Details of the Target

General Information of Target

Target ID	LDTP12363
Target Name	Lysophosphatidic acid phosphatase type 6 (ACP6)
Gene Name	ACP6
Gene ID	51205
Synonyms	ACPL1; LPAP; Lysophosphatidic acid phosphatase type 6; EC 3.1.3.2; Acid phosphatase 6, lysophosphatidic; Acid phosphatase-like protein 1; PACPL1
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MDFLVLFLFYLASVLMGLVLICVCSKTHSLKGLARGGAQIFSCIIPECLQRAVHGLLHYL FHTRNHTFIVLHLVLQGMVYTEYTWEVFGYCQELELSLHYLLLPYLLLGVNLFFFTLTCG TNPGIITKANELLFLHVYEFDEVMFPKNVRCSTCDLRKPARSKHCSVCNWCVHRFDHHCV WVNNCIGAWNIRYFLIYVLTLTASAATVAIVSTTFLVHLVVMSDLYQETYIDDLGHLHVM DTVFLIQYLFLTFPRIVFMLGFVVVLSFLLGGYLLFVLYLAATNQTTNEWYRGDWAWCQR CPLVAWPPSAEPQVHRNIHSHGLRSNLQEIFLPAFPCHERKKQE
Target Bioclass	Enzyme
Family	Histidine acid phosphatase family
Subcellular location	Mitochondrion
Function	Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.
Uniprot ID	Q9NPH0
Ensemble ID	ENST00000487562.5
HGNC ID	HGNC:29609

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
HUH1	Substitution: p.E309R	.
HUPT3	SNV: p.D44Y	DBIA Probe Info
JHH7	Substitution: p.E309R	.
LS180	SNV: p.V144A	DBIA Probe Info
MKN45	Substitution: p.E309R	.
NCIH661	SNV: p.P13L	.
OPM2	Substitution: p.E309R	DBIA Probe Info
OVTOKO	Substitution: p.E309R	.
SNU478	Substitution: p.E309R	DBIA Probe Info
TOV21G	SNV: p.G60W	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 12 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
m-APA Probe Info	15.00	LDD0402	[1]
TH211 Probe Info	Y205(11.58)	LDD0257	[2]
STPyne Probe Info	K291(5.04)	LDD0277	[3]
DBIA Probe Info	C267(1.04)	LDD3313	[4]
AHL-Pu-1 Probe Info	C267(2.22)	LDD0171	[5]
5E-2FA Probe Info	N.A.	LDD2235	[6]
IA-alkyne Probe Info	C23(0.00); C175(0.00); C208(0.00)	LDD0162	[7]
NHS Probe Info	N.A.	LDD0010	[8]
Phosphinate-6 Probe Info	N.A.	LDD0018	[9]
Acrolein Probe Info	N.A.	LDD0217	[10]
AOyne Probe Info	13.20	LDD0443	[11]
NAIA_5 Probe Info	N.A.	LDD2223	[12]

PAL-AfBPP Probe

Click To Hide/Show 165 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C002 Probe Info	11.39	LDD1712	[13]
C004 Probe Info	9.13	LDD1714	[13]
C007 Probe Info	8.06	LDD1716	[13]
C010 Probe Info	5.39	LDD1719	[13]
C022 Probe Info	11.24	LDD1728	[13]
C026 Probe Info	5.78	LDD1732	[13]
C039 Probe Info	4.96	LDD1739	[13]
C040 Probe Info	20.82	LDD1740	[13]
C041 Probe Info	9.58	LDD1741	[13]
C044 Probe Info	19.70	LDD1743	[13]
C051 Probe Info	11.24	LDD1749	[13]
C053 Probe Info	9.00	LDD1751	[13]
C055 Probe Info	14.52	LDD1752	[13]
C056 Probe Info	19.56	LDD1753	[13]
C059 Probe Info	12.73	LDD1756	[13]
C060 Probe Info	5.35	LDD1757	[13]
C063 Probe Info	40.50	LDD1760	[13]
C064 Probe Info	19.16	LDD1761	[13]
C067 Probe Info	17.75	LDD1763	[13]
C070 Probe Info	10.27	LDD1766	[13]
C071 Probe Info	20.82	LDD1767	[13]
C072 Probe Info	9.85	LDD1768	[13]
C082 Probe Info	31.56	LDD1774	[13]
C083 Probe Info	5.70	LDD1775	[13]
C085 Probe Info	14.93	LDD1777	[13]
C091 Probe Info	12.13	LDD1782	[13]
C092 Probe Info	25.28	LDD1783	[13]
C095 Probe Info	9.65	LDD1786	[13]
C099 Probe Info	9.85	LDD1788	[13]
C102 Probe Info	7.41	LDD1790	[13]
C106 Probe Info	21.11	LDD1793	[13]
C107 Probe Info	28.25	LDD1794	[13]
C108 Probe Info	10.48	LDD1795	[13]
C112 Probe Info	46.85	LDD1799	[13]
C122 Probe Info	15.45	LDD1808	[13]
C130 Probe Info	14.62	LDD1812	[13]
C134 Probe Info	58.49	LDD1816	[13]
C135 Probe Info	32.90	LDD1817	[13]
C138 Probe Info	9.13	LDD1820	[13]
C139 Probe Info	16.80	LDD1821	[13]
C140 Probe Info	14.52	LDD1822	[13]
C141 Probe Info	10.70	LDD1823	[13]
C143 Probe Info	76.11	LDD1825	[13]
C145 Probe Info	11.96	LDD1827	[13]
C147 Probe Info	8.06	LDD1829	[13]
C153 Probe Info	38.32	LDD1834	[13]
C158 Probe Info	9.06	LDD1838	[13]
C159 Probe Info	7.84	LDD1839	[13]
C160 Probe Info	7.46	LDD1840	[13]
C161 Probe Info	35.51	LDD1841	[13]
C165 Probe Info	20.68	LDD1845	[13]
C166 Probe Info	10.56	LDD1846	[13]
C169 Probe Info	46.53	LDD1849	[13]
C173 Probe Info	5.94	LDD1853	[13]
C176 Probe Info	5.98	LDD1855	[13]
C177 Probe Info	26.17	LDD1856	[13]
C183 Probe Info	10.93	LDD1861	[13]
C185 Probe Info	20.39	LDD1863	[13]
C191 Probe Info	11.55	LDD1868	[13]
C193 Probe Info	8.11	LDD1869	[13]
C194 Probe Info	26.17	LDD1870	[13]
C196 Probe Info	64.89	LDD1872	[13]
C198 Probe Info	10.93	LDD1874	[13]
C199 Probe Info	6.54	LDD1875	[13]
C201 Probe Info	31.78	LDD1877	[13]
C204 Probe Info	7.41	LDD1879	[13]
C206 Probe Info	17.39	LDD1881	[13]
C211 Probe Info	9.06	LDD1885	[13]
C212 Probe Info	5.66	LDD1886	[13]
C214 Probe Info	10.63	LDD1888	[13]
C218 Probe Info	22.94	LDD1892	[13]
C222 Probe Info	7.62	LDD1896	[13]
C225 Probe Info	16.80	LDD1898	[13]
C226 Probe Info	11.16	LDD1899	[13]
C228 Probe Info	37.27	LDD1901	[13]
C229 Probe Info	14.93	LDD1902	[13]
C231 Probe Info	57.68	LDD1904	[13]
C233 Probe Info	24.93	LDD1906	[13]
C234 Probe Info	9.51	LDD1907	[13]
C238 Probe Info	29.86	LDD1911	[13]
C239 Probe Info	6.36	LDD1912	[13]
C240 Probe Info	11.39	LDD1913	[13]
C242 Probe Info	5.10	LDD1915	[13]
C243 Probe Info	30.06	LDD1916	[13]
C244 Probe Info	30.70	LDD1917	[13]
C246 Probe Info	15.67	LDD1919	[13]
C252 Probe Info	13.00	LDD1925	[13]
C255 Probe Info	8.94	LDD1928	[13]
C258 Probe Info	10.41	LDD1931	[13]
C264 Probe Info	20.68	LDD1935	[13]
C265 Probe Info	31.56	LDD1936	[13]
C269 Probe Info	7.46	LDD1939	[13]
C271 Probe Info	8.17	LDD1941	[13]
C273 Probe Info	7.52	LDD1943	[13]
C275 Probe Info	5.46	LDD1945	[13]
C277 Probe Info	8.34	LDD1947	[13]
C282 Probe Info	41.07	LDD1952	[13]
C285 Probe Info	26.91	LDD1955	[13]
C287 Probe Info	16.56	LDD1957	[13]
C288 Probe Info	9.78	LDD1958	[13]
C289 Probe Info	39.40	LDD1959	[13]
C290 Probe Info	15.03	LDD1960	[13]
C292 Probe Info	6.96	LDD1962	[13]
C293 Probe Info	37.27	LDD1963	[13]
C296 Probe Info	15.35	LDD1966	[13]
C297 Probe Info	10.06	LDD1967	[13]
C299 Probe Info	13.09	LDD1968	[13]
C305 Probe Info	15.89	LDD1974	[13]
C314 Probe Info	30.48	LDD1981	[13]
C317 Probe Info	8.11	LDD1983	[13]
C320 Probe Info	6.32	LDD1986	[13]
C322 Probe Info	7.01	LDD1988	[13]
C328 Probe Info	99.73	LDD1992	[13]
C333 Probe Info	22.01	LDD1996	[13]
C335 Probe Info	7.84	LDD1998	[13]
C339 Probe Info	6.11	LDD2002	[13]
C342 Probe Info	14.12	LDD2004	[13]
C343 Probe Info	17.15	LDD2005	[13]
C346 Probe Info	11.16	LDD2007	[13]
C347 Probe Info	8.11	LDD2008	[13]
C348 Probe Info	14.62	LDD2009	[13]
C349 Probe Info	44.32	LDD2010	[13]
C350 Probe Info	99.73	LDD2011	[13]
C351 Probe Info	7.84	LDD2012	[13]
C353 Probe Info	39.12	LDD2014	[13]
C354 Probe Info	16.34	LDD2015	[13]
C355 Probe Info	28.25	LDD2016	[13]
C356 Probe Info	55.33	LDD2017	[13]
C357 Probe Info	6.87	LDD2018	[13]
C360 Probe Info	15.03	LDD2021	[13]
C361 Probe Info	18.90	LDD2022	[13]
C362 Probe Info	25.28	LDD2023	[13]
C363 Probe Info	68.12	LDD2024	[13]
C366 Probe Info	17.75	LDD2027	[13]
C367 Probe Info	7.67	LDD2028	[13]
C380 Probe Info	9.71	LDD2039	[13]
C382 Probe Info	11.96	LDD2041	[13]
C383 Probe Info	12.13	LDD2042	[13]
C388 Probe Info	60.13	LDD2047	[13]
C390 Probe Info	99.73	LDD2049	[13]
C391 Probe Info	62.68	LDD2050	[13]
C392 Probe Info	11.16	LDD2051	[13]
C393 Probe Info	15.24	LDD2052	[13]
C394 Probe Info	6.87	LDD2053	[13]
C395 Probe Info	9.71	LDD2054	[13]
C396 Probe Info	15.03	LDD2055	[13]
C397 Probe Info	15.67	LDD2056	[13]
C398 Probe Info	9.06	LDD2057	[13]
C399 Probe Info	8.63	LDD2058	[13]
C400 Probe Info	9.32	LDD2059	[13]
C403 Probe Info	51.98	LDD2061	[13]
C405 Probe Info	5.90	LDD2063	[13]
C408 Probe Info	5.98	LDD2065	[13]
C413 Probe Info	56.10	LDD2069	[13]
C418 Probe Info	42.22	LDD2073	[13]
C419 Probe Info	63.12	LDD2074	[13]
C424 Probe Info	32.67	LDD2079	[13]
C429 Probe Info	43.41	LDD2084	[13]
C430 Probe Info	23.92	LDD2085	[13]
C431 Probe Info	35.51	LDD2086	[13]
C433 Probe Info	17.88	LDD2088	[13]
FFF probe11 Probe Info	20.00	LDD0471	[14]
FFF probe14 Probe Info	20.00	LDD0477	[14]
FFF probe2 Probe Info	20.00	LDD0463	[14]
OEA-DA Probe Info	17.88	LDD0046	[15]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0026	4SU-RNA+native RNA	DM93	C267(2.22)	LDD0171	[5]
LDCM0214	AC1	HEK-293T	C267(0.98); C183(0.86)	LDD1507	[16]
LDCM0215	AC10	PaTu 8988t	C175(0.59); C183(0.59)	LDD1094	[17]
LDCM0226	AC11	PaTu 8988t	C175(0.71); C183(0.71)	LDD1105	[17]
LDCM0237	AC12	PaTu 8988t	C175(0.66); C183(0.66)	LDD1116	[17]
LDCM0246	AC128	PaTu 8988t	C175(0.74); C183(0.74)	LDD1125	[17]
LDCM0247	AC129	PaTu 8988t	C175(0.79); C183(0.79)	LDD1126	[17]
LDCM0249	AC130	PaTu 8988t	C175(1.04); C183(1.04)	LDD1128	[17]
LDCM0250	AC131	PaTu 8988t	C175(0.89); C183(0.89)	LDD1129	[17]
LDCM0251	AC132	PaTu 8988t	C175(1.02); C183(1.02)	LDD1130	[17]
LDCM0252	AC133	PaTu 8988t	C175(0.43); C183(0.43)	LDD1131	[17]
LDCM0253	AC134	PaTu 8988t	C175(0.61); C183(0.61)	LDD1132	[17]
LDCM0254	AC135	PaTu 8988t	C175(0.46); C183(0.46)	LDD1133	[17]
LDCM0255	AC136	PaTu 8988t	C175(0.62); C183(0.62)	LDD1134	[17]
LDCM0256	AC137	PaTu 8988t	C175(0.49); C183(0.49)	LDD1135	[17]
LDCM0257	AC138	PaTu 8988t	C175(0.82); C183(0.82)	LDD1136	[17]
LDCM0258	AC139	PaTu 8988t	C175(0.87); C183(0.87)	LDD1137	[17]
LDCM0259	AC14	PaTu 8988t	C175(0.76); C183(0.76)	LDD1138	[17]
LDCM0260	AC140	PaTu 8988t	C175(0.81); C183(0.81)	LDD1139	[17]
LDCM0261	AC141	PaTu 8988t	C175(1.01); C183(1.01)	LDD1140	[17]
LDCM0262	AC142	PaTu 8988t	C175(0.89); C183(0.89)	LDD1141	[17]
LDCM0270	AC15	PaTu 8988t	C175(0.68); C183(0.68)	LDD1149	[17]
LDCM0276	AC17	PaTu 8988t	C175(1.21); C183(1.21)	LDD1155	[17]
LDCM0277	AC18	PaTu 8988t	C175(0.87); C183(0.87)	LDD1156	[17]
LDCM0278	AC19	PaTu 8988t	C175(1.20); C183(1.20)	LDD1157	[17]
LDCM0279	AC2	HEK-293T	C267(0.92); C183(0.86)	LDD1518	[16]
LDCM0280	AC20	PaTu 8988t	C175(0.88); C183(0.88)	LDD1159	[17]
LDCM0281	AC21	PaTu 8988t	C175(0.86); C183(0.86)	LDD1160	[17]
LDCM0282	AC22	PaTu 8988t	C175(0.80); C183(0.80)	LDD1161	[17]
LDCM0283	AC23	PaTu 8988t	C175(0.70); C183(0.70)	LDD1162	[17]
LDCM0284	AC24	PaTu 8988t	C175(0.85); C183(0.85)	LDD1163	[17]
LDCM0285	AC25	PaTu 8988t	C175(1.22); C183(1.22)	LDD1164	[17]
LDCM0286	AC26	PaTu 8988t	C175(1.06); C183(1.06)	LDD1165	[17]
LDCM0287	AC27	PaTu 8988t	C175(0.94); C183(0.94)	LDD1166	[17]
LDCM0288	AC28	PaTu 8988t	C175(0.98); C183(0.98)	LDD1167	[17]
LDCM0289	AC29	PaTu 8988t	C175(1.05); C183(1.05)	LDD1168	[17]
LDCM0290	AC3	HEK-293T	C267(0.94); C183(0.94)	LDD1529	[16]
LDCM0291	AC30	PaTu 8988t	C175(1.03); C183(1.03)	LDD1170	[17]
LDCM0292	AC31	PaTu 8988t	C175(1.18); C183(1.18)	LDD1171	[17]
LDCM0293	AC32	PaTu 8988t	C175(0.99); C183(0.99)	LDD1172	[17]
LDCM0294	AC33	PaTu 8988t	C175(0.89); C183(0.89)	LDD1173	[17]
LDCM0295	AC34	PaTu 8988t	C175(0.75); C183(0.75)	LDD1174	[17]
LDCM0296	AC35	PaTu 8988t	C175(1.19); C183(1.19)	LDD1175	[17]
LDCM0297	AC36	PaTu 8988t	C175(1.09); C183(1.09)	LDD1176	[17]
LDCM0298	AC37	PaTu 8988t	C175(0.95); C183(0.95)	LDD1177	[17]
LDCM0299	AC38	PaTu 8988t	C175(1.11); C183(1.11)	LDD1178	[17]
LDCM0300	AC39	PaTu 8988t	C175(1.07); C183(1.07)	LDD1179	[17]
LDCM0301	AC4	HEK-293T	C267(0.95); C183(0.94)	LDD1540	[16]
LDCM0302	AC40	PaTu 8988t	C175(0.91); C183(0.91)	LDD1181	[17]
LDCM0303	AC41	PaTu 8988t	C175(0.99); C183(0.99)	LDD1182	[17]
LDCM0304	AC42	PaTu 8988t	C175(0.89); C183(0.89)	LDD1183	[17]
LDCM0305	AC43	PaTu 8988t	C175(1.16); C183(1.16)	LDD1184	[17]
LDCM0306	AC44	PaTu 8988t	C175(0.50); C183(0.50)	LDD1185	[17]
LDCM0307	AC45	PaTu 8988t	C175(0.73); C183(0.73)	LDD1186	[17]
LDCM0308	AC46	PaTu 8988t	C175(0.84); C183(0.84)	LDD1187	[17]
LDCM0309	AC47	PaTu 8988t	C175(0.74); C183(0.74)	LDD1188	[17]
LDCM0310	AC48	PaTu 8988t	C175(0.71); C183(0.71)	LDD1189	[17]
LDCM0311	AC49	PaTu 8988t	C175(0.57); C183(0.57)	LDD1190	[17]
LDCM0312	AC5	HEK-293T	C267(1.00); C183(1.00)	LDD1551	[16]
LDCM0313	AC50	PaTu 8988t	C175(0.51); C183(0.51)	LDD1192	[17]
LDCM0314	AC51	PaTu 8988t	C175(0.29); C183(0.29)	LDD1193	[17]
LDCM0315	AC52	PaTu 8988t	C175(0.70); C183(0.70)	LDD1194	[17]
LDCM0316	AC53	PaTu 8988t	C175(0.45); C183(0.45)	LDD1195	[17]
LDCM0317	AC54	PaTu 8988t	C175(0.46); C183(0.46)	LDD1196	[17]
LDCM0318	AC55	PaTu 8988t	C175(0.61); C183(0.61)	LDD1197	[17]
LDCM0319	AC56	PaTu 8988t	C175(0.57); C183(0.57)	LDD1198	[17]
LDCM0320	AC57	PaTu 8988t	C175(1.03); C183(1.03)	LDD1199	[17]
LDCM0321	AC58	PaTu 8988t	C175(1.08); C183(1.08)	LDD1200	[17]
LDCM0322	AC59	PaTu 8988t	C175(1.17); C183(1.17)	LDD1201	[17]
LDCM0323	AC6	PaTu 8988t	C175(0.83); C183(0.83)	LDD1202	[17]
LDCM0324	AC60	PaTu 8988t	C175(1.25); C183(1.25)	LDD1203	[17]
LDCM0325	AC61	PaTu 8988t	C175(1.16); C183(1.16)	LDD1204	[17]
LDCM0326	AC62	PaTu 8988t	C175(1.10); C183(1.10)	LDD1205	[17]
LDCM0327	AC63	PaTu 8988t	C175(1.02); C183(1.02)	LDD1206	[17]
LDCM0328	AC64	PaTu 8988t	C175(1.10); C183(1.10)	LDD1207	[17]
LDCM0329	AC65	PaTu 8988t	C175(1.01); C183(1.01)	LDD1208	[17]
LDCM0330	AC66	PaTu 8988t	C175(1.13); C183(1.13)	LDD1209	[17]
LDCM0331	AC67	PaTu 8988t	C175(1.16); C183(1.16)	LDD1210	[17]
LDCM0332	AC68	PaTu 8988t	C175(1.22); C183(1.22)	LDD1211	[17]
LDCM0333	AC69	PaTu 8988t	C175(1.11); C183(1.11)	LDD1212	[17]
LDCM0334	AC7	PaTu 8988t	C175(0.92); C183(0.92)	LDD1213	[17]
LDCM0335	AC70	PaTu 8988t	C175(0.96); C183(0.96)	LDD1214	[17]
LDCM0336	AC71	PaTu 8988t	C175(1.04); C183(1.04)	LDD1215	[17]
LDCM0337	AC72	PaTu 8988t	C175(1.19); C183(1.19)	LDD1216	[17]
LDCM0338	AC73	PaTu 8988t	C175(1.11); C183(1.11)	LDD1217	[17]
LDCM0339	AC74	PaTu 8988t	C175(1.08); C183(1.08)	LDD1218	[17]
LDCM0340	AC75	PaTu 8988t	C175(1.02); C183(1.02)	LDD1219	[17]
LDCM0341	AC76	PaTu 8988t	C175(1.19); C183(1.19)	LDD1220	[17]
LDCM0342	AC77	PaTu 8988t	C175(1.07); C183(1.07)	LDD1221	[17]
LDCM0343	AC78	PaTu 8988t	C175(1.16); C183(1.16)	LDD1222	[17]
LDCM0344	AC79	PaTu 8988t	C175(1.03); C183(1.03)	LDD1223	[17]
LDCM0345	AC8	PaTu 8988t	C175(0.86); C183(0.86)	LDD1224	[17]
LDCM0346	AC80	PaTu 8988t	C175(1.14); C183(1.14)	LDD1225	[17]
LDCM0347	AC81	PaTu 8988t	C175(1.26); C183(1.26)	LDD1226	[17]
LDCM0348	AC82	PaTu 8988t	C175(1.20); C183(1.20)	LDD1227	[17]
LDCM0349	AC83	PaTu 8988t	C175(1.45); C183(1.45)	LDD1228	[17]
LDCM0350	AC84	PaTu 8988t	C175(1.30); C183(1.30)	LDD1229	[17]
LDCM0351	AC85	PaTu 8988t	C175(1.37); C183(1.37)	LDD1230	[17]
LDCM0352	AC86	PaTu 8988t	C175(1.24); C183(1.24)	LDD1231	[17]
LDCM0353	AC87	PaTu 8988t	C175(1.51); C183(1.51)	LDD1232	[17]
LDCM0354	AC88	PaTu 8988t	C175(1.71); C183(1.71)	LDD1233	[17]
LDCM0355	AC89	PaTu 8988t	C175(1.43); C183(1.43)	LDD1234	[17]
LDCM0357	AC90	PaTu 8988t	C175(1.76); C183(1.76)	LDD1236	[17]
LDCM0358	AC91	PaTu 8988t	C175(1.71); C183(1.71)	LDD1237	[17]
LDCM0359	AC92	PaTu 8988t	C175(1.26); C183(1.26)	LDD1238	[17]
LDCM0360	AC93	PaTu 8988t	C175(1.60); C183(1.60)	LDD1239	[17]
LDCM0361	AC94	PaTu 8988t	C175(1.58); C183(1.58)	LDD1240	[17]
LDCM0362	AC95	PaTu 8988t	C175(1.66); C183(1.66)	LDD1241	[17]
LDCM0363	AC96	PaTu 8988t	C175(1.86); C183(1.86)	LDD1242	[17]
LDCM0364	AC97	PaTu 8988t	C175(1.59); C183(1.59)	LDD1243	[17]
LDCM0248	AKOS034007472	PaTu 8988t	C175(0.68); C183(0.68)	LDD1127	[17]
LDCM0356	AKOS034007680	PaTu 8988t	C175(0.63); C183(0.63)	LDD1235	[17]
LDCM0275	AKOS034007705	PaTu 8988t	C175(0.62); C183(0.62)	LDD1154	[17]
LDCM0156	Aniline	NCI-H1299	12.36	LDD0403	[1]
LDCM0020	ARS-1620	HCC44	C175(0.94); C183(0.94)	LDD2171	[17]
LDCM0108	Chloroacetamide	HeLa	N.A.	LDD0222	[10]
LDCM0367	CL1	PaTu 8988t	C175(0.99); C183(0.99)	LDD1246	[17]
LDCM0368	CL10	PaTu 8988t	C175(0.76); C183(0.76)	LDD1247	[17]
LDCM0369	CL100	HEK-293T	C267(1.13); C183(0.92)	LDD1573	[16]
LDCM0370	CL101	PaTu 8988t	C175(0.92); C183(0.92)	LDD1249	[17]
LDCM0371	CL102	PaTu 8988t	C175(0.78); C183(0.78)	LDD1250	[17]
LDCM0372	CL103	PaTu 8988t	C175(0.43); C183(0.43)	LDD1251	[17]
LDCM0373	CL104	PaTu 8988t	C175(0.80); C183(0.80)	LDD1252	[17]
LDCM0374	CL105	PaTu 8988t	C175(1.01); C183(1.01)	LDD1253	[17]
LDCM0375	CL106	PaTu 8988t	C175(0.99); C183(0.99)	LDD1254	[17]
LDCM0376	CL107	PaTu 8988t	C175(0.88); C183(0.88)	LDD1255	[17]
LDCM0377	CL108	PaTu 8988t	C175(0.99); C183(0.99)	LDD1256	[17]
LDCM0378	CL109	PaTu 8988t	C175(1.03); C183(1.03)	LDD1257	[17]
LDCM0379	CL11	PaTu 8988t	C175(0.90); C183(0.90)	LDD1258	[17]
LDCM0380	CL110	PaTu 8988t	C175(0.77); C183(0.77)	LDD1259	[17]
LDCM0381	CL111	PaTu 8988t	C175(0.69); C183(0.69)	LDD1260	[17]
LDCM0382	CL112	PaTu 8988t	C175(1.05); C183(1.05)	LDD1261	[17]
LDCM0383	CL113	PaTu 8988t	C175(1.07); C183(1.07)	LDD1262	[17]
LDCM0384	CL114	PaTu 8988t	C175(1.16); C183(1.16)	LDD1263	[17]
LDCM0385	CL115	PaTu 8988t	C175(1.08); C183(1.08)	LDD1264	[17]
LDCM0386	CL116	PaTu 8988t	C175(1.00); C183(1.00)	LDD1265	[17]
LDCM0387	CL117	PaTu 8988t	C175(1.02); C183(1.02)	LDD1266	[17]
LDCM0388	CL118	PaTu 8988t	C175(0.72); C183(0.72)	LDD1267	[17]
LDCM0389	CL119	PaTu 8988t	C175(1.10); C183(1.10)	LDD1268	[17]
LDCM0390	CL12	PaTu 8988t	C175(0.91); C183(0.91)	LDD1269	[17]
LDCM0391	CL120	PaTu 8988t	C175(1.29); C183(1.29)	LDD1270	[17]
LDCM0392	CL121	PaTu 8988t	C175(0.89); C183(0.89)	LDD1271	[17]
LDCM0393	CL122	PaTu 8988t	C175(0.85); C183(0.85)	LDD1272	[17]
LDCM0394	CL123	PaTu 8988t	C175(0.56); C183(0.56)	LDD1273	[17]
LDCM0395	CL124	PaTu 8988t	C175(0.57); C183(0.57)	LDD1274	[17]
LDCM0396	CL125	PaTu 8988t	C175(1.11); C183(1.11)	LDD1275	[17]
LDCM0397	CL126	PaTu 8988t	C175(1.26); C183(1.26)	LDD1276	[17]
LDCM0398	CL127	PaTu 8988t	C175(1.23); C183(1.23)	LDD1277	[17]
LDCM0399	CL128	PaTu 8988t	C175(1.14); C183(1.14)	LDD1278	[17]
LDCM0400	CL13	PaTu 8988t	C175(0.52); C183(0.52)	LDD1279	[17]
LDCM0401	CL14	PaTu 8988t	C175(0.54); C183(0.54)	LDD1280	[17]
LDCM0402	CL15	PaTu 8988t	C175(1.07); C183(1.07)	LDD1281	[17]
LDCM0403	CL16	PaTu 8988t	C175(0.92); C183(0.92)	LDD1282	[17]
LDCM0404	CL17	PaTu 8988t	C175(0.90); C183(0.90)	LDD1283	[17]
LDCM0405	CL18	PaTu 8988t	C175(0.77); C183(0.77)	LDD1284	[17]
LDCM0406	CL19	PaTu 8988t	C175(0.78); C183(0.78)	LDD1285	[17]
LDCM0407	CL2	PaTu 8988t	C175(0.95); C183(0.95)	LDD1286	[17]
LDCM0408	CL20	PaTu 8988t	C175(0.38); C183(0.38)	LDD1287	[17]
LDCM0409	CL21	PaTu 8988t	C175(0.23); C183(0.23)	LDD1288	[17]
LDCM0410	CL22	PaTu 8988t	C175(0.57); C183(0.57)	LDD1289	[17]
LDCM0411	CL23	PaTu 8988t	C175(0.41); C183(0.41)	LDD1290	[17]
LDCM0412	CL24	PaTu 8988t	C175(1.09); C183(1.09)	LDD1291	[17]
LDCM0413	CL25	PaTu 8988t	C175(0.94); C183(0.94)	LDD1292	[17]
LDCM0414	CL26	PaTu 8988t	C175(0.50); C183(0.50)	LDD1293	[17]
LDCM0415	CL27	PaTu 8988t	C175(0.98); C183(0.98)	LDD1294	[17]
LDCM0416	CL28	PaTu 8988t	C175(0.28); C183(0.28)	LDD1295	[17]
LDCM0417	CL29	PaTu 8988t	C175(0.24); C183(0.24)	LDD1296	[17]
LDCM0418	CL3	PaTu 8988t	C175(1.04); C183(1.04)	LDD1297	[17]
LDCM0419	CL30	PaTu 8988t	C175(0.71); C183(0.71)	LDD1298	[17]
LDCM0420	CL31	PaTu 8988t	C175(0.78); C183(0.78)	LDD1299	[17]
LDCM0421	CL32	PaTu 8988t	C175(0.82); C183(0.82)	LDD1300	[17]
LDCM0422	CL33	PaTu 8988t	C175(0.52); C183(0.52)	LDD1301	[17]
LDCM0423	CL34	PaTu 8988t	C175(0.50); C183(0.50)	LDD1302	[17]
LDCM0424	CL35	PaTu 8988t	C175(0.53); C183(0.53)	LDD1303	[17]
LDCM0425	CL36	PaTu 8988t	C175(0.48); C183(0.48)	LDD1304	[17]
LDCM0426	CL37	PaTu 8988t	C175(0.31); C183(0.31)	LDD1305	[17]
LDCM0428	CL39	PaTu 8988t	C175(0.59); C183(0.59)	LDD1307	[17]
LDCM0429	CL4	PaTu 8988t	C175(0.89); C183(0.89)	LDD1308	[17]
LDCM0430	CL40	PaTu 8988t	C175(0.90); C183(0.90)	LDD1309	[17]
LDCM0431	CL41	PaTu 8988t	C175(0.56); C183(0.56)	LDD1310	[17]
LDCM0432	CL42	PaTu 8988t	C175(0.38); C183(0.38)	LDD1311	[17]
LDCM0433	CL43	PaTu 8988t	C175(0.12); C183(0.12)	LDD1312	[17]
LDCM0434	CL44	PaTu 8988t	C175(0.44); C183(0.44)	LDD1313	[17]
LDCM0435	CL45	PaTu 8988t	C175(0.69); C183(0.69)	LDD1314	[17]
LDCM0436	CL46	PaTu 8988t	C175(1.42); C183(1.42)	LDD1315	[17]
LDCM0437	CL47	PaTu 8988t	C175(1.31); C183(1.31)	LDD1316	[17]
LDCM0438	CL48	PaTu 8988t	C175(1.39); C183(1.39)	LDD1317	[17]
LDCM0439	CL49	PaTu 8988t	C175(1.54); C183(1.54)	LDD1318	[17]
LDCM0440	CL5	PaTu 8988t	C175(0.75); C183(0.75)	LDD1319	[17]
LDCM0441	CL50	PaTu 8988t	C175(1.67); C183(1.67)	LDD1320	[17]
LDCM0442	CL51	PaTu 8988t	C175(1.60); C183(1.60)	LDD1321	[17]
LDCM0443	CL52	PaTu 8988t	C175(1.44); C183(1.44)	LDD1322	[17]
LDCM0444	CL53	PaTu 8988t	C175(1.29); C183(1.29)	LDD1323	[17]
LDCM0445	CL54	PaTu 8988t	C175(1.27); C183(1.27)	LDD1324	[17]
LDCM0446	CL55	PaTu 8988t	C175(1.55); C183(1.55)	LDD1325	[17]
LDCM0447	CL56	PaTu 8988t	C175(0.22); C183(0.22)	LDD1326	[17]
LDCM0448	CL57	PaTu 8988t	C175(0.57); C183(0.57)	LDD1327	[17]
LDCM0449	CL58	PaTu 8988t	C175(1.39); C183(1.39)	LDD1328	[17]
LDCM0450	CL59	PaTu 8988t	C175(0.44); C183(0.44)	LDD1329	[17]
LDCM0451	CL6	PaTu 8988t	C175(1.02); C183(1.02)	LDD1330	[17]
LDCM0452	CL60	PaTu 8988t	C175(1.01); C183(1.01)	LDD1331	[17]
LDCM0453	CL61	HEK-293T	C267(0.90); C183(1.04)	LDD1656	[16]
LDCM0454	CL62	HEK-293T	C267(1.01); C183(0.96)	LDD1657	[16]
LDCM0455	CL63	HEK-293T	C267(1.07); C183(0.97)	LDD1658	[16]
LDCM0456	CL64	HEK-293T	C267(1.11); C183(0.90)	LDD1659	[16]
LDCM0457	CL65	HEK-293T	C267(1.09); C183(0.96)	LDD1660	[16]
LDCM0458	CL66	HEK-293T	C267(1.10); C183(0.91)	LDD1661	[16]
LDCM0459	CL67	HEK-293T	C267(0.97); C183(1.02)	LDD1662	[16]
LDCM0460	CL68	HEK-293T	C267(1.13); C183(0.92)	LDD1663	[16]
LDCM0461	CL69	HEK-293T	C267(1.10); C183(0.93)	LDD1664	[16]
LDCM0462	CL7	PaTu 8988t	C175(0.79); C183(0.79)	LDD1341	[17]
LDCM0463	CL70	HEK-293T	C267(1.19); C183(1.08)	LDD1666	[16]
LDCM0464	CL71	HEK-293T	C267(1.18); C183(0.98)	LDD1667	[16]
LDCM0465	CL72	HEK-293T	C267(1.06); C183(0.94)	LDD1668	[16]
LDCM0466	CL73	HEK-293T	C267(0.94); C183(1.05)	LDD1669	[16]
LDCM0467	CL74	HEK-293T	C267(0.97); C183(0.94)	LDD1670	[16]
LDCM0469	CL76	HEK-293T	C267(1.07); C183(0.92)	LDD1672	[16]
LDCM0470	CL77	HEK-293T	C267(1.37); C183(0.84)	LDD1673	[16]
LDCM0471	CL78	HEK-293T	C267(0.98); C183(1.03)	LDD1674	[16]
LDCM0472	CL79	HEK-293T	C267(0.95); C183(1.04)	LDD1675	[16]
LDCM0473	CL8	PaTu 8988t	C175(0.62); C183(0.62)	LDD1352	[17]
LDCM0474	CL80	HEK-293T	C267(1.01); C183(0.99)	LDD1677	[16]
LDCM0475	CL81	HEK-293T	C267(0.95); C183(1.03)	LDD1678	[16]
LDCM0476	CL82	HEK-293T	C267(1.18); C183(1.08)	LDD1679	[16]
LDCM0477	CL83	HEK-293T	C267(1.10); C183(1.00)	LDD1680	[16]
LDCM0478	CL84	HEK-293T	C267(1.10); C183(0.98)	LDD1681	[16]
LDCM0479	CL85	HEK-293T	C267(0.82); C183(1.04)	LDD1682	[16]
LDCM0480	CL86	HEK-293T	C267(1.07); C183(1.03)	LDD1683	[16]
LDCM0481	CL87	HEK-293T	C267(1.20); C183(0.96)	LDD1684	[16]
LDCM0482	CL88	HEK-293T	C267(1.09); C183(1.05)	LDD1685	[16]
LDCM0483	CL89	HEK-293T	C267(1.02); C183(0.95)	LDD1686	[16]
LDCM0484	CL9	PaTu 8988t	C175(0.80); C183(0.80)	LDD1363	[17]
LDCM0485	CL90	HEK-293T	C267(0.99); C183(0.75)	LDD1688	[16]
LDCM0486	CL91	HEK-293T	C267(0.87); C183(1.05)	LDD1689	[16]
LDCM0487	CL92	HEK-293T	C267(1.22); C183(0.90)	LDD1690	[16]
LDCM0488	CL93	HEK-293T	C267(1.07); C183(0.91)	LDD1691	[16]
LDCM0489	CL94	HEK-293T	C267(1.33); C183(0.94)	LDD1692	[16]
LDCM0490	CL95	HEK-293T	C267(1.42); C183(0.76)	LDD1693	[16]
LDCM0491	CL96	HEK-293T	C267(1.06); C183(0.90)	LDD1694	[16]
LDCM0492	CL97	HEK-293T	C267(1.10); C183(0.89)	LDD1695	[16]
LDCM0493	CL98	HEK-293T	C267(1.03); C183(0.80)	LDD1696	[16]
LDCM0494	CL99	HEK-293T	C267(1.80); C183(0.79)	LDD1697	[16]
LDCM0495	E2913	HEK-293T	C267(1.68); C183(1.07)	LDD1698	[16]
LDCM0572	Fragment10	MDA-MB-231	C267(13.38)	LDD1465	[18]
LDCM0576	Fragment14	MDA-MB-231	C267(1.17)	LDD1471	[18]
LDCM0578	Fragment27	MDA-MB-231	C267(1.33)	LDD1474	[18]
LDCM0587	Fragment29	Ramos	C267(2.13)	LDD1476	[18]
LDCM0468	Fragment33	HEK-293T	C267(1.10); C183(0.92)	LDD1671	[16]
LDCM0566	Fragment4	MDA-MB-231	C267(20.00)	LDD1461	[18]
LDCM0603	Fragment45	MDA-MB-231	C267(20.00)	LDD1482	[18]
LDCM0427	Fragment51	PaTu 8988t	C175(0.42); C183(0.42)	LDD1306	[17]
LDCM0570	Fragment8	MDA-MB-231	C267(20.00)	LDD1462	[18]
LDCM0571	Fragment9	Ramos	C267(2.61)	LDD1464	[18]
LDCM0022	KB02	HEK-293T	C267(0.91); C183(0.94)	LDD1492	[16]
LDCM0023	KB03	HEK-293T	C267(1.06); C183(1.01)	LDD1497	[16]
LDCM0024	KB05	Hs 936.T	C267(1.04)	LDD3313	[4]
LDCM0021	THZ1	HCT 116	C175(0.94); C183(0.94)	LDD2173	[17]

References

1	Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
4	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840
5	Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z. Mass spectrometry data entry: PXD044625
6	Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print. Mass spectrometry data entry: PXD042377
7	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9	DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22. Mass spectrometry data entry: PXD033004
10	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
13	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
14	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
16	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
17	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
18	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.

Details of the Target

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni