Details of the Target

General Information of Target

Target ID	LDTP04004
Target Name	Lysosomal Pro-X carboxypeptidase (PRCP)
Gene Name	PRCP
Gene ID	5547
Synonyms	PCP; Lysosomal Pro-X carboxypeptidase; EC 3.4.16.2; Angiotensinase C; Lysosomal carboxypeptidase C; Proline carboxypeptidase; Prolylcarboxypeptidase; PRCP
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHF GFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFA EHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSY GGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRS WDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQP LPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWS YQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHT NIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRH MKNWIRDFYDSAGKQH
Target Type	Patented-recorded
Target Bioclass	Enzyme
Family	Peptidase S28 family
Subcellular location	Lysosome
Function	Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
TTD ID	T20371
Uniprot ID	P42785
DrugMap ID	TTTJZ4M
Ensemble ID	ENST00000313010.8
HGNC ID	HGNC:9344
ChEMBL ID	CHEMBL2335

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
DU145	SNV: p.A473T	.
HT115	SNV: p.L200R	.
MEWO	SNV: p.T461S	DBIA Probe Info
NCIH2286	SNV: p.D458N	.
SNU245	SNV: p.R71W	.
SW1271	SNV: p.W187L	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 20 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
Alkylaryl probe 2 Probe Info	15.00	LDD0391	[1]
YN-1 Probe Info	100.00	LDD0444	[2]
YN-4 Probe Info	100.00	LDD0445	[2]
OPA-S-S-alkyne Probe Info	K228(2.59)	LDD3494	[3]
P11 Probe Info	19.58	LDD0201	[4]
Alkylaryl probe 1 Probe Info	3.00	LDD0388	[1]
DBIA Probe Info	C331(1.48)	LDD3368	[5]
BTD Probe Info	C233(0.63)	LDD2089	[6]
FBPP2 Probe Info	3.57	LDD0054	[7]
Acrolein Probe Info	N.A.	LDD0221	[8]
ATP probe Probe Info	N.A.	LDD0199	[9]
4-Iodoacetamidophenylacetylene Probe Info	C394(0.00); C310(0.00)	LDD0038	[10]
IA-alkyne Probe Info	C394(0.00); C215(0.00)	LDD0036	[10]
Lodoacetamide azide Probe Info	C394(0.00); C215(0.00); C310(0.00)	LDD0037	[10]
IPM Probe Info	N.A.	LDD2156	[11]
STPyne Probe Info	N.A.	LDD0009	[12]
TFBX Probe Info	N.A.	LDD0148	[13]
Phosphinate-6 Probe Info	N.A.	LDD0018	[14]
Methacrolein Probe Info	N.A.	LDD0218	[8]
NAIA_5 Probe Info	N.A.	LDD2223	[15]

