Details of the Target

General Information of Target

Target ID	LDTP06375
Target Name	Delta(24)-sterol reductase (DHCR24)
Gene Name	DHCR24
Gene ID	1718
Synonyms	KIAA0018; Delta(24)-sterol reductase; EC 1.3.1.72; 24-dehydrocholesterol reductase; 3-beta-hydroxysterol Delta-24-reductase; Diminuto/dwarf1 homolog; Seladin-1
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKL SSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMD ILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKY GLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKL RFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYY KPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVP PKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQ PGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREE FWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH
Target Type	Literature-reported
Target Bioclass	Enzyme
Family	FAD-binding oxidoreductase/transferase type 4 family
Subcellular location	Endoplasmic reticulum membrane
Function	Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
TTD ID	T90935
Uniprot ID	Q15392
DrugMap ID	TTTK0NH
Ensemble ID	ENST00000371269.9
HGNC ID	HGNC:2859
ChEMBL ID	CHEMBL2331059

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
COLO678	Substitution: p.Y328P	DBIA Probe Info
DANG	SNV: p.F14L	DBIA Probe Info
KASUMI2	SNV: p.H465Y	.
RT112	SNV: p.R375H	DBIA Probe Info
SNU1	SNV: p.G371S	DBIA Probe Info

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 24 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
m-APA Probe Info	13.39	LDD0402	[1]
TH211 Probe Info	Y300(16.15); Y378(10.72)	LDD0260	[2]
YN-4 Probe Info	100.00	LDD0445	[3]
BTD Probe Info	C252(2.19); C91(1.30)	LDD1700	[4]
AHL-Pu-1 Probe Info	C91(2.38)	LDD0170	[5]
EA-probe Probe Info	N.A.	LDD0440	[6]
DBIA Probe Info	C252(1.13)	LDD0078	[7]
ATP probe Probe Info	K367(0.00); K496(0.00); K509(0.00); K512(0.00)	LDD0199	[8]
4-Iodoacetamidophenylacetylene Probe Info	C252(0.00); C499(0.00); C474(0.00)	LDD0038	[9]
IA-alkyne Probe Info	C252(0.00); C91(0.00); C499(0.00); C187(0.00)	LDD0036	[9]
Lodoacetamide azide Probe Info	C252(0.00); C499(0.00); C91(0.00); C393(0.00)	LDD0037	[9]
WYneN Probe Info	N.A.	LDD0021	[10]
WYneO Probe Info	N.A.	LDD0022	[10]
IPM Probe Info	C252(0.00); C499(0.00)	LDD0005	[10]
PF-06672131 Probe Info	N.A.	LDD0017	[11]
STPyne Probe Info	K367(0.00); K509(0.00)	LDD0009	[10]
TFBX Probe Info	C499(0.00); C252(0.00)	LDD0148	[12]
VSF Probe Info	N.A.	LDD0007	[10]
Acrolein Probe Info	C499(0.00); C252(0.00); H307(0.00)	LDD0217	[13]
Crotonaldehyde Probe Info	H257(0.00); C499(0.00)	LDD0219	[13]
Methacrolein Probe Info	C499(0.00); C91(0.00)	LDD0218	[13]
W1 Probe Info	C499(0.00); C91(0.00)	LDD0236	[14]
AOyne Probe Info	15.00	LDD0443	[15]
NAIA_5 Probe Info	C393(0.00); C499(0.00); C252(0.00); C474(0.00)	LDD2223	[16]

PAL-AfBPP Probe

Click To Hide/Show 213 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
PARPYnD Probe Info	2.66	LDD0374	[17]
C001 Probe Info	7.57	LDD1711	[18]
C004 Probe Info	16.80	LDD1714	[18]
C006 Probe Info	5.06	LDD1715	[18]
C007 Probe Info	18.38	LDD1716	[18]
C010 Probe Info	5.66	LDD1719	[18]
C011 Probe Info	7.73	LDD1720	[18]
C014 Probe Info	9.58	LDD1723	[18]
C017 Probe Info	6.36	LDD1725	[18]
C018 Probe Info	8.34	LDD1726	[18]
C022 Probe Info	16.91	LDD1728	[18]
C026 Probe Info	8.00	LDD1732	[18]
C036 Probe Info	5.17	LDD1736	[18]
C039 Probe Info	7.57	LDD1739	[18]
C040 Probe Info	13.93	LDD1740	[18]
C041 Probe Info	8.57	LDD1741	[18]
C045 Probe Info	11.55	LDD1744	[18]
C049 Probe Info	8.88	LDD1747	[18]
C053 Probe Info	4.92	LDD1751	[18]
C055 Probe Info	13.93	LDD1752	[18]
C056 Probe Info	30.70	LDD1753	[18]
C058 Probe Info	6.23	LDD1755	[18]
C059 Probe Info	13.18	LDD1756	[18]
C063 Probe Info	21.26	LDD1760	[18]
C064 Probe Info	16.11	LDD1761	[18]
C067 Probe Info	12.13	LDD1763	[18]
C070 Probe Info	14.93	LDD1766	[18]
C071 Probe Info	11.24	LDD1767	[18]
C072 Probe Info	14.22	LDD1768	[18]
C073 Probe Info	19.29	LDD1769	[18]
C082 Probe Info	5.90	LDD1774	[18]
C085 Probe Info	14.03	LDD1777	[18]
C086 Probe Info	5.78	LDD1778	[18]
C087 Probe Info	8.75	LDD1779	[18]
C091 Probe Info	12.30	LDD1782	[18]
C092 Probe Info	21.56	LDD1783	[18]
C094 Probe Info	24.42	LDD1785	[18]
C095 Probe Info	7.11	LDD1786	[18]
C100 Probe Info	7.01	LDD1789	[18]
C106 Probe Info	28.84	LDD1793	[18]
C107 Probe Info	13.45	LDD1794	[18]
C108 Probe Info	15.67	LDD1795	[18]
C110 Probe Info	6.54	LDD1797	[18]
C112 Probe Info	22.63	LDD1799	[18]
C115 Probe Info	5.78	LDD1802	[18]
C122 Probe Info	7.11	LDD1808	[18]
C125 Probe Info	9.99	LDD1809	[18]
C129 Probe Info	10.63	LDD1811	[18]
C130 Probe Info	11.88	LDD1812	[18]
C134 Probe Info	30.70	LDD1816	[18]
C135 Probe Info	12.91	LDD1817	[18]
