Details of the Target

General Information of Target

Target ID LDTP00281
Target Name Golgi integral membrane protein 4 (GOLIM4)
Gene Name GOLIM4
Gene ID 27333
Synonyms
GIMPC; GOLPH4; GPP130; Golgi integral membrane protein 4; Golgi integral membrane protein, cis; GIMPc; Golgi phosphoprotein 4; Golgi-localized phosphoprotein of 130 kDa; Golgi phosphoprotein of 130 kDa
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQ
LQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQM
LKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLRE
ENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDT
LNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAE
DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEE
HDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQ
VEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQ
AHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEA
DRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAG
NPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEV
RDDNRPKGREEHYEEEEEEEEDGAAVAEKSHRRAEM
Target Bioclass
Other
Family
GOLIM4 family
Subcellular location
Golgi apparatus, Golgi stack membrane
Function Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.
Uniprot ID
O00461
Ensemble ID
ENST00000470487.6
HGNC ID
HGNC:15448

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		71.99  LDD0318  [1]
Probe 1
 Probe Info  		Y157(9.37)  LDD3495  [2]
IPM
 Probe Info  		C6(1.79)  LDD1702  [3]
Acrolein
 Probe Info  		N.A.  LDD0221  [4]
DBIA
 Probe Info  		C6(0.98)  LDD1509  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [6]
CY4
 Probe Info  		Q413(0.00); Q414(0.00)  LDD0247  [7]
STPyne
 Probe Info  		N.A.  LDD0009  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
PAL-AfBPP Probe
Click To Hide/Show 167 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		8.06  LDD1711  [9]
C004
 Probe Info  		15.56  LDD1714  [9]
C007
 Probe Info  		10.78  LDD1716  [9]
C010
 Probe Info  		7.01  LDD1719  [9]
C011
 Probe Info  		6.45  LDD1720  [9]
C017
 Probe Info  		5.90  LDD1725  [9]
C022
 Probe Info  		27.67  LDD1728  [9]
C026
 Probe Info  		13.00  LDD1732  [9]
C027
 Probe Info  		8.69  LDD1733  [9]
C039
 Probe Info  		5.21  LDD1739  [9]
C040
 Probe Info  		19.84  LDD1740  [9]
C041
 Probe Info  		11.79  LDD1741  [9]
C044
 Probe Info  		5.58  LDD1743  [9]
C049
 Probe Info  		9.85  LDD1747  [9]
C055
 Probe Info  		39.67  LDD1752  [9]
C056
 Probe Info  		57.28  LDD1753  [9]
C059
 Probe Info  		7.73  LDD1756  [9]
C063
 Probe Info  		25.11  LDD1760  [9]
C064
 Probe Info  		10.93  LDD1761  [9]
C067
 Probe Info  		5.74  LDD1763  [9]
C070
 Probe Info  		17.03  LDD1766  [9]
C072
 Probe Info  		12.82  LDD1768  [9]
C082
 Probe Info  		12.13  LDD1774  [9]
C085
 Probe Info  		11.55  LDD1777  [9]
C087
 Probe Info  		17.03  LDD1779  [9]
C091
 Probe Info  		39.12  LDD1782  [9]
C092
 Probe Info  		41.07  LDD1783  [9]
C094
 Probe Info  		41.64  LDD1785  [9]
C095
 Probe Info  		6.50  LDD1786  [9]
C106
 Probe Info  		35.51  LDD1793  [9]
C107
 Probe Info  		20.25  LDD1794  [9]
C108
 Probe Info  		17.03  LDD1795  [9]
C112
 Probe Info  		67.65  LDD1799  [9]
C129
 Probe Info  		8.69  LDD1811  [9]
C130
 Probe Info  		19.97  LDD1812  [9]
C134
 Probe Info  		44.32  LDD1816  [9]
C135
 Probe Info  		22.01  LDD1817  [9]
C139
 Probe Info  		21.56  LDD1821  [9]
C140
 Probe Info  		9.51  LDD1822  [9]
C141
 Probe Info  		18.25  LDD1823  [9]
C143
 Probe Info  		34.06  LDD1825  [9]
C147
 Probe Info  		9.92  LDD1829  [9]
C149
 Probe Info  		6.41  LDD1830  [9]
C153
 Probe Info  		26.17  LDD1834  [9]
C159
 Probe Info  		16.34  LDD1839  [9]
C160
 Probe Info  		19.97  LDD1840  [9]
C161
 Probe Info  		31.78  LDD1841  [9]
C163
 Probe Info  		11.24  LDD1843  [9]
C165
 Probe Info  		16.68  LDD1845  [9]
C166
 Probe Info  		14.42  LDD1846  [9]
C169
 Probe Info  		32.90  LDD1849  [9]
C170
 Probe Info  		13.93  LDD1850  [9]
C177
 Probe Info  		8.11  LDD1856  [9]
C178
 Probe Info  		26.35  LDD1857  [9]
C183
 Probe Info  		6.54  LDD1861  [9]
C186
 Probe Info  		16.22  LDD1864  [9]
C187
 Probe Info  		89.88  LDD1865  [9]
C191
 Probe Info  		45.25  LDD1868  [9]
C193
 Probe Info  		30.48  LDD1869  [9]
C194
 Probe Info  		13.93  LDD1870  [9]
C196
 Probe Info  		16.45  LDD1872  [9]
C197
 Probe Info  		9.06  LDD1873  [9]
C198
 Probe Info  		17.27  LDD1874  [9]
C201
 Probe Info  		48.84  LDD1877  [9]
C206
 Probe Info  		30.06  LDD1881  [9]
C210
 Probe Info  		50.56  LDD1884  [9]
C211
 Probe Info  		11.00  LDD1885  [9]
C213
 Probe Info  		19.29  LDD1887  [9]
C216
 Probe Info  		5.17  LDD1890  [9]
C217
 Probe Info  		6.73  LDD1891  [9]
C218
 Probe Info  		32.45  LDD1892  [9]
C219
 Probe Info  		18.90  LDD1893  [9]
C220
 Probe Info  		37.01  LDD1894  [9]
C221
 Probe Info  		5.21  LDD1895  [9]
C223
 Probe Info  		6.45  LDD1897  [9]
C225
 Probe Info  		7.16  LDD1898  [9]
C226
 Probe Info  		8.00  LDD1899  [9]
C228
 Probe Info  		26.17  LDD1901  [9]
C229
 Probe Info  		14.22  LDD1902  [9]
C231
 Probe Info  		33.82  LDD1904  [9]
C232
 Probe Info  		41.36  LDD1905  [9]
C233
 Probe Info  		21.56  LDD1906  [9]
C234
 Probe Info  		9.25  LDD1907  [9]
C235
 Probe Info  		33.13  LDD1908  [9]
C238
 Probe Info  		30.91  LDD1911  [9]
C240
 Probe Info  		15.03  LDD1913  [9]
C243
 Probe Info  		34.30  LDD1916  [9]
C244
 Probe Info  		27.28  LDD1917  [9]
C245
 Probe Info  		9.71  LDD1918  [9]
C246
 Probe Info  		41.36  LDD1919  [9]
C249
 Probe Info  		28.44  LDD1922  [9]
C252
 Probe Info  		22.01  LDD1925  [9]
C255
 Probe Info  		5.58  LDD1928  [9]
C264
 Probe Info  		29.24  LDD1935  [9]
C265
 Probe Info  		22.01  LDD1936  [9]
C269
 Probe Info  		8.57  LDD1939  [9]
C270
 Probe Info  		10.06  LDD1940  [9]
C273
 Probe Info  		7.57  LDD1943  [9]
C277
 Probe Info  		17.03  LDD1947  [9]
C282
 Probe Info  		21.56  LDD1952  [9]
C284
 Probe Info  		20.82  LDD1954  [9]
C285
 Probe Info  		24.59  LDD1955  [9]
C287
 Probe Info  		10.93  LDD1957  [9]
C288
 Probe Info  		12.82  LDD1958  [9]
C289
 Probe Info  		29.65  LDD1959  [9]
C290
 Probe Info  		6.19  LDD1960  [9]
C293
 Probe Info  		34.30  LDD1963  [9]
C296
 Probe Info  		19.70  LDD1966  [9]
C299
 Probe Info  		12.21  LDD1968  [9]
C304
 Probe Info  		5.50  LDD1973  [9]
C305
 Probe Info  		28.84  LDD1974  [9]
C310
 Probe Info  		18.13  LDD1977  [9]
C313
 Probe Info  		24.08  LDD1980  [9]
C314
 Probe Info  		20.97  LDD1981  [9]
C317
 Probe Info  		10.20  LDD1983  [9]
C322
 Probe Info  		10.41  LDD1988  [9]
C326
 Probe Info  		14.12  LDD1990  [9]
C338
 Probe Info  		15.67  LDD2001  [9]
C339
 Probe Info  		12.21  LDD2002  [9]
C343
 Probe Info  		21.71  LDD2005  [9]
C346
 Probe Info  		12.13  LDD2007  [9]
C348
 Probe Info  		23.59  LDD2009  [9]
C349
 Probe Info  		29.45  LDD2010  [9]
C350
 Probe Info  		56.89  LDD2011  [9]
C353
 Probe Info  		10.06  LDD2014  [9]
C354
 Probe Info  		11.96  LDD2015  [9]
C356
 Probe Info  		9.58  LDD2017  [9]
C357
 Probe Info  		5.35  LDD2018  [9]
C362
 Probe Info  		30.70  LDD2023  [9]
C363
 Probe Info  		16.00  LDD2024  [9]
C366
 Probe Info  		8.51  LDD2027  [9]
C373
 Probe Info  		6.96  LDD2033  [9]
C376
 Probe Info  		8.51  LDD2036  [9]
C378
 Probe Info  		6.50  LDD2037  [9]
C380
 Probe Info  		5.94  LDD2039  [9]
C382
 Probe Info  		14.12  LDD2041  [9]
C383
 Probe Info  		15.45  LDD2042  [9]
C386
 Probe Info  		11.79  LDD2045  [9]
C388
 Probe Info  		95.01  LDD2047  [9]
C399
 Probe Info  		12.64  LDD2058  [9]
C403
 Probe Info  		21.86  LDD2061  [9]
C405
 Probe Info  		19.16  LDD2063  [9]
C407
 Probe Info  		99.73  LDD2064  [9]
C408
 Probe Info  		17.27  LDD2065  [9]
C409
 Probe Info  		14.12  LDD2066  [9]
C413
 Probe Info  		20.11  LDD2069  [9]
C419
 Probe Info  		19.03  LDD2074  [9]
C420
 Probe Info  		14.83  LDD2075  [9]
C423
 Probe Info  		10.78  LDD2078  [9]
C424
 Probe Info  		13.27  LDD2079  [9]
C426
 Probe Info  		22.01  LDD2081  [9]
C429
 Probe Info  		44.02  LDD2084  [9]
C430
 Probe Info  		13.00  LDD2085  [9]
C431
 Probe Info  		44.32  LDD2086  [9]
C433
 Probe Info  		9.25  LDD2088  [9]
FFF probe11
 Probe Info  		19.91  LDD0471  [10]
FFF probe12
 Probe Info  		20.00  LDD0473  [10]
FFF probe13
 Probe Info  		20.00  LDD0475  [10]
FFF probe14
 Probe Info  		20.00  LDD0477  [10]
FFF probe15
 Probe Info  		10.75  LDD0478  [10]
FFF probe2
 Probe Info  		19.28  LDD0463  [10]
FFF probe3
 Probe Info  		17.41  LDD0464  [10]
FFF probe6
 Probe Info  		17.20  LDD0482  [10]
FFF probe7
 Probe Info  		13.26  LDD0483  [10]
FFF probe9
 Probe Info  		20.00  LDD0470  [10]
JN0003
 Probe Info  		20.00  LDD0469  [10]
OEA-DA
 Probe Info  		20.00  LDD0046  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C6(0.98)  LDD1509  [5]
 LDCM0278  AC19 HEK-293T C6(1.19)  LDD1517  [5]
 LDCM0287  AC27 HEK-293T C6(0.95)  LDD1526  [5]
 LDCM0290  AC3 HEK-293T C6(0.98)  LDD1529  [5]
 LDCM0296  AC35 HEK-293T C6(1.13)  LDD1535  [5]
 LDCM0305  AC43 HEK-293T C6(1.06)  LDD1544  [5]
 LDCM0314  AC51 HEK-293T C6(0.94)  LDD1553  [5]
 LDCM0322  AC59 HEK-293T C6(1.00)  LDD1561  [5]
 LDCM0108  Chloroacetamide HeLa H435(0.00); H339(0.00); H430(0.00)  LDD0222  [4]
 LDCM0406  CL19 HEK-293T C6(1.03)  LDD1610  [5]
 LDCM0420  CL31 HEK-293T C6(1.05)  LDD1624  [5]
 LDCM0433  CL43 HEK-293T C6(1.06)  LDD1637  [5]
 LDCM0446  CL55 HEK-293T C6(1.09)  LDD1649  [5]
 LDCM0459  CL67 HEK-293T C6(1.02)  LDD1662  [5]
 LDCM0462  CL7 HEK-293T C6(1.09)  LDD1665  [5]
 LDCM0472  CL79 HEK-293T C6(1.01)  LDD1675  [5]
 LDCM0486  CL91 HEK-293T C6(1.03)  LDD1689  [5]
 LDCM0189  Compound 16 HEK-293T 33.33  LDD0492  [10]
 LDCM0185  Compound 17 HEK-293T 3.55  LDD0512  [10]
 LDCM0184  Compound 20 HEK-293T 11.44  LDD0503  [10]
 LDCM0191  Compound 21 HEK-293T 5.97  LDD0493  [10]
 LDCM0190  Compound 34 HEK-293T 30.30  LDD0497  [10]
 LDCM0192  Compound 35 HEK-293T 9.26  LDD0491  [10]
 LDCM0193  Compound 36 HEK-293T 13.71  LDD0511  [10]
 LDCM0194  Compound 37 HEK-293T 6.13  LDD0498  [10]
 LDCM0195  Compound 38 HEK-293T 15.50  LDD0499  [10]
 LDCM0197  Compound 40 HEK-293T 14.29  LDD0495  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C6(1.79)  LDD1702  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0022  KB02 ICC18 C6(1.95)  LDD2385  [12]
 LDCM0023  KB03 ICC3 C6(7.20)  LDD2808  [12]
 LDCM0024  KB05 ICC26 C6(1.96)  LDD3224  [12]
 LDCM0109  NEM HeLa N.A.  LDD0224  [4]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
11 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840