(0.94)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C258(1.39); C136(1.16)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C258(1.66); C136(0.99)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C258(1.56); C136(0.93)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C258(1.64); C136(1.13)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C258(1.05); C136(0.91); C255(0.84)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C258(1.46); C136(1.03)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C258(1.93); C136(1.06)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C258(2.10); C136(1.22)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C258(3.28); C136(0.99)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C258(1.84); C136(1.01)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C258(2.42); C136(1.12)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C258(3.22); C136(0.97)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C258(1.94); C136(1.09)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C258(4.86); C136(0.99)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C258(0.83); C136(0.86); C255(1.26)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C258(3.83); C136(1.10)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C258(2.59); C136(1.10)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C258(2.54); C136(1.32)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C258(2.59); C136(1.04)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C258(2.47); C136(1.22)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C258(1.70); C136(1.22)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C258(1.00); C136(0.92); C255(0.95)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C258(1.10); C136(1.07); C255(1.04)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C258(0.98); C136(0.88); C255(0.69)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C258(0.93); C136(0.94); C255(0.78)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C258(0.96); C136(1.12); C255(1.25)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C258(1.11); C136(0.84); C255(0.95)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C258(1.27); C136(0.89); C255(1.17)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C258(0.94); C136(0.82); C255(0.86)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C258(1.22); C136(1.08); C255(1.38)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C258(0.86); C136(0.88); C255(0.77)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C258(0.88); C136(0.91); C255(0.80)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C258(1.01); C136(0.93); C255(0.99)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C258(0.92); C136(0.90); C255(0.86)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C258(1.13); C136(0.88); C255(0.95)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C258(0.96); C136(0.97); C255(0.81)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C258(2.78); C136(0.95); C255(1.47)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C258(0.92); C136(0.85); C255(0.70)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C258(0.98); C136(0.98); C255(1.06)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C258(0.81); C136(0.98); C255(1.16)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C258(0.99); C136(1.15); C255(0.98)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C258(1.10); C136(1.16); C255(0.99)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C258(1.29); C136(1.19); C255(1.11)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C258(1.30); C136(1.15); C255(0.95)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C258(1.48); C136(1.38); C255(1.08)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C258(1.61); C136(1.34); C255(0.85)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C258(1.70); C136(1.12); C255(1.13)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C258(0.96); C136(0.95); C255(1.38)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C258(1.19); C136(1.39); C255(1.08)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C258(0.90); C136(1.33); C255(0.94)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C258(1.01); C136(1.44); C255(0.88)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C258(1.03); C136(1.15); C255(1.02)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C258(1.12); C136(1.31); C255(1.00)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C258(1.26); C136(1.08); C255(1.13)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C258(1.27); C136(2.18); C255(0.94)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C258(1.16); C136(1.10); C255(0.99)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C258(1.59); C136(1.21); C255(1.01)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C258(1.11); C136(1.24); C255(1.27)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C258(1.18); C136(1.23); C255(1.04)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C258(1.07); C136(1.13); C255(0.92)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C258(1.27); C136(1.37); C255(1.08)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C258(1.11); C136(1.36); C255(0.95)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C258(1.36); C136(1.76); C255(0.92)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C258(1.07); C136(1.25); C255(1.18)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C258(0.99); C136(1.08); C255(1.01)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C258(0.95); C136(1.08); C255(0.87)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C258(0.97); C136(1.43); C255(0.97)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C258(1.20); C136(1.62); C255(1.71)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C258(0.94); C136(1.00); C255(2.75)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C258(2.50); C136(0.82); C255(1.67)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C258(1.19); C136(1.07); C255(0.84)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C258(1.25); C136(1.05); C255(0.88)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C258(1.05); C136(0.83); C255(1.08)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C258(1.11); C136(0.88); C255(1.24)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C258(0.99); C136(0.89); C255(0.93)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C258(1.14); C136(0.79); C255(0.83)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C258(1.13); C136(0.83); C255(0.82)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C258(0.94); C136(0.78); C255(0.77)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C258(0.83); C136(0.75); C255(0.76)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C136(0.97); C355(1.00); C118(1.00); C331(1.01)  LDD1698  [27]
 LDCM0202  EV-93 T cell C255, C258(4.46)  LDD0527  [28]
 LDCM0625  F8 Ramos C136(1.13); C448(0.40)  LDD2187  [29]
 LDCM0572  Fragment10 MDA-MB-231 C258(5.50)  LDD1465  [30]
 LDCM0573  Fragment11 Ramos C136(0.02); C448(0.33)  LDD2190  [29]
 LDCM0574  Fragment12 MDA-MB-231 C258(13.40)  LDD1468  [30]
 LDCM0575  Fragment13 MDA-MB-231 C258(1.60)  LDD1469  [30]
 LDCM0576  Fragment14 MDA-MB-231 C258(1.86)  LDD1471  [30]
 LDCM0579  Fragment20 Ramos C136(2.65); C448(0.58)  LDD2194  [29]
 LDCM0580  Fragment21 MDA-MB-231 C258(2.82)  LDD1473  [30]
 LDCM0582  Fragment23 Ramos C136(1.18); C448(1.12)  LDD2196  [29]
 LDCM0578  Fragment27 Ramos C136(1.07); C448(1.01)  LDD2197  [29]
 LDCM0586  Fragment28 Ramos C136(0.88); C448(0.45)  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C136(1.84); C448(0.42)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C136(1.27)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C448(0.49)  LDD2201  [29]
 LDCM0468  Fragment33 HCT 116 C258(1.15); C136(1.54); C255(1.08)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C136(1.01); C448(0.31)  LDD2203  [29]
 LDCM0566  Fragment4 MDA-MB-231 C258(1.20)  LDD1461  [30]
 LDCM0427  Fragment51 HCT 116 C258(1.72); C136(1.12)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C136(3.63); C448(0.37)  LDD2204  [29]
 LDCM0614  Fragment56 Ramos C136(1.60); C448(0.35)  LDD2205  [29]
 LDCM0569  Fragment7 Ramos C136(1.46); C448(0.43)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C448(0.58)  LDD2188  [29]
 LDCM0107  IAA HeLa C448(0.00); H241(0.00); C355(0.00)  LDD0221  [19]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [6]
 LDCM0022  KB02 HCT 116 C136(1.25); C258(1.25)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C136(1.14); C258(4.42)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C136(2.00); C258(1.09)  LDD0082  [10]
 LDCM0109  NEM HeLa H241(0.00); C448(0.00)  LDD0223  [19]
 LDCM0099  Phenelzine HEK-293T 3.00  LDD0386  [5]
 LDCM0131  RA190 MM1.R C258(1.31); C448(1.23); C355(1.22)  LDD0304  [31]
 LDCM0021  THZ1 HCT 116 C255(0.92); C136(1.06)  LDD2173  [10]
 LDCM0008  Tranylcypromine SH-SY5Y 2.24  LDD0054  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cystatin-F (CST7) Cystatin family O76096
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gsk2793660 . D0V4XG
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(S)-2-amino-n-(1-cyano-2-phenylethyl)Acetamide Small molecular drug D0U4TA
Gnf-pf-5434 Small molecular drug D0L9VP
Pmid3941405c3d Small molecular drug D0IV5D

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
5 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
30 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
31 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.