C136 Probe Info	5.78	LDD1818	[18]
C139 Probe Info	17.39	LDD1821	[18]
C140 Probe Info	19.70	LDD1822	[18]
C141 Probe Info	11.55	LDD1823	[18]
C143 Probe Info	16.34	LDD1825	[18]
C145 Probe Info	13.55	LDD1827	[18]
C147 Probe Info	14.62	LDD1829	[18]
C153 Probe Info	18.90	LDD1834	[18]
C159 Probe Info	18.64	LDD1839	[18]
C160 Probe Info	17.39	LDD1840	[18]
C161 Probe Info	25.63	LDD1841	[18]
C164 Probe Info	7.06	LDD1844	[18]
C165 Probe Info	14.52	LDD1845	[18]
C166 Probe Info	12.21	LDD1846	[18]
C169 Probe Info	28.84	LDD1849	[18]
C170 Probe Info	24.08	LDD1850	[18]
C171 Probe Info	27.67	LDD1851	[18]
C173 Probe Info	13.74	LDD1853	[18]
C174 Probe Info	15.56	LDD1854	[18]
C177 Probe Info	7.46	LDD1856	[18]
C178 Probe Info	17.03	LDD1857	[18]
C179 Probe Info	6.77	LDD1858	[18]
C180 Probe Info	7.94	LDD1859	[18]
C183 Probe Info	12.55	LDD1861	[18]
C184 Probe Info	11.71	LDD1862	[18]
C185 Probe Info	13.55	LDD1863	[18]
C187 Probe Info	18.00	LDD1865	[18]
C191 Probe Info	31.78	LDD1868	[18]
C193 Probe Info	5.82	LDD1869	[18]
C194 Probe Info	14.62	LDD1870	[18]
C197 Probe Info	8.17	LDD1873	[18]
C198 Probe Info	18.00	LDD1874	[18]
C199 Probe Info	6.36	LDD1875	[18]
C200 Probe Info	8.34	LDD1876	[18]
C201 Probe Info	44.32	LDD1877	[18]
C204 Probe Info	20.39	LDD1879	[18]
C205 Probe Info	5.90	LDD1880	[18]
C206 Probe Info	38.32	LDD1881	[18]
C208 Probe Info	44.63	LDD1883	[18]
C211 Probe Info	10.13	LDD1885	[18]
C213 Probe Info	26.91	LDD1887	[18]
C216 Probe Info	4.96	LDD1890	[18]
C218 Probe Info	22.32	LDD1892	[18]
C219 Probe Info	9.99	LDD1893	[18]
C220 Probe Info	40.79	LDD1894	[18]
C222 Probe Info	7.21	LDD1896	[18]
C225 Probe Info	8.51	LDD1898	[18]
C226 Probe Info	10.48	LDD1899	[18]
C228 Probe Info	36.00	LDD1901	[18]
C229 Probe Info	11.47	LDD1902	[18]
C231 Probe Info	30.06	LDD1904	[18]
C232 Probe Info	39.40	LDD1905	[18]
C233 Probe Info	13.64	LDD1906	[18]
C234 Probe Info	6.59	LDD1907	[18]
C235 Probe Info	29.65	LDD1908	[18]
C240 Probe Info	16.22	LDD1913	[18]
C242 Probe Info	9.65	LDD1915	[18]
C243 Probe Info	26.35	LDD1916	[18]
C246 Probe Info	24.59	LDD1919	[18]
C249 Probe Info	13.74	LDD1922	[18]
C252 Probe Info	12.21	LDD1925	[18]
C253 Probe Info	9.45	LDD1926	[18]
C256 Probe Info	5.21	LDD1929	[18]
C258 Probe Info	7.01	LDD1931	[18]
C260 Probe Info	5.21	LDD1932	[18]
C264 Probe Info	29.04	LDD1935	[18]
C265 Probe Info	21.56	LDD1936	[18]
C266 Probe Info	8.17	LDD1937	[18]
C269 Probe Info	6.02	LDD1939	[18]
C270 Probe Info	6.87	LDD1940	[18]
C271 Probe Info	11.96	LDD1941	[18]
C277 Probe Info	21.26	LDD1947	[18]
C280 Probe Info	23.92	LDD1950	[18]
C281 Probe Info	12.04	LDD1951	[18]
C282 Probe Info	24.08	LDD1952	[18]
C284 Probe Info	20.97	LDD1954	[18]
C286 Probe Info	7.57	LDD1956	[18]
C287 Probe Info	13.74	LDD1957	[18]
C288 Probe Info	19.97	LDD1958	[18]
C289 Probe Info	28.05	LDD1959	[18]
C290 Probe Info	19.70	LDD1960	[18]
C293 Probe Info	26.54	LDD1963	[18]
C296 Probe Info	18.77	LDD1966	[18]
C297 Probe Info	14.83	LDD1967	[18]
C302 Probe Info	6.45	LDD1971	[18]
C304 Probe Info	5.70	LDD1973	[18]
C305 Probe Info	18.00	LDD1974	[18]
C307 Probe Info	9.92	LDD1975	[18]
C311 Probe Info	11.24	LDD1978	[18]
C312 Probe Info	6.19	LDD1979	[18]
C316 Probe Info	5.94	LDD1982	[18]
C317 Probe Info	9.45	LDD1983	[18]
C322 Probe Info	7.67	LDD1988	[18]
C323 Probe Info	6.77	LDD1989	[18]
C326 Probe Info	16.91	LDD1990	[18]
C329 Probe Info	14.62	LDD1993	[18]
C332 Probe Info	5.13	LDD1995	[18]
C333 Probe Info	6.23	LDD1996	[18]
C342 Probe Info	12.38	LDD2004	[18]
C343 Probe Info	12.82	LDD2005	[18]
C346 Probe Info	11.08	LDD2007	[18]
C347 Probe Info	5.06	LDD2008	[18]
C348 Probe Info	12.47	LDD2009	[18]
C349 Probe Info	19.03	LDD2010	[18]
C350 Probe Info	57.68	LDD2011	[18]
C351 Probe Info	13.00	LDD2012	[18]
C353 Probe Info	16.22	LDD2014	[18]
C354 Probe Info	8.00	LDD2015	[18]
C355 Probe Info	24.59	LDD2016	[18]
C356 Probe Info	11.63	LDD2017	[18]
C357 Probe Info	6.45	LDD2018	[18]
C362 Probe Info	31.12	LDD2023	[18]
C363 Probe Info	17.27	LDD2024	[18]
C364 Probe Info	22.78	LDD2025	[18]
C366 Probe Info	7.36	LDD2027	[18]
C367 Probe Info	7.16	LDD2028	[18]
C373 Probe Info	7.06	LDD2033	[18]
C374 Probe Info	10.06	LDD2034	[18]
C376 Probe Info	8.22	LDD2036	[18]
C379 Probe Info	8.00	LDD2038	[18]
C380 Probe Info	17.03	LDD2039	[18]
C382 Probe Info	9.71	LDD2041	[18]
C383 Probe Info	15.45	LDD2042	[18]
C384 Probe Info	10.34	LDD2043	[18]
C386 Probe Info	15.35	LDD2045	[18]
C387 Probe Info	7.57	LDD2046	[18]
C388 Probe Info	51.27	LDD2047	[18]
C390 Probe Info	20.53	LDD2049	[18]
C399 Probe Info	7.31	LDD2058	[18]
C403 Probe Info	28.64	LDD2061	[18]
C405 Probe Info	5.82	LDD2063	[18]
C407 Probe Info	13.64	LDD2064	[18]
C408 Probe Info	6.15	LDD2065	[18]
C409 Probe Info	4.99	LDD2066	[18]
C413 Probe Info	18.77	LDD2069	[18]
C419 Probe Info	11.00	LDD2074	[18]
