Details of the Target

General Information of Target

Target ID LDTP06477
Target Name Methylsterol monooxygenase 1 (MSMO1)
Gene Name MSMO1
Gene ID 6307
Synonyms
DESP4; ERG25; SC4MOL; Methylsterol monooxygenase 1; EC 1.14.18.9; C-4 methylsterol oxidase; Sterol-C4-methyl oxidase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATNESVSIFSSASLAVEYVDSLLPENPLQEPFKNAWNYMLNNYTKFQIATWGSLIVHEA
LYFLFCLPGFLFQFIPYMKKYKIQKDKPETWENQWKCFKVLLFNHFCIQLPLICGTYYFT
EYFNIPYDWERMPRWYFLLARCFGCAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAPF
GMEAEYAHPLETLILGTGFFIGIVLLCDHVILLWAWVTIRLLETIDVHSGYDIPLNPLNL
IPFYAGSRHHDFHHMNFIGNYASTFTWWDRIFGTDSQYNAYNEKRKKFEKKTE
Target Bioclass
Enzyme
Family
Sterol desaturase family
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol. Also involved in drug metabolism, as it can metabolize eldecalcitol (ED-71 or 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol), a second-generation vitamin D analog, into 1alpha,2beta,25-trihydroxy vitamin D3; this reaction occurs via enzymatic hydroxylation and spontaneous O-dehydroxypropylation.
Uniprot ID
Q15800
Ensemble ID
ENST00000261507.11
HGNC ID
HGNC:10545

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EGI1 SNV: p.V57L .
ETK1 SNV: p.E89G .
HCT15 SNV: p.G69E .
IM95 Deletion: p.K80NfsTer33 .
JHH1 SNV: p.V204L .
KMRC1 SNV: p.D208G .
MOLT4 SNV: p.N239I .
SKN SNV: p.F103C .
SKNMC SNV: p.H153R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y39(20.00)  LDD0260  [1]
STPyne
 Probe Info  		K167(3.83)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K284(1.82)  LDD3494  [3]
HPAP
 Probe Info  		3.07  LDD0063  [4]
DBIA
 Probe Info  		C142(1.43); C145(1.43)  LDD1109  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
AOyne
 Probe Info  		7.20  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 121 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		9.38  LDD1714  [8]
C011
 Probe Info  		5.94  LDD1720  [8]
C022
 Probe Info  		15.45  LDD1728  [8]
C026
 Probe Info  		11.47  LDD1732  [8]
C039
 Probe Info  		6.19  LDD1739  [8]
C040
 Probe Info  		13.64  LDD1740  [8]
C041
 Probe Info  		11.55  LDD1741  [8]
C044
 Probe Info  		5.43  LDD1743  [8]
C049
 Probe Info  		19.70  LDD1747  [8]
C052
 Probe Info  		5.70  LDD1750  [8]
C053
 Probe Info  		7.26  LDD1751  [8]
C055
 Probe Info  		20.25  LDD1752  [8]
C056
 Probe Info  		18.13  LDD1753  [8]
C063
 Probe Info  		27.67  LDD1760  [8]
C067
 Probe Info  		5.82  LDD1763  [8]
C070
 Probe Info  		17.39  LDD1766  [8]
C072
 Probe Info  		9.78  LDD1768  [8]
C075
 Probe Info  		5.03  LDD1770  [8]
C082
 Probe Info  		6.19  LDD1774  [8]
C087
 Probe Info  		6.92  LDD1779  [8]
C091
 Probe Info  		41.07  LDD1782  [8]
C092
 Probe Info  		60.13  LDD1783  [8]
C094
 Probe Info  		69.55  LDD1785  [8]
C100
 Probe Info  		6.23  LDD1789  [8]
C106
 Probe Info  		38.32  LDD1793  [8]
C107
 Probe Info  		15.03  LDD1794  [8]
C108
 Probe Info  		25.46  LDD1795  [8]
C112
 Probe Info  		38.59  LDD1799  [8]
C129
 Probe Info  		7.31  LDD1811  [8]
C130
 Probe Info  		16.11  LDD1812  [8]
C134
 Probe Info  		34.06  LDD1816  [8]
C135
 Probe Info  		17.75  LDD1817  [8]
C139
 Probe Info  		12.91  LDD1821  [8]
C140
 Probe Info  		13.55  LDD1822  [8]
C141
 Probe Info  		25.11  LDD1823  [8]
C143
 Probe Info  		39.40  LDD1825  [8]
C153
 Probe Info  		52.71  LDD1834  [8]
C156
 Probe Info  		5.78  LDD1836  [8]
C159
 Probe Info  		17.39  LDD1839  [8]
C160
 Probe Info  		22.16  LDD1840  [8]
C161
 Probe Info  		21.71  LDD1841  [8]
C163
 Probe Info  		8.88  LDD1843  [8]
C165
 Probe Info  		12.55  LDD1845  [8]
C169
 Probe Info  		29.65  LDD1849  [8]
C174
 Probe Info  		6.59  LDD1854  [8]
C178
 Probe Info  		31.12  LDD1857  [8]
