Details of the Target

General Information of Target

Target ID LDTP06892
Target Name Protein Hikeshi (HIKESHI)
Gene Name HIKESHI
Gene ID 51501
Synonyms
C11orf73; Protein Hikeshi
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYESINHVVVFMLGTIPFPEGMGGSVYFSYPD
SNGMPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGAMNIVRTPSVAQIGISVELLDS
MAQQTPVGNAAVSSVDSFTQFTQKMLDNFYNFASSFAVSQAQMTPSPSEMFIPANVVLKW
YENFQRRLAQNPLFWKT
Target Bioclass
Other
Family
OPI10 family
Subcellular location
Cytoplasm
Function
Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
Uniprot ID
Q53FT3
Ensemble ID
ENST00000278483.8
HGNC ID
HGNC:26938

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K196(5.88)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
DBIA
 Probe Info  		C4(1.27)  LDD0547  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
m-APA
 Probe Info  		N.A.  LDD2233  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		14.32  LDD1740  [7]
C106
 Probe Info  		46.53  LDD1793  [7]
C153
 Probe Info  		53.45  LDD1834  [7]
C169
 Probe Info  		19.97  LDD1849  [7]
C286
 Probe Info  		15.78  LDD1956  [7]
C288
 Probe Info  		12.21  LDD1958  [7]
C289
 Probe Info  		25.11  LDD1959  [7]
C293
 Probe Info  		56.10  LDD1963  [7]
C350
 Probe Info  		39.95  LDD2011  [7]
C353
 Probe Info  		6.11  LDD2014  [7]
C409
 Probe Info  		5.50  LDD2066  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C4(0.52)  LDD1093  [3]
 LDCM0215  AC10 HEK-293T C4(0.94)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C4(1.04)  LDD1509  [8]
 LDCM0230  AC113 HCT 116 C4(1.27)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C4(0.84)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C4(1.07)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C4(0.86)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C4(0.90)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C4(1.01)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C4(0.84)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C4(0.97)  LDD1510  [8]
 LDCM0238  AC120 HCT 116 C4(0.86)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C4(1.08)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C4(0.81)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C4(0.99)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C4(0.87)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C4(0.98)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C4(0.93)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C4(0.88)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C4(0.76)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C4(1.01)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C4(1.04)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C4(1.13)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C4(1.04)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C4(0.85)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C4(0.70)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C4(0.68)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C4(0.89)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C4(0.79)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C4(0.79)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C4(0.54)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C4(0.97)  LDD1512  [8]
 LDCM0260  AC140 HCT 116 C4(0.94)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C4(0.76)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C4(0.70)  LDD0579  [3]
 LDCM0270  AC15 HEK-293T C4(1.05)  LDD1513  [8]
 LDCM0276  AC17 HCT 116 C4(0.96)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C4(0.98)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C4(1.22)  LDD0595  [3]
 LDCM0279  AC2 PaTu 8988t C4(0.70)  LDD1158  [3]
 LDCM0280  AC20 HCT 116 C4(1.00)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C4(1.06)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C4(1.02)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C4(1.13)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C4(1.06)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C4(0.98)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C4(1.01)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C4(1.01)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C4(0.97)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C4(1.19)  LDD0606  [3]
 LDCM0290  AC3 PaTu 8988t C4(0.81)  LDD1169  [3]
 LDCM0291  AC30 HCT 116 C4(1.32)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C4(1.18)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C4(1.03)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C4(1.12)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C4(0.93)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C4(0.80)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C4(0.75)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C4(0.96)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C4(0.84)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C4(0.89)  LDD0617  [3]
 LDCM0301  AC4 PaTu 8988t C4(0.68)  LDD1180  [3]
 LDCM0302  AC40 HCT 116 C4(0.85)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C4(0.91)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C4(0.85)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C4(0.73)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C4(0.74)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C4(1.05)  LDD0624  [3]
 LDCM0308  AC46 PaTu 8988t C4(0.74)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C4(0.64)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C4(0.82)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C4(0.55)  LDD1190  [3]
 LDCM0312  AC5 PaTu 8988t C4(0.61)  LDD1191  [3]
 LDCM0313  AC50 PaTu 8988t C4(0.51)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C4(0.28)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C4(0.61)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C4(0.53)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C4(0.59)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C4(0.47)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C4(0.48)  LDD1198  [3]
 LDCM0320  AC57 HEK-293T C4(0.91)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C4(0.93)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C4(1.00)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C4(0.98)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C4(0.87)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C4(0.94)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C4(0.90)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C4(0.92)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C4(0.91)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C4(0.92)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C4(1.04)  LDD1569  [8]
 LDCM0349  AC83 HCT 116 C4(0.95)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C4(0.79)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C4(0.74)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C4(0.83)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C4(0.81)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C4(0.62)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C4(1.02)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C4(0.88)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C4(0.81)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C4(1.40)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C4(0.71)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C4(0.81)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C4(0.73)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C4(0.82)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C4(0.68)  LDD0681  [3]
 LDCM0248  AKOS034007472 HEK-293T C4(0.98)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C4(0.91)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C4(0.96)  LDD1514  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HCT 116 C4(0.98)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C4(0.99)  LDD0685  [3]
 LDCM0369  CL100 PaTu 8988t C4(0.72)  LDD1248  [3]
 LDCM0370  CL101 HEK-293T C4(0.91)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C4(0.92)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C4(0.94)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C4(1.01)  LDD1577  [8]
 LDCM0374  CL105 HCT 116 C4(1.01)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C4(1.14)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C4(1.10)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C4(1.00)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C4(1.05)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C4(0.93)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C4(1.07)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C4(0.95)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C4(0.95)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C4(0.89)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C4(0.96)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C4(0.79)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C4(1.10)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C4(0.59)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C4(1.15)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C4(0.97)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C4(1.01)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C4(0.99)  LDD0708  [3]
 LDCM0392  CL121 PaTu 8988t C4(0.71)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C4(0.56)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C4(0.65)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C4(0.84)  LDD1274  [3]
 LDCM0396  CL125 HEK-293T C4(0.85)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C4(0.88)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C4(0.81)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C4(0.85)  LDD1603  [8]
 LDCM0400  CL13 HCT 116 C4(0.97)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C4(1.00)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C4(0.95)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C4(0.74)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C4(0.87)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C4(0.88)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C4(1.21)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C4(1.04)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C4(0.98)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C4(1.04)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C4(1.82)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C4(0.87)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C4(0.79)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C4(0.88)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C4(0.94)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C4(1.34)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C4(1.15)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C4(0.96)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C4(1.05)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C4(1.00)  LDD0736  [3]
 LDCM0420  CL31 PaTu 8988t C4(1.37)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C4(0.88)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C4(0.86)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C4(0.93)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C4(0.99)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C4(0.33)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C4(0.88)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C4(0.86)  LDD1307  [3]
 LDCM0429  CL4 HCT 116 C4(0.94)  LDD0746  [3]
 LDCM0430  CL40 PaTu 8988t C4(0.92)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C4(0.85)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C4(1.06)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C4(0.75)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C4(0.66)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C4(0.88)  LDD1314  [3]
 LDCM0436  CL46 HEK-293T C4(1.04)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C4(1.05)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C4(1.02)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C4(0.94)  LDD1643  [8]
 LDCM0440  CL5 HCT 116 C4(0.99)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C4(0.96)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C4(1.11)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C4(0.97)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C4(1.01)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C4(1.09)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C4(0.97)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C4(0.95)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C4(0.98)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C4(1.16)  LDD1653  [8]
 LDCM0451  CL6 HCT 116 C4(0.92)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C4(1.07)  LDD1655  [8]
 LDCM0453  CL61 PaTu 8988t C4(0.61)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C4(0.63)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C4(0.81)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C4(0.67)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C4(0.73)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C4(0.66)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C4(0.66)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C4(0.62)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C4(0.53)  LDD1340  [3]
 LDCM0462  CL7 HCT 116 C4(0.98)  LDD0779  [3]
 LDCM0463  CL70 PaTu 8988t C4(0.58)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C4(0.65)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C4(1.01)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C4(0.49)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C4(0.62)  LDD1346  [3]
 LDCM0469  CL76 HEK-293T C4(0.93)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C4(0.84)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C4(1.02)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C4(1.08)  LDD1675  [8]
 LDCM0473  CL8 HCT 116 C4(0.86)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C4(1.02)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C4(1.27)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C4(1.03)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C4(1.04)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C4(0.95)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C4(0.92)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C4(0.97)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C4(0.95)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C4(1.00)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C4(1.01)  LDD1686  [8]
 LDCM0484  CL9 HCT 116 C4(0.94)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C4(0.88)  LDD1688  [8]
 LDCM0486  CL91 PaTu 8988t C4(0.65)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C4(0.71)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C4(0.58)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C4(0.62)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C4(0.53)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C4(0.65)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C4(0.70)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C4(0.53)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C4(0.77)  LDD1373  [3]
 LDCM0495  E2913 HEK-293T C4(0.95)  LDD1698  [8]
 LDCM0625  F8 Ramos C4(0.98)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C4(0.82)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C4(0.05)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C4(0.89)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C4(0.93)  LDD2192  [9]
 LDCM0576  Fragment14 Ramos C4(1.02)  LDD2193  [9]
 LDCM0579  Fragment20 Ramos C4(0.99)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C4(0.82)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C4(0.80)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C4(0.76)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C4(0.98)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C4(1.08)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C4(0.93)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C4(0.71)  LDD2201  [9]
 LDCM0468  Fragment33 PaTu 8988t C4(0.57)  LDD1347  [3]
 LDCM0596  Fragment38 Ramos C4(0.73)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C4(1.08)  LDD2184  [9]
 LDCM0427  Fragment51 PaTu 8988t C4(0.91)  LDD1306  [3]
 LDCM0610  Fragment52 Ramos C4(0.87)  LDD2204  [9]
 LDCM0614  Fragment56 Ramos C4(1.01)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C4(0.74)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C4(1.04)  LDD2188  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 HEK-293T C4(0.95)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C4(0.95)  LDD1497  [8]
 LDCM0024  KB05 COLO792 C4(2.77)  LDD3310  [10]
 LDCM0109  NEM HeLa N.A.  LDD0224  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840