C420 Probe Info	12.64	LDD2075	[18]
C422 Probe Info	7.84	LDD2077	[18]
C424 Probe Info	18.64	LDD2079	[18]
C425 Probe Info	23.26	LDD2080	[18]
C426 Probe Info	13.36	LDD2081	[18]
C428 Probe Info	15.35	LDD2083	[18]
C429 Probe Info	22.63	LDD2084	[18]
C430 Probe Info	5.78	LDD2085	[18]
C431 Probe Info	18.13	LDD2086	[18]
C433 Probe Info	9.38	LDD2088	[18]
FFF probe11 Probe Info	20.00	LDD0471	[19]
FFF probe12 Probe Info	20.00	LDD0487	[19]
FFF probe13 Probe Info	20.00	LDD0475	[19]
FFF probe14 Probe Info	16.86	LDD0477	[19]
FFF probe15 Probe Info	8.78	LDD0478	[19]
FFF probe2 Probe Info	20.00	LDD0463	[19]
FFF probe3 Probe Info	20.00	LDD0464	[19]
FFF probe6 Probe Info	20.00	LDD0482	[19]
FFF probe9 Probe Info	9.79	LDD0470	[19]
JN0003 Probe Info	20.00	LDD0469	[19]
STS-1 Probe Info	N.A.	LDD0136	[20]
STS-2 Probe Info	N.A.	LDD0138	[20]
A-DA Probe Info	2.32	LDD0142	[21]
BD-F Probe Info	W337(0.00); D341(0.00); L339(0.00)	LDD0024	[22]
LD-F Probe Info	D341(0.00); W337(0.00)	LDD0015	[22]
OEA-DA Probe Info	20.00	LDD0046	[23]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0519	1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one	MDA-MB-231	C252(0.87)	LDD2112	[4]
LDCM0524	2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide	MDA-MB-231	C91(0.60); C252(1.31)	LDD2117	[4]
LDCM0558	2-Cyano-N-phenylacetamide	MDA-MB-231	C91(0.99)	LDD2152	[4]
LDCM0510	3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile	MDA-MB-231	C252(1.22)	LDD2103	[4]
LDCM0025	4SU-RNA	DM93	C91(2.38)	LDD0170	[5]
LDCM0214	AC1	HCT 116	C252(1.12); C499(0.68); C91(1.04)	LDD0531	[7]
LDCM0215	AC10	HCT 116	C252(1.00); C499(0.76); C91(1.47)	LDD0532	[7]
LDCM0216	AC100	HCT 116	C252(0.93); C499(0.71); C91(2.00)	LDD0533	[7]
LDCM0217	AC101	HCT 116	C252(1.07); C499(0.76); C91(1.29)	LDD0534	[7]
LDCM0218	AC102	HCT 116	C252(1.00); C499(0.83); C91(1.16)	LDD0535	[7]
LDCM0219	AC103	HCT 116	C252(0.95); C499(0.60); C91(1.04)	LDD0536	[7]
LDCM0220	AC104	HCT 116	C252(0.97); C499(1.22); C91(1.56)	LDD0537	[7]
LDCM0221	AC105	HCT 116	C252(0.96); C499(0.69); C91(1.30)	LDD0538	[7]
LDCM0222	AC106	HCT 116	C252(0.97); C499(0.71); C91(1.35)	LDD0539	[7]
LDCM0223	AC107	HCT 116	C252(0.95); C499(0.72); C91(1.07)	LDD0540	[7]
LDCM0224	AC108	HCT 116	C252(0.98); C499(0.54); C91(1.68)	LDD0541	[7]
LDCM0225	AC109	HCT 116	C252(0.99); C499(1.01); C91(1.44)	LDD0542	[7]
LDCM0226	AC11	HCT 116	C252(1.06); C499(0.83); C91(1.00)	LDD0543	[7]
LDCM0227	AC110	HCT 116	C252(0.98); C499(0.54); C91(1.96)	LDD0544	[7]
LDCM0228	AC111	HCT 116	C252(0.99); C499(0.74); C91(1.32)	LDD0545	[7]
LDCM0229	AC112	HCT 116	C252(1.00); C499(0.51); C91(1.18)	LDD0546	[7]
LDCM0230	AC113	HCT 116	C252(1.06); C499(0.91); C91(0.96)	LDD0547	[7]
LDCM0231	AC114	HCT 116	C252(1.04); C499(0.70); C91(0.91)	LDD0548	[7]
LDCM0232	AC115	HCT 116	C252(1.04); C499(0.67); C91(1.07)	LDD0549	[7]
LDCM0233	AC116	HCT 116	C252(1.07); C499(0.69); C91(1.18)	LDD0550	[7]
LDCM0234	AC117	HCT 116	C252(1.16); C499(0.79); C91(1.13)	LDD0551	[7]
LDCM0235	AC118	HCT 116	C252(1.00); C499(0.84); C91(1.51)	LDD0552	[7]
LDCM0236	AC119	HCT 116	C252(1.00); C499(0.72); C91(1.60)	LDD0553	[7]
LDCM0237	AC12	HCT 116	C252(0.83); C499(1.01); C91(1.44)	LDD0554	[7]
LDCM0238	AC120	HCT 116	C252(0.92); C499(0.72); C91(1.05)	LDD0555	[7]
LDCM0239	AC121	HCT 116	C252(1.06); C499(0.78); C91(0.90)	LDD0556	[7]
LDCM0240	AC122	HCT 116	C252(1.04); C499(0.78); C91(1.28)	LDD0557	[7]
LDCM0241	AC123	HCT 116	C252(1.07); C499(0.81); C91(0.88)	LDD0558	[7]
LDCM0242	AC124	HCT 116	C252(1.12); C499(0.88); C91(1.14)	LDD0559	[7]
LDCM0243	AC125	HCT 116	C252(1.05); C499(0.77); C91(1.06)	LDD0560	[7]
LDCM0244	AC126	HCT 116	C252(1.03); C499(0.70); C91(1.57)	LDD0561	[7]
LDCM0245	AC127	HCT 116	C252(1.06); C499(0.73); C91(1.37)	LDD0562	[7]
LDCM0246	AC128	HCT 116	C252(0.92); C474(0.60); C499(0.84); C91(0.91)	LDD0563	[7]
LDCM0247	AC129	HCT 116	C252(1.04); C474(0.76); C499(0.97); C91(1.12)	LDD0564	[7]
LDCM0249	AC130	HCT 116	C252(1.08); C474(0.75); C499(1.13); C91(2.02)	LDD0566	[7]
LDCM0250	AC131	HCT 116	C252(1.19); C474(1.09); C499(0.73); C91(1.39)	LDD0567	[7]
LDCM0251	AC132	HCT 116	C252(1.15); C474(0.89); C499(0.81); C91(1.36)	LDD0568	[7]
LDCM0252	AC133	HCT 116	C252(1.09); C474(0.63); C499(0.96); C91(1.43)	LDD0569	[7]
LDCM0253	AC134	HCT 116	C252(1.07); C474(0.61); C499(0.73); C91(1.73)	LDD0570	[7]
LDCM0254	AC135	HCT 116	C252(0.98); C474(0.69); C499(0.85); C91(0.69)	LDD0571	[7]
LDCM0255	AC136	HCT 116	C252(1.07); C474(0.81); C499(0.85); C91(1.33)	LDD0572	[7]
LDCM0256	AC137	HCT 116	C252(0.93); C474(0.95); C499(0.76); C91(1.36)	LDD0573	[7]
LDCM0257	AC138	HCT 116	C252(0.95); C474(0.63); C499(0.52); C91(1.10)	LDD0574	[7]
LDCM0258	AC139	HCT 116	C252(1.10); C474(0.60); C499(0.68); C91(1.15)	LDD0575	[7]