PAL-AfBPP Probe

Click To Hide/Show 210 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
ILS-1 PP Probe Info	14.71	LDD0417	[16]
C001 Probe Info	7.16	LDD1711	[17]
C004 Probe Info	6.41	LDD1714	[17]
C007 Probe Info	7.46	LDD1716	[17]
C008 Probe Info	6.41	LDD1717	[17]
C009 Probe Info	5.78	LDD1718	[17]
C010 Probe Info	10.56	LDD1719	[17]
C011 Probe Info	9.06	LDD1720	[17]
C012 Probe Info	6.06	LDD1721	[17]
C018 Probe Info	12.82	LDD1726	[17]
C021 Probe Info	5.17	LDD1727	[17]
C022 Probe Info	13.45	LDD1728	[17]
C024 Probe Info	6.15	LDD1730	[17]
C026 Probe Info	15.78	LDD1732	[17]
C028 Probe Info	9.00	LDD1734	[17]
C038 Probe Info	6.59	LDD1738	[17]
C040 Probe Info	21.11	LDD1740	[17]
C041 Probe Info	23.75	LDD1741	[17]
C042 Probe Info	5.31	LDD1742	[17]
C044 Probe Info	5.10	LDD1743	[17]
C045 Probe Info	5.31	LDD1744	[17]
C052 Probe Info	5.94	LDD1750	[17]
C053 Probe Info	5.31	LDD1751	[17]
C055 Probe Info	13.00	LDD1752	[17]
C060 Probe Info	5.13	LDD1757	[17]
C063 Probe Info	25.46	LDD1760	[17]
C064 Probe Info	9.00	LDD1761	[17]
C065 Probe Info	8.82	LDD1762	[17]
C067 Probe Info	5.50	LDD1763	[17]
C070 Probe Info	13.18	LDD1766	[17]
C071 Probe Info	14.22	LDD1767	[17]
C072 Probe Info	13.83	LDD1768	[17]
C073 Probe Info	5.03	LDD1769	[17]
C075 Probe Info	6.73	LDD1770	[17]
C078 Probe Info	9.45	LDD1771	[17]
C079 Probe Info	5.17	LDD1772	[17]
C082 Probe Info	10.63	LDD1774	[17]
C085 Probe Info	15.14	LDD1777	[17]
C087 Probe Info	14.72	LDD1779	[17]
C089 Probe Info	10.48	LDD1781	[17]
C091 Probe Info	12.73	LDD1782	[17]
C099 Probe Info	12.04	LDD1788	[17]
C102 Probe Info	8.06	LDD1790	[17]
C106 Probe Info	22.32	LDD1793	[17]
C107 Probe Info	11.39	LDD1794	[17]
C108 Probe Info	17.03	LDD1795	[17]
C110 Probe Info	12.73	LDD1797	[17]
C111 Probe Info	5.21	LDD1798	[17]
C112 Probe Info	20.39	LDD1799	[17]
C130 Probe Info	13.45	LDD1812	[17]
C135 Probe Info	16.68	LDD1817	[17]
C139 Probe Info	14.52	LDD1821	[17]
C140 Probe Info	17.39	LDD1822	[17]
C141 Probe Info	18.51	LDD1823	[17]
C142 Probe Info	13.83	LDD1824	[17]
C143 Probe Info	18.00	LDD1825	[17]
C145 Probe Info	26.17	LDD1827	[17]
C147 Probe Info	16.22	LDD1829	[17]
C149 Probe Info	8.51	LDD1830	[17]
C153 Probe Info	18.38	LDD1834	[17]
C156 Probe Info	8.34	LDD1836	[17]
C159 Probe Info	15.03	LDD1839	[17]
C160 Probe Info	16.45	LDD1840	[17]
C161 Probe Info	24.08	LDD1841	[17]
C163 Probe Info	10.48	LDD1843	[17]
C165 Probe Info	14.52	LDD1845	[17]
C166 Probe Info	8.51	LDD1846	[17]
C170 Probe Info	14.12	LDD1850	[17]
C171 Probe Info	8.82	LDD1851	[17]
C173 Probe Info	8.57	LDD1853	[17]
C176 Probe Info	17.39	LDD1855	[17]
C177 Probe Info	29.24	LDD1856	[17]
C178 Probe Info	25.46	LDD1857	[17]
C183 Probe Info	9.00	LDD1861	[17]
C185 Probe Info	5.31	LDD1863	[17]
C186 Probe Info	9.38	LDD1864	[17]
C193 Probe Info	11.71	LDD1869	[17]
C194 Probe Info	10.78	LDD1870	[17]
C195 Probe Info	5.74	LDD1871	[17]
C197 Probe Info	7.94	LDD1873	[17]
C198 Probe Info	13.74	LDD1874	[17]
C204 Probe Info	4.96	LDD1879	[17]
C205 Probe Info	9.51	LDD1880	[17]
C206 Probe Info	23.26	LDD1881	[17]
C208 Probe Info	8.51	LDD1883	[17]
C211 Probe Info	16.45	LDD1885	[17]
C212 Probe Info	7.46	LDD1886	[17]
C213 Probe Info	19.84	LDD1887	[17]
C215 Probe Info	7.41	LDD1889	[17]
C216 Probe Info	5.58	LDD1890	[17]
C217 Probe Info	6.87	LDD1891	[17]
C219 Probe Info	7.31	LDD1893	[17]
C220 Probe Info	13.00	LDD1894	[17]
C221 Probe Info	7.31	LDD1895	[17]
C222 Probe Info	7.78	LDD1896	[17]
C223 Probe Info	5.62	LDD1897	[17]
C225 Probe Info	13.83	LDD1898	[17]
C226 Probe Info	17.88	LDD1899	[17]
C228 Probe Info	19.70	LDD1901	[17]
C229 Probe Info	16.00	LDD1902	[17]
C231 Probe Info	16.22	LDD1904	[17]
C233 Probe Info	28.05	LDD1906	[17]
C234 Probe Info	11.31	LDD1907	[17]
C235 Probe Info	19.29	LDD1908	[17]
C237 Probe Info	6.63	LDD1910	[17]
C240 Probe Info	9.45	LDD1913	[17]
C243 Probe Info	15.24	LDD1916	[17]
C249 Probe Info	19.56	LDD1922	[17]
C255 Probe Info	10.78	LDD1928	[17]
C256 Probe Info	4.96	LDD1929	[17]
C258 Probe Info	10.27	LDD1931	[17]
C260 Probe Info	10.63	LDD1932	[17]
C264 Probe Info	16.22	LDD1935	[17]
C269 Probe Info	7.73	LDD1939	[17]
C270 Probe Info	8.69	LDD1940	[17]
C272 Probe Info	10.93	LDD1942	[17]
C273 Probe Info	11.08	LDD1943	[17]
C277 Probe Info	13.00	LDD1947	[17]
C280 Probe Info	15.03	LDD1950	[17]
C281 Probe Info	4.99	LDD1951	[17]
C286 Probe Info	8.94	LDD1956	[17]
C287 Probe Info	11.96	LDD1957	[17]
C288 Probe Info	13.83	LDD1958	[17]
C290 Probe Info	12.04	LDD1960	[17]
C297 Probe Info	7.52	LDD1967	[17]
C299 Probe Info	8.82	LDD1968	[17]
C300 Probe Info	7.21	LDD1969	[17]
C301 Probe Info	6.02	LDD1970	[17]
C302 Probe Info	5.10	LDD1971	[17]
C303 Probe Info	12.04	LDD1972	[17]
C305 Probe Info	15.56	LDD1974	[17]
C307 Probe Info	8.17	LDD1975	[17]
C311 Probe Info	5.62	LDD1978	[17]
C314 Probe Info	17.75	LDD1981	[17]
C317 Probe Info	5.74	LDD1983	[17]
C320 Probe Info	5.98	LDD1986	[17]
C326 Probe Info	16.34	LDD1990	[17]
C327 Probe Info	5.54	LDD1991	[17]
C329 Probe Info	6.23	LDD1993	[17]
C337 Probe Info	4.92	LDD2000	[17]
C338 Probe Info	12.73	LDD2001	[17]
C339 Probe Info	10.48	LDD2002	[17]
C340 Probe Info	7.31	LDD2003	[17]
C342 Probe Info	10.48	LDD2004	[17]
C343 Probe Info	13.83	LDD2005	[17]
C344 Probe Info	5.90	LDD2006	[17]
C346 Probe Info	18.90	LDD2007	[17]
C348 Probe Info	21.86	LDD2009	[17]
C349 Probe Info	18.00	LDD2010	[17]
C350 Probe Info	34.06	LDD2011	[17]
C351 Probe Info	5.98	LDD2012	[17]
C353 Probe Info	26.35	LDD2014	[17]
C354 Probe Info	35.75	LDD2015	[17]
C355 Probe Info	49.18	LDD2016	[17]
C356 Probe Info	26.35	LDD2017	[17]
C357 Probe Info	12.38	LDD2018	[17]
C359 Probe Info	5.78	LDD2020	[17]
C360 Probe Info	14.22	LDD2021	[17]
C361 Probe Info	21.41	LDD2022	[17]
C366 Probe Info	5.28	LDD2027	[17]
C367 Probe Info	6.28	LDD2028	[17]
C369 Probe Info	6.19	LDD2030	[17]
C373 Probe Info	7.41	LDD2033	[17]
C374 Probe Info	7.41	LDD2034	[17]
C376 Probe Info	11.71	LDD2036	[17]
C378 Probe Info	10.13	LDD2037	[17]
C380 Probe Info	8.06	LDD2039	[17]
C382 Probe Info	12.73	LDD2041	[17]
C383 Probe Info	17.63	LDD2042	[17]
C385 Probe Info	6.96	LDD2044	[17]
C386 Probe Info	15.24	LDD2045	[17]
C387 Probe Info	8.75	LDD2046	[17]
C389 Probe Info	6.59	LDD2048	[17]
C390 Probe Info	97.68	LDD2049	[17]
C391 Probe Info	41.93	LDD2050	[17]
C392 Probe Info	10.06	LDD2051	[17]
C393 Probe Info	11.31	LDD2052	[17]
C394 Probe Info	6.28	LDD2053	[17]
C395 Probe Info	4.92	LDD2054	[17]
C396 Probe Info	14.32	LDD2055	[17]
C399 Probe Info	11.31	LDD2058	[17]
C405 Probe Info	9.92	LDD2063	[17]
C408 Probe Info	9.06	LDD2065	[17]
C413 Probe Info	25.11	LDD2069	[17]
C414 Probe Info	9.00	LDD2070	[17]
C416 Probe Info	9.00	LDD2071	[17]
C418 Probe Info	43.41	LDD2073	[17]
C419 Probe Info	27.47	LDD2074	[17]
C420 Probe Info	43.71	LDD2075	[17]
