Details of the Target

General Information of Target

Target ID LDTP02375
Target Name Poly [ADP-ribose] polymerase 1 (PARP1)
Gene Name PARP1
Gene ID 142
Synonyms
ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; PARP-1; EC 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; DNA ADP-ribosyltransferase PARP1; EC 2.4.2.-; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1; EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus; Poly [ADP-ribose] polymerase 1, 89-kDa form; Poly [ADP-ribose] polymerase 1, processed N-terminus; NT-PARP-1; Poly [ADP-ribose] polymerase 1, 24-kDa form; Poly [ADP-ribose] polymerase 1, 28-kDa form)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV
GHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKS
NRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ
LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKA
QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSG
QLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE
TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT
GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSP
WGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE
HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNK
LEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPG
TKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAV
SQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRG
GSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE
REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM
VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSA
NISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
Target Type
Successful
Target Bioclass
Enzyme
Family
ARTD/PARP family
Subcellular location
Cytoplasm; Chromosome
Function
Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1. Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site. Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1. Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity. PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains. In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation. Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5. In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair. In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity. Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II. Acts both as a positive and negative regulator of transcription elongation, depending on the context. Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing. Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9. Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression. Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos. Also acts as a negative regulator of the cGAS-STING pathway. Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS. Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes. Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.; [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis. This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis.; [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.
TTD ID
T06273
Uniprot ID
P09874
DrugMap ID
TTVDSZ0
Ensemble ID
ENST00000366794.10
HGNC ID
HGNC:270
ChEMBL ID
CHEMBL3105

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 44 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
11RK72
 Probe Info  		3.65  LDD0327  [1]
11RK73
 Probe Info  		2.23  LDD0328  [1]
CHEMBL5175495
 Probe Info  		6.42  LDD0196  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
TH211
 Probe Info  		Y310(20.00); Y775(20.00); Y794(20.00); Y309(10.27)  LDD0257  [4]
TH216
 Probe Info  		Y310(20.00); Y309(19.06)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
YN-4
 Probe Info  		100.00  LDD0445  [5]
ONAyne
 Probe Info  		K87(0.00); K447(0.00); K331(0.00); K700(0.00)  LDD0273  [6]
Probe 1
 Probe Info  		Y176(16.63); Y344(23.94); Y570(46.77); Y645(6.15)  LDD3495  [7]
AHL-Pu-1
 Probe Info  		C908(2.61); C845(2.03)  LDD0169  [8]
HHS-475
 Probe Info  		Y889(0.35); Y344(0.67); Y645(6.02)  LDD0264  [9]
HHS-465
 Probe Info  		Y158(9.00); Y176(10.00); Y344(10.00); Y645(8.53)  LDD2237  [10]
DBIA
 Probe Info  		C311(1.09)  LDD0078  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
AMP probe
 Probe Info  		N.A.  LDD0200  [13]
ATP probe
 Probe Info  		K119(0.00); K621(0.00); K548(0.00); K551(0.00)  LDD0199  [13]
m-APA
 Probe Info  		N.A.  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C429(0.00); C24(0.00); C256(0.00); C908(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C256(0.00); C295(0.00); C429(0.00); C311(0.00)  LDD0032  [15]
Lodoacetamide azide
 Probe Info  		C429(0.00); C908(0.00); C311(0.00); C256(0.00)  LDD0037  [14]
BTD
 Probe Info  		N.A.  LDD0004  [16]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
TFBX
 Probe Info  		N.A.  LDD0027  [17]
1d-yne
 Probe Info  		N.A.  LDD0356  [19]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
ENE
 Probe Info  		N.A.  LDD0006  [16]
IPM
 Probe Info  		N.A.  LDD0005  [16]
NHS
 Probe Info  		K192(0.00); K7(0.00); K695(0.00); K700(0.00)  LDD0010  [16]
PF-06672131
 Probe Info  		N.A.  LDD0152  [21]
SF
 Probe Info  		Y645(0.00); K414(0.00); Y176(0.00); Y9(0.00)  LDD0028  [22]
STPyne
 Probe Info  		K600(0.00); K196(0.00); K621(0.00); K748(0.00)  LDD0009  [16]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [23]
Ox-W18
 Probe Info  		W79(0.00); W246(0.00); W318(0.00); W333(0.00)  LDD2175  [24]
1c-yne
 Probe Info  		K571(0.00); K607(0.00); K637(0.00); K269(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		H742(0.00); C162(0.00); C256(0.00); H541(0.00)  LDD0217  [25]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [25]
Crotonaldehyde
 Probe Info  		C311(0.00); C162(0.00); C429(0.00); H627(0.00)  LDD0219  [25]
Methacrolein
 Probe Info  		C429(0.00); C162(0.00); C256(0.00); C56(0.00)  LDD0218  [25]
W1
 Probe Info  		C162(0.00); C429(0.00); C256(0.00)  LDD0236  [26]
NAIA_5
 Probe Info  		C429(0.00); C24(0.00); C908(0.00)  LDD2223  [18]
TER-AC
 Probe Info  		N.A.  LDD0426  [27]
HHS-482
 Probe Info  		Y645(1.09); Y889(0.62)  LDD2239  [10]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
PARPYnD
 Probe Info  		2.83  LDD0374  [28]
C203
 Probe Info  		8.82  LDD1878  [29]
C361
 Probe Info  		20.97  LDD2022  [29]
C417
 Probe Info  		8.63  LDD2072  [29]
FFF probe3
 Probe Info  		7.71  LDD0464  [30]
FFF probe6
 Probe Info  		6.55  LDD0467  [30]
STS-1
 Probe Info  		N.A.  LDD0136  [31]
STS-2
 Probe Info  		N.A.  LDD0138  [31]
CA
 Probe Info  		1.85  LDD0419  [32]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [33]
AR-1
 Probe Info  		1.49  LDD0439  [34]
AR-2
 Probe Info  		1.69  LDD0437  [34]
Diazir
 Probe Info  		N.A.  LDD0011  [16]
DA-2
 Probe Info  		N.A.  LDD0071  [35]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C24(0.32); C256(0.46); C845(0.82)  LDD2142  [36]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C24(0.72); C845(1.06)  LDD2112  [36]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C429(0.55); C24(0.52); C256(0.52)  LDD2095  [36]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C429(0.84); C256(0.93)  LDD2130  [36]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C24(0.94); C256(0.77); C845(1.04)  LDD2117  [36]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C24(1.23); C256(1.53); C845(3.28)  LDD2152  [36]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C256(0.88); C845(1.08)  LDD2103  [36]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C429(0.54); C256(0.51)  LDD2132  [36]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C256(0.56)  LDD2131  [36]
 LDCM0025  4SU-RNA DM93 C311(2.04); C162(2.32)  LDD0170  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C908(2.61); C845(2.03)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C162(1.05); C24(1.35); C256(1.40); C295(0.82)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C24(1.10); C256(1.05); C295(0.57); C298(0.57)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C24(1.02); C256(0.71); C295(0.35); C298(0.35)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C24(0.92); C256(0.66); C295(0.38); C298(0.38)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C24(0.96); C256(0.67); C295(0.40); C298(0.40)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C24(0.92); C256(0.46); C295(0.21); C298(0.21)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C24(0.98); C256(0.56); C295(0.22); C298(0.22)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C24(0.98); C256(0.52); C295(0.24); C298(0.24)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C24(0.92); C256(0.53); C295(0.25); C298(0.25)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C24(0.95); C256(0.92); C295(0.35); C298(0.33)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C24(0.91); C256(0.97); C295(0.27); C298(0.28)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C24(0.98); C256(1.00); C295(0.30); C298(0.34)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C24(0.98); C256(1.11); C295(0.54); C298(0.54)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C24(0.87); C256(0.77); C295(0.34); C298(0.30)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C24(0.85); C256(0.74); C295(0.27); C298(0.29)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C24(0.90); C256(0.76); C295(0.29); C298(0.30)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C162(0.96); C24(0.97); C256(1.14); C295(0.73)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C162(1.12); C24(1.07); C256(0.94); C295(0.55)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C162(1.13); C24(1.08); C256(0.70); C295(0.40)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C162(1.05); C24(1.00); C256(0.78); C295(0.45)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C162(0.94); C24(1.03); C256(0.90); C295(0.50)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C162(0.98); C24(1.22); C256(1.00); C295(0.63)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C162(0.96); C24(0.99); C256(0.92); C295(0.59)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C24(1.06); C256(1.30); C295(0.78); C298(0.78)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C162(1.19); C24(0.85); C256(0.88); C295(0.56)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C162(0.88); C24(1.22); C256(1.08); C295(0.73)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C162(0.88); C24(1.03); C256(1.11); C295(0.80)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C162(0.81); C24(1.03); C256(1.14); C295(0.79)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C162(0.75); C24(1.05); C256(1.06); C295(0.75)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C162(0.84); C24(1.12); C256(1.02); C295(0.74)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C162(0.80); C24(1.16); C256(0.80); C295(0.47)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C162(0.79); C24(1.23); C256(0.87); C295(0.45)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C162(0.29); C24(0.65); C256(1.01); C295(0.50)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C162(0.26); C24(1.07); C256(1.11); C295(1.70)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C162(0.26); C24(0.88); C256(1.12); C295(0.79)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C162(0.31); C24(1.24); C256(1.01); C295(1.38)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C162(0.25); C24(0.98); C256(1.34); C295(1.18)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C162(0.29); C24(1.01); C256(1.10); C295(0.73)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C162(0.24); C24(0.90); C256(0.88); C295(0.76)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C162(0.35); C24(1.00); C256(0.94); C295(0.84)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C162(0.33); C24(0.97); C256(1.06); C295(0.80)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C162(0.33); C24(1.15); C256(1.12); C295(1.11)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C162(0.31); C24(1.07); C256(0.90); C295(0.66)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C162(0.32); C24(1.03); C256(0.99); C295(0.91)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C24(1.19); C256(0.99); C295(0.62); C298(0.62)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C162(0.32); C24(1.01); C256(0.73); C295(0.68)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C162(0.29); C24(1.10); C256(0.77); C295(0.95)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C162(0.33); C24(1.13); C256(1.34); C295(1.27)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C24(0.79); C256(0.85); C162(0.92); C311(0.98)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C295(0.63); C256(0.63); C162(0.99); C311(1.03)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C256(0.79); C162(0.96); C311(1.01); C24(1.07)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C256(0.65); C295(0.91); C162(0.97); C311(0.98)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C256(0.60); C295(0.75); C162(0.98); C24(1.00)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C256(0.58); C295(0.61); C311(0.87); C162(0.95)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C256(0.57); C295(0.63); C311(0.86); C162(1.00)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C295(0.54); C298(0.54); C256(0.91); C24(1.12)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C256(0.87); C162(0.94); C295(1.00); C24(1.01)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C162(0.89); C311(0.91); C24(1.01); C256(1.09)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C295(0.55); C256(0.64); C311(1.02); C24(1.14)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C256(0.64); C295(0.65); C162(0.78); C311(0.92)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C162(0.94); C24(1.15); C256(0.76); C295(0.88)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C162(0.88); C24(1.21); C256(0.77); C295(1.00)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C162(0.84); C24(1.11); C256(1.00); C295(1.20)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C162(0.92); C24(1.14); C256(1.04); C295(0.86)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C295(0.82); C298(0.82); C162(0.97); C429(1.02)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C295(0.47); C298(0.47); C162(0.82); C311(0.88)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C295(0.82); C298(0.82); C162(0.97); C311(0.99)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C162(0.77); C295(0.80); C298(0.80); C429(0.97)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C295(0.92); C298(0.92); C24(0.99); C311(1.00)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C295(0.68); C298(0.68); C311(1.02); C429(1.06)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C295(0.89); C298(0.89); C162(1.04); C311(1.10)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C295(0.75); C298(0.75); C162(0.82); C311(0.97)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C162(0.86); C311(0.95); C429(1.03); C24(1.05)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C295(0.67); C298(0.67); C429(0.75); C256(0.89)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C295(0.64); C298(0.64); C256(0.74); C429(0.79)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C295(0.59); C298(0.59); C429(0.63); C256(0.84)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C295(0.61); C298(0.61); C429(0.74); C256(0.77)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C256(0.52); C295(0.62); C298(0.62); C24(0.71)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C295(0.82); C298(0.82); C429(0.89); C162(0.89)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C295(0.50); C298(0.50); C256(0.53); C429(0.63)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C295(0.55); C298(0.55); C429(0.63); C256(0.72)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C295(0.42); C298(0.42); C429(0.53); C256(0.55)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C429(0.55); C295(0.65); C298(0.65); C256(0.81)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C295(0.38); C298(0.38); C429(0.50); C256(0.75)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C162(0.97); C24(0.98); C429(1.04); C311(1.18)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C429(0.92); C311(0.97); C24(1.05); C162(1.31)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C429(0.85); C24(1.04); C311(1.05); C162(1.26)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C429(0.89); C311(0.92); C24(1.05); C256(1.15)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C311(0.95); C295(0.98); C298(0.98); C24(0.98)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C295(0.61); C298(0.61); C429(0.75); C162(0.82)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C295(0.77); C298(0.77); C429(0.80); C24(0.88)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C429(0.78); C24(0.88); C311(0.97); C295(1.04)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C429(0.83); C311(0.90); C295(0.90); C298(0.90)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C311(0.82); C429(0.88); C24(0.94); C295(1.14)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C429(0.83); C295(0.89); C298(0.89); C24(0.98)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C295(0.70); C298(0.70); C24(0.81); C429(0.82)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C24(0.71); C311(0.82); C256(1.02); C295(1.04)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C295(0.76); C298(0.85); C311(0.87); C24(0.90)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C24(0.73); C311(0.89); C295(1.23); C298(1.30)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C295(0.44); C298(0.47); C429(0.61); C256(0.69)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C295(0.59); C298(0.59); C429(0.74); C311(0.95)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C295(0.47); C298(0.52); C429(0.69); C256(0.73)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C311(0.96); C24(0.99); C256(1.48); C298(1.53)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C295(0.78); C298(0.79); C311(0.84); C24(0.96)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C295(0.56); C298(0.57); C429(0.80); C256(0.80)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C295(0.59); C298(0.63); C429(0.74); C311(0.81)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C295(0.46); C429(0.50); C298(0.53); C311(0.77)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C429(0.43); C295(0.49); C298(0.53); C311(0.74)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C256(0.56); C162(0.93); C311(0.99); C429(1.09)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C256(0.53); C429(0.97); C162(0.98); C311(0.99)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C256(0.39); C429(0.74); C162(0.87); C311(1.01)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C295(0.59); C298(0.59); C311(0.83); C256(0.87)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C256(0.66); C429(0.76); C311(0.92); C162(0.99)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C256(0.87); C429(0.88); C162(0.92); C311(1.13)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C256(0.39); C429(0.59); C162(0.82); C311(1.02)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C429(0.53); C256(0.62); C162(0.89); C311(1.08)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C256(0.39); C429(0.51); C162(0.91); C311(1.06)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C429(0.49); C256(0.50); C311(0.94); C162(0.99)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C256(0.59); C429(0.66); C162(0.87); C311(1.00)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C256(0.38); C429(0.60); C162(0.95); C24(1.01)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C295(0.60); C298(0.60); C256(0.86); C24(0.87)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C295(0.57); C298(0.57); C256(0.79); C24(0.84)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C295(0.72); C298(0.72); C311(0.89); C256(0.91)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C295(0.42); C298(0.42); C256(0.64); C311(0.90)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C295(0.89); C298(0.89); C24(0.94); C311(0.96)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C295(0.53); C298(0.53); C256(0.77); C311(0.88)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C295(0.42); C298(0.42); C256(0.74); C311(0.88)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C295(0.45); C298(0.45); C256(0.67); C24(0.90)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C295(0.47); C298(0.47); C256(0.75); C311(0.87)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C295(0.42); C298(0.42); C256(0.75); C24(0.87)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C295(0.44); C298(0.44); C256(0.65); C24(0.75)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C24(0.78); C311(0.97); C295(0.98); C298(0.98)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C295(0.70); C298(0.70); C256(0.86); C311(0.90)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C295(0.61); C298(0.61); C311(0.85); C24(0.86)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C295(0.53); C298(0.53); C24(0.84); C256(0.84)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C24(0.91); C311(0.95); C256(1.04); C295(1.39)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C295(0.55); C298(0.55); C256(0.80); C24(0.97)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C295(0.32); C298(0.32); C256(0.61); C162(1.04)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C295(0.36); C298(0.36); C256(0.55); C162(1.04)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C295(0.60); C298(0.60); C256(0.75); C162(0.78)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C295(0.57); C298(0.57); C162(0.60); C256(0.70)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C162(0.59); C295(0.86); C298(0.86); C256(1.00)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C162(0.58); C295(0.74); C298(0.74); C256(0.80)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C295(0.45); C298(0.45); C162(0.56); C256(0.60)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C162(0.81); C311(1.11); C256(1.12); C24(1.29)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C295(0.29); C298(0.29); C162(0.54); C256(0.74)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C295(0.33); C298(0.33); C256(0.62); C162(0.67)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C295(0.63); C298(0.63); C162(0.72); C256(0.81)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C162(0.67); C295(0.81); C298(0.81); C256(0.99)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C162(0.63); C256(0.89); C295(0.99); C298(0.99)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C295(0.52); C298(0.52); C162(0.73); C256(0.82)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C295(0.39); C298(0.39); C256(0.56); C162(0.70)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C295(0.14); C298(0.14); C256(0.42); C311(0.52)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C295(0.49); C298(0.49); C311(0.67); C256(0.74)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C24(0.39)  LDD2138  [36]
 LDCM0520  AKOS000195272 MDA-MB-231 C429(0.86); C24(0.88); C256(0.91)  LDD2113  [36]
 LDCM0248  AKOS034007472 HCT 116 C24(1.14); C256(1.07); C295(0.77); C298(0.77)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C295(0.61); C298(0.61); C311(0.98); C24(1.01)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C295(0.25); C298(0.25); C256(0.68); C311(0.95)  LDD0592  [11]
 LDCM0174  Arenobufagin Hep-G2 1.69  LDD0437  [34]
 LDCM0020  ARS-1620 HCC44 C311(1.09)  LDD0078  [11]
 LDCM0147  AZ0108 MDA-MB-468 1.96  LDD0376  [28]
 LDCM0146  AZ9482 MDA-MB-468 2.52  LDD0375  [28]
 LDCM0498  BS-3668 MDA-MB-231 C429(0.43); C24(0.43)  LDD2091  [36]
 LDCM0164  Camptothecin MCF-7 1.85  LDD0419  [32]
 LDCM0108  Chloroacetamide HeLa H742(0.00); H627(0.00); C429(0.00); C162(0.00)  LDD0222  [25]
 LDCM0367  CL1 HCT 116 C24(0.88); C429(0.89); C295(0.96); C298(0.96)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C295(0.53); C298(0.53); C429(0.82); C311(0.82)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C295(0.72); C298(0.72); C429(0.78); C162(0.97)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C295(0.52); C298(0.52); C256(0.81); C311(1.00)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C295(0.84); C298(0.84); C311(0.89); C256(0.95)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C295(0.73); C298(0.73); C256(1.09); C429(1.25)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C295(0.74); C298(0.74); C256(1.05); C311(1.06)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C295(0.63); C298(0.63); C311(0.86); C162(0.88)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C295(0.41); C298(0.41); C311(0.81); C429(0.98)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C295(0.36); C298(0.36); C311(0.79); C162(0.87)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C295(0.31); C298(0.31); C311(0.76); C162(0.90)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C295(0.60); C298(0.60); C311(0.80); C162(0.89)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C295(0.37); C298(0.37); C429(0.68); C162(0.73)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C295(0.51); C298(0.51); C311(0.72); C162(0.83)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C295(0.62); C298(0.62); C162(0.83); C311(0.85)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C256(0.74); C295(0.82); C298(0.82); C429(0.83)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C256(0.54); C295(0.55); C298(0.55); C429(0.59)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C256(0.48); C24(0.68); C295(0.71); C298(0.71)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C256(0.56); C295(0.69); C298(0.69); C24(0.73)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C295(0.61); C298(0.61); C429(0.73); C256(0.75)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C24(0.62); C295(0.70); C298(0.70); C256(0.80)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C162(0.73); C295(0.95); C298(0.95); C429(0.95)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C295(0.81); C298(0.81); C162(0.91); C24(0.92)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C295(0.42); C298(0.42); C429(0.64); C256(0.74)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C429(0.89); C311(0.94); C162(0.97); C24(0.99)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C311(0.71); C24(0.81); C256(0.90); C429(0.98)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C24(0.77); C295(0.85); C311(0.87); C298(0.89)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C295(0.53); C298(0.58); C24(0.74); C256(0.76)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C295(0.46); C298(0.49); C429(0.56); C256(0.74)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C162(0.79); C256(0.88); C429(0.88); C311(0.94)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C162(0.81); C24(0.85); C256(0.90); C311(0.91)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C256(0.78); C429(0.87); C162(0.91); C311(0.98)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C256(0.49); C429(0.89); C162(0.90); C311(0.90)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C256(0.86); C429(0.86); C311(0.88); C295(0.89)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C295(0.72); C298(0.72); C162(0.88); C311(0.90)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C429(0.75); C256(0.89); C295(0.92); C298(0.92)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C429(0.86); C311(0.91); C256(0.91); C24(0.92)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C311(0.93); C162(0.94); C24(0.97); C295(0.98)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C162(0.81); C311(0.94); C429(0.98); C24(1.06)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C295(0.81); C298(0.81); C162(0.83); C429(0.86)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C162(0.88); C24(0.94); C429(1.04); C311(1.05)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C295(0.50); C298(0.50); C429(0.63); C311(0.70)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C295(0.43); C298(0.43); C429(0.57); C311(0.68)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C295(0.43); C298(0.43); C429(0.47); C256(0.74)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C295(0.65); C298(0.65); C429(0.73); C311(0.81)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C295(0.42); C298(0.42); C429(0.55); C311(0.65)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C162(0.86); C24(1.04); C256(0.76); C295(0.48)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C162(0.70); C24(0.98); C256(0.82); C295(0.69)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C162(0.90); C24(1.09); C256(1.00); C295(0.65)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C162(0.66); C24(1.17); C256(0.86); C295(0.63)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C162(0.87); C24(1.20); C256(0.83); C295(0.60)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C162(1.04); C24(1.10); C256(1.09); C295(1.13)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C162(0.92); C24(1.22); C256(0.99); C295(0.96)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C24(1.01); C256(0.88); C295(0.58); C298(0.58)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C24(0.89); C256(0.95); C295(0.66); C298(0.66)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C24(0.90); C256(0.83); C295(0.54); C298(0.54)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C24(0.83); C256(0.66); C295(0.31); C298(0.31)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C24(0.91); C256(0.68); C295(0.28); C298(0.28)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C24(0.94); C256(0.61); C295(0.34); C298(0.34)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C24(0.92); C256(0.64); C295(0.28); C298(0.28)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C24(0.96); C256(0.70); C295(0.29); C298(0.29)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C162(0.96); C24(0.70); C256(0.91); C295(1.15)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C24(0.96); C256(0.64); C295(0.40); C298(0.40)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C24(1.01); C256(0.79); C295(0.42); C298(0.42)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C24(0.72); C256(0.74); C295(0.23); C298(0.23)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C24(0.85); C256(0.71); C295(0.29); C298(0.29)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C24(0.93); C256(0.74); C295(0.46); C298(0.46)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C24(0.88); C256(0.76); C295(0.35); C298(0.35)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C162(0.82); C24(0.92); C256(1.07); C295(1.72)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C162(0.81); C24(0.82); C256(1.06); C295(1.44)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C162(0.87); C24(1.05); C256(0.84); C295(1.44)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C162(0.88); C24(1.21); C256(1.16); C295(1.34)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C162(1.11); C24(1.17); C256(0.98); C295(0.69)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C162(0.93); C24(1.18); C256(1.13); C295(1.33)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C162(0.80); C24(1.13); C256(0.96); C295(1.26)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C162(0.88); C24(1.05); C256(1.07); C295(1.50)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C162(0.72); C24(0.81); C256(0.83); C295(1.53)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C162(0.83); C24(1.00); C256(1.19); C295(1.49)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C162(0.96); C24(1.06); C256(1.15); C295(1.74)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C162(0.91); C24(1.00); C256(0.93); C295(1.22)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C162(0.91); C24(0.97); C256(1.10); C295(1.48)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C162(0.80); C24(1.07); C256(1.02); C295(1.35)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C162(0.88); C24(1.16); C256(1.14); C295(1.24)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C162(1.04); C24(0.98); C256(1.03); C295(0.80)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C162(0.85); C24(1.10); C256(0.99); C295(1.08)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C24(1.21); C256(0.98); C295(0.82); C298(0.89)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C24(1.18); C256(1.00); C295(0.76); C298(0.83)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C24(1.25); C256(0.93); C295(0.71); C298(0.72)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C24(1.14); C256(0.62); C295(0.54); C298(0.56)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C24(1.14); C256(0.96); C295(0.72); C298(0.73)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C24(1.16); C256(0.55); C295(0.37); C298(0.38)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C24(1.24); C256(0.67); C295(0.56); C298(0.52)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C24(1.14); C256(0.86); C295(0.69); C298(0.66)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C24(1.18); C256(1.14); C295(1.00); C298(1.02)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C162(0.91); C24(1.10); C256(0.80); C295(0.48)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C24(1.08); C256(0.92); C295(0.69); C298(0.73)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C24(1.23); C256(0.84); C295(0.59); C298(0.63)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C24(1.10); C256(0.89); C295(0.94); C298(0.93)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C24(1.24); C256(0.80); C295(0.91); C298(0.78)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C24(1.20); C256(0.72); C295(0.67); C298(0.66)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C162(0.94); C24(0.92); C256(0.92); C295(0.97)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C162(0.90); C24(0.91); C256(1.09); C295(1.13)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C162(0.99); C24(1.16); C256(1.38); C295(0.90)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C162(0.93); C24(1.01); C256(1.38); C295(0.77)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C162(0.63); C24(0.99); C256(0.65); C295(0.38)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C162(1.08); C24(1.19); C256(1.25); C295(1.07)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C162(0.87); C24(1.15); C256(1.02); C295(0.92)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C162(0.85); C24(1.17); C256(1.18); C295(0.70)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C162(0.81); C24(0.90); C256(1.44); C295(0.65)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C162(0.87); C24(0.97); C256(1.08); C295(0.50)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C162(0.84); C24(0.87); C256(1.49); C295(0.62)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C162(0.83); C24(0.94); C256(1.07); C295(0.78)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C162(0.70); C24(1.06); C256(0.94); C295(0.65)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C162(0.70); C24(1.15); C256(1.08); C295(0.67)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C162(0.87); C24(1.17); C256(1.22); C295(0.64)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C162(1.11); C24(0.85); C256(0.84); C295(0.62)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C162(0.84); C24(0.97); C256(1.12); C295(1.21)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C162(0.80); C24(1.08); C256(1.04); C295(0.78)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C162(0.90); C24(1.02); C256(1.04); C295(0.76)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C162(1.02); C24(1.19); C256(1.21); C295(0.89)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C162(1.05); C24(1.14); C256(1.09); C295(0.67)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C162(0.77); C24(0.97); C256(0.98); C295(0.61)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C162(0.93); C24(0.99); C256(1.08); C295(0.79)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C162(0.84); C24(1.01); C256(1.08); C295(0.81)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C162(0.93); C24(1.11); C256(1.02); C295(0.66)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C162(0.84); C24(1.26); C256(1.20); C295(0.67)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C256(0.94); C429(0.88); C162(0.81); C311(0.98)  LDD1698  [37]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C24(1.58); C429(1.31); C162(0.75)  LDD1702  [36]
 LDCM0625  F8 Ramos C845(0.98); C256(0.91); C311(0.14)  LDD2187  [38]
 LDCM0572  Fragment10 Ramos C845(0.94); C311(0.03)  LDD2189  [38]
 LDCM0573  Fragment11 Ramos C845(2.16); C256(3.36)  LDD2190  [38]
 LDCM0574  Fragment12 Ramos C845(0.58); C256(0.73); C311(0.60)  LDD2191  [38]
 LDCM0575  Fragment13 Ramos C845(0.85)  LDD2192  [38]
 LDCM0576  Fragment14 Ramos C845(0.65); C256(0.63); C311(0.14)  LDD2193  [38]
 LDCM0579  Fragment20 Ramos C845(0.54); C256(0.62)  LDD2194  [38]
 LDCM0580  Fragment21 Ramos C845(0.91)  LDD2195  [38]
 LDCM0582  Fragment23 Ramos C845(0.89); C311(0.02)  LDD2196  [38]
 LDCM0578  Fragment27 Ramos C845(1.07)  LDD2197  [38]
 LDCM0586  Fragment28 Ramos C845(1.04)  LDD2198  [38]
 LDCM0588  Fragment30 Ramos C845(1.34); C256(0.56); C311(0.03)  LDD2199  [38]
 LDCM0589  Fragment31 Ramos C845(0.82)  LDD2200  [38]
 LDCM0590  Fragment32 Ramos C845(0.78)  LDD2201  [38]
 LDCM0468  Fragment33 HCT 116 C24(1.23); C256(0.88); C295(0.69); C298(0.73)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C845(0.93); C256(1.04); C311(0.86)  LDD2203  [38]
 LDCM0566  Fragment4 Ramos C311(0.08)  LDD2184  [38]
 LDCM0427  Fragment51 HCT 116 C24(0.69); C256(0.50); C295(0.25); C298(0.25)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C845(1.03)  LDD2204  [38]
 LDCM0569  Fragment7 Ramos C845(0.73); C256(0.66); C311(0.22)  LDD2186  [38]
 LDCM0571  Fragment9 Ramos C845(0.81); C311(0.17)  LDD2188  [38]
 LDCM0116  HHS-0101 DM93 Y889(0.35); Y344(0.67); Y645(6.02)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y775(0.27); Y344(0.49); Y930(0.55); Y889(0.67)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y889(0.33); Y775(0.47); Y344(0.59); Y645(0.92)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y889(0.43); Y775(0.54); Y344(1.06); Y645(1.12)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y889(0.27); Y344(0.39); Y645(1.18); Y775(1.28)  LDD0268  [9]
 LDCM0107  IAA HeLa H822(0.00); H742(0.00); H544(0.00); H627(0.00)  LDD0221  [25]
 LDCM0022  KB02 HCT 116 C311(6.69); C429(1.68); C162(1.23); C24(1.18)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C311(8.40); C429(1.36); C162(1.11); C24(1.34)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C311(9.55); C429(1.84); C162(1.46); C24(1.45)  LDD0082  [11]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C256(1.00); C845(0.88)  LDD2102  [36]
 LDCM0109  NEM HeLa H822(0.00); H742(0.00); H66(0.00); H544(0.00)  LDD0223  [25]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C429(0.49); C24(0.36); C256(1.02)  LDD2089  [36]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C256(1.50); C845(0.97)  LDD2090  [36]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C24(0.92); C845(0.57)  LDD2092  [36]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C429(0.86); C24(0.93); C256(0.88); C845(0.44)  LDD2093  [36]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C24(1.04); C256(1.64); C845(1.03)  LDD2094  [36]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C24(1.01); C256(0.75)  LDD2096  [36]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C256(0.71)  LDD2097  [36]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C24(0.64); C256(0.42); C845(0.81)  LDD2098  [36]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C429(0.94); C24(0.96); C256(1.31); C845(0.90)  LDD2099  [36]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C24(0.37); C256(0.38); C845(1.10)  LDD2100  [36]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C429(1.12); C256(0.83)  LDD2101  [36]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C24(0.37); C256(0.32); C845(1.29)  LDD2104  [36]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C24(1.11); C256(0.91); C845(0.77)  LDD2105  [36]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C845(1.03)  LDD2106  [36]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C24(1.03); C256(1.20); C845(1.09)  LDD2107  [36]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C24(0.46); C256(0.78); C845(1.07)  LDD2108  [36]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C429(0.18); C24(0.66); C256(0.42); C845(0.71)  LDD2109  [36]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C256(0.33); C845(2.04)  LDD2110  [36]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C429(0.89); C24(0.85); C256(0.89); C845(1.08)  LDD2111  [36]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C24(0.46); C256(0.50); C845(0.98)  LDD2114  [36]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C429(0.66); C24(0.43); C256(0.54)  LDD2115  [36]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C24(1.07); C256(1.02)  LDD2116  [36]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C429(0.52); C24(1.04); C256(0.96)  LDD2118  [36]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C429(2.45); C24(1.95); C256(2.63); C845(2.84)  LDD2119  [36]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C24(0.62); C256(0.76); C845(0.86)  LDD2120  [36]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C429(0.26); C24(1.01); C256(0.99)  LDD2122  [36]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C429(0.71); C24(0.76); C256(0.82); C845(0.69)  LDD2123  [36]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C429(0.34); C256(0.86); C845(0.77)  LDD2124  [36]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C24(0.60); C256(0.64); C845(0.71)  LDD2125  [36]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C429(0.44); C256(0.94)  LDD2126  [36]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C429(0.70); C24(0.91); C256(0.69); C845(0.99)  LDD2127  [36]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C24(0.68); C256(0.89)  LDD2128  [36]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C24(1.28); C256(1.32); C845(0.87)  LDD2129  [36]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C429(0.83); C256(0.49)  LDD2133  [36]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C429(0.47); C845(0.84)  LDD2134  [36]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C429(1.38); C24(1.65); C256(1.71); C845(0.58)  LDD2135  [36]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C429(0.87); C24(1.18); C256(0.98); C845(0.89)  LDD2136  [36]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C429(0.89); C24(0.94); C256(0.90); C845(1.02)  LDD2137  [36]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C256(2.15); C429(1.23); C24(0.65)  LDD1700  [36]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C429(0.51); C256(0.66); C845(0.71)  LDD2140  [36]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C24(0.49); C256(0.53); C845(0.69)  LDD2141  [36]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C429(0.95); C24(0.86); C256(0.91)  LDD2143  [36]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C429(2.94); C24(2.14); C256(2.86)  LDD2144  [36]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C24(0.22); C256(0.53); C845(7.25)  LDD2145  [36]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C429(0.78); C24(0.77); C256(0.79); C845(0.96)  LDD2146  [36]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C429(2.92); C24(2.01); C256(3.66)  LDD2147  [36]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C429(0.46); C256(0.51)  LDD2148  [36]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C429(0.69); C256(1.14)  LDD2149  [36]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C429(0.29); C24(0.36); C256(0.57)  LDD2150  [36]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C24(0.88); C256(1.19)  LDD2151  [36]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C256(1.36); C845(0.65)  LDD2153  [36]
 LDCM0148  Olaparib MDA-MB-468 2.81  LDD0377  [28]
 LDCM0131  RA190 MM1.R C429(1.46); C295(1.36); C298(1.36); C311(1.33)  LDD0304  [39]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [33]
 LDCM0021  THZ1 HCT 116 C162(1.01); C311(1.07); C24(1.06); C256(1.09)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aprataxin and PNK-like factor (APLF) APLF family Q8IW19
Poly [ADP-ribose] polymerase 1 (PARP1) ARTD/PARP family P09874
DNA (cytosine-5)-methyltransferase 1 (DNMT1) C5-methyltransferase family P26358
Tyrosine--tRNA ligase, cytoplasmic (YARS1) Class-I aminoacyl-tRNA synthetase family P54577
ATP-dependent DNA helicase Q1 (RECQL) Helicase family P46063
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN) Helicase family Q14191
Caspase-3 (CASP3) Peptidase C14A family P42574
E3 SUMO-protein ligase PIAS4 (PIAS4) PIAS family Q8N2W9
ADP-ribose glycohydrolase OARD1 (OARD1) . Q9Y530
Aprataxin (APTX) . Q7Z2E3
E3 ubiquitin-protein ligase RNF146 (RNF146) . Q9NTX7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCAAT/enhancer-binding protein alpha (CEBPA) BZIP family P49715
Transcription factor E2F1 (E2F1) E2F/DP family Q01094
Transcriptional regulator ERG (ERG) ETS family P11308
High mobility group protein B1 (HMGB1) HMGB family P09429
Zinc finger protein 423 (ZNF423) Krueppel C2H2-type zinc-finger protein family Q2M1K9
Zinc finger protein SNAI1 (SNAI1) Snail C2H2-type zinc-finger protein family O95863
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-24 (IL24) IL-10 family Q13007
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
DNA repair protein XRCC1 (XRCC1) . P18887

The Drug(s) Related To This Target

Approved
Click To Hide/Show 12 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ku-0058948 Small molecular drug D09LSX
Nicotinamide Small molecular drug D06NVJ
Niraparib Small molecular drug DB11793
Niraparib Tosylate Small molecular drug D0DN0W
Olaparib Small molecular drug DB09074
Rucaparib Small molecular drug DB12332
Talazoparib Small molecular drug DB11760
Theophylline Small molecular drug DB00277
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cc-486 Small molecular drug D09NTC
Nicaraven Small molecular drug D0Z2UW
Phase 2
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amxi 5001 Small molecular drug D8TE4F
Pmid27841036-compound-37 Small molecular drug D0F5TD
Stenoparib Small molecular drug DP48WE
Ag140699 . D06KZL
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nms-03305293 Small molecular drug DO0LP3
Preclinical
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pj34 Small molecular drug D04WDX
Cph-102 . D04ABS
Investigative
Click To Hide/Show 96 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(E)-n-(4-phenylthiazol-2-yl) Cinnamamide Small molecular drug D04ZQJ
1,2,3,4,4a,5-hexahydrophenanthridin-6(10bh)-one Small molecular drug D0FF4M
1,7,8,9-tetrahydro-1,5-diaza-trindene-4,6-dione Small molecular drug D0NU5Z
2,3-dihydro-1h-benzo[De]Isoquinolin-1-one Small molecular drug D05HJG
2,8-dimethyl-3h-quinazolin-4-one Small molecular drug D07SRJ
2-(2-chlorophenyl)-2h-indazole-7-carboxamide Small molecular drug D0TH7S
2-(3'-methoxyphenyl) Benzimidazole-4-carboxamide Small molecular drug D01YIR
2-(3-chlorophenyl)-2h-indazole-7-carboxamide Small molecular drug D0XZ5D
2-(3-piperidin-1-yl-propyl)-3h-quinazolin-4-one Small molecular drug D0U5WY
2-(4-amino-phenyl)-8-hydroxy-3h-quinazolin-4-one Small molecular drug D00TUB
2-(4-amino-phenyl)-8-methyl-3h-quinazolin-4-one Small molecular drug D0GA0Y
2-(4-azido-phenyl)-8-methoxy-3h-quinazolin-4-one Small molecular drug D0WO3P
2-(4-chlorophenyl)-2h-indazole-7-carboxamide Small molecular drug D0PT1K
2-(4-chlorophenyl)-5-quinoxalinecarboxamide Small molecular drug D08ZVM
2-(4-hydroxy-phenyl)-8-methyl-3h-quinazolin-4-one Small molecular drug D0Y1MH
2-(4-methoxy-phenyl)-8-methyl-3h-quinazolin-4-one Small molecular drug D0B2WX
2-(4-methoxyphenyl)Quinoline-8-carboxamide Small molecular drug D04TDX
2-benzyl-2h-indazole-7-carboxamide Small molecular drug D02QZF
2-ethylquinoline-8-carboxamide Small molecular drug D0Z3PB
2-methylquinoline-8-carboxamide Small molecular drug D0S8HZ
2-phenyl-2h-benzo[D][1,2,3]Triazole-4-carboxamide Small molecular drug D0I2AF
2-phenyl-2h-indazole-7-carboxamide Small molecular drug D0IX3I
2-phenylpyrazolo-[1,5-a]Pyridine-7-carboxamide Small molecular drug D08OUR
2-phenylquinoline-8-carboxamide Small molecular drug D0Z9DY
2h-isoquinolin-1-one Small molecular drug D07CRG
3-(4-aminophenyl)Quinoxaline-5-carboxamide Small molecular drug D08GMO
3-(4-cyanophenyl)Quinoxaline-5-carboxamide Small molecular drug D0M9TW
3-(4-methoxyphenyl)Quinoxaline-5-carboxamide Small molecular drug D0L1RZ
3-aminobenzamide Small molecular drug D0K2PD
3-aminobenzo[C][1,5]Naphthyridin-6(5h)-one Small molecular drug D0EI6X
3-ethenylquinoline-8-carboxamide Small molecular drug D0K7JT
3-ethylquinoline-8-carboxamide Small molecular drug D0UF0U
3-ethynylquinoline-8-carboxamide Small molecular drug D00OZA
3-hydroxy-benzamide Small molecular drug D05ZTI
3-methoxybenzamide Small molecular drug D02MPP
3-methylquinoline-8-carboxamide Small molecular drug D08XPZ
3-morpholin-4-ylmethyl-5h-phenanthridin-6-one Small molecular drug D0F8ZI
3-phenylquinoline-8-carboxamide Small molecular drug D0L1NQ
3-prop-1-ynylquinoline-8-carboxamide Small molecular drug D0T5TT
34-dihydro-5-methyl-isoquinolinone Small molecular drug DB03722
4-(4-morpholin-4-yl-butyl)-2h-phthalazin-1-one Small molecular drug D0GJ8U
4-(5-morpholin-4-yl-pentyl)-2h-phthalazin-1-one Small molecular drug D05WYN
4-amino-1,8-naphthalimide Small molecular drug D03JTS
4-benzylphthalazin-1(2h)-one Small molecular drug D08QWR
4-methylpyrrolo[3,4-c]Carbazole-1,3(2h,6h)-dione Small molecular drug D05GMW
5-amino-3,4-dihydroisoquinolin-1(2h)-one Small molecular drug D05RXG
5-aminoisoquinolin-1(2h)-one Small molecular drug D07WPL
5-chloro-2-methyl-3h-quinazolin-4-one Small molecular drug D01EVX
5-methylpyrrolo[3,4-c]Carbazole-1,3(2h,6h)-dione Small molecular drug D02XLC
6-amino-benzo[De]Isoquinoline-13-dione Small molecular drug DB07096
8-amino-6h,11h-indeno[1,2-c]Isoquinolin-5-one Small molecular drug D04ATU
8-fluoro-6h,11h-indeno[1,2-c]Isoquinolin-5-one Small molecular drug D0O0GA
8-hydroxy-2-(4-nitro-phenyl)-3h-quinazolin-4-one Small molecular drug D0G5VD
8-hydroxy-2-phenyl-3h-quinazolin-4-one Small molecular drug D0O6WW
8-methoxy-2-(4-nitro-phenyl)-3h-quinazolin-4-one Small molecular drug D0OF1I
8-methoxy-2-methyl-3h-quinazolin-4-one Small molecular drug D0T3SY
8-methoxy-2-phenyl-3h-quinazolin-4-one Small molecular drug D06NKJ
8-methyl-2-(4-nitro-phenyl)-3h-quinazolin-4-one Small molecular drug D07BPT
8-methyl-2-phenyl-3h-quinazolin-4-one Small molecular drug D0E5EW
8-nitro-6h,11h-indeno[1,2-c]Isoquinolin-5-one Small molecular drug D0E0QT
9-amino-6h,11h-indeno[1,2-c]Isoquinolin-5-one Small molecular drug D04UPQ
9-fluoro-6h,11h-indeno[1,2-c]Isoquinolin-5-one Small molecular drug D07BBR
A-620223 Small molecular drug D0VY5O
Ag-014376 Small molecular drug D05XMG
Benzo[C][1,5]Naphthyridin-6(5h)-one Small molecular drug D0M6WJ
Bz3 Small molecular drug D01RXM
Bz6 Small molecular drug D04LDH
Carba-nicotinamide-adenine-dinucleotide Small molecular drug D0JD1O
Carba-nicotinamide-adenine-dinucleotide Small molecular drug DB02498
Cep-6800 Small molecular drug D02GPJ
Dr2313 Small molecular drug D0W7XH
Eb-47 Small molecular drug D04AYN
Ku-58684 Small molecular drug D07QPV
Me0328 Small molecular drug D04QRM
N-(4-phenylthiazol-2-yl)Isonicotinamide Small molecular drug D00WMC
Pd-128763 Small molecular drug D0E2VC
Pyrrolo[3,4-c]Carbazole-1,3(2h,6h)-dione Small molecular drug D0R7HU
Pyrrolo[3,4-e]Indole-1,3(2h,6h)-dione Small molecular drug D03VNZ
Quinoline-8-carboxamide Small molecular drug D07AGU
Ti3 Small molecular drug D0E7UW
Ti4 Small molecular drug D0L6LO
[2(R,S)-2-sulfanylheptanoyl]-phe-ala Small molecular drug D09SZG
2-{3-[4-(4-fluorophenyl)-36-dihydro-1(2h)-pyridinyl]Propyl}-8-methyl-4(3h)-quinazolinone . DB03072
5-fluoro-1-[4-(4-phenyl-36-dihydropyridin-1(2h)-yl)Butyl]Quinazoline-24(1h3h)-dione . DB07787
Ang-2684 . D05APM
Ang-2864 . D02JHW
Bpi-704001 . D0R7FS
Bz5 . D0ZK3L
Hydamtiq . D0CA2S
Iniparib . DB13877
Ino-1002 . D08AOV
Kr-33889 . D05SYO
S-070 . D0P4DG
S-111 . D0EQ1J
Thieno-phenanthridin-6-one . D0EW8Y
Veliparib . DB07232
Patented
Click To Hide/Show 28 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
3-oxo-2,3-dihydro-1h-indazole-4-carboxamide Derivative 1 Small molecular drug D01KFW
3-oxo-2,3-dihydro-1h-indazole-4-carboxamide Derivative 2 Small molecular drug D0M0WS
3-oxo-2,3-dihydro-1h-indazole-4-carboxamide Derivative 3 Small molecular drug D09HUV
3-oxo-2,3-dihydro-1h-indazole-4-carboxamide Derivative 4 Small molecular drug D02QFM
3-oxo-2,3-dihydro-1h-indazole-4-carboxamide Derivative 5 Small molecular drug D09ZIM
3-phenyl Isoquinolin-1(2h) Derivative 1 Small molecular drug D0TD8R
3-phenyl Isoquinolin-1(2h) Derivative 2 Small molecular drug D0G8HX
4-carboxamido-isoindolinone Derivative 1 Small molecular drug D0O9FC
4-carboxamido-isoindolinone Derivative 2 Small molecular drug D08YPU
4-carboxamido-isoindolinone Derivative 3 Small molecular drug D0R0PO
4-carboxamido-isoindolinone Derivative 4 Small molecular drug D0Z5DI
4-carboxamido-isoindolinone Derivative 5 Small molecular drug D0GH4V
7-azaindole Derivative 8 Small molecular drug D09WUA
Benzimidazole Carboxamide Derivative 1 Small molecular drug D01PYO
Dihydrodiazepinocarbazolone Derivative 1 Small molecular drug D0P3YA
Dihydropyrido Phthalazinone Derivative 1 Small molecular drug D0B3QI
Dihydropyrido Phthalazinone Derivative 2 Small molecular drug D0J4GY
Phthalazine Derivative 3 Small molecular drug D0M9TG
Phthalazine Ketone Derivative 1 Small molecular drug D05ZBB
Phthalazine Ketone Derivative 2 Small molecular drug D0B4FV
Phthalazine Ketone Derivative 3 Small molecular drug D0AN7Z
Pmid27841036-compound-33 Small molecular drug D02KMI
Quinazolinedione Derivative 1 Small molecular drug D0J2SR
Quinazolinedione Derivative 2 Small molecular drug D0IX2C
Quinazolinedione Derivative 3 Small molecular drug D08KAH
Tetra-cyclic Pyridophthalazinone Derivative 1 Small molecular drug D0Z8IR
Tetra-hydro-quinoline Derivative 1 Small molecular drug D0MP4W
Tricyclic Indole Compound 13 Small molecular drug D0E9JI
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nu1025 Small molecular drug D0O3FX

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