General Information of Experiment

Probe Name C018  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 17 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 12.8
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 11.6
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 10.9
 LDTP03540  Heme oxygenase 2 (HMOX2) 9.3
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 8.3
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 7.8
 LDTP13751  Exonuclease 1 (EXO1) 6.2
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 5.9
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 5.9
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 5.8
 LDTP02359  Heme oxygenase 1 (HMOX1) 5.6
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 5.6
 LDTP01769  Dihydrofolate reductase (DHFR) 5.5
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 5.4
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 5.3
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 5.3
 LDTP00559  Transcription intermediary factor 1-alpha (TRIM24) 5.0
Transporter and channel
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 13.0
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 10.8
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 9.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 8.1
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 7.4
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.5
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 5.2
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 5.2
Other
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 10.6
 LDTP05375  Nucleobindin-1 (NUCB1) 8.5
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 7.6
 LDTP10469  Engulfment and cell motility protein 2 (ELMO2) 6.6
 LDTP02205  Tubulin beta chain (TUBB) 6.4
 LDTP05998  Tubulin beta-2A chain (TUBB2A) 6.4
 LDTP11076  Apolipoprotein L2 (APOL2) 5.9
 LDTP17652  Uncharacterized protein KIAA2013 (KIAA2013) 5.7
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 5.2
 LDTP05160  Nucleobindin-2 (NUCB2) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587