Details of the Target

General Information of Target

Target ID LDTP04529
Target Name 2-iminobutanoate/2-iminopropanoate deaminase (RIDA)
Gene Name RIDA
Gene ID 10247
Synonyms
HRSP12; 2-iminobutanoate/2-iminopropanoate deaminase; EC 3.5.99.10; 14.5 kDa translational inhibitor protein; hp14.5; p14.5; Heat-responsive protein 12; Reactive intermediate imine deaminase A homolog; Translation inhibitor L-PSP ribonuclease; UK114 antigen homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSLIRRVISTAKAPGAIGPYSQAVLVDRTIYISGQIGMDPSSGQLVSGGVAEEAKQALK
NMGEILKAAGCDFTNVVKTTVLLADINDFNTVNEIYKQYFKSNFPARAAYQVAALPKGSR
IEIEAVAIQGPLTTASL
Target Bioclass
Enzyme
Family
RutC family
Subcellular location
Cytoplasm
Function
Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.; Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.
Uniprot ID
P52758
Ensemble ID
ENST00000254878.8
HGNC ID
HGNC:16897

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
SAA-alkyne
 Probe Info  		1.12  LDD0252  [1]
DBIA
 Probe Info  		C71(3.83)  LDD3312  [2]
BTD
 Probe Info  		C71(1.04)  LDD2089  [3]
HHS-475
 Probe Info  		Y21(2.42)  LDD0264  [4]
AMP probe
 Probe Info  		N.A.  LDD0200  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		N.A.  LDD2156  [8]
NHS
 Probe Info  		N.A.  LDD0010  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
STPyne
 Probe Info  		N.A.  LDD0009  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
HHS-465
 Probe Info  		K117(0.00); K97(0.00); Y21(0.00)  LDD2240  [12]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C002
 Probe Info  		12.38  LDD1712  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C71(1.07)  LDD1508  [14]
 LDCM0216  AC100 HEK-293T C71(0.79)  LDD0814  [15]
 LDCM0217  AC101 HEK-293T C71(0.75)  LDD0815  [15]
 LDCM0218  AC102 HEK-293T C71(0.70)  LDD0816  [15]
 LDCM0219  AC103 HEK-293T C71(0.86)  LDD0817  [15]
 LDCM0220  AC104 HEK-293T C71(0.66)  LDD0818  [15]
 LDCM0221  AC105 HEK-293T C71(0.99)  LDD0819  [15]
 LDCM0222  AC106 HEK-293T C71(1.20)  LDD0820  [15]
 LDCM0223  AC107 HEK-293T C71(0.69)  LDD0821  [15]
 LDCM0224  AC108 HEK-293T C71(1.03)  LDD0822  [15]
 LDCM0225  AC109 HEK-293T C71(0.91)  LDD0823  [15]
 LDCM0227  AC110 HEK-293T C71(0.70)  LDD0825  [15]
 LDCM0228  AC111 HEK-293T C71(0.64)  LDD0826  [15]
 LDCM0229  AC112 HEK-293T C71(0.70)  LDD0827  [15]
 LDCM0230  AC113 HEK-293T C71(0.72)  LDD0828  [15]
 LDCM0231  AC114 HEK-293T C71(0.82)  LDD0829  [15]
 LDCM0232  AC115 HEK-293T C71(0.87)  LDD0830  [15]
 LDCM0233  AC116 HEK-293T C71(0.78)  LDD0831  [15]
 LDCM0234  AC117 HEK-293T C71(0.68)  LDD0832  [15]
 LDCM0235  AC118 HEK-293T C71(0.81)  LDD0833  [15]
 LDCM0236  AC119 HEK-293T C71(0.57)  LDD0834  [15]
 LDCM0238  AC120 HEK-293T C71(0.54)  LDD0836  [15]
 LDCM0239  AC121 HEK-293T C71(0.59)  LDD0837  [15]
 LDCM0240  AC122 HEK-293T C71(0.56)  LDD0838  [15]
 LDCM0241  AC123 HEK-293T C71(0.59)  LDD0839  [15]
 LDCM0242  AC124 HEK-293T C71(0.67)  LDD0840  [15]
 LDCM0243  AC125 HEK-293T C71(0.60)  LDD0841  [15]
 LDCM0244  AC126 HEK-293T C71(0.47)  LDD0842  [15]
 LDCM0245  AC127 HEK-293T C71(0.37)  LDD0843  [15]
 LDCM0246  AC128 HEK-293T C71(1.02)  LDD0844  [15]
 LDCM0247  AC129 HEK-293T C71(0.91)  LDD0845  [15]
 LDCM0249  AC130 HEK-293T C71(1.02)  LDD0847  [15]
 LDCM0250  AC131 HEK-293T C71(1.25)  LDD0848  [15]
 LDCM0251  AC132 HEK-293T C71(1.14)  LDD0849  [15]
 LDCM0252  AC133 HEK-293T C71(0.86)  LDD0850  [15]
 LDCM0253  AC134 HEK-293T C71(1.02)  LDD0851  [15]
 LDCM0254  AC135 HEK-293T C71(0.76)  LDD0852  [15]
 LDCM0255  AC136 HEK-293T C71(0.75)  LDD0853  [15]
 LDCM0256  AC137 HEK-293T C71(0.74)  LDD0854  [15]
 LDCM0257  AC138 HEK-293T C71(0.77)  LDD0855  [15]
 LDCM0258  AC139 HEK-293T C71(0.76)  LDD0856  [15]
 LDCM0259  AC14 HEK-293T C71(0.98)  LDD1512  [14]
 LDCM0260  AC140 HEK-293T C71(0.92)  LDD0858  [15]
 LDCM0261  AC141 HEK-293T C71(0.84)  LDD0859  [15]
 LDCM0262  AC142 HEK-293T C71(1.00)  LDD0860  [15]
 LDCM0263  AC143 HEK-293T C71(0.73)  LDD0861  [15]
 LDCM0264  AC144 HEK-293T C71(0.83)  LDD0862  [15]
 LDCM0265  AC145 HEK-293T C71(0.90)  LDD0863  [15]
 LDCM0266  AC146 HEK-293T C71(0.95)  LDD0864  [15]
 LDCM0267  AC147 HEK-293T C71(0.81)  LDD0865  [15]
 LDCM0268  AC148 HEK-293T C71(0.89)  LDD0866  [15]
 LDCM0269  AC149 HEK-293T C71(1.34)  LDD0867  [15]
 LDCM0270  AC15 HEK-293T C71(1.01)  LDD1513  [14]
 LDCM0271  AC150 HEK-293T C71(0.99)  LDD0869  [15]
 LDCM0272  AC151 HEK-293T C71(0.96)  LDD0870  [15]
 LDCM0273  AC152 HEK-293T C71(0.84)  LDD0871  [15]
 LDCM0274  AC153 HEK-293T C71(1.05)  LDD0872  [15]
 LDCM0621  AC154 HEK-293T C71(1.03)  LDD2162  [15]
 LDCM0622  AC155 HEK-293T C71(0.95)  LDD2163  [15]
 LDCM0623  AC156 HEK-293T C71(0.84)  LDD2164  [15]
 LDCM0624  AC157 HEK-293T C71(0.74)  LDD2165  [15]
 LDCM0277  AC18 HEK-293T C71(0.92)  LDD1516  [14]
 LDCM0279  AC2 HEK-293T C71(1.06)  LDD1518  [14]
 LDCM0281  AC21 HEK-293T C71(1.05)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C71(0.99)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C71(0.97)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C71(0.94)  LDD1523  [14]
 LDCM0286  AC26 HEK-293T C71(1.01)  LDD1525  [14]
 LDCM0289  AC29 HEK-293T C71(1.10)  LDD1528  [14]
 LDCM0291  AC30 HEK-293T C71(1.01)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C71(1.06)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C71(1.01)  LDD1532  [14]
 LDCM0295  AC34 HEK-293T C71(1.14)  LDD1534  [14]
 LDCM0298  AC37 HEK-293T C71(1.15)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C71(1.06)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C71(1.05)  LDD1539  [14]
 LDCM0302  AC40 HEK-293T C71(0.94)  LDD1541  [14]
 LDCM0304  AC42 HEK-293T C71(1.08)  LDD1543  [14]
 LDCM0307  AC45 HEK-293T C71(1.07)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C71(1.09)  LDD0906  [15]
 LDCM0309  AC47 HEK-293T C71(0.42)  LDD0907  [15]
 LDCM0310  AC48 HEK-293T C71(0.66)  LDD0908  [15]
 LDCM0311  AC49 HEK-293T C71(0.73)  LDD0909  [15]
 LDCM0312  AC5 HEK-293T C71(1.08)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C71(0.64)  LDD0911  [15]
 LDCM0314  AC51 HEK-293T C71(0.53)  LDD0912  [15]
 LDCM0315  AC52 HEK-293T C71(0.54)  LDD0913  [15]
 LDCM0316  AC53 HEK-293T C71(0.72)  LDD0914  [15]
 LDCM0317  AC54 HEK-293T C71(0.57)  LDD0915  [15]
 LDCM0318  AC55 HEK-293T C71(0.62)  LDD0916  [15]
 LDCM0319  AC56 HEK-293T C71(0.71)  LDD0917  [15]
 LDCM0321  AC58 HEK-293T C71(1.04)  LDD1560  [14]
 LDCM0323  AC6 HEK-293T C71(0.99)  LDD1562  [14]
 LDCM0325  AC61 HEK-293T C71(0.97)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C71(0.97)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C71(0.96)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C71(0.94)  LDD1567  [14]
 LDCM0332  AC68 HEK-293T C71(1.16)  LDD0930  [15]
 LDCM0333  AC69 HEK-293T C71(1.11)  LDD0931  [15]
 LDCM0334  AC7 HEK-293T C71(0.98)  LDD1568  [14]
 LDCM0335  AC70 HEK-293T C71(0.92)  LDD0933  [15]
