Probe Name	PARPYnD					Probe Info
Probe concentration	1 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	TMT
Competitor Name	AZ0108					Competitor Info
Competitor Concentration	5 uM
In Vivo Experiment Model	Model Type			Living cell
	Derived Tissue			Breast
	Disease Model		Breast adenocarcinoma [ICD-11:2C60]
	Model Name		Human breast adenocarcinoma cells (MDA-MB-468)

Target ID	Target Name					Binding Ratio
LDTP13240	Poly [ADP-ribose] polymerase 2 (PARP2)					2.5
LDTP15484	Saccharopine dehydrogenase-like oxidoreductase (SCCPDH)					2.1
LDTP04183	Lanosterol synthase (LSS)					2.0
LDTP13282	Prenylcysteine oxidase 1 (PCYOX1)					2.0
LDTP02375	Poly [ADP-ribose] polymerase 1 (PARP1)					2.0
LDTP02175	Epoxide hydrolase 1 (EPHX1)					1.8
LDTP06375	Delta(24)-sterol reductase (DHCR24)					1.7
LDTP04051	Nicotinamide phosphoribosyltransferase (NAMPT)					1.7
LDTP08979	Prostaglandin reductase 2 (PTGR2)					1.6
LDTP04437	Aldehyde dehydrogenase family 3 member A2 (ALDH3A2)					1.6
LDTP06307	Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)					1.5
LDTP05348	Sterol 26-hydroxylase, mitochondrial (CYP27A1)					1.5
LDTP05171	Dermcidin (DCD)					1.4

Target ID	Target Name					Binding Ratio
LDTP14157	RNA-binding protein 8A (RBM8A)					1.6

Target ID	Target Name					Binding Ratio
LDTP05977	Nascent polypeptide-associated complex subunit alpha (NACA)					0.6

1	Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.