General Information of Experiment

Probe Name SAA-alkyne  Probe Info 
Probe concentration 20 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Bone marrow
Disease Model Promyelocytic leukemia [ICD-11:2A60]
Model Name Human promyelocytic leukemia cells (NB-4)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02505  Lysosomal protective protein (CTSA) 1.1
 LDTP04529  2-iminobutanoate/2-iminopropanoate deaminase (RIDA) 1.1
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 1.1
 LDTP02342  Dihydropteridine reductase (QDPR) 1.1
 LDTP01514  NADH dehydrogenase 1 beta subcomplex subunit 4 (NDUFB4) 1.1
 LDTP02783  Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3) 1.1
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) 1.1
 LDTP15939  PITH domain-containing protein 1 (PITHD1) 1.1
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 1.1
 LDTP03540  Heme oxygenase 2 (HMOX2) 1.1
 LDTP10386  ERO1-like protein alpha (ERO1A) 1.1
 LDTP03626  Peroxiredoxin-2 (PRDX2) 1.1
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) 1.1
 LDTP03515  Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3) 1.1
 LDTP06427  Translin (TSN) 1.1
 LDTP05503  Peroxiredoxin-1 (PRDX1) 1.1
Transporter and channel
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00546  Secretory carrier-associated membrane protein 1 (SCAMP1) 1.1
 LDTP02823  CD44 antigen (CD44) 1.1
 LDTP06633  Reticulon-1 (RTN1) 1.1
 LDTP14157  RNA-binding protein 8A (RBM8A) 1.1
 LDTP02546  Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) 1.1
 LDTP14509  ATP synthase subunit d, mitochondrial (ATP5PD) 1.1
 LDTP05510  Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) 1.1
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11098  Rhox homeobox family member 2 (RHOXF2) 1.1
Other
Click to Show/Hide to Show 22 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03545  Alpha-2-macroglobulin receptor-associated protein (LRPAP1) 1.3
 LDTP00759  Tumor protein D54 (TPD52L2) 1.2
 LDTP10003  Myeloid-derived growth factor (MYDGF) 1.2
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) 1.2
 LDTP04627  UV excision repair protein RAD23 homolog B (RAD23B) 1.1
 LDTP13257  Ragulator complex protein LAMTOR3 (LAMTOR3) 1.1
 LDTP04722  BH3-interacting domain death agonist (BID) 1.1
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) 1.1
 LDTP05160  Nucleobindin-2 (NUCB2) 1.1
 LDTP06347  Rab GTPase-binding effector protein 1 (RABEP1) 1.1
 LDTP01171  Zinc finger protein ZPR1 (ZPR1) 1.1
 LDTP12412  Reticulon-4 (RTN4) 1.1
 LDTP08744  Regulatory-associated protein of mTOR (RPTOR) 1.1
 LDTP01021  Perilipin-3 (PLIN3) 1.1
 LDTP02077  Integrin beta-2 (ITGB2) 1.1
 LDTP13309  Prefoldin subunit 2 (PFDN2) 1.1
 LDTP00887  Calumenin (CALU) 1.1
 LDTP02869  Stathmin (STMN1) 1.1
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) 1.1
 LDTP08902  CDGSH iron-sulfur domain-containing protein 2 (CISD2) 1.1
 LDTP13982  Mitochondrial fission 1 protein (FIS1) 1.1
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) 1.1

References

1 Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.