Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C255  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 32.9
 LDTP01769  Dihydrofolate reductase (DHFR) 32.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 27.7
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 20.8
 LDTP05841  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C) 13.8
 LDTP03787  Choline kinase alpha (CHKA) 13.5
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 10.8
 LDTP02359  Heme oxygenase 1 (HMOX1) 10.7
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 10.6
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 9.4
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 8.9
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 7.6
 LDTP02505  Lysosomal protective protein (CTSA) 7.5
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 7.2
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 6.1
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 6.1
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 5.3
 LDTP02837  Beta-galactosidase (GLB1) 5.2
Transporter and channel
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 23.3
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.4
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 17.6
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 14.7
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 9.3
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 8.6
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 6.7
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 6.0
 LDTP07236  Protein GPR107 (GPR107) 6.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 5.7
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 5.4
Other
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 15.9
 LDTP14172  Sorting nexin-9 (SNX9) 10.6
 LDTP00105  Protein unc-119 homolog B (UNC119B) 8.6
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 7.8
 LDTP14058  Rap guanine nucleotide exchange factor 2 (RAPGEF2) 7.6
 LDTP05960  Trophoblast glycoprotein (TPBG) 7.4
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 7.1
 LDTP05998  Tubulin beta-2A chain (TUBB2A) 6.6
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 6.2
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 6.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 5.6
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 5.5
 LDTP09970  RNA-binding protein with multiple splicing (RBPMS) 5.5
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 5.4
 LDTP02037  Tubulin beta-4A chain (TUBB4A) 5.2
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 5.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587