LDCM0259	AC14	HCT 116	C252(0.94); C499(0.81); C91(0.99)	LDD0576	[7]
LDCM0260	AC140	HCT 116	C252(1.06); C474(0.52); C499(0.50); C91(2.02)	LDD0577	[7]
LDCM0261	AC141	HCT 116	C252(0.99); C474(0.65); C499(0.45); C91(1.26)	LDD0578	[7]
LDCM0262	AC142	HCT 116	C252(1.19); C474(1.28); C499(0.79); C91(0.96)	LDD0579	[7]
LDCM0263	AC143	HCT 116	C252(1.12); C499(0.92); C91(0.99)	LDD0580	[7]
LDCM0264	AC144	HCT 116	C499(0.40); C91(0.77); C252(1.04)	LDD0581	[7]
LDCM0265	AC145	HCT 116	C499(0.55); C91(0.89); C252(1.10)	LDD0582	[7]
LDCM0266	AC146	HCT 116	C499(0.48); C252(0.89); C91(1.17)	LDD0583	[7]
LDCM0267	AC147	HCT 116	C499(0.38); C252(1.13); C91(1.15)	LDD0584	[7]
LDCM0268	AC148	HCT 116	C499(0.42); C91(1.02); C252(1.14)	LDD0585	[7]
LDCM0269	AC149	HCT 116	C499(0.40); C252(0.90); C91(0.98)	LDD0586	[7]
LDCM0270	AC15	HCT 116	C499(0.70); C252(1.01); C91(1.22)	LDD0587	[7]
LDCM0271	AC150	HCT 116	C499(0.62); C252(1.00); C91(1.04)	LDD0588	[7]
LDCM0272	AC151	HCT 116	C499(0.64); C91(1.07); C252(1.52)	LDD0589	[7]
LDCM0273	AC152	HCT 116	C499(0.37); C91(1.00); C252(1.13)	LDD0590	[7]
LDCM0274	AC153	HCT 116	C499(0.47); C91(0.98); C252(1.20)	LDD0591	[7]
LDCM0621	AC154	HCT 116	C252(1.13); C499(0.37); C91(1.18)	LDD2158	[7]
LDCM0622	AC155	HCT 116	C252(1.29); C499(0.40); C91(1.04)	LDD2159	[7]
LDCM0623	AC156	HCT 116	C252(1.07); C499(0.83); C91(1.07)	LDD2160	[7]
LDCM0624	AC157	HCT 116	C252(1.32); C499(0.84); C91(0.91)	LDD2161	[7]
LDCM0276	AC17	HCT 116	C499(1.01); C252(1.15); C91(1.16)	LDD0593	[7]
LDCM0277	AC18	HCT 116	C91(1.01); C499(1.03); C252(1.11)	LDD0594	[7]
LDCM0278	AC19	HCT 116	C91(0.88); C499(1.01); C252(1.15)	LDD0595	[7]
LDCM0279	AC2	HCT 116	C499(0.70); C252(1.06); C91(1.21)	LDD0596	[7]
LDCM0280	AC20	HCT 116	C499(0.87); C252(1.10); C91(1.11)	LDD0597	[7]
LDCM0281	AC21	HCT 116	C499(0.92); C252(1.06); C91(1.16)	LDD0598	[7]
LDCM0282	AC22	HCT 116	C499(1.00); C91(1.11); C252(1.15)	LDD0599	[7]
LDCM0283	AC23	HCT 116	C91(0.89); C499(0.90); C252(1.01)	LDD0600	[7]
LDCM0284	AC24	HCT 116	C91(0.82); C499(0.98); C252(1.14)	LDD0601	[7]
LDCM0285	AC25	HCT 116	C499(0.74); C91(0.88); C252(0.98)	LDD0602	[7]
LDCM0286	AC26	HCT 116	C499(0.61); C91(1.01); C252(1.12)	LDD0603	[7]
LDCM0287	AC27	HCT 116	C499(0.62); C91(0.91); C252(1.05)	LDD0604	[7]
LDCM0288	AC28	HCT 116	C499(0.60); C252(0.94); C91(1.53)	LDD0605	[7]
LDCM0289	AC29	HCT 116	C499(0.52); C252(1.02); C91(1.13)	LDD0606	[7]
LDCM0290	AC3	HCT 116	C499(0.71); C252(1.16); C91(1.20)	LDD0607	[7]
LDCM0291	AC30	HCT 116	C499(0.50); C252(1.00); C91(1.14)	LDD0608	[7]
LDCM0292	AC31	HCT 116	C499(0.62); C91(1.05); C252(1.21)	LDD0609	[7]
LDCM0293	AC32	HCT 116	C499(0.46); C91(1.07); C252(1.18)	LDD0610	[7]
LDCM0294	AC33	HCT 116	C499(0.45); C91(0.95); C252(0.95)	LDD0611	[7]
LDCM0295	AC34	HCT 116	C499(0.45); C91(0.93); C252(0.98)	LDD0612	[7]
LDCM0296	AC35	HCT 116	C252(0.97); C91(1.21); C499(1.48)	LDD0613	[7]
LDCM0297	AC36	HCT 116	C252(0.95); C499(1.21); C91(1.29)	LDD0614	[7]
LDCM0298	AC37	HCT 116	C252(1.03); C499(1.34); C91(1.38)	LDD0615	[7]
LDCM0299	AC38	HCT 116	C252(1.02); C91(1.20); C499(1.20)	LDD0616	[7]
LDCM0300	AC39	HCT 116	C252(1.02); C499(1.06); C91(1.27)	LDD0617	[7]
LDCM0301	AC4	HCT 116	C499(0.51); C91(1.05); C252(1.15)	LDD0618	[7]
LDCM0302	AC40	HCT 116	C499(0.83); C252(1.03); C91(1.17)	LDD0619	[7]
LDCM0303	AC41	HCT 116	C252(1.05); C499(1.08); C91(1.21)	LDD0620	[7]
LDCM0304	AC42	HCT 116	C499(0.97); C252(0.97); C91(1.08)	LDD0621	[7]
LDCM0305	AC43	HCT 116	C252(0.98); C499(1.11); C91(1.29)	LDD0622	[7]
LDCM0306	AC44	HCT 116	C252(1.07); C91(1.16); C499(1.19)	LDD0623	[7]
LDCM0307	AC45	HCT 116	C252(1.08); C499(1.16); C91(1.25)	LDD0624	[7]
LDCM0308	AC46	HCT 116	C91(0.89); C252(1.11); C499(1.22)	LDD0625	[7]
LDCM0309	AC47	HCT 116	C91(0.92); C252(1.09); C499(1.11)	LDD0626	[7]
LDCM0310	AC48	HCT 116	C91(0.90); C252(1.09); C499(1.64)	LDD0627	[7]
LDCM0311	AC49	HCT 116	C499(0.86); C252(1.00); C91(1.15)	LDD0628	[7]
LDCM0312	AC5	HCT 116	C499(0.52); C252(1.17); C91(1.31)	LDD0629	[7]
LDCM0313	AC50	HCT 116	C499(0.90); C252(1.00); C91(1.09)	LDD0630	[7]
LDCM0314	AC51	HCT 116	C91(0.74); C252(0.96); C499(1.56)	LDD0631	[7]
LDCM0315	AC52	HCT 116	C91(0.93); C252(1.04); C499(1.34)	LDD0632	[7]
LDCM0316	AC53	HCT 116	C91(0.91); C252(1.02); C499(1.05)	LDD0633	[7]
LDCM0317	AC54	HCT 116	C499(0.86); C91(1.05); C252(1.09)	LDD0634	[7]
LDCM0318	AC55	HCT 116	C91(0.98); C252(1.04); C499(1.11)	LDD0635	[7]
LDCM0319	AC56	HCT 116	C499(1.11); C252(1.13); C91(1.14)	LDD0636	[7]
LDCM0320	AC57	HCT 116	C499(0.31); C252(1.03); C91(1.45)	LDD0637	[7]
LDCM0321	AC58	HCT 116	C499(0.36); C252(0.97); C91(1.49)	LDD0638	[7]
LDCM0322	AC59	HCT 116	C499(0.27); C252(1.07); C91(1.58)	LDD0639	[7]
LDCM0323	AC6	HCT 116	C499(0.60); C252(1.05); C91(1.65)	LDD0640	[7]
