Details of the Probe

General Information of Probe

Probe ID
LDPC0246
Probe Name
YN-4
Synonyms
CHEMBL5192185; YN-4; GLXC-26068; BDBM50594443; N-Ethynyl-4-(((4-(3-ethynylphenoxy)quinazolin-6-yl)oxy)methyl)-N-methylbenzenesulfonamide
Probe Type
ABPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 469.5
Lipid-water partition coefficient (xlogp) 4.6
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C26H19N3O4S
IUPAC Name
N-ethynyl-4-[[4-(3-ethynylphenoxy)quinazolin-6-yl]oxymethyl]-N-methylbenzenesulfonamide
Canonical SMILES
CN(C#C)S(=O)(=O)C1=CC=C(C=C1)COC2=CC3=C(C=C2)N=CN=C3OC4=CC=CC(=C4)C#C
InChI
InChI=1S/C26H19N3O4S/c1-4-19-7-6-8-22(15-19)33-26-24-16-21(11-14-25(24)27-18-28-26)32-17-20-9-12-23(13-10-20)34(30,31)29(3)5-2/h1-2,6-16,18H,17H2,3H3
InChIKey
DVPGLMQVEAWGCU-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

183 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) LDTP03835 100.00  LDD0445 
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (DECR1) LDTP06612 100.00  LDD0445 
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) LDTP05782 100.00  LDD0445 
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) LDTP00714 100.00  LDD0445 
26S proteasome regulatory subunit 8 (PSMC5) LDTP04963 100.00  LDD0445 
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) LDTP06325 100.00  LDD0445 
4-aminobutyrate aminotransferase, mitochondrial (ABAT) LDTP05163 100.00  LDD0445 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 100.00  LDD0445 
7-dehydrocholesterol reductase (DHCR7) LDTP13131 100.00  LDD0445 
Acetyl-CoA carboxylase 1 (ACACA) LDTP05742 100.00  LDD0445 
Actin, cytoplasmic 1 (ACTB) LDTP04876 100.00  LDD0445 
Acylglycerol kinase, mitochondrial (AGK) LDTP06905 100.00  LDD0445 
Adenosylhomocysteinase (AHCY) LDTP03242 100.00  LDD0445 
ADP-dependent glucokinase (ADPGK) LDTP11127 100.00  LDD0445 
Alcohol dehydrogenase class-3 (ADH5) LDTP02587 100.00  LDD0445 
Aldehyde dehydrogenase 1A1 (ALDH1A1) LDTP01767 100.00  LDD0445 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 100.00  LDD0445 
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) LDTP03560 100.00  LDD0445 
Aldehyde dehydrogenase, mitochondrial (ALDH2) LDTP02074 100.00  LDD0445 
Aldo-keto reductase family 1 member B10 (AKR1B10) LDTP00912 100.00  LDD0445 
Aldo-keto reductase family 1 member C1 (AKR1C1) LDTP05436 100.00  LDD0445 
Aldo-keto reductase family 1 member D1 (AKR1D1) LDTP04482 100.00  LDD0445 
All-trans-retinol 13,14-reductase (RETSAT) LDTP15097 100.00  LDD0445 
Alpha-enolase (ENO1) LDTP02159 100.00  LDD0445 
Androgen-induced gene 1 protein (AIG1) LDTP12697 100.00  LDD0445 
Antigen peptide transporter 1 (TAP1) LDTP05408 100.00  LDD0445 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 100.00  LDD0445 
Arginine--tRNA ligase, cytoplasmic (RARS1) LDTP04601 100.00  LDD0445 
Aspartate aminotransferase, mitochondrial (GOT2) LDTP01783 100.00  LDD0445 
Aspartate--tRNA ligase, cytoplasmic (DARS1) LDTP02752 100.00  LDD0445 
ATP-binding cassette sub-family D member 3 (ABCD3) LDTP03424 100.00  LDD0445 
ATP-citrate synthase (ACLY) LDTP04561 100.00  LDD0445 
ATP-dependent 6-phosphofructokinase, liver type (PFKL) LDTP02925 100.00  LDD0445 
ATP-dependent RNA helicase A (DHX9) LDTP05550 100.00  LDD0445 
ATP-dependent RNA helicase DDX3Y (DDX3Y) LDTP00664 100.00  LDD0445 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 100.00  LDD0445 
Bifunctional glutamate/proline--tRNA ligase (EPRS1) LDTP02222 100.00  LDD0445 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 100.00  LDD0445 
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) LDTP04358 100.00  LDD0445 
Catechol O-methyltransferase (COMT) LDTP03145 100.00  LDD0445 
Cathepsin B (CTSB) LDTP02223 100.00  LDD0445 
Cathepsin D (CTSD) LDTP02198 100.00  LDD0445 
Choline dehydrogenase, mitochondrial (CHDH) LDTP15505 100.00  LDD0445 
Cullin-associated NEDD8-dissociated protein 1 (CAND1) LDTP08296 100.00  LDD0445 
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) LDTP03610 100.00  LDD0445 
Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) LDTP03189 100.00  LDD0445 
Cytochrome b5 type B (CYB5B) LDTP00697 100.00  LDD0445 
Cytochrome P450 1A1 (CYP1A1) LDTP02054 100.00  LDD0445 
Cytochrome P450 4F3 (CYP4F3) LDTP05563 100.00  LDD0445 
Cytosol aminopeptidase (LAP3) LDTP03455 100.00  LDD0445 
D-3-phosphoglycerate dehydrogenase (PHGDH) LDTP00701 100.00  LDD0445 
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) LDTP05809 100.00  LDD0445 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 100.00  LDD0445 
Delta(24)-sterol reductase (DHCR24) LDTP06375 100.00  LDD0445 
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) LDTP05724 100.00  LDD0445 
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) LDTP04646 100.00  LDD0445 
Dermcidin (DCD) LDTP05171 100.00  LDD0445 
DNA repair nuclease/redox regulator APEX1 (APEX1) LDTP03398 100.00  LDD0445 
DNA topoisomerase 1 (TOP1) LDTP02567 100.00  LDD0445 
DNA-dependent protein kinase catalytic subunit (PRKDC) LDTP05136 100.00  LDD0445 
Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LDTP13087 100.00  LDD0445 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 100.00  LDD0445 
Elongation factor 2 (EEF2) LDTP02672 100.00  LDD0445 
Elongation factor Tu, mitochondrial (TUFM) LDTP04251 100.00  LDD0445 
Endoplasmic reticulum chaperone BiP (HSPA5) LDTP02534 100.00  LDD0445 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 100.00  LDD0445 
Epoxide hydrolase 1 (EPHX1) LDTP02175 100.00  LDD0445 
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) LDTP09063 100.00  LDD0445 
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) LDTP03915 100.00  LDD0445 
F-box only protein 2 (FBXO2) LDTP13419 100.00  LDD0445 
Farnesyl pyrophosphate synthase (FDPS) LDTP02721 100.00  LDD0445 
Fatty acid CoA ligase Acsl3 (ACSL3) LDTP01634 100.00  LDD0445 
Fatty acid synthase (FASN) LDTP04243 100.00  LDD0445 
Fructose-bisphosphate aldolase A (ALDOA) LDTP02008 4.85  LDD0445 
Glucose-6-phosphate isomerase (GPI) LDTP02162 100.00  LDD0445 
Glutamate dehydrogenase 1, mitochondrial (GLUD1) LDTP01768 100.00  LDD0445 
Glutathione reductase, mitochondrial (GSR) LDTP01771 100.00  LDD0445 
Glutathione S-transferase 3, mitochondrial (MGST3) LDTP00464 100.00  LDD0445 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 100.00  LDD0445 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 100.00  LDD0445 
Glycerol kinase (GK) LDTP03628 100.00  LDD0445 
Glycerol kinase 2 (GK2) LDTP06116 100.00  LDD0445 
Glycogen phosphorylase, muscle form (PYGM) LDTP02553 100.00  LDD0445 
GTP-binding nuclear protein Ran (RAN) LDTP05007 100.00  LDD0445 
Heat shock cognate 71 kDa protein (HSPA8) LDTP02541 100.00  LDD0445 
Heat shock protein HSP 90-alpha (HSP90AA1) LDTP02225 100.00  LDD0445 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 100.00  LDD0445 
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) LDTP02611 100.00  LDD0445 
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) LDTP01333 100.00  LDD0445 
Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) LDTP04211 100.00  LDD0445 
L-lactate dehydrogenase A chain (LDHA) LDTP01766 100.00  LDD0445 
L-xylulose reductase (DCXR) LDTP08082 100.00  LDD0445 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 100.00  LDD0445 
Lanosterol synthase (LSS) LDTP04183 100.00  LDD0445 
Leucine--tRNA ligase, cytoplasmic (LARS1) LDTP13056 100.00  LDD0445 
Liver carboxylesterase 1 (CES1) LDTP03207 100.00  LDD0445 
Long-chain-fatty-acid--CoA ligase 4 (ACSL4) LDTP00982 100.00  LDD0445 
Lysophosphatidylcholine acyltransferase 2 (LPCAT2) LDTP07967 100.00  LDD0445 
Lysophosphatidylserine lipase ABHD12 (ABHD12) LDTP08799 100.00  LDD0445 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 100.00  LDD0445 
Malate dehydrogenase, cytoplasmic (MDH1) LDTP03907 100.00  LDD0445 
Malate dehydrogenase, mitochondrial (MDH2) LDTP03908 100.00  LDD0445 
Methionine--tRNA ligase, cytoplasmic (MARS1) LDTP04730 100.00  LDD0445 
Microsomal glutathione S-transferase 1 (MGST1) LDTP02506 100.00  LDD0445 
Minor histocompatibility antigen H13 (HM13) LDTP09396 100.00  LDD0445 
Myosin-10 (MYH10) LDTP03765 100.00  LDD0445 
NAD(P)H dehydrogenase [quinone] 1 (NQO1) LDTP02798 100.00  LDD0445 
NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial (NDUFB11) LDTP12752 100.00  LDD0445 
NADH-ubiquinone oxidoreductase chain 5 (MT-ND5) LDTP01986 100.00  LDD0445 
NADPH--cytochrome P450 reductase (POR) LDTP02848 100.00  LDD0445 
NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR) LDTP03179 100.00  LDD0445 
Neutral alpha-glucosidase AB (GANAB) LDTP06192 100.00  LDD0445 
Neutral cholesterol ester hydrolase 1 (NCEH1) LDTP07591 100.00  LDD0445 
Nucleolar RNA helicase 2 (DDX21) LDTP12469 100.00  LDD0445 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 100.00  LDD0445 
Patatin-like phospholipase domain-containing protein 2 (PNPLA2) LDTP10077 100.00  LDD0445 
Peptidyl-prolyl cis-trans isomerase A (PPIA) LDTP05028 100.00  LDD0445 
Peptidyl-prolyl cis-trans isomerase B (PPIB) LDTP03216 100.00  LDD0445 
Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2) LDTP13989 100.00  LDD0445 
Peroxiredoxin-1 (PRDX1) LDTP05503 100.00  LDD0445 
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2) LDTP06638 100.00  LDD0445 
Phosphoglycerate kinase 1 (PGK1) LDTP01787 100.00  LDD0445 
Poly [ADP-ribose] polymerase 1 (PARP1) LDTP02375 100.00  LDD0445 
Potassium-transporting ATPase alpha chain 2 (ATP12A) LDTP04623 100.00  LDD0445 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 100.00  LDD0445 
Probable ATP-dependent RNA helicase DDX17 (DDX17) LDTP09899 100.00  LDD0445 
Probable ATP-dependent RNA helicase DDX5 (DDX5) LDTP02924 100.00  LDD0445 
Protein arginine N-methyltransferase 9 (PRMT9) LDTP07525 100.00  LDD0445 
Protein disulfide-isomerase (P4HB) LDTP02188 100.00  LDD0445 
Protein disulfide-isomerase A3 (PDIA3) LDTP03521 100.00  LDD0445 
Protein disulfide-isomerase A5 (PDIA5) LDTP06145 100.00  LDD0445 
Protein disulfide-isomerase A6 (PDIA6) LDTP06314 100.00  LDD0445 
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) LDTP03152 100.00  LDD0445 
Puromycin-sensitive aminopeptidase-like protein (NPEPPSL1) LDTP16607 100.00  LDD0445 
Putative ATP-dependent RNA helicase DDX11-like protein 8 (DDX11L8) LDTP14392 100.00  LDD0445 
Putative elongation factor 1-alpha-like 3 (EEF1A1P5) LDTP15029 100.00  LDD0445 
Putative nucleoside diphosphate kinase (NME2P1) LDTP16807 100.00  LDD0445 
Pyruvate carboxylase, mitochondrial (PC) LDTP02576 100.00  LDD0445 
Pyruvate kinase PKM (PKM) LDTP02733 100.00  LDD0445 
Ras-related protein Rab-1A (RAB1A) LDTP05006 100.00  LDD0445 
Retinal dehydrogenase 2 (ALDH1A2) LDTP01419 100.00  LDD0445 
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) LDTP04471 100.00  LDD0445 
RNA-splicing ligase RtcB homolog (RTCB) LDTP13992 100.00  LDD0445 
RuvB-like 2 (RUVBL2) LDTP13787 100.00  LDD0445 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 100.00  LDD0445 
Serine/threonine-protein phosphatase CPPED1 (CPPED1) LDTP11107 100.00  LDD0445 
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC) LDTP03819 100.00  LDD0445 
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (ACADSB) LDTP04072 100.00  LDD0445 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 100.00  LDD0445 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 100.00  LDD0445 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 100.00  LDD0445 
Squalene monooxygenase (SQLE) LDTP06142 100.00  LDD0445 
Squalene synthase (FDFT1) LDTP03842 100.00  LDD0445 
Staphylococcal nuclease domain-containing protein 1 (SND1) LDTP07929 100.00  LDD0445 
Stearoyl-CoA desaturase (SCD) LDTP00344 100.00  LDD0445 
Sterol 26-hydroxylase, mitochondrial (CYP27A1) LDTP05348 100.00  LDD0445 
Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA) LDTP03572 100.00  LDD0445 
Synaptic vesicle membrane protein VAT-1 homolog (VAT1) LDTP10887 100.00  LDD0445 
Thiol S-methyltransferase TMT1A (TMT1A) LDTP12056 100.00  LDD0445 
Thioredoxin (TXN) LDTP02502 100.00  LDD0445 
Thioredoxin domain-containing protein 5 (TXNDC5) LDTP09067 100.00  LDD0445 
Thioredoxin-related transmembrane protein 1 (TMX1) LDTP11874 100.00  LDD0445 
Transaldolase (TALDO1) LDTP03847 100.00  LDD0445 
Transitional endoplasmic reticulum ATPase (VCP) LDTP04665 100.00  LDD0445 
Transketolase (TKT) LDTP03487 100.00  LDD0445 
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) LDTP03912 100.00  LDD0445 
Trifunctional enzyme subunit beta, mitochondrial (HADHB) LDTP04671 100.00  LDD0445 
Triokinase/FMN cyclase (TKFC) LDTP06779 100.00  LDD0445 
Triosephosphate isomerase (TPI1) LDTP04851 100.00  LDD0445 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 100.00  LDD0445 
Tubulin alpha-1B chain (TUBA1B) LDTP05074 100.00  LDD0445 
Tyrosine--tRNA ligase, cytoplasmic (YARS1) LDTP04617 100.00  LDD0445 
U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200) LDTP01283 100.00  LDD0445 
Ubiquitin-like modifier-activating enzyme 1 (UBA1) LDTP03166 100.00  LDD0445 
UDP-glucose 6-dehydrogenase (UGDH) LDTP01033 100.00  LDD0445 
UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) LDTP12851 100.00  LDD0445 
UDP-glucuronosyltransferase 2A3 (UGT2A3) LDTP17417 100.00  LDD0445 
Valine--tRNA ligase (VARS1) LDTP03366 100.00  LDD0445 
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) LDTP04289 100.00  LDD0445 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) LDTP12954 100.00  LDD0445 
Vitamin K epoxide reductase complex subunit 1 (VKORC1) LDTP11070 100.00  LDD0445 
X-ray repair cross-complementing protein 5 (XRCC5) LDTP02642 100.00  LDD0445 
Xaa-Pro dipeptidase (PEPD) LDTP02639 100.00  LDD0445 
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⏷ Show the Full List of 183 Enzyme
76 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein epsilon (YWHAE) LDTP04969 100.00  LDD0445 
14-3-3 protein theta (YWHAQ) LDTP03385 100.00  LDD0445 
14-3-3 protein zeta/delta (YWHAZ) LDTP05043 100.00  LDD0445 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 100.00  LDD0445 
ADP/ATP translocase 2 (SLC25A5) LDTP02087 100.00  LDD0445 
Amino acid transporter heavy chain SLC3A2 (SLC3A2) LDTP02256 100.00  LDD0445 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 100.00  LDD0445 
ATP synthase subunit alpha, mitochondrial (ATP5F1A) LDTP03327 100.00  LDD0445 
ATP synthase subunit gamma, mitochondrial (ATP5F1C) LDTP03810 100.00  LDD0445 
Calnexin (CANX) LDTP03405 100.00  LDD0445 
Calreticulin (CALR) LDTP03402 100.00  LDD0445 
Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 100.00  LDD0445 
CD151 antigen (CD151) LDTP04187 100.00  LDD0445 
Chloride intracellular channel protein 1 (CLIC1) LDTP00244 100.00  LDD0445 
Clathrin heavy chain 1 (CLTC) LDTP05252 100.00  LDD0445 
Clathrin interactor 1 (CLINT1) LDTP06177 100.00  LDD0445 
Cytochrome c oxidase subunit 7C, mitochondrial (COX7C) LDTP02818 100.00  LDD0445 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 100.00  LDD0445 
Desmoplakin (DSP) LDTP02815 100.00  LDD0445 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) LDTP02057 100.00  LDD0445 
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) LDTP13393 100.00  LDD0445 
Equilibrative nucleoside transporter 1 (SLC29A1) LDTP10985 100.00  LDD0445 
Exportin-1 (XPO1) LDTP00501 100.00  LDD0445 
Exportin-5 (XPO5) LDTP12142 100.00  LDD0445 
Filamin-A (FLNA) LDTP03107 100.00  LDD0445 
Filamin-B (FLNB) LDTP01197 100.00  LDD0445 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 100.00  LDD0445 
Importin subunit beta-1 (KPNB1) LDTP06242 100.00  LDD0445 
Importin-5 (IPO5) LDTP00266 100.00  LDD0445 
Importin-7 (IPO7) LDTP01574 100.00  LDD0445 
Kinesin-1 heavy chain (KIF5B) LDTP03664 100.00  LDD0445 
Large neutral amino acids transporter small subunit 1 (SLC7A5) LDTP05305 100.00  LDD0445 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 100.00  LDD0445 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 100.00  LDD0445 
Mitochondrial import receptor subunit TOM40 homolog (TOMM40) LDTP01748 100.00  LDD0445 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 100.00  LDD0445 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 100.00  LDD0445 
Monocarboxylate transporter 4 (SLC16A3) LDTP00635 100.00  LDD0445 
Multidrug and toxin extrusion protein 1 (SLC47A1) LDTP10309 100.00  LDD0445 
Neutral amino acid transporter B(0) (SLC1A5) LDTP06462 100.00  LDD0445 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 100.00  LDD0445 
Nuclear pore membrane glycoprotein 210 (NUP210) LDTP09502 100.00  LDD0445 
Protein ERGIC-53 (LMAN1) LDTP04237 100.00  LDD0445 
Protein FAM8A1 (FAM8A1) LDTP16190 100.00  LDD0445 
Protein GPR107 (GPR107) LDTP07236 100.00  LDD0445 
Protein RFT1 homolog (RFT1) LDTP10073 100.00  LDD0445 
Protein SEC13 homolog (SEC13) LDTP04707 100.00  LDD0445 
Protein transport protein Sec31A (SEC31A) LDTP01478 100.00  LDD0445 
Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) LDTP04932 100.00  LDD0445 
Protein transport protein Sec61 subunit beta (SEC61B) LDTP04866 100.00  LDD0445 
Reactive oxygen species modulator 1 (ROMO1) LDTP04873 100.00  LDD0445 
Secretory carrier-associated membrane protein 3 (SCAMP3) LDTP00451 100.00  LDD0445 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 100.00  LDD0445 
Signal recognition particle subunit SRP68 (SRP68) LDTP13262 100.00  LDD0445 
Small ribosomal subunit protein RACK1 (RACK1) LDTP05057 100.00  LDD0445 
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) LDTP10731 100.00  LDD0445 
Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1) LDTP02068 100.00  LDD0445 
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) LDTP02544 100.00  LDD0445 
Solute carrier family 25 member 3 (SLC25A3) LDTP05238 100.00  LDD0445 
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) LDTP05273 100.00  LDD0445 
T-complex protein 1 subunit delta (CCT4) LDTP04391 100.00  LDD0445 
Talin-1 (TLN1) LDTP14031 100.00  LDD0445 
Transmembrane 4 L6 family member 1 (TM4SF1) LDTP14661 100.00  LDD0445 
Transmembrane 9 superfamily member 2 (TM9SF2) LDTP15845 100.00  LDD0445 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 100.00  LDD0445 
Transmembrane 9 superfamily member 4 (TM9SF4) LDTP09789 100.00  LDD0445 
Transmembrane emp24 domain-containing protein 1 (TMED1) LDTP05875 100.00  LDD0445 
Transmembrane protein 214 (TMEM214) LDTP07477 100.00  LDD0445 
Transportin-1 (TNPO1) LDTP09949 100.00  LDD0445 
Tricarboxylate transport protein, mitochondrial (SLC25A1) LDTP04553 100.00  LDD0445 
Vesicle-associated membrane protein-associated protein A (VAPA) LDTP12966 100.00  LDD0445 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 100.00  LDD0445 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 100.00  LDD0445 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 100.00  LDD0445 
Wolframin (WFS1) LDTP01380 100.00  LDD0445 
Zinc transporter SLC39A7 (SLC39A7) LDTP09769 100.00  LDD0445 
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⏷ Show the Full List of 76 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Signal transducer and activator of transcription 3 (STAT3) LDTP03903 100.00  LDD0445 
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167 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
A-kinase anchor protein 7 isoforms alpha and beta (AKAP7) LDTP00839 100.00  LDD0445 
Adenylyl cyclase-associated protein 1 (CAP1) LDTP05294 100.00  LDD0445 
Albumin (ALB) LDTP01963 100.00  LDD0445 
Alpha-2-macroglobulin (A2M) LDTP01814 100.00  LDD0445 
Alpha-actinin-4 (ACTN4) LDTP00843 100.00  LDD0445 
Annexin A4 (ANXA4) LDTP02354 100.00  LDD0445 
Apolipoprotein B-100 (APOB) LDTP02013 100.00  LDD0445 
Asialoglycoprotein receptor 1 (ASGR1) LDTP02191 100.00  LDD0445 
Bifunctional purine biosynthesis protein ATIC (ATIC) LDTP03612 100.00  LDD0445 
Catenin beta-1 (CTNNB1) LDTP03712 100.00  LDD0445 
CCHC-type zinc finger nucleic acid binding protein (CNBP) LDTP04995 100.00  LDD0445 
Centrosomal protein of 97 kDa (CEP97) LDTP08523 100.00  LDD0445 
Claudin-6 (CLDN6) LDTP04761 100.00  LDD0445 
Coatomer subunit alpha (COPA) LDTP04571 100.00  LDD0445 
Coatomer subunit beta (COPB1) LDTP04570 100.00  LDD0445 
Coatomer subunit beta' (COPB2) LDTP03767 100.00  LDD0445 
Complement C3 (C3) LDTP01815 100.00  LDD0445 
Coronin-1C (CORO1C) LDTP13580 100.00  LDD0445 
Cysteine and histidine-rich domain-containing protein 1 (CHORDC1) LDTP13269 100.00  LDD0445 
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) LDTP06083 100.00  LDD0445 
DnaJ homolog subfamily C member 11 (DNAJC11) LDTP12677 100.00  LDD0445 
Echinoderm microtubule-associated protein-like 4 (EML4) LDTP12214 100.00  LDD0445 
Elongation factor 1-gamma (EEF1G) LDTP03367 100.00  LDD0445 
Endoplasmin (HSP90B1) LDTP02734 100.00  LDD0445 
Eukaryotic translation initiation factor 3 subunit A (EIF3A) LDTP06055 100.00  LDD0445 
Eukaryotic translation initiation factor 3 subunit C (EIF3C) LDTP10919 100.00  LDD0445 
F-actin-capping protein subunit alpha-1 (CAPZA1) LDTP04544 100.00  LDD0445 
Fascin (FSCN1) LDTP06598 100.00  LDD0445 
Focadhesin (FOCAD) LDTP07235 100.00  LDD0445 
Glypican-3 (GPC3) LDTP04439 100.00  LDD0445 
Guanine nucleotide-binding protein subunit beta-4 (GNB4) LDTP12141 100.00  LDD0445 
Heat shock 70 kDa protein 6 (HSPA6) LDTP02884 100.00  LDD0445 
Heat shock protein 75 kDa, mitochondrial (TRAP1) LDTP05697 100.00  LDD0445 
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) LDTP02364 100.00  LDD0445 
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) LDTP06032 100.00  LDD0445 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 100.00  LDD0445 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 100.00  LDD0445 
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) LDTP04952 100.00  LDD0445 
Heterogeneous nuclear ribonucleoprotein L (HNRNPL) LDTP02750 100.00  LDD0445 
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) LDTP00991 100.00  LDD0445 
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) LDTP05259 100.00  LDD0445 
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) LDTP03182 100.00  LDD0445 
Histone H2A type 1-J (H2AC14) LDTP10999 100.00  LDD0445 
Histone H2B type 1-M (H2BC14) LDTP11000 100.00  LDD0445 
Histone H3.2 (H3C15; H3C14; H3C13) LDTP07899 100.00  LDD0445 
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) LDTP05004 100.00  LDD0445 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 100.00  LDD0445 
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) LDTP12904 100.00  LDD0445 
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) LDTP00272 100.00  LDD0445 
Integrin beta-4 (ITGB4) LDTP02829 100.00  LDD0445 
Interleukin enhancer-binding factor 3 (ILF3) LDTP05689 100.00  LDD0445 
Keratin, type I cytoskeletal 10 (KRT10) LDTP02674 100.00  LDD0445 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 100.00  LDD0445 
Keratin, type I cytoskeletal 19 (KRT19) LDTP02304 100.00  LDD0445 
Keratin, type I cytoskeletal 9 (KRT9) LDTP03755 100.00  LDD0445 
Keratin, type II cytoskeletal 1 (KRT1) LDTP02031 100.00  LDD0445 
Keratin, type II cytoskeletal 2 epidermal (KRT2) LDTP03792 100.00  LDD0445 
Keratin, type II cytoskeletal 8 (KRT8) LDTP02125 100.00  LDD0445 
Large ribosomal subunit protein eL13 (RPL13) LDTP03354 100.00  LDD0445 
Large ribosomal subunit protein eL14 (RPL14) LDTP04389 100.00  LDD0445 
Large ribosomal subunit protein eL15 (RPL15) LDTP04919 100.00  LDD0445 
Large ribosomal subunit protein eL18 (RPL18) LDTP05509 100.00  LDD0445 
Large ribosomal subunit protein eL19 (RPL19) LDTP05196 100.00  LDD0445 
Large ribosomal subunit protein eL20 (RPL18A) LDTP05360 100.00  LDD0445 
Large ribosomal subunit protein eL22 (RPL22) LDTP03728 100.00  LDD0445 
Large ribosomal subunit protein eL24 (RPL24) LDTP05186 100.00  LDD0445 
Large ribosomal subunit protein eL28 (RPL28) LDTP04108 100.00  LDD0445 
Large ribosomal subunit protein eL29 (RPL29) LDTP04140 100.00  LDD0445 
Large ribosomal subunit protein eL30 (RPL30) LDTP05021 100.00  LDD0445 
Large ribosomal subunit protein eL32 (RPL32) LDTP05025 100.00  LDD0445 
Large ribosomal subunit protein eL33 (RPL35A) LDTP02940 100.00  LDD0445 
Large ribosomal subunit protein eL34 (RPL34) LDTP04233 100.00  LDD0445 
Large ribosomal subunit protein eL36 (RPL36) LDTP14012 100.00  LDD0445 
Large ribosomal subunit protein eL37 (RPL37) LDTP04943 100.00  LDD0445 
Large ribosomal subunit protein eL43 (RPL37A) LDTP04926 100.00  LDD0445 
Large ribosomal subunit protein eL6 (RPL6) LDTP05378 100.00  LDD0445 
Large ribosomal subunit protein eL8 (RPL7A) LDTP04990 100.00  LDD0445 
Large ribosomal subunit protein uL1 (RPL10A) LDTP05024 100.00  LDD0445 
Large ribosomal subunit protein uL13 (RPL13A) LDTP03899 100.00  LDD0445 
Large ribosomal subunit protein uL14 (RPL23) LDTP05008 100.00  LDD0445 
Large ribosomal subunit protein uL15 (RPL27A) LDTP04105 100.00  LDD0445 
Large ribosomal subunit protein uL16 (RPL10) LDTP03395 100.00  LDD0445 
Large ribosomal subunit protein uL18 (RPL5) LDTP04106 100.00  LDD0445 
Large ribosomal subunit protein uL2 (RPL8) LDTP05027 100.00  LDD0445 
Large ribosomal subunit protein uL22 (RPL17) LDTP02961 100.00  LDD0445 
Large ribosomal subunit protein uL3 (RPL3) LDTP03865 100.00  LDD0445 
Large ribosomal subunit protein uL30 (RPL7) LDTP02944 100.00  LDD0445 
Large ribosomal subunit protein uL4 (RPL4) LDTP03815 100.00  LDD0445 
Large ribosomal subunit protein uL5 (RPL11) LDTP05026 100.00  LDD0445 
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) LDTP03658 100.00  LDD0445 
Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) LDTP03997 100.00  LDD0445 
Lipase maturation factor 2 (LMF2) LDTP15887 100.00  LDD0445 
M-phase phosphoprotein 9 (MPHOSPH9) LDTP10894 100.00  LDD0445 
Matrin-3 (MATR3) LDTP04027 100.00  LDD0445 
Mitochondrial antiviral-signaling protein (MAVS) LDTP08058 100.00  LDD0445 
Myb-binding protein 1A (MYBBP1A) LDTP11079 100.00  LDD0445 
Myosin light polypeptide 6 (MYL6) LDTP04875 100.00  LDD0445 
Nesprin-2 (SYNE2) LDTP09702 100.00  LDD0445 
Nucleolar complex protein 2 homolog (NOC2L) LDTP14011 100.00  LDD0445 
Nucleolar protein 56 (NOP56) LDTP00313 100.00  LDD0445 
Nucleolin (NCL) LDTP02990 100.00  LDD0445 
Nucleophosmin (NPM1) LDTP02164 100.00  LDD0445 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 100.00  LDD0445 
Perilipin-2 (PLIN2) LDTP10889 100.00  LDD0445 
Peroxiredoxin-like 2A (PRXL2A) LDTP11140 100.00  LDD0445 
Phosphatidylethanolamine-binding protein 1 (PEBP1) LDTP03520 100.00  LDD0445 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 100.00  LDD0445 
POTE ankyrin domain family member E (POTEE) LDTP07634 100.00  LDD0445 
Pre-mRNA-processing factor 6 (PRPF6) LDTP01456 100.00  LDD0445 
Pre-mRNA-processing-splicing factor 8 (PRPF8) LDTP07526 100.00  LDD0445 
Prelamin-A/C (LMNA) LDTP01932 100.00  LDD0445 
Profilin-1 (PFN1) LDTP02218 100.00  LDD0445 
Proliferating cell nuclear antigen (PCNA) LDTP02596 100.00  LDD0445 
Proteasome activator complex subunit 2 (PSME2) LDTP13519 100.00  LDD0445 
Proteasome inhibitor PI31 subunit (PSMF1) LDTP09779 100.00  LDD0445 
Protein THEM6 (THEM6) LDTP19831 100.00  LDD0445 
Protein transport protein Sec23A (SEC23A) LDTP06390 100.00  LDD0445 
Rab GDP dissociation inhibitor beta (GDI2) LDTP04355 100.00  LDD0445 
Receptor expression-enhancing protein 5 (REEP5) LDTP05257 100.00  LDD0445 
Reticulon-4 (RTN4) LDTP12412 100.00  LDD0445 
Rho GTPase-activating protein 6 (ARHGAP6) LDTP00703 100.00  LDD0445 
Ribosomal L1 domain-containing protein 1 (RSL1D1) LDTP01379 100.00  LDD0445 
Ribosomal protein eL42-like (RPL36AL) LDTP15677 100.00  LDD0445 
Ribosomal protein eS27-like (RPS27L) LDTP07909 100.00  LDD0445 
RRP12-like protein (RRP12) LDTP14980 100.00  LDD0445 
RUS family member 1 (RUSF1) LDTP10357 100.00  LDD0445 
Sec1 family domain-containing protein 1 (SCFD1) LDTP09615 100.00  LDD0445 
Sequestosome-1 (SQSTM1) LDTP05898 100.00  LDD0445 
Serine incorporator 1 (SERINC1) LDTP12544 100.00  LDD0445 
Serotransferrin (TF) LDTP01970 100.00  LDD0445 
Serpin H1 (SERPINH1) LDTP04363 100.00  LDD0445 
Small ribosomal subunit protein eS1 (RPS3A) LDTP04913 100.00  LDD0445 
Small ribosomal subunit protein eS27 (RPS27) LDTP03987 100.00  LDD0445 
Small ribosomal subunit protein eS28 (RPS28) LDTP05015 100.00  LDD0445 
Small ribosomal subunit protein eS4, X isoform (RPS4X) LDTP04997 100.00  LDD0445 
Small ribosomal subunit protein eS6 (RPS6) LDTP05002 100.00  LDD0445 
Small ribosomal subunit protein eS8 (RPS8) LDTP04964 100.00  LDD0445 
Small ribosomal subunit protein uS10 (RPS20) LDTP04880 100.00  LDD0445 
Small ribosomal subunit protein uS11 (RPS14) LDTP04970 100.00  LDD0445 
Small ribosomal subunit protein uS15 (RPS13) LDTP04974 100.00  LDD0445 
Small ribosomal subunit protein uS2 (RPSA) LDTP02312 100.00  LDD0445 
Small ribosomal subunit protein uS4 (RPS9) LDTP04109 100.00  LDD0445 
Small ribosomal subunit protein uS5 (RPS2) LDTP02809 100.00  LDD0445 
Small ribosomal subunit protein uS7 (RPS5) LDTP04110 100.00  LDD0445 
Small ribosomal subunit protein uS9 (RPS16) LDTP04966 100.00  LDD0445 
Small ubiquitin-related modifier 4 (SUMO4) LDTP07378 100.00  LDD0445 
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) LDTP05985 100.00  LDD0445 
Splicing factor 3B subunit 1 (SF3B1) LDTP01251 100.00  LDD0445 
Splicing factor 3B subunit 3 (SF3B3) LDTP06376 100.00  LDD0445 
Splicing factor U2AF 26 kDa subunit (U2AF1L4) LDTP09562 100.00  LDD0445 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 100.00  LDD0445 
T-complex protein 1 subunit alpha (TCP1) LDTP02934 100.00  LDD0445 
T-complex protein 1 subunit gamma (CCT3) LDTP04249 100.00  LDD0445 
T-complex protein 1 subunit theta (CCT8) LDTP04390 100.00  LDD0445 
T-complex protein 1 subunit zeta-2 (CCT6B) LDTP09777 100.00  LDD0445 
Tetraspanin-6 (TSPAN6) LDTP14458 100.00  LDD0445 
TraB domain-containing protein (TRABD) LDTP19963 100.00  LDD0445 
Transducin beta-like protein 2 (TBL2) LDTP16285 100.00  LDD0445 
Tubulin beta chain (TUBB) LDTP02205 100.00  LDD0445 
Tubulin beta-4B chain (TUBB4B) LDTP05076 100.00  LDD0445 
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) LDTP05033 100.00  LDD0445 
UPF0729 protein C18orf32 (C18orf32) LDTP15599 100.00  LDD0445 
Uromodulin-like 1 (UMODL1) LDTP06959 100.00  LDD0445 
Vesicle transport protein SFT2B (SFT2D2) LDTP01630 100.00  LDD0445 
Vesicle-trafficking protein SEC22b (SEC22B) LDTP01206 100.00  LDD0445 
Vigilin (HDLBP) LDTP05239 100.00  LDD0445 
Villin-1 (VIL1) LDTP02339 100.00  LDD0445 
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Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs DMSO
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
100 uM
Quantitative Method
LFQ
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Liver
Disease Model
Hepatoblastoma [ICD-11:DB91]
Model Name
Human hepatoblastoma cells (Hep-G2)
Interaction Atlas ID
 LDD0445 
Download The Altas

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.