General Information of Experiment

Probe Name C002  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 14 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09031  Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) 28.6
 LDTP04529  2-iminobutanoate/2-iminopropanoate deaminase (RIDA) 12.4
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 11.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 10.6
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 9.1
 LDTP10101  Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) 8.6
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 6.9
 LDTP12505  CTP synthase 2 (CTPS2) 6.9
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 6.6
 LDTP12670  SET domain-containing protein 4 (SETD4) 6.4
 LDTP10215  Carboxymethylenebutenolidase homolog (CMBL) 5.8
 LDTP00479  Histone acetyltransferase type B catalytic subunit (HAT1) 5.6
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 5.4
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 4.9
Transporter and channel
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 57.3
 LDTP15948  Transmembrane protein 126A (TMEM126A) 6.6
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 6.6
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 6.5
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 5.9
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 5.3
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 5.1
 LDTP07531  Sideroflexin-4 (SFXN4) 5.1
Other
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 12.4
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 10.4
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) 10.4
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 7.8
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 6.9
 LDTP13630  Neudesin (NENF) 6.9
 LDTP12395  Large ribosomal subunit protein mL40 (MRPL40) 6.5
 LDTP11076  Apolipoprotein L2 (APOL2) 6.2
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 5.1
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 5.0
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587