LDCM0324	AC60	HCT 116	C499(0.33); C91(1.10); C252(1.13)	LDD0641	[7]
LDCM0325	AC61	HCT 116	C499(0.66); C252(1.17); C91(1.23)	LDD0642	[7]
LDCM0326	AC62	HCT 116	C499(0.31); C252(1.21); C91(1.36)	LDD0643	[7]
LDCM0327	AC63	HCT 116	C499(0.37); C252(1.11); C91(1.62)	LDD0644	[7]
LDCM0328	AC64	HCT 116	C499(0.32); C252(1.08); C91(1.26)	LDD0645	[7]
LDCM0329	AC65	HCT 116	C499(0.41); C252(1.15); C91(1.50)	LDD0646	[7]
LDCM0330	AC66	HCT 116	C499(0.43); C252(1.12); C91(1.37)	LDD0647	[7]
LDCM0331	AC67	HCT 116	C499(0.38); C252(1.18); C91(1.22)	LDD0648	[7]
LDCM0332	AC68	HCT 116	C474(0.69); C252(0.90); C499(0.90); C91(1.00)	LDD0649	[7]
LDCM0333	AC69	HCT 116	C474(0.85); C252(0.90); C499(1.10); C91(1.30)	LDD0650	[7]
LDCM0334	AC7	HCT 116	C499(0.78); C252(1.02); C91(1.46)	LDD0651	[7]
LDCM0335	AC70	HCT 116	C474(0.69); C252(0.96); C91(1.11); C499(1.20)	LDD0652	[7]
LDCM0336	AC71	HCT 116	C252(0.89); C474(0.95); C91(1.01); C499(1.17)	LDD0653	[7]
LDCM0337	AC72	HCT 116	C252(0.91); C474(1.08); C499(1.20); C91(1.20)	LDD0654	[7]
LDCM0338	AC73	HCT 116	C252(0.91); C474(1.04); C499(1.21); C91(1.42)	LDD0655	[7]
LDCM0339	AC74	HCT 116	C252(0.89); C499(1.07); C91(1.25); C474(1.54)	LDD0656	[7]
LDCM0340	AC75	HCT 116	C252(0.88); C499(0.98); C474(1.17); C91(1.65)	LDD0657	[7]
LDCM0341	AC76	HCT 116	C474(0.71); C252(0.89); C499(1.03); C91(1.08)	LDD0658	[7]
LDCM0342	AC77	HCT 116	C474(0.65); C252(0.94); C499(1.01); C91(1.37)	LDD0659	[7]
LDCM0343	AC78	HCT 116	C252(0.96); C91(0.97); C499(1.07); C474(1.12)	LDD0660	[7]
LDCM0344	AC79	HCT 116	C474(0.88); C252(0.96); C91(1.12); C499(1.14)	LDD0661	[7]
LDCM0345	AC8	HCT 116	C499(0.64); C252(0.94); C91(1.31)	LDD0662	[7]
LDCM0346	AC80	HCT 116	C474(0.91); C252(0.96); C499(1.17); C91(1.18)	LDD0663	[7]
LDCM0347	AC81	HCT 116	C252(0.99); C91(1.05); C499(1.22); C474(1.40)	LDD0664	[7]
LDCM0348	AC82	HCT 116	C252(1.00); C91(1.22); C474(1.24); C499(1.30)	LDD0665	[7]
LDCM0349	AC83	HCT 116	C252(0.82); C499(0.83); C91(1.26)	LDD0666	[7]
LDCM0350	AC84	HCT 116	C252(0.80); C499(0.82); C91(1.61)	LDD0667	[7]
LDCM0351	AC85	HCT 116	C499(0.94); C252(1.02); C91(1.36)	LDD0668	[7]
LDCM0352	AC86	HCT 116	C499(0.94); C252(0.99); C91(1.22)	LDD0669	[7]
LDCM0353	AC87	HCT 116	C499(0.79); C252(0.98); C91(1.34)	LDD0670	[7]
LDCM0354	AC88	HCT 116	C499(0.79); C252(0.86); C91(1.52)	LDD0671	[7]
LDCM0355	AC89	HCT 116	C252(0.83); C499(0.85); C91(1.26)	LDD0672	[7]
LDCM0357	AC90	HCT 116	C499(0.70); C252(1.08); C91(1.76)	LDD0674	[7]
LDCM0358	AC91	HCT 116	C252(0.79); C499(1.10); C91(1.13)	LDD0675	[7]
LDCM0359	AC92	HCT 116	C252(0.83); C499(1.11); C91(1.43)	LDD0676	[7]
LDCM0360	AC93	HCT 116	C252(0.97); C499(1.05); C91(1.52)	LDD0677	[7]
LDCM0361	AC94	HCT 116	C252(1.01); C499(1.48); C91(1.64)	LDD0678	[7]
LDCM0362	AC95	HCT 116	C499(0.68); C252(0.92); C91(1.51)	LDD0679	[7]
LDCM0363	AC96	HCT 116	C252(0.86); C499(1.34); C91(1.81)	LDD0680	[7]
LDCM0364	AC97	HCT 116	C499(0.65); C252(0.87); C91(1.74)	LDD0681	[7]
LDCM0365	AC98	HCT 116	C499(0.61); C252(1.05); C91(1.54)	LDD0682	[7]
LDCM0366	AC99	HCT 116	C499(0.69); C252(0.98); C91(1.34)	LDD0683	[7]
LDCM0520	AKOS000195272	MDA-MB-231	C252(0.83)	LDD2113	[4]
LDCM0248	AKOS034007472	HCT 116	C252(1.04); C499(1.13); C91(1.43)	LDD0565	[7]
LDCM0356	AKOS034007680	HCT 116	C499(0.91); C252(1.02); C91(1.35)	LDD0673	[7]
LDCM0275	AKOS034007705	HCT 116	C499(0.53); C252(0.97); C91(1.55)	LDD0592	[7]
LDCM0020	ARS-1620	HCC44	C252(1.13)	LDD0078	[7]
LDCM0147	AZ0108	MDA-MB-468	1.73	LDD0376	[17]
LDCM0108	Chloroacetamide	HeLa	C499(0.00); C252(0.00); H307(0.00)	LDD0222	[13]
LDCM0632	CL-Sc	Hep-G2	C499(20.00); C91(1.26)	LDD2227	[16]
LDCM0367	CL1	HCT 116	C91(0.98); C252(0.99); C499(1.10)	LDD0684	[7]
LDCM0368	CL10	HCT 116	C499(0.98); C252(1.09); C91(1.40)	LDD0685	[7]
LDCM0369	CL100	HCT 116	C499(0.52); C91(0.82); C252(1.00)	LDD0686	[7]
LDCM0370	CL101	HCT 116	C499(0.62); C91(0.93); C252(1.00)	LDD0687	[7]
LDCM0371	CL102	HCT 116	C499(0.87); C252(0.99); C91(1.10)	LDD0688	[7]
LDCM0372	CL103	HCT 116	C499(0.87); C252(0.95); C91(1.29)	LDD0689	[7]
LDCM0373	CL104	HCT 116	C499(0.94); C252(1.08); C91(1.27)	LDD0690	[7]
LDCM0374	CL105	HCT 116	C91(0.98); C499(1.15); C252(1.21)	LDD0691	[7]
LDCM0375	CL106	HCT 116	C91(0.86); C499(1.18); C252(1.20)	LDD0692	[7]
LDCM0376	CL107	HCT 116	C91(1.16); C499(1.22); C252(1.23)	LDD0693	[7]
LDCM0377	CL108	HCT 116	C91(1.22); C252(1.24); C499(1.28)	LDD0694	[7]
LDCM0378	CL109	HCT 116	C499(1.12); C252(1.15); C91(1.57)	LDD0695	[7]
LDCM0379	CL11	HCT 116	C499(0.91); C252(1.06); C91(1.16)	LDD0696	[7]
LDCM0380	CL110	HCT 116	C499(1.03); C252(1.13); C91(1.15)	LDD0697	[7]
LDCM0381	CL111	HCT 116	C499(0.86); C91(1.00); C252(1.28)	LDD0698	[7]
LDCM0382	CL112	HCT 116	C499(0.86); C91(0.90); C252(1.00)	LDD0699	[7]
LDCM0383	CL113	HCT 116	C499(0.43); C252(0.84); C91(1.00)	LDD0700	[7]
