General Information of Experiment

Probe Name C075  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 6.7
 LDTP02359  Heme oxygenase 1 (HMOX1) 5.9
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 5.1
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 5.0
Transporter and channel
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 12.3
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 9.1
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 8.1
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 6.2
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 5.2
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 5.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 5.0
Other
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 10.6
 LDTP05160  Nucleobindin-2 (NUCB2) 6.2

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587