C183
 Probe Info  		9.85  LDD1861  [8]
C186
 Probe Info  		12.13  LDD1864  [8]
C187
 Probe Info  		36.50  LDD1865  [8]
C191
 Probe Info  		10.06  LDD1868  [8]
C193
 Probe Info  		5.58  LDD1869  [8]
C201
 Probe Info  		99.73  LDD1877  [8]
C204
 Probe Info  		5.58  LDD1879  [8]
C205
 Probe Info  		5.03  LDD1880  [8]
C206
 Probe Info  		53.82  LDD1881  [8]
C207
 Probe Info  		24.08  LDD1882  [8]
C217
 Probe Info  		6.02  LDD1891  [8]
C218
 Probe Info  		41.64  LDD1892  [8]
C219
 Probe Info  		26.72  LDD1893  [8]
C220
 Probe Info  		89.26  LDD1894  [8]
C225
 Probe Info  		20.25  LDD1898  [8]
C226
 Probe Info  		12.38  LDD1899  [8]
C228
 Probe Info  		45.25  LDD1901  [8]
C229
 Probe Info  		13.00  LDD1902  [8]
C231
 Probe Info  		44.94  LDD1904  [8]
C232
 Probe Info  		44.02  LDD1905  [8]
C233
 Probe Info  		29.86  LDD1906  [8]
C234
 Probe Info  		6.63  LDD1907  [8]
C235
 Probe Info  		34.30  LDD1908  [8]
C238
 Probe Info  		11.00  LDD1911  [8]
C240
 Probe Info  		12.04  LDD1913  [8]
C243
 Probe Info  		11.47  LDD1916  [8]
C246
 Probe Info  		14.52  LDD1919  [8]
C252
 Probe Info  		12.04  LDD1925  [8]
C264
 Probe Info  		23.26  LDD1935  [8]
C265
 Probe Info  		18.64  LDD1936  [8]
C270
 Probe Info  		7.01  LDD1940  [8]
C273
 Probe Info  		9.25  LDD1943  [8]
C277
 Probe Info  		31.56  LDD1947  [8]
C285
 Probe Info  		23.43  LDD1955  [8]
C286
 Probe Info  		10.41  LDD1956  [8]
C287
 Probe Info  		37.53  LDD1957  [8]
C288
 Probe Info  		15.03  LDD1958  [8]
C289
 Probe Info  		41.07  LDD1959  [8]
C290
 Probe Info  		9.65  LDD1960  [8]
C293
 Probe Info  		32.67  LDD1963  [8]
C296
 Probe Info  		21.71  LDD1966  [8]
C307
 Probe Info  		5.74  LDD1975  [8]
C314
 Probe Info  		14.93  LDD1981  [8]
C322
 Probe Info  		5.78  LDD1988  [8]
C326
 Probe Info  		8.06  LDD1990  [8]
C343
 Probe Info  		33.13  LDD2005  [8]
C348
 Probe Info  		26.54  LDD2009  [8]
C349
 Probe Info  		47.18  LDD2010  [8]
C350
 Probe Info  		96.34  LDD2011  [8]
C354
 Probe Info  		7.36  LDD2015  [8]
C356
 Probe Info  		11.08  LDD2017  [8]
C357
 Probe Info  		8.11  LDD2018  [8]
C362
 Probe Info  		47.18  LDD2023  [8]
C363
 Probe Info  		17.27  LDD2024  [8]
C364
 Probe Info  		14.93  LDD2025  [8]
C376
 Probe Info  		12.73  LDD2036  [8]
C382
 Probe Info  		10.20  LDD2041  [8]
C383
 Probe Info  		17.39  LDD2042  [8]
C386
 Probe Info  		14.22  LDD2045  [8]
C387
 Probe Info  		7.06  LDD2046  [8]
C388
 Probe Info  		50.91  LDD2047  [8]
C390
 Probe Info  		29.45  LDD2049  [8]
C399
 Probe Info  		9.92  LDD2058  [8]
C403
 Probe Info  		23.75  LDD2061  [8]
C407
 Probe Info  		21.41  LDD2064  [8]
C409
 Probe Info  		6.11  LDD2066  [8]
C424
 Probe Info  		8.17  LDD2079  [8]
C426
 Probe Info  		14.22  LDD2081  [8]
C429
 Probe Info  		22.47  LDD2084  [8]
C431
 Probe Info  		34.06  LDD2086  [8]
STS-2
 Probe Info  		N.A.  LDD0138  [9]
Staurosporine capture compound
 Probe Info  		2.00  LDD0083  [10]
BD-F
 Probe Info  		D232(0.00); H228(0.00); I225(0.00)  LDD0024  [11]
LD-F
 Probe Info  		I225(0.00); L221(0.00); S229(0.00)  LDD0015  [11]
OEA-DA
 Probe Info  		4.36  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 PaTu 8988t C142(1.43); C145(1.43)  LDD1109  [5]
 LDCM0231  AC114 PaTu 8988t C142(1.35); C145(1.35)  LDD1110  [5]
 LDCM0232  AC115 PaTu 8988t C142(1.34); C145(1.34)  LDD1111  [5]
 LDCM0233  AC116 PaTu 8988t C142(1.51); C145(1.51)  LDD1112  [5]
 LDCM0234  AC117 PaTu 8988t C142(1.51); C145(1.51)  LDD1113  [5]
 LDCM0235  AC118 PaTu 8988t C142(1.18); C145(1.18)  LDD1114  [5]
 LDCM0236  AC119 PaTu 8988t C142(1.49); C145(1.49)  LDD1115  [5]
 LDCM0237  AC12 HEK-293T C145(0.99)  LDD1510  [13]
 LDCM0238  AC120 PaTu 8988t C142(1.44); C145(1.44)  LDD1117  [5]
 LDCM0239  AC121 PaTu 8988t C142(1.29); C145(1.29)  LDD1118  [5]
 LDCM0240  AC122 PaTu 8988t C142(1.41); C145(1.41)  LDD1119  [5]
 LDCM0241  AC123 PaTu 8988t C142(1.26); C145(1.26)  LDD1120  [5]
 LDCM0242  AC124 PaTu 8988t C142(1.18); C145(1.18)  LDD1121  [5]
 LDCM0243  AC125 PaTu 8988t C142(1.47); C145(1.47)  LDD1122  [5]
 LDCM0244  AC126 PaTu 8988t C142(1.50); C145(1.50)  LDD1123  [5]
 LDCM0245  AC127 PaTu 8988t C142(1.17); C145(1.17)  LDD1124  [5]
 LDCM0246  AC128 PaTu 8988t C142(1.33); C145(1.33)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C142(0.99); C145(0.99)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C142(1.10); C145(1.10)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C142(1.25); C145(1.25)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C142(1.07); C145(1.07)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C142(1.08); C145(1.08)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C142(1.15); C145(1.15)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C142(1.52); C145(1.52)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C142(1.12); C145(1.12)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C142(1.09); C145(1.09)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C142(1.64); C145(1.64)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C142(1.37); C145(1.37)  LDD1137  [5]
 LDCM0259  AC14 HEK-293T C145(1.05)  LDD1512  [13]
 LDCM0260  AC140 PaTu 8988t C142(1.28); C145(1.28)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C142(1.23); C145(1.23)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C142(1.07); C145(1.07)  LDD1141  [5]
 LDCM0270  AC15 HEK-293T C145(1.01)  LDD1513  [13]
 LDCM0276  AC17 PaTu 8988t C142(1.04); C145(1.04)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C142(0.82); C145(0.82)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C142(0.95); C145(0.95)  LDD1157  [5]
 LDCM0280  AC20 PaTu 8988t C142(0.98); C145(0.98)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C142(0.88); C145(0.88)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C142(1.22); C145(1.22)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C142(0.97); C145(0.97)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C142(0.95); C145(0.95)  LDD1163  [5]
 LDCM0288  AC28 HEK-293T C145(0.89)  LDD1527  [13]
 LDCM0291  AC30 HEK-293T C145(1.01)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C145(1.09)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C145(0.94)  LDD1532  [13]
 LDCM0297  AC36 HEK-293T C145(0.98)  LDD1536  [13]
 LDCM0299  AC38 HEK-293T C145(1.07)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C145(0.92)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C145(1.01)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C145(1.00)  LDD1541  [13]
 LDCM0306  AC44 HEK-293T C145(0.95)  LDD1545  [13]
 LDCM0308  AC46 HEK-293T C145(1.14)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C145(0.97)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C145(1.05)  LDD1549  [13]
 LDCM0315  AC52 HEK-293T C145(0.98)  LDD1554  [13]
 LDCM0317  AC54 HEK-293T C145(1.08)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C145(1.04)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C145(1.01)  LDD1558  [13]
 LDCM0323  AC6 HEK-293T C145(1.12)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C145(1.02)  LDD1563  [13]
 LDCM0326  AC62 HEK-293T C145(1.02)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C145(0.90)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C145(1.02)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C145(0.93)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C145(0.96)  LDD1569  [13]
 LDCM0275  AKOS034007705 HEK-293T C145(1.01)  LDD1514  [13]
 LDCM0367  CL1 HEK-293T C145(0.95)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C145(1.03)  LDD1572  [13]
 LDCM0370  CL101 HEK-293T C145(1.14)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C145(1.04)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C145(1.01)  LDD1576  [13]
 LDCM0374  CL105 PaTu 8988t C142(0.95); C145(0.95)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C142(1.02); C145(1.02)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C142(0.73); C145(0.73)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C142(0.90); C145(0.90)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C142(1.04); C145(1.04)  LDD1257  [5]
 LDCM0379  CL11 HEK-293T C145(0.99)  LDD1583  [13]
 LDCM0380  CL110 PaTu 8988t C142(0.95); C145(0.95)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C142(0.94); C145(0.94)  LDD1260  [5]
 LDCM0383  CL113 HEK-293T C145(1.03)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C145(1.00)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C145(0.96)  LDD1589  [13]
 LDCM0387  CL117 HEK-293T C145(1.12)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C145(1.18)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C145(1.08)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C145(0.85)  LDD1594  [13]
 LDCM0392  CL121 HEK-293T C145(1.07)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C145(1.02)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C145(1.06)  LDD1598  [13]
 LDCM0396  CL125 HEK-293T C145(1.32)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C145(1.15)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C145(1.03)  LDD1602  [13]
 LDCM0400  CL13 HEK-293T C145(0.99)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C145(1.14)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C145(1.09)  LDD1606  [13]
 LDCM0407  CL2 HEK-293T C145(1.06)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C145(1.05)  LDD1612  [13]
 LDCM0410  CL22 HEK-293T C145(1.00)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C145(0.98)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C145(0.91)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C145(1.16)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C145(1.21)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C145(1.00)  LDD1619  [13]
 LDCM0418  CL3 HEK-293T C145(1.15)  LDD1622  [13]
 LDCM0421  CL32 HEK-293T C145(1.04)  LDD1625  [13]
 LDCM0423  CL34 HEK-293T C145(1.02)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C145(0.91)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C145(0.94)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C145(1.07)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C145(0.96)  LDD1632  [13]
 LDCM0434  CL44 HEK-293T C145(1.01)  LDD1638  [13]
 LDCM0436  CL46 PaTu 8988t C142(1.01); C145(1.01)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C142(1.03); C145(1.03)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C142(1.09); C145(1.09)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C142(1.28); C145(1.28)  LDD1318  [5]
 LDCM0441  CL50 PaTu 8988t C142(1.01); C145(1.01)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C142(1.19); C145(1.19)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C142(1.19); C145(1.19)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C142(1.13); C145(1.13)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C142(1.15); C145(1.15)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C142(1.07); C145(1.07)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C142(0.52); C145(0.52)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C142(1.28); C145(1.28)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C142(1.13); C145(1.13)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C142(1.21); C145(1.21)  LDD1329  [5]
 LDCM0452  CL60 PaTu 8988t C142(1.15); C145(1.15)  LDD1331  [5]
 LDCM0453  CL61 HEK-293T C145(1.12)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C145(1.18)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C145(0.98)  LDD1658  [13]
 LDCM0460  CL68 HEK-293T C145(1.02)  LDD1663  [13]
 LDCM0463  CL70 HEK-293T C145(1.01)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C145(0.96)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C145(0.94)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C145(1.23)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C145(0.99)  LDD1670  [13]
 LDCM0469  CL76 PaTu 8988t C142(1.27); C145(1.27)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C142(0.86); C145(0.86)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C142(0.89); C145(0.89)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C142(0.87); C145(0.87)  LDD1351  [5]
 LDCM0473  CL8 HEK-293T C145(1.16)  LDD1676  [13]
 LDCM0474  CL80 PaTu 8988t C142(1.44); C145(1.44)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C142(1.02); C145(1.02)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C142(0.91); C145(0.91)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C142(0.90); C145(0.90)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C142(0.92); C145(0.92)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C142(0.93); C145(0.93)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C142(0.80); C145(0.80)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C142(0.92); C145(0.92)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C142(0.98); C145(0.98)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C142(1.00); C145(1.00)  LDD1362  [5]
 LDCM0485  CL90 PaTu 8988t C142(0.98); C145(0.98)  LDD1364  [5]
 LDCM0487  CL92 HEK-293T C145(1.05)  LDD1690  [13]
 LDCM0489  CL94 HEK-293T C145(1.18)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C145(1.03)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C145(1.17)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C145(1.05)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C145(1.18)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C145(1.11)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C145(1.12)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C145(1.14)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C145(0.95)  LDD1631  [13]
 LDCM0014  Panhematin K562 3.07  LDD0063  [4]
 LDCM0019  Staurosporine Hep-G2 2.00  LDD0083  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ultra-long-chain fatty acid omega-hydroxylase (CYP4F22) Cytochrome P450 family Q6NT55
Vesicle transport protein GOT1A (GOLT1A) GOT1 family Q6ZVE7
Heme oxygenase 1 (HMOX1) Heme oxygenase family P09601
Matrix metalloproteinase-14 (MMP14) Peptidase M10A family P50281
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntaxin-3 (STX3) Syntaxin family Q13277
Transmembrane protein 242 (TMEM242) TMEM242 family Q9NWH2
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (STRIT1) . P0DN84
Transmembrane protein 65 (TMEM65) . Q6PI78
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
Transmembrane protein 11, mitochondrial (TMEM11) TMEM11 family P17152
Protein YIF1A (YIF1A) YIF1 family O95070
DnaJ homolog subfamily C member 30, mitochondrial (DNAJC30) . Q96LL9
Transmembrane protein 140 (TMEM140) . Q9NV12

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
10 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
11 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402