LDCM0384	CL114	HCT 116	C499(0.51); C91(0.96); C252(1.02)	LDD0701	[7]
LDCM0385	CL115	HCT 116	C499(0.54); C252(0.92); C91(0.93)	LDD0702	[7]
LDCM0386	CL116	HCT 116	C499(0.68); C91(0.93); C252(1.11)	LDD0703	[7]
LDCM0387	CL117	HCT 116	C252(0.97); C499(1.03); C91(1.15)	LDD0704	[7]
LDCM0388	CL118	HCT 116	C252(0.98); C499(1.00); C91(1.33)	LDD0705	[7]
LDCM0389	CL119	HCT 116	C499(1.02); C252(1.03); C91(1.28)	LDD0706	[7]
LDCM0390	CL12	HCT 116	C499(1.12); C252(1.13); C91(1.42)	LDD0707	[7]
LDCM0391	CL120	HCT 116	C252(1.00); C499(1.07); C91(1.47)	LDD0708	[7]
LDCM0392	CL121	HCT 116	C499(0.95); C252(1.04); C91(1.14)	LDD0709	[7]
LDCM0393	CL122	HCT 116	C91(0.86); C252(1.06); C499(1.18)	LDD0710	[7]
LDCM0394	CL123	HCT 116	C91(0.83); C499(0.84); C252(1.00)	LDD0711	[7]
LDCM0395	CL124	HCT 116	C499(0.90); C91(1.01); C252(1.03)	LDD0712	[7]
LDCM0396	CL125	HCT 116	C499(0.57); C252(1.08); C91(1.56)	LDD0713	[7]
LDCM0397	CL126	HCT 116	C499(0.37); C252(1.02); C91(1.97)	LDD0714	[7]
LDCM0398	CL127	HCT 116	C499(0.58); C252(1.15); C91(1.89)	LDD0715	[7]
LDCM0399	CL128	HCT 116	C499(0.25); C252(1.11); C91(1.63)	LDD0716	[7]
LDCM0400	CL13	HCT 116	C499(0.94); C252(0.95); C91(1.06)	LDD0717	[7]
LDCM0401	CL14	HCT 116	C499(0.93); C252(0.95); C91(1.13)	LDD0718	[7]
LDCM0402	CL15	HCT 116	C499(0.80); C252(0.88); C91(1.44)	LDD0719	[7]
LDCM0403	CL16	HCT 116	C252(1.02); C91(1.51)	LDD0720	[7]
LDCM0404	CL17	HCT 116	C474(0.64); C252(1.07); C91(1.10)	LDD0721	[7]
LDCM0405	CL18	HCT 116	C474(0.83); C252(1.05); C91(1.38)	LDD0722	[7]
LDCM0406	CL19	HCT 116	C474(0.79); C252(0.95); C91(1.06)	LDD0723	[7]
LDCM0407	CL2	HCT 116	C252(0.98); C91(1.07); C499(1.19)	LDD0724	[7]
LDCM0408	CL20	HCT 116	C474(0.76); C252(1.05); C91(1.06)	LDD0725	[7]
LDCM0409	CL21	HCT 116	C474(0.64); C252(0.92); C91(1.16)	LDD0726	[7]
LDCM0410	CL22	HCT 116	C252(0.99); C474(1.00); C91(1.18)	LDD0727	[7]
LDCM0411	CL23	HCT 116	C252(1.04); C474(1.29); C91(1.38)	LDD0728	[7]
LDCM0412	CL24	HCT 116	C474(0.73); C252(1.04); C91(1.53)	LDD0729	[7]
LDCM0413	CL25	HCT 116	C252(1.17); C474(0.92); C91(1.37)	LDD0730	[7]
LDCM0414	CL26	HCT 116	C252(1.18); C474(0.96); C91(1.24)	LDD0731	[7]
LDCM0415	CL27	HCT 116	C252(1.07); C474(0.85); C91(1.03)	LDD0732	[7]
LDCM0416	CL28	HCT 116	C252(1.03); C474(0.77); C91(1.34)	LDD0733	[7]
LDCM0417	CL29	HCT 116	C252(1.00); C474(0.86); C91(2.00)	LDD0734	[7]
LDCM0418	CL3	HCT 116	C252(0.84); C499(0.90); C91(1.00)	LDD0735	[7]
LDCM0419	CL30	HCT 116	C252(1.49); C474(0.99); C91(1.24)	LDD0736	[7]
LDCM0420	CL31	HCT 116	C252(0.96); C474(0.77); C499(0.78); C91(1.45)	LDD0737	[7]
LDCM0421	CL32	HCT 116	C252(1.09); C474(1.22); C499(0.87); C91(1.18)	LDD0738	[7]
LDCM0422	CL33	HCT 116	C252(0.97); C474(0.72); C499(0.80); C91(1.38)	LDD0739	[7]
LDCM0423	CL34	HCT 116	C252(1.04); C474(0.62); C499(0.83); C91(0.66)	LDD0740	[7]
LDCM0424	CL35	HCT 116	C252(1.05); C474(0.84); C499(0.78); C91(1.67)	LDD0741	[7]
LDCM0425	CL36	HCT 116	C252(0.92); C474(0.48); C499(0.71); C91(0.97)	LDD0742	[7]
LDCM0426	CL37	HCT 116	C252(0.89); C474(0.54); C499(0.81); C91(1.17)	LDD0743	[7]
LDCM0428	CL39	HCT 116	C252(1.04); C474(0.61); C499(0.73); C91(1.25)	LDD0745	[7]
LDCM0429	CL4	HCT 116	C252(0.88); C499(0.73); C91(1.03)	LDD0746	[7]
LDCM0430	CL40	HCT 116	C252(0.84); C474(0.51); C499(0.61); C91(1.30)	LDD0747	[7]
LDCM0431	CL41	HCT 116	C252(1.01); C474(0.47); C499(0.84); C91(1.08)	LDD0748	[7]
LDCM0432	CL42	HCT 116	C252(1.02); C474(0.86); C499(0.73); C91(1.28)	LDD0749	[7]
LDCM0433	CL43	HCT 116	C252(0.97); C474(0.80); C499(0.73); C91(1.26)	LDD0750	[7]
LDCM0434	CL44	HCT 116	C252(0.94); C474(0.71); C499(0.81); C91(1.21)	LDD0751	[7]
LDCM0435	CL45	HCT 116	C252(1.02); C474(0.68); C499(0.59); C91(1.36)	LDD0752	[7]
LDCM0436	CL46	HCT 116	C252(1.19); C499(1.03); C91(0.82)	LDD0753	[7]
LDCM0437	CL47	HCT 116	C252(1.21); C499(1.10); C91(0.95)	LDD0754	[7]
LDCM0438	CL48	HCT 116	C252(1.17); C499(1.12); C91(1.00)	LDD0755	[7]
LDCM0439	CL49	HCT 116	C252(1.10); C499(1.31); C91(0.99)	LDD0756	[7]
LDCM0440	CL5	HCT 116	C252(1.09); C499(0.95); C91(1.29)	LDD0757	[7]
LDCM0441	CL50	HCT 116	C252(0.90); C499(1.03); C91(0.96)	LDD0758	[7]
LDCM0442	CL51	HCT 116	C252(1.03); C499(0.96); C91(0.88)	LDD0759	[7]
LDCM0443	CL52	HCT 116	C252(1.15); C499(0.90); C91(0.90)	LDD0760	[7]
LDCM0444	CL53	HCT 116	C252(1.02); C499(0.88); C91(0.88)	LDD0761	[7]
LDCM0445	CL54	HCT 116	C252(1.18); C499(0.94); C91(1.08)	LDD0762	[7]
LDCM0446	CL55	HCT 116	C252(1.17); C499(1.13); C91(0.92)	LDD0763	[7]
LDCM0447	CL56	HCT 116	C252(1.09); C499(1.08); C91(1.00)	LDD0764	[7]
LDCM0448	CL57	HCT 116	C252(1.01); C499(1.14); C91(1.04)	LDD0765	[7]
LDCM0449	CL58	HCT 116	C252(1.20); C499(1.10); C91(0.91)	LDD0766	[7]
LDCM0450	CL59	HCT 116	C252(1.13); C499(1.14); C91(0.92)	LDD0767	[7]
LDCM0451	CL6	HCT 116	C252(0.98); C499(1.04); C91(1.31)	LDD0768	[7]
LDCM0452	CL60	HCT 116	C252(1.11); C499(1.08); C91(1.08)	LDD0769	[7]
LDCM0453	CL61	HCT 116	C252(1.28); C499(0.85); C91(1.40)	LDD0770	[7]
LDCM0454	CL62	HCT 116	C252(1.21); C499(0.75); C91(1.34)	LDD0771	[7]
LDCM0455	CL63	HCT 116	C252(1.20); C499(0.62); C91(1.44)	LDD0772	[7]
LDCM0456	CL64	HCT 116	C252(1.08); C499(0.42); C91(1.66)	LDD0773	[7]
LDCM0457	CL65	HCT 116	C252(1.11); C499(0.68); C91(1.67)	LDD0774	[7]
LDCM0458	CL66	HCT 116	C252(1.14); C499(0.40); C91(1.73)	LDD0775	[7]
LDCM0459	CL67	HCT 116	C252(1.11); C499(0.41); C91(1.28)	LDD0776	[7]
LDCM0460	CL68	HCT 116	C252(1.20); C499(0.57); C91(1.49)	LDD0777	[7]
LDCM0461	CL69	HCT 116	C252(1.11); C499(1.31); C91(1.62)	LDD0778	[7]
LDCM0462	CL7	HCT 116	C252(1.16); C499(1.09); C91(1.13)	LDD0779	[7]
LDCM0463	CL70	HCT 116	C252(1.32); C499(0.76); C91(1.31)	LDD0780	[7]
LDCM0464	CL71	HCT 116	C252(1.14); C499(0.52); C91(1.36)	LDD0781	[7]
LDCM0465	CL72	HCT 116	C252(1.20); C499(0.84); C91(1.34)	LDD0782	[7]
LDCM0466	CL73	HCT 116	C252(1.10); C499(0.43); C91(1.79)	LDD0783	[7]
LDCM0467	CL74	HCT 116	C252(1.10); C499(0.44); C91(1.57)	LDD0784	[7]
LDCM0469	CL76	HCT 116	C252(0.90); C499(0.72); C91(1.34)	LDD0786	[7]
LDCM0470	CL77	HCT 116	C252(0.88); C499(0.67); C91(1.50)	LDD0787	[7]
LDCM0471	CL78	HCT 116	C252(0.98); C499(0.57); C91(1.11)	LDD0788	[7]
LDCM0472	CL79	HCT 116	C252(0.95); C499(0.61); C91(0.96)	LDD0789	[7]
LDCM0473	CL8	HCT 116	C252(0.83); C499(0.76); C91(1.64)	LDD0790	[7]
LDCM0474	CL80	HCT 116	C252(0.97); C499(0.93); C91(0.98)	LDD0791	[7]
LDCM0475	CL81	HCT 116	C252(0.91); C499(0.62); C91(1.01)	LDD0792	[7]
LDCM0476	CL82	HCT 116	C252(0.97); C499(0.63); C91(1.04)	LDD0793	[7]
LDCM0477	CL83	HCT 116	C252(0.98); C499(0.58); C91(1.00)	LDD0794	[7]
LDCM0478	CL84	HCT 116	C252(0.95); C499(0.58); C91(1.07)	LDD0795	[7]
LDCM0479	CL85	HCT 116	C252(0.95); C499(0.58); C91(1.17)	LDD0796	[7]
LDCM0480	CL86	HCT 116	C252(0.94); C499(0.67); C91(1.52)	LDD0797	[7]
LDCM0481	CL87	HCT 116	C252(0.88); C499(0.64); C91(1.61)	LDD0798	[7]
LDCM0482	CL88	HCT 116	C252(0.87); C499(0.62); C91(1.31)	LDD0799	[7]
LDCM0483	CL89	HCT 116	C252(0.93); C499(0.64); C91(1.06)	LDD0800	[7]
LDCM0484	CL9	HCT 116	C252(1.04); C499(0.95); C91(1.24)	LDD0801	[7]
LDCM0485	CL90	HCT 116	C252(0.82); C499(0.73); C91(1.52)	LDD0802	[7]
LDCM0486	CL91	HCT 116	C252(1.07); C499(0.73); C91(0.80)	LDD0803	[7]
LDCM0487	CL92	HCT 116	C252(0.92); C499(0.79); C91(1.06)	LDD0804	[7]
LDCM0488	CL93	HCT 116	C252(1.01); C499(0.79); C91(0.79)	LDD0805	[7]
LDCM0489	CL94	HCT 116	C252(0.97); C499(0.56); C91(1.09)	LDD0806	[7]
LDCM0490	CL95	HCT 116	C252(0.91); C499(0.53); C91(1.25)	LDD0807	[7]
LDCM0491	CL96	HCT 116	C252(1.02); C499(0.57); C91(1.02)	LDD0808	[7]
LDCM0492	CL97	HCT 116	C252(1.05); C499(0.51); C91(1.17)	LDD0809	[7]
LDCM0493	CL98	HCT 116	C252(1.11); C499(0.49); C91(1.18)	LDD0810	[7]
LDCM0494	CL99	HCT 116	C252(1.08); C499(0.49); C91(1.31)	LDD0811	[7]
LDCM0189	Compound 16	HEK-293T	45.45	LDD0492	[19]
LDCM0185	Compound 17	HEK-293T	5.45	LDD0504	[19]
LDCM0184	Compound 20	HEK-293T	16.95	LDD0503	[19]
LDCM0191	Compound 21	HEK-293T	3.32	LDD0493	[19]
LDCM0187	Compound 32	HEK-293T	11.36	LDD0507	[19]
LDCM0188	Compound 33	HEK-293T	6.69	LDD0505	[19]
LDCM0190	Compound 34	HEK-293T	16.95	LDD0497	[19]
LDCM0192	Compound 35	HEK-293T	9.48	LDD0491	[19]
LDCM0194	Compound 37	HEK-293T	14.39	LDD0498	[19]
LDCM0195	Compound 38	HEK-293T	15.75	LDD0499	[19]
LDCM0196	Compound 39	HEK-293T	7.02	LDD0496	[19]
LDCM0197	Compound 40	HEK-293T	18.35	LDD0495	[19]
LDCM0495	E2913	HEK-293T	C474(1.14); C252(0.86); C91(1.22); C499(0.78)	LDD1698	[24]
LDCM0213	Electrophilic fragment 2	MDA-MB-231	C252(2.55)	LDD1702	[4]
LDCM0175	Ethacrynic acid	HeLa	N.A.	LDD0440	[6]
LDCM0625	F8	Ramos	C252(0.99); C499(0.94); 1.20; C91(1.37)	LDD2187	[25]
LDCM0082	FK866	A-549	2.32	LDD0142	[21]
LDCM0572	Fragment10	Ramos	C252(0.51); C499(1.39)	LDD2189	[25]
LDCM0573	Fragment11	Ramos	C252(0.24); 2.04	LDD2190	[25]
LDCM0574	Fragment12	Ramos	C252(0.41); C499(1.64)	LDD2191	[25]
LDCM0575	Fragment13	Ramos	C252(0.44); C499(1.03)	LDD2192	[25]
LDCM0576	Fragment14	Ramos	C252(1.31); C499(2.21); C91(1.37)	LDD2193	[25]
LDCM0579	Fragment20	Ramos	C252(0.40)	LDD2194	[25]
LDCM0580	Fragment21	Ramos	C252(1.01); C499(1.01)	LDD2195	[25]
LDCM0582	Fragment23	Ramos	C252(0.40); C499(0.80)	LDD2196	[25]
LDCM0578	Fragment27	Ramos	C252(0.46); C499(0.80)	LDD2197	[25]
LDCM0586	Fragment28	Ramos	C252(0.76); C499(0.51); 1.00; C91(3.15)	LDD2198	[25]
LDCM0588	Fragment30	Ramos	C252(0.52); C499(0.82)	LDD2199	[25]
LDCM0589	Fragment31	Ramos	C252(0.47); C499(1.02)	LDD2200	[25]
LDCM0590	Fragment32	Ramos	C252(0.31); C499(1.04)	LDD2201	[25]
LDCM0468	Fragment33	HCT 116	C252(1.44); C499(0.46); C91(1.72)	LDD0785	[7]
LDCM0596	Fragment38	Ramos	C252(0.53); C499(0.75)	LDD2203	[25]
LDCM0566	Fragment4	Ramos	C252(1.30); C499(1.88); 2.50; C91(2.34)	LDD2184	[25]
LDCM0427	Fragment51	HCT 116	C252(0.82); C474(0.70); C499(0.43); C91(1.85)	LDD0744	[7]
LDCM0610	Fragment52	Ramos	C252(1.13); C499(1.12)	LDD2204	[25]
LDCM0614	Fragment56	Ramos	C252(0.53); C499(0.83)	LDD2205	[25]
LDCM0569	Fragment7	Ramos	C252(0.81); C499(2.33)	LDD2186	[25]
LDCM0571	Fragment9	Ramos	C252(0.59)	LDD2188	[25]
LDCM0015	HNE	MDA-MB-231	0.99; C252(0.96)	LDD0346	[25]
LDCM0107	IAA	HeLa	C499(0.00); H257(0.00)	LDD0221	[13]
LDCM0022	KB02	HCT 116	C252(1.11)	LDD0080	[7]
LDCM0023	KB03	HCT 116	C252(1.15)	LDD0081	[7]
LDCM0024	KB05	HCT 116	C252(1.02)	LDD0082	[7]
LDCM0509	N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide	MDA-MB-231	C252(0.93)	LDD2102	[4]
LDCM0109	NEM	HeLa	H381(0.00); H307(0.00)	LDD0223	[13]
LDCM0496	Nucleophilic fragment 11a	MDA-MB-231	C499(0.83)	LDD2089	[4]
LDCM0500	Nucleophilic fragment 13a	MDA-MB-231	C91(0.95); C252(1.00)	LDD2093	[4]
LDCM0504	Nucleophilic fragment 15a	MDA-MB-231	C252(1.15)	LDD2097	[4]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C91(0.38); C252(0.93)	LDD2099	[4]
LDCM0507	Nucleophilic fragment 16b	MDA-MB-231	C252(0.83)	LDD2100	[4]
LDCM0508	Nucleophilic fragment 17a	MDA-MB-231	C252(0.88)	LDD2101	[4]
LDCM0511	Nucleophilic fragment 18b	MDA-MB-231	C252(0.56)	LDD2104	[4]
LDCM0513	Nucleophilic fragment 19b	MDA-MB-231	C252(0.87)	LDD2106	[4]
LDCM0514	Nucleophilic fragment 20a	MDA-MB-231	C252(1.06); C499(0.97)	LDD2107	[4]
LDCM0515	Nucleophilic fragment 20b	MDA-MB-231	C252(0.58)	LDD2108	[4]
LDCM0516	Nucleophilic fragment 21a	MDA-MB-231	C91(0.45); C252(0.48)	LDD2109	[4]
LDCM0517	Nucleophilic fragment 21b	MDA-MB-231	C252(1.02)	LDD2110	[4]
LDCM0518	Nucleophilic fragment 22a	MDA-MB-231	C91(1.00); C252(1.16)	LDD2111	[4]
LDCM0521	Nucleophilic fragment 23b	MDA-MB-231	C252(0.70)	LDD2114	[4]
LDCM0522	Nucleophilic fragment 24a	MDA-MB-231	C252(0.57)	LDD2115	[4]
LDCM0526	Nucleophilic fragment 26a	MDA-MB-231	C91(1.82); C252(2.47)	LDD2119	[4]
LDCM0530	Nucleophilic fragment 28a	MDA-MB-231	C91(0.52); C252(0.74)	LDD2123	[4]
LDCM0532	Nucleophilic fragment 29a	MDA-MB-231	C91(0.62); C499(1.71)	LDD2125	[4]
LDCM0534	Nucleophilic fragment 30a	MDA-MB-231	C91(0.52); C252(0.96)	LDD2127	[4]
LDCM0536	Nucleophilic fragment 31	MDA-MB-231	C91(0.35)	LDD2129	[4]
LDCM0540	Nucleophilic fragment 35	MDA-MB-231	C252(0.63)	LDD2133	[4]
LDCM0541	Nucleophilic fragment 36	MDA-MB-231	C252(3.45)	LDD2134	[4]
LDCM0542	Nucleophilic fragment 37	MDA-MB-231	C91(1.12); C252(1.05)	LDD2135	[4]
LDCM0543	Nucleophilic fragment 38	MDA-MB-231	C91(1.20)	LDD2136	[4]
LDCM0544	Nucleophilic fragment 39	MDA-MB-231	C91(0.42); C252(0.94)	LDD2137	[4]
LDCM0211	Nucleophilic fragment 3b	MDA-MB-231	C252(2.19); C91(1.30)	LDD1700	[4]
LDCM0546	Nucleophilic fragment 40	MDA-MB-231	C91(0.42)	LDD2140	[4]
LDCM0547	Nucleophilic fragment 41	MDA-MB-231	C252(0.66)	LDD2141	[4]
LDCM0550	Nucleophilic fragment 5a	MDA-MB-231	C91(1.41)	LDD2144	[4]
LDCM0551	Nucleophilic fragment 5b	MDA-MB-231	C252(4.42)	LDD2145	[4]
LDCM0552	Nucleophilic fragment 6a	MDA-MB-231	C91(1.03); C252(0.71)	LDD2146	[4]
LDCM0554	Nucleophilic fragment 7a	MDA-MB-231	C252(4.29)	LDD2148	[4]
LDCM0556	Nucleophilic fragment 8a	MDA-MB-231	C91(0.99)	LDD2150	[4]
LDCM0627	NUDT7-COV-1	HEK-293T	C499(1.39); C474(0.96); C91(0.28)	LDD2206	[26]
LDCM0148	Olaparib	MDA-MB-468	1.51	LDD0377	[17]
LDCM0628	OTUB2-COV-1	HEK-293T	C499(2.85); C499(1.00); C252(0.84); C91(0.81)	LDD2207	[26]
LDCM0021	THZ1	HCT 116	C499(1.01)	LDD2173	[7]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Preclinical

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
T-226293				Small molecular drug	D0K6NS

Investigative

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Diazacholesterol				.	D06IAT

References

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3	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
5	Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z. Mass spectrometry data entry: PXD044625
6	Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
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10	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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12	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
13	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
17	Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.
18	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
19	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21	A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
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Details of the Target

Citation

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni