Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C409  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 41 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 20.5
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 14.4
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 12.8
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 11.5
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 9.7
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 8.8
 LDTP03540  Heme oxygenase 2 (HMOX2) 8.6
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 8.2
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 8.2
 LDTP14092  Protein phosphatase methylesterase 1 (PPME1) 7.7
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 7.6
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 7.5
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 7.4
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 7.3
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 7.3
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 7.2
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 7.1
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 7.0
 LDTP06617  Ceramide glucosyltransferase (UGCG) 6.6
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 6.3
 LDTP04456  Ubiquitin carboxyl-terminal hydrolase 11 (USP11) 6.3
 LDTP13058  Thioredoxin domain-containing protein 16 (TXNDC16) 6.2
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 6.1
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 5.9
 LDTP12599  Ubiquitin-like-conjugating enzyme ATG3 (ATG3) 5.8
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 5.6
 LDTP00697  Cytochrome b5 type B (CYB5B) 5.5
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 5.5
 LDTP05560  Peroxisomal bifunctional enzyme (EHHADH) 5.4
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 5.4
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 5.2
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 5.2
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 5.1
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 5.0
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 5.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 5.0
 LDTP04565  Methionine aminopeptidase 1 (METAP1) 5.0
 LDTP06227  Prostaglandin reductase 1 (PTGR1) 5.0
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 5.0
 LDTP09228  N-acylneuraminate cytidylyltransferase (CMAS) 4.9
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 4.9
Transporter and channel
Click to Show/Hide to Show 27 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 49.2
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 25.3
 LDTP08881  Transmembrane protein 199 (TMEM199) 22.2
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 19.8
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 11.6
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 11.0
 LDTP20002  Transmembrane protein 160 (TMEM160) 10.8
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 9.8
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 8.9
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 8.7
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 8.6
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 7.8
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 6.6
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 6.4
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 6.3
 LDTP12383  Protein GPR108 (GPR108) 6.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 6.1
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 6.0
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 6.0
 LDTP11213  Nucleoporin NDC1 (NDC1) 6.0
 LDTP00592  Surfeit locus protein 4 (SURF4) 6.0
 LDTP05978  THO complex subunit 5 homolog (THOC5) 5.7
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 5.7
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 5.7
 LDTP07236  Protein GPR107 (GPR107) 5.5
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 5.3
 LDTP03546  Translocator protein (TSPO) 5.2
Other
Click to Show/Hide to Show 34 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 22.9
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 19.7
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 14.1
 LDTP09297  Large ribosomal subunit protein mL64 (GADD45GIP1) 13.5
 LDTP18883  Protein CEBPZOS (CEBPZOS) 13.2
 LDTP05160  Nucleobindin-2 (NUCB2) 12.6
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 12.2
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 11.4
 LDTP10056  Protein FAM162A (FAM162A) 10.6
 LDTP08594  Negative elongation factor C/D (NELFCD) 9.1
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 7.6
 LDTP04914  Large ribosomal subunit protein uL24 (RPL26) 7.3
 LDTP07574  Superkiller complex protein 3 (SKIC3) 7.3
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 7.0
 LDTP09626  Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) 6.4
 LDTP03321  Small ribosomal subunit protein eS12 (RPS12) 6.4
 LDTP16080  Protein FAM114A2 (FAM114A2) 6.0
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 5.7
 LDTP12925  CCR4-NOT transcription complex subunit 2 (CNOT2) 5.7
 LDTP05375  Nucleobindin-1 (NUCB1) 5.7
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 5.7
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 5.7
 LDTP01522  Reticulon-3 (RTN3) 5.7
 LDTP15664  Actin-related protein 2/3 complex subunit 1A (ARPC1A) 5.6
 LDTP00202  AH receptor-interacting protein (AIP) 5.6
 LDTP06892  Protein Hikeshi (HIKESHI) 5.5
 LDTP04973  Small ribosomal subunit protein uS14 (RPS29) 5.4
 LDTP12412  Reticulon-4 (RTN4) 5.4
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 5.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) 5.3
 LDTP09773  Protein FAM3C (FAM3C) 5.3
 LDTP12746  Gem-associated protein 8 (GEMIN8) 5.2
 LDTP10263  KIF-binding protein (KIFBP) 5.1
 LDTP14453  RNA-binding protein Musashi homolog 1 (MSI1) 5.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587