C425 Probe Info	11.39	LDD2080	[17]
C428 Probe Info	10.93	LDD2083	[17]
C429 Probe Info	53.08	LDD2084	[17]
C430 Probe Info	13.93	LDD2085	[17]
C431 Probe Info	38.32	LDD2086	[17]
C432 Probe Info	6.06	LDD2087	[17]
C433 Probe Info	25.28	LDD2088	[17]
FFF probe11 Probe Info	10.06	LDD0471	[18]
FFF probe12 Probe Info	20.00	LDD0487	[18]
FFF probe13 Probe Info	16.13	LDD0475	[18]
FFF probe14 Probe Info	14.45	LDD0477	[18]
FFF probe15 Probe Info	9.43	LDD0478	[18]
FFF probe2 Probe Info	6.38	LDD0463	[18]
FFF probe3 Probe Info	16.27	LDD0464	[18]
FFF probe4 Probe Info	12.82	LDD0466	[18]
FFF probe6 Probe Info	20.00	LDD0482	[18]
FFF probe7 Probe Info	17.27	LDD0483	[18]
FFF probe9 Probe Info	13.64	LDD0470	[18]
JN0003 Probe Info	15.16	LDD0469	[18]
Kambe_31 Probe Info	2.60	LDD0135	[19]
OEA-DA Probe Info	20.00	LDD0046	[20]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0502	1-(Cyanoacetyl)piperidine	MDA-MB-231	C233(0.48)	LDD2095	[6]
LDCM0537	2-Cyano-N,N-dimethylacetamide	MDA-MB-231	C233(0.81)	LDD2130	[6]
LDCM0524	2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide	MDA-MB-231	C233(0.87)	LDD2117	[6]
LDCM0214	AC1	HEK-293T	C310(1.07)	LDD1507	[21]
LDCM0215	AC10	HEK-293T	C310(1.00)	LDD1508	[21]
LDCM0226	AC11	HEK-293T	C310(0.94)	LDD1509	[21]
LDCM0237	AC12	HEK-293T	C310(1.05)	LDD1510	[21]
LDCM0259	AC14	HEK-293T	C310(0.92); C394(0.95)	LDD1512	[21]
LDCM0270	AC15	HEK-293T	C310(1.08)	LDD1513	[21]
LDCM0276	AC17	HEK-293T	C310(0.96)	LDD1515	[21]
LDCM0277	AC18	HEK-293T	C310(0.94)	LDD1516	[21]
LDCM0278	AC19	HEK-293T	C310(1.06)	LDD1517	[21]
LDCM0279	AC2	HEK-293T	C310(0.98)	LDD1518	[21]
LDCM0280	AC20	HEK-293T	C310(1.10)	LDD1519	[21]
LDCM0281	AC21	HEK-293T	C310(0.97)	LDD1520	[21]
LDCM0282	AC22	HEK-293T	C310(0.89); C394(0.96)	LDD1521	[21]
LDCM0283	AC23	HEK-293T	C310(0.98)	LDD1522	[21]
LDCM0284	AC24	HEK-293T	C310(0.98)	LDD1523	[21]
LDCM0285	AC25	HEK-293T	C310(1.01)	LDD1524	[21]
LDCM0286	AC26	HEK-293T	C310(1.01)	LDD1525	[21]
LDCM0287	AC27	HEK-293T	C310(1.02)	LDD1526	[21]
LDCM0288	AC28	HEK-293T	C310(1.05)	LDD1527	[21]
LDCM0289	AC29	HEK-293T	C310(0.90)	LDD1528	[21]
LDCM0290	AC3	HEK-293T	C310(1.08)	LDD1529	[21]
LDCM0291	AC30	HEK-293T	C310(0.99); C394(0.80)	LDD1530	[21]
LDCM0292	AC31	HEK-293T	C310(1.04)	LDD1531	[21]
LDCM0293	AC32	HEK-293T	C310(0.94)	LDD1532	[21]
LDCM0294	AC33	HEK-293T	C310(1.01)	LDD1533	[21]
LDCM0295	AC34	HEK-293T	C310(1.00)	LDD1534	[21]
LDCM0296	AC35	HEK-293T	C310(0.98)	LDD1535	[21]
LDCM0297	AC36	HEK-293T	C310(1.04)	LDD1536	[21]
LDCM0298	AC37	HEK-293T	C310(0.96)	LDD1537	[21]
LDCM0299	AC38	HEK-293T	C310(0.91); C394(0.97)	LDD1538	[21]
LDCM0300	AC39	HEK-293T	C310(0.98)	LDD1539	[21]
LDCM0301	AC4	HEK-293T	C310(1.09)	LDD1540	[21]
LDCM0302	AC40	HEK-293T	C310(0.98)	LDD1541	[21]
LDCM0303	AC41	HEK-293T	C310(1.00)	LDD1542	[21]
LDCM0304	AC42	HEK-293T	C310(0.98)	LDD1543	[21]
LDCM0305	AC43	HEK-293T	C310(0.99)	LDD1544	[21]
LDCM0306	AC44	HEK-293T	C310(1.07)	LDD1545	[21]
LDCM0307	AC45	HEK-293T	C310(0.98)	LDD1546	[21]
LDCM0308	AC46	HEK-293T	C310(0.95); C394(0.97)	LDD1547	[21]
LDCM0309	AC47	HEK-293T	C310(1.04)	LDD1548	[21]
LDCM0310	AC48	HEK-293T	C310(0.96)	LDD1549	[21]
LDCM0311	AC49	HEK-293T	C310(0.98)	LDD1550	[21]
LDCM0312	AC5	HEK-293T	C310(0.96)	LDD1551	[21]
LDCM0313	AC50	HEK-293T	C310(1.01)	LDD1552	[21]
LDCM0314	AC51	HEK-293T	C310(1.01)	LDD1553	[21]
LDCM0315	AC52	HEK-293T	C310(1.06)	LDD1554	[21]
LDCM0316	AC53	HEK-293T	C310(0.98)	LDD1555	[21]
LDCM0317	AC54	HEK-293T	C310(0.94); C394(0.87)	LDD1556	[21]
LDCM0318	AC55	HEK-293T	C310(0.99)	LDD1557	[21]
LDCM0319	AC56	HEK-293T	C310(0.93)	LDD1558	[21]
LDCM0320	AC57	HEK-293T	C310(1.04)	LDD1559	[21]
LDCM0321	AC58	HEK-293T	C310(1.04)	LDD1560	[21]
LDCM0322	AC59	HEK-293T	C310(1.00)	LDD1561	[21]
LDCM0323	AC6	HEK-293T	C310(0.95); C394(0.89)	LDD1562	[21]
LDCM0324	AC60	HEK-293T	C310(1.02)	LDD1563	[21]
LDCM0325	AC61	HEK-293T	C310(0.96)	LDD1564	[21]
LDCM0326	AC62	HEK-293T	C310(0.93); C394(0.97)	LDD1565	[21]
LDCM0327	AC63	HEK-293T	C310(1.04)	LDD1566	[21]
LDCM0328	AC64	HEK-293T	C310(0.98)	LDD1567	[21]
LDCM0334	AC7	HEK-293T	C310(1.08)	LDD1568	[21]
LDCM0345	AC8	HEK-293T	C310(1.02)	LDD1569	[21]
LDCM0545	Acetamide	MDA-MB-231	C233(0.38)	LDD2138	[6]
LDCM0248	AKOS034007472	HEK-293T	C310(0.97)	LDD1511	[21]
LDCM0356	AKOS034007680	HEK-293T	C310(0.99)	LDD1570	[21]
LDCM0275	AKOS034007705	HEK-293T	C310(0.93)	LDD1514	[21]
LDCM0498	BS-3668	MDA-MB-231	C233(0.52)	LDD2091	[6]
LDCM0088	C45	HEK-293T	19.58	LDD0201	[4]
LDCM0108	Chloroacetamide	HeLa	C233(0.00); H232(0.00)	LDD0222	[8]
LDCM0367	CL1	HEK-293T	C233(0.97); C310(1.09)	LDD1571	[21]
LDCM0368	CL10	HEK-293T	C310(1.23); C394(1.47)	LDD1572	[21]
LDCM0369	CL100	HEK-293T	C310(1.08)	LDD1573	[21]
LDCM0370	CL101	HEK-293T	C233(1.01); C310(0.99)	LDD1574	[21]
LDCM0371	CL102	HEK-293T	C310(1.16); C394(1.08)	LDD1575	[21]
LDCM0372	CL103	HEK-293T	C310(0.89)	LDD1576	[21]
LDCM0373	CL104	HEK-293T	C310(1.02)	LDD1577	[21]
LDCM0374	CL105	HEK-293T	C233(1.01); C310(1.01)	LDD1578	[21]
LDCM0375	CL106	HEK-293T	C310(1.01); C394(0.99)	LDD1579	[21]
LDCM0376	CL107	HEK-293T	C310(0.97)	LDD1580	[21]
LDCM0377	CL108	HEK-293T	C310(0.95)	LDD1581	[21]
LDCM0378	CL109	HEK-293T	C233(1.08); C310(1.20)	LDD1582	[21]
LDCM0379	CL11	HEK-293T	C310(1.10)	LDD1583	[21]
LDCM0380	CL110	HEK-293T	C310(1.18); C394(0.93)	LDD1584	[21]
LDCM0381	CL111	HEK-293T	C310(0.98)	LDD1585	[21]
LDCM0382	CL112	HEK-293T	C310(1.06)	LDD1586	[21]
LDCM0383	CL113	HEK-293T	C233(1.17); C310(1.05)	LDD1587	[21]
LDCM0384	CL114	HEK-293T	C310(1.10); C394(1.01)	LDD1588	[21]
LDCM0385	CL115	HEK-293T	C310(0.90)	LDD1589	[21]
LDCM0386	CL116	HEK-293T	C310(0.98)	LDD1590	[21]
LDCM0387	CL117	HEK-293T	C233(1.07); C310(1.01)	LDD1591	[21]
LDCM0388	CL118	HEK-293T	C310(0.91); C394(1.00)	LDD1592	[21]
LDCM0389	CL119	HEK-293T	C310(0.94)	LDD1593	[21]
LDCM0390	CL12	HEK-293T	C310(0.94)	LDD1594	[21]
LDCM0391	CL120	HEK-293T	C310(0.99)	LDD1595	[21]
LDCM0392	CL121	HEK-293T	C233(0.93); C310(1.11)	LDD1596	[21]
LDCM0393	CL122	HEK-293T	C310(1.04); C394(0.99)	LDD1597	[21]
LDCM0394	CL123	HEK-293T	C310(1.06)	LDD1598	[21]
LDCM0395	CL124	HEK-293T	C310(1.08)	LDD1599	[21]
LDCM0396	CL125	HEK-293T	C233(0.56); C310(1.06)	LDD1600	[21]
LDCM0397	CL126	HEK-293T	C310(0.99); C394(1.02)	LDD1601	[21]
LDCM0398	CL127	HEK-293T	C310(0.99)	LDD1602	[21]
LDCM0399	CL128	HEK-293T	C310(0.98)	LDD1603	[21]
LDCM0400	CL13	HEK-293T	C233(1.01); C310(1.00)	LDD1604	[21]
LDCM0401	CL14	HEK-293T	C310(0.88); C394(1.04)	LDD1605	[21]
LDCM0402	CL15	HEK-293T	C310(1.02)	LDD1606	[21]
LDCM0403	CL16	HEK-293T	C310(1.00)	LDD1607	[21]
LDCM0404	CL17	HEK-293T	C310(1.27)	LDD1608	[21]
LDCM0405	CL18	HEK-293T	C310(1.07)	LDD1609	[21]
LDCM0406	CL19	HEK-293T	C310(0.93)	LDD1610	[21]
LDCM0407	CL2	HEK-293T	C310(0.94); C394(1.09)	LDD1611	[21]
LDCM0408	CL20	HEK-293T	C310(1.03)	LDD1612	[21]
LDCM0409	CL21	HEK-293T	C310(1.00)	LDD1613	[21]
LDCM0410	CL22	HEK-293T	C310(0.94); C394(1.53)	LDD1614	[21]
LDCM0411	CL23	HEK-293T	C310(1.05)	LDD1615	[21]
LDCM0412	CL24	HEK-293T	C310(0.93)	LDD1616	[21]
LDCM0413	CL25	HEK-293T	C233(0.90); C310(1.07)	LDD1617	[21]
LDCM0414	CL26	HEK-293T	C310(0.97); C394(0.91)	LDD1618	[21]
LDCM0415	CL27	HEK-293T	C310(0.88)	LDD1619	[21]
LDCM0416	CL28	HEK-293T	C310(0.94)	LDD1620	[21]
LDCM0417	CL29	HEK-293T	C310(1.03)	LDD1621	[21]
LDCM0418	CL3	HEK-293T	C310(1.06)	LDD1622	[21]
LDCM0419	CL30	HEK-293T	C310(1.01)	LDD1623	[21]
LDCM0420	CL31	HEK-293T	C310(1.00)	LDD1624	[21]
LDCM0421	CL32	HEK-293T	C310(0.96)	LDD1625	[21]
LDCM0422	CL33	HEK-293T	C310(1.21)	LDD1626	[21]
LDCM0423	CL34	HEK-293T	C310(0.97); C394(1.19)	LDD1627	[21]
LDCM0424	CL35	HEK-293T	C310(1.09)	LDD1628	[21]
LDCM0425	CL36	HEK-293T	C310(0.98)	LDD1629	[21]
LDCM0426	CL37	HEK-293T	C233(0.81); C310(1.03)	LDD1630	[21]
LDCM0428	CL39	HEK-293T	C310(1.02)	LDD1632	[21]
LDCM0429	CL4	HEK-293T	C310(1.05)	LDD1633	[21]
LDCM0430	CL40	HEK-293T	C310(0.94)	LDD1634	[21]
LDCM0431	CL41	HEK-293T	C310(1.05)	LDD1635	[21]
LDCM0432	CL42	HEK-293T	C310(0.98)	LDD1636	[21]
LDCM0433	CL43	HEK-293T	C310(0.98)	LDD1637	[21]
LDCM0434	CL44	HEK-293T	C310(1.03)	LDD1638	[21]
LDCM0435	CL45	HEK-293T	C310(0.97)	LDD1639	[21]
LDCM0436	CL46	HEK-293T	C310(1.02); C394(1.25)	LDD1640	[21]
LDCM0437	CL47	HEK-293T	C310(1.00)	LDD1641	[21]
LDCM0438	CL48	HEK-293T	C310(0.99)	LDD1642	[21]
LDCM0439	CL49	HEK-293T	C233(0.80); C310(1.13)	LDD1643	[21]
LDCM0440	CL5	HEK-293T	C310(0.94)	LDD1644	[21]
LDCM0441	CL50	HEK-293T	C310(1.02); C394(0.99)	LDD1645	[21]
LDCM0443	CL52	HEK-293T	C310(1.02)	LDD1646	[21]
LDCM0444	CL53	HEK-293T	C310(1.18)	LDD1647	[21]
LDCM0445	CL54	HEK-293T	C310(1.19)	LDD1648	[21]
LDCM0446	CL55	HEK-293T	C310(0.95)	LDD1649	[21]
LDCM0447	CL56	HEK-293T	C310(1.06)	LDD1650	[21]
LDCM0448	CL57	HEK-293T	C310(1.07)	LDD1651	[21]
LDCM0449	CL58	HEK-293T	C310(1.02); C394(1.30)	LDD1652	[21]
LDCM0450	CL59	HEK-293T	C310(1.08)	LDD1653	[21]
LDCM0451	CL6	HEK-293T	C310(1.13)	LDD1654	[21]
LDCM0452	CL60	HEK-293T	C310(0.90)	LDD1655	[21]
LDCM0453	CL61	HEK-293T	C233(0.88); C310(1.05)	LDD1656	[21]
LDCM0454	CL62	HEK-293T	C310(0.94); C394(1.02)	LDD1657	[21]
LDCM0455	CL63	HEK-293T	C310(0.94)	LDD1658	[21]
LDCM0456	CL64	HEK-293T	C310(1.04)	LDD1659	[21]
LDCM0457	CL65	HEK-293T	C310(0.99)	LDD1660	[21]
LDCM0458	CL66	HEK-293T	C310(0.96)	LDD1661	[21]
LDCM0459	CL67	HEK-293T	C310(1.03)	LDD1662	[21]
LDCM0460	CL68	HEK-293T	C310(1.05)	LDD1663	[21]
LDCM0461	CL69	HEK-293T	C310(0.97)	LDD1664	[21]
LDCM0462	CL7	HEK-293T	C310(1.00)	LDD1665	[21]
LDCM0463	CL70	HEK-293T	C310(0.89); C394(1.38)	LDD1666	[21]
LDCM0464	CL71	HEK-293T	C310(1.12)	LDD1667	[21]
LDCM0465	CL72	HEK-293T	C310(0.90)	LDD1668	[21]
LDCM0466	CL73	HEK-293T	C233(0.97); C310(1.12)	LDD1669	[21]
LDCM0467	CL74	HEK-293T	C310(0.94); C394(1.12)	LDD1670	[21]
LDCM0469	CL76	HEK-293T	C310(1.00)	LDD1672	[21]
LDCM0470	CL77	HEK-293T	C310(1.18)	LDD1673	[21]
LDCM0471	CL78	HEK-293T	C310(0.95)	LDD1674	[21]
LDCM0472	CL79	HEK-293T	C310(1.01)	LDD1675	[21]
LDCM0473	CL8	HEK-293T	C310(1.98)	LDD1676	[21]
LDCM0474	CL80	HEK-293T	C310(1.10)	LDD1677	[21]
LDCM0475	CL81	HEK-293T	C310(0.91)	LDD1678	[21]
LDCM0476	CL82	HEK-293T	C310(0.94); C394(1.17)	LDD1679	[21]
LDCM0477	CL83	HEK-293T	C310(1.08)	LDD1680	[21]
LDCM0478	CL84	HEK-293T	C310(1.02)	LDD1681	[21]
LDCM0479	CL85	HEK-293T	C233(0.58); C310(1.13)	LDD1682	[21]
LDCM0480	CL86	HEK-293T	C310(1.00); C394(0.92)	LDD1683	[21]
LDCM0481	CL87	HEK-293T	C310(0.99)	LDD1684	[21]
LDCM0482	CL88	HEK-293T	C310(1.01)	LDD1685	[21]
LDCM0483	CL89	HEK-293T	C310(0.98)	LDD1686	[21]
LDCM0484	CL9	HEK-293T	C310(0.96)	LDD1687	[21]
LDCM0485	CL90	HEK-293T	C310(1.24)	LDD1688	[21]
LDCM0486	CL91	HEK-293T	C310(0.98)	LDD1689	[21]
LDCM0487	CL92	HEK-293T	C310(1.10)	LDD1690	[21]
LDCM0488	CL93	HEK-293T	C310(1.03)	LDD1691	[21]
LDCM0489	CL94	HEK-293T	C310(0.92); C394(1.12)	LDD1692	[21]
LDCM0490	CL95	HEK-293T	C310(1.65)	LDD1693	[21]
LDCM0491	CL96	HEK-293T	C310(1.09)	LDD1694	[21]
LDCM0492	CL97	HEK-293T	C233(1.00); C310(1.24)	LDD1695	[21]
LDCM0493	CL98	HEK-293T	C310(1.04); C394(0.97)	LDD1696	[21]
LDCM0494	CL99	HEK-293T	C310(0.93)	LDD1697	[21]
LDCM0189	Compound 16	HEK-293T	15.15	LDD0492	[18]
LDCM0185	Compound 17	HEK-293T	5.87	LDD0504	[18]
LDCM0182	Compound 18	HEK-293T	10.00	LDD0501	[18]
LDCM0184	Compound 20	HEK-293T	16.39	LDD0503	[18]
LDCM0191	Compound 21	HEK-293T	3.75	LDD0493	[18]
LDCM0186	Compound 31	HEK-293T	6.94	LDD0506	[18]
LDCM0187	Compound 32	HEK-293T	20.00	LDD0507	[18]
LDCM0188	Compound 33	HEK-293T	6.27	LDD0505	[18]
LDCM0190	Compound 34	HEK-293T	15.50	LDD0497	[18]
LDCM0192	Compound 35	HEK-293T	10.58	LDD0491	[18]
LDCM0193	Compound 36	HEK-293T	11.76	LDD0494	[18]
LDCM0194	Compound 37	HEK-293T	7.87	LDD0498	[18]
LDCM0195	Compound 38	HEK-293T	13.99	LDD0499	[18]
LDCM0196	Compound 39	HEK-293T	12.99	LDD0496	[18]
LDCM0197	Compound 40	HEK-293T	17.24	LDD0495	[18]
LDCM0181	Compound 41	HEK-293T	9.90	LDD0502	[18]
LDCM0183	Compound 42	HEK-293T	5.28	LDD0500	[18]
LDCM0495	E2913	HEK-293T	C310(0.89)	LDD1698	[21]
LDCM0468	Fragment33	HEK-293T	C310(0.91)	LDD1671	[21]
LDCM0427	Fragment51	HEK-293T	C310(0.92); C394(1.02)	LDD1631	[21]
LDCM0107	IAA	HeLa	N.A.	LDD0221	[8]
LDCM0079	kambe_cp64	PC-3	2.60	LDD0135	[19]
LDCM0022	KB02	HEK-293T	C310(0.94)	LDD1492	[21]
LDCM0023	KB03	HEK-293T	C310(0.96)	LDD1497	[21]
LDCM0024	KB05	OAW-28	C331(1.48)	LDD3368	[5]
LDCM0109	NEM	HeLa	N.A.	LDD0224	[8]
LDCM0496	Nucleophilic fragment 11a	MDA-MB-231	C233(0.63)	LDD2089	[6]
LDCM0500	Nucleophilic fragment 13a	MDA-MB-231	C233(1.00)	LDD2093	[6]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C233(1.18)	LDD2099	[6]
LDCM0515	Nucleophilic fragment 20b	MDA-MB-231	C233(0.86)	LDD2108	[6]
LDCM0516	Nucleophilic fragment 21a	MDA-MB-231	C233(0.89); C310(0.42)	LDD2109	[6]
LDCM0527	Nucleophilic fragment 26b	MDA-MB-231	C233(0.53)	LDD2120	[6]
LDCM0530	Nucleophilic fragment 28a	MDA-MB-231	C233(0.88)	LDD2123	[6]
LDCM0532	Nucleophilic fragment 29a	MDA-MB-231	C233(0.70)	LDD2125	[6]
LDCM0534	Nucleophilic fragment 30a	MDA-MB-231	C233(0.99)	LDD2127	[6]
LDCM0536	Nucleophilic fragment 31	MDA-MB-231	C310(0.88)	LDD2129	[6]
LDCM0543	Nucleophilic fragment 38	MDA-MB-231	C233(1.43)	LDD2136	[6]
LDCM0544	Nucleophilic fragment 39	MDA-MB-231	C233(0.90); C310(0.79)	LDD2137	[6]
LDCM0546	Nucleophilic fragment 40	MDA-MB-231	C233(0.81)	LDD2140	[6]
LDCM0552	Nucleophilic fragment 6a	MDA-MB-231	C233(0.84)	LDD2146	[6]
LDCM0556	Nucleophilic fragment 8a	MDA-MB-231	C233(0.47)	LDD2150	[6]
LDCM0099	Phenelzine	MDA-MB-231	3.00	LDD0388	[1]
LDCM0008	Tranylcypromine	SH-SY5Y	3.57	LDD0054	[7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

GPCR

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
G-protein coupled receptor 37-like 1 (GPR37L1)				G-protein coupled receptor 1 family	O60883

The Drug(s) Related To This Target

Investigative

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Pmid24157366c35				Small molecular drug	D0N6AM

Patented

Click To Hide/Show 23 Drug(s) Interacting with This Target

Drug Name	Drug Type	External ID
Benzodihydroisofuran Derivative 1	Small molecular drug	D03GPW
Benzodihydroisofuran Derivative 2	Small molecular drug	D0LZ4A
Benzodihydroisofuran Derivative 3	Small molecular drug	D05NQZ
Benzodihydroisofuran Derivative 4	Small molecular drug	D07KNI
Cyclohexane Carboxamide Derivative 1	Small molecular drug	D0AF0O
Cyclohexane Carboxamide Derivative 2	Small molecular drug	D03WDH
Cyclohexane Carboxamide Derivative 3	Small molecular drug	D0QM9Q
Cyclopentane Carboxamide Derivative 1	Small molecular drug	D0L8VH
Cyclopentane Carboxamide Derivative 2	Small molecular drug	D00YYA
Imidazole Derivative 8	Small molecular drug	D0L6CM
Imidazole Derivative 9	Small molecular drug	D0X8ZF
Piperidinyl Pyrazole Derivative 1	Small molecular drug	D03ASG
Piperidinyl Pyrazole Derivative 2	Small molecular drug	D0J3TN
Piperidinyl Pyrazole Derivative 3	Small molecular drug	D0R3WH
Piperidinyl Pyrazole Derivative 4	Small molecular drug	D01GEE
Piperidinyl Triazole Derivative 1	Small molecular drug	D0K1GJ
Piperidinyl Triazole Derivative 2	Small molecular drug	D0S3AL
Piperidinyl Triazole Derivative 3	Small molecular drug	D0NT8N
Piperidinyl Triazole Derivative 4	Small molecular drug	D07RIZ
Piperidinyl Triazole Derivative 5	Small molecular drug	D0A0QQ
Piperidinyl Triazole Derivative 6	Small molecular drug	D0S4XV
Proline Amide Derivative 1	Small molecular drug	D0A6QI
Pyrrolidine Carboxamide Derivative 2	Small molecular drug	D01RBE

References

1	Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3	A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w. Mass spectrometry data entry: PXD042888
4	Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
5	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840
6	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
7	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
8	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
11	Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25. Mass spectrometry data entry: PXD031019
12	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
14	DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22. Mass spectrometry data entry: PXD033004
15	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
16	A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3. Mass spectrometry data entry: PXD014175
17	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
18	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19	Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
20	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
21	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402

Details of the Target

Citation

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni