Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe9  Probe Info 
Probe concentration Probe:200uM; negative probe:200uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 102 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 20.0
 LDTP05905  Acid ceramidase (ASAH1) 20.0
 LDTP02141  Alpha-galactosidase A (GLA) 20.0
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 20.0
 LDTP05652  Aspartyl/asparaginyl beta-hydroxylase (ASPH) 20.0
 LDTP02837  Beta-galactosidase (GLB1) 20.0
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 20.0
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 20.0
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 20.0
 LDTP02911  Calpain-2 catalytic subunit (CAPN2) 20.0
 LDTP01372  Carboxypeptidase D (CPD) 20.0
 LDTP02001  Catalase (CAT) 20.0
 LDTP02223  Cathepsin B (CTSB) 20.0
 LDTP02198  Cathepsin D (CTSD) 20.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 20.0
 LDTP00185  Deoxyribonuclease-2-alpha (DNASE2) 20.0
 LDTP05171  Dermcidin (DCD) 20.0
 LDTP02362  Dihydrolipoyl dehydrogenase, mitochondrial (DLD) 20.0
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 20.0
 LDTP10441  E3 ubiquitin-protein ligase Itchy homolog (ITCH) 20.0
 LDTP01444  E3 UFM1-protein ligase 1 (UFL1) 20.0
 LDTP13853  Epididymis-specific alpha-mannosidase (MAN2B2) 20.0
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 20.0
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 20.0
 LDTP10888  Legumain (LGMN) 20.0
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 20.0
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 20.0
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 20.0
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 20.0
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 20.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 20.0
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 20.0
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 20.0
 LDTP05623  Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2) 20.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 20.0
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 20.0
 LDTP05548  Protein-glutamine gamma-glutamyltransferase E (TGM3) 20.0
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 20.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 20.0
 LDTP00316  Ribonuclease T2 (RNASET2) 20.0
 LDTP12135  Sialate O-acetylesterase (SIAE) 20.0
 LDTP00544  Sphingolipid delta(4)-desaturase DES1 (DEGS1) 20.0
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 20.0
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 20.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 20.0
 LDTP03366  Valine--tRNA ligase (VARS1) 20.0
 LDTP02539  Lysosomal acid phosphatase (ACP2) 19.7
 LDTP00886  Nardilysin (NRDC) 19.2
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 18.8
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 18.3
 LDTP03858  Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) 17.9
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 17.2
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 17.1
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 16.0
 LDTP10862  Proteasome subunit beta type-7 (PSMB7) 15.5
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 14.5
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 14.3
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 14.2
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 13.6
 LDTP01770  NADH-cytochrome b5 reductase 3 (CYB5R3) 13.6
 LDTP02534  Endoplasmic reticulum chaperone BiP (HSPA5) 13.6
 LDTP03817  Lon protease homolog, mitochondrial (LONP1) 13.5
 LDTP03688  Serine hydroxymethyltransferase, cytosolic (SHMT1) 12.9
 LDTP05971  Mannosyl-oligosaccharide glucosidase (MOGS) 12.9
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 12.6
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) 12.5
 LDTP10774  Elongation factor G, mitochondrial (GFM1) 12.4
 LDTP05992  Bleomycin hydrolase (BLMH) 12.3
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 12.0
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 12.0
 LDTP04901  Ras-related protein Rab-14 (RAB14) 11.7
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 10.7
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 10.5
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 9.8
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 9.8
 LDTP13751  Exonuclease 1 (EXO1) 9.6
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 9.6
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 9.3
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 8.8
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) 8.5
 LDTP02718  Glucosidase 2 subunit beta (PRKCSH) 8.0
 LDTP12166  Ras-related GTP-binding protein C (RRAGC) 7.7
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 7.6
 LDTP04909  ATP-binding cassette sub-family E member 1 (ABCE1) 7.4
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 6.7
 LDTP04440  Peroxisomal multifunctional enzyme type 2 (HSD17B4) 6.7
 LDTP02622  Creatine kinase U-type, mitochondrial (CKMT1A; CKMT1B) 6.6
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 6.4
 LDTP03424  ATP-binding cassette sub-family D member 3 (ABCD3) 6.4
 LDTP08590  DnaJ homolog subfamily C member 10 (DNAJC10) 6.0
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 6.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) 6.0
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 6.0
 LDTP13156  SUMO-activating enzyme subunit 2 (UBA2) 5.8
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 5.7
 LDTP05841  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C) 5.7
 LDTP05193  ADP-ribosylation factor 5 (ARF5) 5.6
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 5.4
 LDTP06455  Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) 5.4
 LDTP04531  Hexokinase-2 (HK2) 5.2
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 5.2
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 5.1
Transporter and channel
Click to Show/Hide to Show 51 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11116  45 kDa calcium-binding protein (SDF4) 20.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 20.0
 LDTP02815  Desmoplakin (DSP) 20.0
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 20.0
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 20.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 20.0
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 20.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 20.0
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 20.0
 LDTP02215  Prosaposin (PSAP) 20.0
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 20.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 20.0
 LDTP00592  Surfeit locus protein 4 (SURF4) 20.0
 LDTP01969  Transferrin receptor protein 1 (TFRC) 20.0
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 20.0
 LDTP20002  Transmembrane protein 160 (TMEM160) 20.0
 LDTP05690  Vesicular integral-membrane protein VIP36 (LMAN2) 20.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 20.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.0
 LDTP00310  Syntenin-1 (SDCBP) 19.3
 LDTP02058  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2) 18.1
 LDTP12042  Proton-activated chloride channel (PACC1) 17.9
 LDTP06660  MICOS complex subunit MIC60 (IMMT) 17.6
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 15.5
 LDTP04293  Transmembrane emp24 domain-containing protein 10 (TMED10) 14.6
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 13.8
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 13.7
 LDTP01748  Mitochondrial import receptor subunit TOM40 homolog (TOMM40) 13.2
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 13.0
 LDTP04787  Transmembrane protein 33 (TMEM33) 12.9
 LDTP04213  Phosphatidylinositol transfer protein beta isoform (PITPNB) 12.9
 LDTP10036  BOS complex subunit NCLN (NCLN) 12.6
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 9.3
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 9.0
 LDTP13393  Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) 8.2
 LDTP03405  Calnexin (CANX) 8.1
 LDTP05510  Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) 8.0
 LDTP12090  Sideroflexin-1 (SFXN1) 7.9
 LDTP03402  Calreticulin (CALR) 7.5
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 7.4
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 7.1
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) 6.3
 LDTP04501  Importin subunit alpha-1 (KPNA2) 5.6
 LDTP10741  Vacuolar protein sorting-associated protein 35 (VPS35) 5.5
 LDTP05938  Sorting nexin-1 (SNX1) 5.5
 LDTP02256  Amino acid transporter heavy chain SLC3A2 (SLC3A2) 5.3
 LDTP04309  Nuclear pore complex protein Nup153 (NUP153) 5.2
 LDTP13262  Signal recognition particle subunit SRP68 (SRP68) 5.2
 LDTP03870  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST) 5.1
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 5.0
 LDTP13416  Stomatin-like protein 2, mitochondrial (STOML2) 5.0
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05065  Y-box-binding protein 1 (YBX1) 11.9
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 20.0
Other
Click to Show/Hide to Show 62 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01814  Alpha-2-macroglobulin (A2M) 20.0
 LDTP00887  Calumenin (CALU) 20.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 20.0
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 20.0
 LDTP02927  Ganglioside GM2 activator (GM2A) 20.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 20.0
 LDTP09054  Golgi membrane protein 1 (GOLM1) 20.0
 LDTP08425  Hornerin (HRNR) 20.0
 LDTP07136  Keratinocyte proline-rich protein (KPRP) 20.0
 LDTP07605  La-related protein 1 (LARP1) 20.0
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 20.0
 LDTP09787  Nicastrin (NCSTN) 20.0
 LDTP05375  Nucleobindin-1 (NUCB1) 20.0
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 20.0
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 20.0
 LDTP03071  Pregnancy zone protein (PZP) 20.0
 LDTP06352  Reticulocalbin-1 (RCN1) 20.0
 LDTP06097  Reticulocalbin-2 (RCN2) 20.0
 LDTP06305  WD repeat-containing protein 43 (WDR43) 20.0
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 16.0
 LDTP13630  Neudesin (NENF) 15.7
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 15.5
 LDTP00512  Protein transport protein Sec16A (SEC16A) 13.1
 LDTP11207  Acidic leucine-rich nuclear phosphoprotein 32 family member E (ANP32E) 12.9
 LDTP02756  Junction plakoglobin (JUP) 12.7
 LDTP10700  KH domain-containing RNA-binding protein QKI (QKI) 12.4
 LDTP05870  Splicing factor 3B subunit 2 (SF3B2) 12.3
 LDTP06082  Dynactin subunit 1 (DCTN1) 12.3
 LDTP05035  Growth factor receptor-bound protein 2 (GRB2) 12.1
 LDTP04903  Actin-related protein 2 (ACTR2) 11.9
 LDTP02297  Vimentin (VIM) 9.4
 LDTP08760  Cell cycle and apoptosis regulator protein 2 (CCAR2) 8.5
 LDTP06584  Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) 8.2
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) 7.1
 LDTP02165  Tropomyosin alpha-3 chain (TPM3) 7.1
 LDTP04092  Crk-like protein (CRKL) 7.1
 LDTP05277  Protein SET (SET) 6.8
 LDTP06444  Microtubule-associated protein RP/EB family member 1 (MAPRE1) 6.6
 LDTP06094  Src substrate cortactin (CTTN) 6.4
 LDTP02734  Endoplasmin (HSP90B1) 6.2
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 6.2
 LDTP06301  Eukaryotic translation initiation factor 4H (EIF4H) 6.2
 LDTP05360  Large ribosomal subunit protein eL20 (RPL18A) 6.2
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 6.1
 LDTP04356  Emerin (EMD) 6.1
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 6.0
 LDTP10924  Prohibitin-2 (PHB2) 5.9
 LDTP13817  Nuclear migration protein nudC (NUDC) 5.9
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 5.8
 LDTP04181  Coatomer subunit delta (ARCN1) 5.7
 LDTP05400  Lamin-B2 (LMNB2) 5.6
 LDTP09081  SERPINE1 mRNA-binding protein 1 (SERBP1) 5.6
 LDTP05922  Dynactin subunit 2 (DCTN2) 5.5
 LDTP03775  RNA-binding protein FUS (FUS) 5.5
 LDTP10185  FAS-associated factor 2 (FAF2) 5.2
 LDTP13760  Structural maintenance of chromosomes protein 3 (SMC3) 5.2
 LDTP01932  Prelamin-A/C (LMNA) 5.1
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 5.1
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 5.1
 LDTP03712  Catenin beta-1 (CTNNB1) 5.0
 LDTP11695  Kinesin light chain 2 (KLC2) 5.0
 LDTP06507  Zyxin (ZYX) 5.0

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.