Details of the Target

General Information of Target

Target ID LDTP03712
Target Name Catenin beta-1 (CTNNB1)
Gene Name CTNNB1
Gene ID 1499
Synonyms
CTNNB; Catenin beta-1; Beta-catenin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L
Target Type
Successful
Target Bioclass
Other
Family
Beta-catenin family
Subcellular location
Cytoplasm
Function
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4. Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts.
TTD ID
T82795
Uniprot ID
P35222
DrugMap ID
TTRPKQG
Ensemble ID
ENST00000349496.11
HGNC ID
HGNC:2514
ChEMBL ID
CHEMBL5866

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-4
 Probe Info  		100.00  LDD0445  [1]
STPyne
 Probe Info  		K170(1.19)  LDD0277  [2]
IPM
 Probe Info  		C466(0.00); C619(0.00); C350(0.00); C520(0.00)  LDD0241  [3]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [4]
BTD
 Probe Info  		C520(1.17)  LDD2093  [5]
Jackson_14
 Probe Info  		2.00  LDD0123  [6]
DBIA
 Probe Info  		C350(1.18); C439(1.09); C466(1.06); C520(0.83)  LDD0531  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C619(0.00); C520(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C381(0.00); C466(0.00); C619(0.00)  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
PF-06672131
 Probe Info  		N.A.  LDD0152  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
YN-1
 Probe Info  		N.A.  LDD0447  [1]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
1c-yne
 Probe Info  		K170(0.00); K133(0.00); K233(0.00)  LDD0228  [13]
1d-yne
 Probe Info  		N.A.  LDD0357  [13]
Acrolein
 Probe Info  		H134(0.00); C619(0.00); H488(0.00)  LDD0217  [14]
Methacrolein
 Probe Info  		C619(0.00); H176(0.00)  LDD0218  [14]
W1
 Probe Info  		C466(0.00); C520(0.00); C350(0.00); Y489(0.00)  LDD0236  [3]
NAIA_5
 Probe Info  		C466(0.00); C213(0.00); C439(0.00); C520(0.00)  LDD2223  [15]
TER-AC
 Probe Info  		N.A.  LDD0426  [16]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C423
 Probe Info  		7.84  LDD2078  [17]
FFF probe13
 Probe Info  		7.04  LDD0475  [18]
FFF probe14
 Probe Info  		12.66  LDD0477  [18]
FFF probe2
 Probe Info  		14.66  LDD0463  [18]
FFF probe3
 Probe Info  		14.70  LDD0464  [18]
FFF probe9
 Probe Info  		5.04  LDD0470  [18]
OEA-DA
 Probe Info  		3.38  LDD0046  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C466(0.39)  LDD2142  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C520(0.93)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C520(1.39)  LDD2152  [5]
 LDCM0214  AC1 HCT 116 C350(1.18); C439(1.09); C466(1.06); C520(0.83)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C350(1.04); C439(1.00); C466(0.91); C520(0.90)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C350(1.14); C439(0.54); C466(0.77); C520(0.64)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C350(0.77); C439(0.57); C466(0.78); C520(0.66)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C350(0.71); C439(0.61); C466(0.76); C520(0.61)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C350(0.67); C439(0.52); C466(0.64); C520(0.68)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C350(0.71); C439(0.65); C466(0.69); C520(0.61)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C350(0.87); C439(0.49); C466(0.66); C520(0.67)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C350(0.78); C439(0.51); C466(0.66); C520(0.69)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C350(0.68); C439(0.57); C466(0.65); C520(0.63)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C350(0.99); C439(0.62); C466(0.74); C520(0.70)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C350(0.78); C439(0.72); C466(0.72); C520(0.74)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C350(1.18); C439(1.07); C466(0.79); C520(0.78)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C350(0.74); C439(0.68); C466(0.68); C520(0.71)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C350(0.70); C439(0.68); C466(0.78); C520(0.70)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C350(0.72); C439(0.60); C466(0.65); C520(0.62)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C350(1.16); C439(1.00); C466(1.11); C520(1.03)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C350(1.12); C439(0.98); C466(0.97); C520(1.12)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C350(1.15); C439(0.94); C466(1.08); C520(1.02)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C350(1.31); C439(0.92); C466(0.93); C520(0.89)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C350(1.30); C439(0.89); C466(1.21); C520(1.00)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C350(1.31); C439(0.99); C466(1.26); C520(0.98)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C350(1.37); C439(0.87); C466(1.09); C520(0.86)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C350(1.09); C439(0.99); C466(0.84); C520(0.89)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C350(0.74); C439(0.90); C466(0.97); C520(0.71)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C350(1.00); C439(1.13); C466(1.22); C520(0.88)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C350(1.26); C439(0.93); C466(0.93); C520(0.92)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C350(1.02); C439(1.10); C466(1.34); C520(0.95)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C350(1.14); C439(1.10); C466(1.20); C520(1.03)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C350(1.07); C439(1.02); C466(0.83); C520(0.99)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C350(0.94); C439(1.11); C466(0.98); C520(0.97)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C350(1.54); C439(1.03); C466(1.53); C520(1.05)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C466(0.94); C520(1.44)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C466(1.03); C520(2.03)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C466(1.09); C520(1.50)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C466(1.13); C520(1.86)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C466(1.18); C520(1.37)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C466(1.15); C520(1.37)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C466(1.08); C520(1.33)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C466(1.06); C520(1.43)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C466(1.14); C520(1.09)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C466(1.27); C520(1.09)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C466(1.20); C520(1.17)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C466(1.22); C520(1.35)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C350(0.82); C439(0.96); C466(0.81); C520(0.88)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C466(1.32); C520(1.31)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C466(1.26); C520(1.27)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C466(1.19); C520(1.24)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C350(0.78); C439(0.76); C466(0.96); C520(1.02)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C350(0.69); C466(0.94); C520(0.98); C439(1.13)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C350(0.86); C466(0.90); C520(1.02); C439(1.04)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C350(0.77); C520(0.95); C466(1.05); C439(1.08)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C466(0.87); C350(0.88); C520(1.03); C439(1.05)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C350(0.74); C466(1.01); C439(1.09); C520(1.12)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C350(0.46); C520(0.90); C466(0.95); C439(0.98)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C520(0.84); C350(0.88); C466(0.90); C439(0.90)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C350(0.55); C520(0.85); C466(1.08); C439(1.13)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C350(0.50); C466(0.97); C520(1.01); C439(1.20)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C350(0.36); C466(0.88); C520(0.89); C439(1.18)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C350(0.28); C466(0.87); C520(1.16); C439(1.32)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C350(0.39); C439(1.05); C466(0.92); C520(1.04)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C350(0.36); C439(1.09); C466(0.99); C520(1.05)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C350(0.39); C439(0.97); C466(1.01); C520(1.12)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C350(0.39); C439(1.20); C466(0.95); C520(1.44)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C466(1.00); C439(1.09); C520(1.19); C350(1.27)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C520(0.72); C350(1.03); C439(1.14); C466(1.16)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C520(1.11); C350(1.13); C439(1.20); C466(1.30)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C520(0.88); C439(0.89); C466(1.04); C350(1.37)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C350(0.93); C439(0.94); C466(0.96); C520(1.12)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C520(0.92); C466(0.99); C439(1.12); C350(1.25)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C466(0.98); C520(1.02); C350(1.08); C439(1.19)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C350(0.88); C466(1.01); C520(1.02); C439(1.07)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C350(0.88); C439(1.05); C466(1.08); C520(1.25)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C520(0.83); C466(0.89); C439(1.12); C350(1.49)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C466(0.84); C439(0.87); C520(1.02); C350(1.40)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C439(0.74); C520(0.82); C466(0.85); C350(1.13)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C520(0.77); C439(0.82); C466(0.97); C350(1.47)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C439(0.64); C520(0.67); C466(0.78); C350(1.18)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C466(0.94); C520(0.94); C439(1.07); C350(1.29)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C520(0.66); C439(0.67); C466(0.68); C350(0.99)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C439(0.67); C466(0.87); C520(0.99); C350(1.31)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C439(0.63); C466(0.78); C520(0.84); C350(1.07)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C520(0.67); C466(0.84); C350(0.91); C439(0.95)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C520(0.72); C439(0.76); C466(0.79); C350(0.82)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C520(0.72); C466(0.87); C350(1.18)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C466(0.91); C520(0.98); C350(1.02)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C466(0.89); C350(1.10); C520(1.11)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C520(0.85); C466(0.90); C350(1.01)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C520(0.94); C466(1.02); C350(1.07)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C520(0.90); C466(0.99); C439(1.12); C350(1.41)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C466(0.88); C350(0.93); C520(0.97)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C520(0.82); C466(1.01); C350(1.17)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C466(0.87); C520(0.96); C350(0.97)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C466(0.93); C520(1.01); C350(1.49)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C466(0.90); C350(0.96); C520(1.07)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C466(1.05); C520(1.07); C350(1.08)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C466(0.92); C439(0.96); C350(0.99); C520(1.01)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C466(0.94); C439(0.96); C520(1.10); C350(1.20)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C439(1.02); C520(1.10); C350(1.19); C466(1.42)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C439(0.92); C520(1.04); C350(1.07); C466(1.13)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C520(0.87); C439(1.02); C466(1.10); C350(1.17)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C439(0.94); C466(1.06); C520(1.17); C350(1.44)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C439(0.90); C466(1.17); C350(1.19); C520(1.26)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C466(0.97); C439(1.00); C520(1.05); C350(1.28)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C439(0.91); C466(0.92); C520(1.02); C350(1.71)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C520(0.89); C466(0.94); C439(1.23); C350(1.27)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C439(0.92); C466(1.07); C520(1.18); C350(1.40)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C439(0.90); C466(1.16); C520(1.25); C350(1.72)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C439(0.82); C520(0.89); C466(0.91); C350(1.11)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C466(0.76); C350(0.79); C439(0.81); C520(0.86)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C520(0.79); C439(0.82); C466(0.99); C350(1.05)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C439(0.83); C520(0.90); C350(0.91); C466(0.93)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C439(0.81); C520(0.84); C350(0.94); C466(0.96)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C439(0.74); C520(0.75); C466(0.84); C350(1.18)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C439(0.86); C466(0.88); C520(1.02); C350(1.27)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C439(0.82); C466(0.82); C520(0.90); C350(1.40)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C439(0.91); C520(0.95); C466(0.98); C350(1.42)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C520(0.88); C439(0.88); C350(1.17); C466(1.18)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C520(0.89); C439(0.89); C350(1.01); C466(1.12)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C520(0.79); C439(0.97); C466(1.03); C350(1.34)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C350(0.69); C439(0.91); C520(1.02); C466(1.47)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C350(0.82); C439(1.06); C520(1.11); C466(1.37)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C520(0.86); C439(0.90); C466(0.94); C350(0.94)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C466(0.71); C350(1.07); C520(1.08); C439(1.11)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C350(0.73); C439(1.07); C520(1.13); C466(1.76)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C520(1.07); C350(1.16); C466(1.16); C439(1.52)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C350(0.97); C466(1.12); C520(1.31); C439(1.32)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C350(0.74); C520(1.23); C439(1.26); C466(1.71)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C350(1.09); C466(1.21); C520(1.28); C439(1.63)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C350(1.04); C439(1.14); C466(1.20); C520(1.31)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C350(0.71); C439(1.19); C520(1.35); C466(1.58)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C350(0.79); C466(0.89); C520(1.12); C439(1.25)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C466(0.85); C350(1.10); C520(1.11); C439(1.40)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C520(0.72); C439(0.90); C466(0.92); C350(0.96)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C350(0.97); C439(0.99); C520(1.09); C466(1.36)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C350(0.89); C520(0.93); C439(0.99); C466(1.14)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C466(0.93); C350(0.94); C520(1.10); C439(1.50)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C520(0.87); C350(0.96); C439(0.98); C466(1.13)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C520(0.78); C350(0.91); C439(1.03); C466(1.06)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C520(0.77); C439(0.90); C350(0.95); C466(1.17)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C520(0.86); C439(0.96); C350(1.00); C466(1.02)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C350(1.00); C439(1.01); C466(1.04); C520(1.05)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C520(0.88); C350(0.93); C439(0.97); C466(1.00)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C439(0.86); C520(0.92); C466(0.99); C350(1.14)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C439(0.93); C520(1.09); C466(1.10); C350(1.36)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C439(0.90); C520(0.98); C466(1.06); C350(1.25)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C439(0.93); C520(0.97); C350(1.21); C466(1.24)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C520(0.79); C439(0.90); C466(0.91); C350(1.02)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C520(0.91); C439(1.01); C350(1.29); C466(1.54)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C439(0.94); C466(1.01); C520(1.10); C350(1.18)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C439(1.07); C520(1.08); C350(1.24); C466(1.68)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C439(0.79); C520(0.85); C466(0.97); C350(1.38)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C439(0.56); C520(0.60); C466(0.65); C350(0.88)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C439(0.62); C466(0.70); C520(0.73); C350(0.95)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C350(1.02); C439(1.20); C466(0.92); C520(0.95)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C466(0.88); C520(0.93); C350(0.97); C439(1.02)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C520(0.82); C439(0.88); C350(0.92); C466(0.98)  LDD0592  [7]
 LDCM0108  Chloroacetamide HeLa C573(0.00); C520(0.00); C619(0.00); C466(0.00)  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C350(0.90)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C350(0.91); C439(0.97); C466(0.98); C520(1.02)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C466(0.86); C439(0.93); C520(0.97); C350(1.41)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C520(0.81); C439(1.01); C350(1.07); C466(1.12)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C520(0.80); C466(0.80); C350(0.82); C439(0.84)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C350(0.80); C466(0.91); C520(0.97); C439(1.04)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C350(0.97); C466(1.03); C520(1.05); C439(1.07)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C350(0.78); C439(0.96); C520(1.00); C466(1.01)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C466(0.80); C520(0.85); C350(1.10); C439(1.19)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C520(0.81); C350(1.01); C466(1.01); C439(1.36)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C466(0.88); C520(0.89); C350(1.06); C439(1.24)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C520(0.88); C466(1.09); C350(1.10); C439(1.31)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C520(0.92); C466(0.96); C439(1.05); C350(1.26)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C439(0.85); C466(0.91); C520(0.96); C350(1.38)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C520(0.86); C466(0.91); C350(0.98); C439(1.24)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C466(0.73); C520(0.90); C350(0.91); C439(1.18)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C439(0.77); C466(0.93); C520(0.95); C350(1.09)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C439(0.67); C466(0.69); C520(0.80); C350(0.93)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C439(0.58); C466(0.68); C520(0.72); C350(0.96)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C520(0.60); C439(0.67); C466(0.79); C350(0.94)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C520(0.67); C439(0.83); C350(0.84); C466(0.86)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C350(0.89); C520(1.02); C466(1.11)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C466(0.94); C520(1.04); C350(1.23)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C466(0.94); C520(0.99); C350(1.42)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C439(1.06); C466(1.10); C520(1.14); C350(1.72)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C520(0.95); C466(1.00); C350(1.27)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C520(0.67); C466(0.70); C439(0.90); C350(1.09)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C350(0.74); C520(0.98); C439(0.99); C466(1.01)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C520(0.93); C466(0.94); C439(1.01); C350(1.02)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C466(0.96); C439(0.97); C520(1.04); C350(1.30)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C520(0.85); C439(0.92); C466(0.94); C350(1.23)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C520(0.72); C350(0.77); C466(0.77); C439(0.81)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C520(0.79); C350(0.83); C466(0.84); C439(0.86)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C520(0.81); C466(0.87); C439(0.92); C350(1.53)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C439(0.95); C466(0.97); C350(1.05); C520(1.07)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C439(0.87); C466(1.05); C350(1.07); C520(1.17)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C520(0.93); C466(0.98); C439(1.01); C350(1.09)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C466(0.68); C520(0.70); C439(0.80); C350(0.96)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C439(0.74); C466(0.79); C350(1.04); C520(1.06)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C466(0.82); C439(0.82); C520(1.12); C350(1.18)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C466(0.81); C439(0.84); C350(0.95); C520(1.08)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C439(0.90); C520(0.99); C466(1.03); C350(1.06)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C466(0.68); C439(0.74); C520(0.96); C350(1.08)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C466(0.72); C439(0.79); C350(1.00); C520(1.02)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C350(0.72); C466(0.73); C439(0.88); C520(0.88)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C466(0.79); C520(0.89); C350(0.89); C439(0.91)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C466(0.67); C439(0.92); C520(1.04); C350(1.13)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C350(1.07); C439(0.93); C466(0.70); C520(0.90)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C350(1.03); C439(0.78); C466(0.64); C520(0.94)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C350(1.09); C439(0.86); C466(0.73); C520(0.94)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C350(1.35); C439(0.88); C466(0.66); C520(1.03)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C350(1.25); C439(0.84); C466(0.74); C520(0.87)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C350(1.05); C439(0.99); C466(1.02); C520(1.02)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C350(1.28); C439(0.90); C466(0.58); C520(0.90)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C350(1.12); C439(0.91); C466(0.81); C520(1.00)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C350(0.83); C439(0.88); C466(0.82); C520(0.89)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C350(0.70); C439(0.81); C466(0.64); C520(0.84)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C350(0.78); C439(0.80); C466(0.72); C520(0.80)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C350(1.15); C439(0.79); C466(0.90); C520(0.95)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C350(0.68); C439(0.72); C466(0.78); C520(0.92)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C350(1.01); C439(0.82); C466(0.86); C520(1.08)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C350(0.83); C439(0.90); C466(0.80); C520(0.92)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C350(0.93); C439(0.90); C466(0.91); C520(1.00)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C350(0.78); C439(0.72); C466(0.65); C520(0.90)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C350(0.75); C439(0.85); C466(0.89); C520(0.99)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C350(0.75); C439(0.86); C466(0.84); C520(0.95)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C350(0.97); C439(0.92); C466(0.84); C520(1.03)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C350(1.07); C439(0.88); C466(0.86); C520(0.85)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C350(1.10); C439(0.81); C466(0.86); C520(0.80)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C350(1.30); C439(0.96); C466(1.17); C520(1.18)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C350(0.97); C439(0.93); C466(1.09); C520(1.10)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C350(0.97); C439(1.01); C466(1.11); C520(1.24)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C350(1.33); C439(1.24); C466(1.07); C520(1.30)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C350(1.29); C439(1.25); C466(1.19); C520(1.10)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C350(1.15); C439(1.12); C466(1.25); C520(1.27)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C350(1.47); C439(1.08); C466(1.07); C520(1.36)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C350(1.13); C439(0.86); C466(1.08); C520(1.19)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C350(0.77); C439(0.92); C466(1.21); C520(1.35)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C350(1.15); C439(1.00); C466(1.01); C520(1.34)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C350(0.97); C439(1.11); C466(1.18); C520(1.61)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C350(1.01); C439(1.07); C466(0.95); C520(1.08)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C350(1.13); C439(1.15); C466(0.87); C520(1.07)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C350(1.13); C439(0.97); C466(0.99); C520(1.26)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C350(1.12); C439(1.09); C466(0.98); C520(1.18)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C350(1.27); C439(0.82); C466(1.13); C520(0.94)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C350(1.21); C439(1.01); C466(1.15); C520(1.08)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C350(1.45); C439(0.90); C466(0.83); C520(1.03)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C350(1.56); C439(0.87); C466(0.94); C520(0.94)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C350(1.13); C439(0.82); C466(0.81); C520(0.88)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C350(1.20); C439(0.87); C466(0.89); C520(0.91)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C350(1.16); C439(0.92); C466(1.05); C520(0.86)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C350(1.21); C439(0.88); C466(0.79); C520(0.87)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C350(1.44); C439(0.88); C466(0.90); C520(0.80)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C350(2.05); C439(0.78); C466(0.76); C520(1.00)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C350(1.25); C439(0.77); C466(0.73); C520(0.90)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C350(1.49); C439(1.11); C466(1.34); C520(1.00)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C350(1.72); C439(0.86); C466(0.72); C520(0.96)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C350(1.43); C439(0.86); C466(0.88); C520(0.86)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C350(1.37); C439(0.83); C466(1.15); C520(0.91)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C350(1.40); C439(0.84); C466(0.81); C520(0.95)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C350(1.33); C439(0.85); C466(0.77); C520(0.90)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C350(0.73); C439(0.88); C466(0.90); C520(0.97)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C350(0.63); C439(0.74); C466(0.78); C520(0.89)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C350(0.81); C439(0.91); C466(0.85); C520(0.88)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C350(0.81); C439(0.83); C466(1.08); C520(1.08)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C350(0.92); C439(0.63); C466(1.16); C520(0.99)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C350(0.90); C439(0.86); C466(0.92); C520(1.00)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C350(0.97); C439(0.89); C466(0.96); C520(0.98)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C350(1.20); C439(0.89); C466(1.30); C520(1.13)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C350(0.81); C439(0.72); C466(1.03); C520(1.01)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C350(0.76); C439(0.83); C466(0.94); C520(0.99)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C350(0.74); C439(0.82); C466(0.90); C520(1.03)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C350(0.82); C439(0.79); C466(0.86); C520(0.98)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C350(1.01); C439(0.91); C466(0.82); C520(0.95)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C350(0.86); C439(0.85); C466(0.93); C520(1.05)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C350(0.86); C439(0.91); C466(1.09); C520(1.07)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C350(1.15); C439(0.97); C466(1.13); C520(1.02)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C350(0.91); C439(0.70); C466(0.96); C520(1.07)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C350(1.21); C439(0.86); C466(0.94); C520(0.76)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C350(1.04); C439(0.85); C466(0.85); C520(0.76)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C350(0.94); C439(1.04); C466(0.90); C520(0.87)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C350(0.99); C439(0.86); C466(1.09); C520(0.73)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C350(0.94); C439(0.78); C466(0.86); C520(0.73)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C350(1.05); C439(0.83); C466(0.86); C520(0.77)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C350(1.03); C439(0.79); C466(0.88); C520(0.79)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C350(1.14); C439(0.90); C466(0.89); C520(0.80)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C350(1.46); C439(0.91); C466(0.87); C520(0.80)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C350(0.84); C520(0.81); C466(1.03); C213(0.95)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C520(1.06); C350(1.01)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C350(1.49); C439(0.88); C466(0.85); C520(0.80)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C350(0.81); C439(0.78); C466(0.90); C520(0.90)  LDD0744  [7]
 LDCM0107  IAA HeLa C619(0.00); H578(0.00)  LDD0221  [14]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [4]
 LDCM0022  KB02 HEK-293T C520(0.91); C466(1.02); C350(0.90)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C520(0.96); C466(0.95); C350(0.99)  LDD1497  [20]
 LDCM0024  KB05 COLO792 C439(2.05)  LDD3310  [21]
 LDCM0109  NEM HeLa H134(0.00); H488(0.00); H475(0.00)  LDD0223  [14]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C520(1.17)  LDD2093  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C466(0.34)  LDD2104  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C520(0.87)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C520(0.90); C619(0.65)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C520(1.21)  LDD2111  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C520(1.79)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C520(1.45)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C520(0.84); C466(1.01); C619(0.95)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C466(0.94)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C520(0.72)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C520(1.01)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C520(1.57)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C520(0.90)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C520(2.10); C466(0.88)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C520(0.87)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C466(0.42)  LDD2141  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C619(0.32)  LDD2145  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C520(0.88)  LDD2146  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C520(0.99)  LDD2150  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C520(2.00)  LDD2153  [5]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.00  LDD0123  [6]
 LDCM0112  W16 Hep-G2 C350(2.24)  LDD0239  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 28 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA (cytosine-5)-methyltransferase 1 (DNMT1) C5-methyltransferase family P26358
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Cystathionine beta-synthase (CBS) Cysteine synthase/cystathionine beta-synthase family P35520
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Glyceraldehyde-3-phosphate dehydrogenase family P04406
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
Histone deacetylase 6 (HDAC6) Histone deacetylase family Q9UBN7
RNA polymerase-associated protein LEO1 (LEO1) LEO1 family Q8WVC0
Protein NDRG1 (NDRG1) NDRG family Q92597
Nitric oxide synthase 3 (NOS3) NOS family P29474
Caspase-6 (CASP6) Peptidase C14A family P55212
Glycogen synthase kinase-3 beta (GSK3B) CMGC Ser/Thr protein kinase family P49841
TRAF2 and NCK-interacting protein kinase (TNIK) STE Ser/Thr protein kinase family Q9UKE5
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Ephrin type-A receptor 2 (EPHA2) Tyr protein kinase family P29317
Fibroblast growth factor receptor 1 (FGFR1) Tyr protein kinase family P11362
Insulin-like growth factor 1 receptor (IGF1R) Tyr protein kinase family P08069
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Receptor-type tyrosine-protein phosphatase C (PTPRC) Protein-tyrosine phosphatase family P08575
Receptor-type tyrosine-protein phosphatase eta (PTPRJ) Protein-tyrosine phosphatase family Q12913
Receptor-type tyrosine-protein phosphatase gamma (PTPRG) Protein-tyrosine phosphatase family P23470
Pyruvate kinase PKM (PKM) Pyruvate kinase family P14618
Telomerase reverse transcriptase (TERT) Reverse transcriptase family O14746
RuvB-like 1 (RUVBL1) RuvB family Q9Y265
GTP-binding nuclear protein Ran (RAN) Ran family P62826
DNA topoisomerase 2-alpha (TOP2A) Type II topoisomerase family P11388
Bis(5'-adenosyl)-triphosphatase (FHIT) . P49789
CREB-binding protein (CREBBP) . Q92793
E3 ubiquitin-protein ligase UBR5 (UBR5) . O95071
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Alpha-crystallin B chain (CRYAB) Small heat shock protein (HSP20) family P02511
Bridge-like lipid transfer protein family member 1 (BLTP1) . Q2LD37
Cadherin-1 (CDH1) . P12830
Transcription factor
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein SATB1 (SATB1) CUT homeobox family Q01826
Early growth response protein 1 (EGR1) EGR C2H2-type zinc-finger protein family P18146
Zinc finger protein GLIS2 (GLIS2) GLI C2H2-type zinc-finger protein family Q9BZE0
Androgen receptor (AR) Nuclear hormone receptor family P10275
Lymphoid enhancer-binding factor 1 (LEF1) TCF/LEF family Q9UJU2
Transcription factor 7 (TCF7) TCF/LEF family P36402
Transcription factor 7-like 2 (TCF7L2) TCF/LEF family Q9NQB0
Forkhead box protein M1 (FOXM1) . Q08050
Hypoxia-inducible factor 1-alpha (HIF1A) . Q16665
Nuclear factor NF-kappa-B p105 subunit (NFKB1) . P19838
Protein AF-10 (MLLT10) . P55197
Runt-related transcription factor 3 (RUNX3) . Q13761
Transcription factor 4 (TCF4) . P15884
Transcription factor p65 (RELA) . Q04206
Transcription factor SOX-17 (SOX17) . Q9H6I2
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) G-protein coupled receptor 2 family Q03431
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inactive tyrosine-protein kinase 7 (PTK7) Tyr protein kinase family Q13308
Other
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenomatous polyposis coli protein (APC) Adenomatous polyposis coli (APC) family P25054
Alpha-actinin-4 (ACTN4) Alpha-actinin family O43707
APC membrane recruitment protein 1 (AMER1) Amer family Q5JTC6
Apoptosis-stimulating of p53 protein 2 (TP53BP2) ASPP family Q13625
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
B-cell CLL/lymphoma 9 protein (BCL9) BCL9 family O00512
Parafibromin (CDC73) CDC73 family Q6P1J9
Beta-catenin-interacting protein 1 (CTNNBIP1) CTNNBIP1 family Q9NSA3
Dapper homolog 1 (DACT1) Dapper family Q9NYF0
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Fermitin family homolog 2 (FERMT2) Kindlin family Q96AC1
Paxillin (PXN) Paxillin family P49023
Alpha-2-macroglobulin (A2M) Protease inhibitor I39 (alpha-2-macroglobulin) family P01023
Jerky protein homolog (JRK) Tigger transposable element derived protein family O75564
Catenin alpha-1 (CTNNA1) Vinculin/alpha-catenin family P35221
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937
Axin-1 (AXIN1) . O15169
Axin-2 (AXIN2) . Q9Y2T1
Cadherin-2 (CDH2) . P19022
Cadherin-5 (CDH5) . P33151
Emerin (EMD) . P50402
F-box/WD repeat-containing protein 11 (FBXW11) . Q9UKB1
F-box/WD repeat-containing protein 1A (BTRC) . Q9Y297
KN motif and ankyrin repeat domain-containing protein 1 (KANK1) . Q14678
Methyl-CpG-binding protein 2 (MECP2) . P51608
Protein numb homolog (NUMB) . P49757
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) . P46940
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
WW domain-containing transcription regulator protein 1 (WWTR1) . Q9GZV5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Urea Small molecular drug DB03904
Recombinant Human Endostatin . D05YAG
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ceq-508 siRNA drug D00GBZ
C 82 . D0DA5M

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840