 LDCM0336  AC71 HEK-293T C71(0.85)  LDD0934  [15]
 LDCM0337  AC72 HEK-293T C71(0.89)  LDD0935  [15]
 LDCM0338  AC73 HEK-293T C71(0.80)  LDD0936  [15]
 LDCM0339  AC74 HEK-293T C71(0.66)  LDD0937  [15]
 LDCM0340  AC75 HEK-293T C71(0.78)  LDD0938  [15]
 LDCM0341  AC76 HEK-293T C71(0.64)  LDD0939  [15]
 LDCM0342  AC77 HEK-293T C71(0.69)  LDD0940  [15]
 LDCM0343  AC78 HEK-293T C71(0.68)  LDD0941  [15]
 LDCM0344  AC79 HEK-293T C71(0.80)  LDD0942  [15]
 LDCM0345  AC8 HEK-293T C71(1.01)  LDD1569  [14]
 LDCM0346  AC80 HEK-293T C71(0.72)  LDD0944  [15]
 LDCM0347  AC81 HEK-293T C71(0.84)  LDD0945  [15]
 LDCM0348  AC82 HEK-293T C71(0.55)  LDD0946  [15]
 LDCM0365  AC98 HEK-293T C71(0.97)  LDD0963  [15]
 LDCM0366  AC99 HEK-293T C71(0.87)  LDD0964  [15]
 LDCM0520  AKOS000195272 MDA-MB-231 C71(0.69)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C71(0.94)  LDD1511  [14]
 LDCM0275  AKOS034007705 HEK-293T C71(0.96)  LDD1514  [14]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 HEK-293T C71(0.71)  LDD0965  [15]
 LDCM0368  CL10 HEK-293T C71(0.36)  LDD0966  [15]
 LDCM0369  CL100 HEK-293T C71(1.00)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C71(0.98)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C71(0.92)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C71(0.93)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C71(1.02)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C71(0.94)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C71(1.03)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C71(1.08)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C71(1.01)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C71(0.99)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C71(0.35)  LDD0977  [15]
 LDCM0380  CL110 HEK-293T C71(0.98)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C71(1.07)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C71(1.05)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C71(0.98)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C71(1.03)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C71(1.10)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C71(0.99)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C71(0.95)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C71(0.96)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C71(0.97)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C71(0.59)  LDD0988  [15]
 LDCM0391  CL120 HEK-293T C71(1.06)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C71(0.57)  LDD0990  [15]
 LDCM0393  CL122 HEK-293T C71(0.66)  LDD0991  [15]
 LDCM0394  CL123 HEK-293T C71(0.79)  LDD0992  [15]
 LDCM0395  CL124 HEK-293T C71(0.63)  LDD0993  [15]
 LDCM0396  CL125 HEK-293T C71(0.99)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C71(0.97)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C71(0.99)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C71(1.03)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C71(0.69)  LDD0998  [15]
 LDCM0401  CL14 HEK-293T C71(0.55)  LDD0999  [15]
 LDCM0402  CL15 HEK-293T C71(0.47)  LDD1000  [15]
 LDCM0403  CL16 HEK-293T C71(0.89)  LDD1001  [15]
 LDCM0404  CL17 HEK-293T C71(0.97)  LDD1002  [15]
 LDCM0405  CL18 HEK-293T C71(0.70)  LDD1003  [15]
 LDCM0406  CL19 HEK-293T C71(0.96)  LDD1004  [15]
 LDCM0407  CL2 HEK-293T C71(0.78)  LDD1005  [15]
 LDCM0408  CL20 HEK-293T C71(0.74)  LDD1006  [15]
 LDCM0409  CL21 HEK-293T C71(0.59)  LDD1007  [15]
 LDCM0410  CL22 HEK-293T C71(0.66)  LDD1008  [15]
 LDCM0411  CL23 HEK-293T C71(0.62)  LDD1009  [15]
 LDCM0412  CL24 HEK-293T C71(0.92)  LDD1010  [15]
 LDCM0413  CL25 HEK-293T C71(0.75)  LDD1011  [15]
 LDCM0414  CL26 HEK-293T C71(0.61)  LDD1012  [15]
 LDCM0415  CL27 HEK-293T C71(0.71)  LDD1013  [15]
 LDCM0416  CL28 HEK-293T C71(0.66)  LDD1014  [15]
 LDCM0417  CL29 HEK-293T C71(0.58)  LDD1015  [15]
 LDCM0418  CL3 HEK-293T C71(0.79)  LDD1016  [15]
 LDCM0419  CL30 HEK-293T C71(0.62)  LDD1017  [15]
 LDCM0422  CL33 HEK-293T C71(0.90)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C71(1.01)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C71(0.96)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C71(1.06)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C71(0.93)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C71(1.06)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C71(0.69)  LDD1027  [15]
 LDCM0430  CL40 HEK-293T C71(0.99)  LDD1634  [14]
 LDCM0432  CL42 HEK-293T C71(1.11)  LDD1636  [14]
 LDCM0435  CL45 HEK-293T C71(0.94)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C71(1.04)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C71(0.98)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C71(0.97)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C71(0.98)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C71(0.59)  LDD1038  [15]
 LDCM0441  CL50 HEK-293T C71(0.95)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C71(1.08)  LDD1646  [14]
 LDCM0445  CL54 HEK-293T C71(1.20)  LDD1648  [14]
 LDCM0448  CL57 HEK-293T C71(1.06)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C71(1.02)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C71(1.11)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C71(0.65)  LDD1049  [15]
 LDCM0452  CL60 HEK-293T C71(1.05)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C71(0.74)  LDD1051  [15]
 LDCM0454  CL62 HEK-293T C71(0.65)  LDD1052  [15]
 LDCM0455  CL63 HEK-293T C71(0.73)  LDD1053  [15]
 LDCM0456  CL64 HEK-293T C71(0.75)  LDD1054  [15]
 LDCM0457  CL65 HEK-293T C71(0.87)  LDD1055  [15]
 LDCM0458  CL66 HEK-293T C71(0.98)  LDD1056  [15]
 LDCM0459  CL67 HEK-293T C71(0.88)  LDD1057  [15]
 LDCM0460  CL68 HEK-293T C71(0.60)  LDD1058  [15]
 LDCM0461  CL69 HEK-293T C71(0.84)  LDD1059  [15]
 LDCM0462  CL7 HEK-293T C71(0.49)  LDD1060  [15]
 LDCM0463  CL70 HEK-293T C71(0.96)  LDD1061  [15]
 LDCM0464  CL71 HEK-293T C71(0.73)  LDD1062  [15]
 LDCM0465  CL72 HEK-293T C71(0.73)  LDD1063  [15]
 LDCM0466  CL73 HEK-293T C71(0.82)  LDD1064  [15]
 LDCM0467  CL74 HEK-293T C71(0.54)  LDD1065  [15]
 LDCM0469  CL76 HEK-293T C71(1.12)  LDD1672  [14]
 LDCM0471  CL78 HEK-293T C71(1.04)  LDD1674  [14]
 LDCM0475  CL81 HEK-293T C71(0.99)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C71(1.12)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C71(1.17)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C71(1.02)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C71(1.00)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C71(1.03)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C71(0.95)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C71(0.99)  LDD1685  [14]
 LDCM0484  CL9 HEK-293T C71(0.94)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C71(1.11)  LDD1688  [14]
 LDCM0488  CL93 HEK-293T C71(1.00)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C71(1.03)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C71(1.01)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C71(1.02)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C71(0.93)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C71(1.01)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C71(1.07)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C71(0.96)  LDD1698  [14]
 LDCM0572  Fragment10 Ramos C71(0.54)  LDD2189  [16]
 LDCM0574  Fragment12 Ramos C71(0.78)  LDD2191  [16]
 LDCM0579  Fragment20 Ramos C71(0.59)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C71(0.93)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C71(0.74)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C71(0.84)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C71(0.85)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C71(1.53)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C71(0.83)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C71(0.57)  LDD2201  [16]
 LDCM0468  Fragment33 HEK-293T C71(0.35)  LDD1066  [15]
 LDCM0596  Fragment38 Ramos C71(1.21)  LDD2203  [16]
 LDCM0427  Fragment51 HEK-293T C71(0.99)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C71(1.08)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C71(0.75)  LDD2205  [16]
 LDCM0571  Fragment9 Ramos C71(0.57)  LDD2188  [16]
 LDCM0116  HHS-0101 DM93 Y21(2.42)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y21(1.73)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y21(2.88)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y21(1.58)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y21(3.35)  LDD0268  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0022  KB02 HEK-293T C71(0.98)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C71(0.98)  LDD1497  [14]
 LDCM0024  KB05 HMCB C71(3.83)  LDD3312  [2]
 LDCM0109  NEM HeLa N.A.  LDD0224  [11]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C71(1.04)  LDD2089  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C71(0.52)  LDD2096  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C71(1.14)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C71(1.10)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C71(0.99)  LDD2101  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C71(0.77)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C71(0.76)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C71(0.60)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C71(1.04)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C71(0.68)  LDD2115  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C71(0.82)  LDD2120  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C71(0.79)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C71(0.85)  LDD2125  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C71(0.53)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C71(0.48)  LDD2134  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C71(0.93)  LDD2143  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C71(0.79)  LDD2146  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C71(2.19)  LDD2147  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C71(0.48)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C71(0.64)  LDD2150  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C71(0.43)  LDD2151  [3]

References

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2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578