Details of the Target

General Information of Target

Target ID LDTP11098
Target Name Rhox homeobox family member 2 (RHOXF2)
Gene Name RHOXF2
Gene ID 84528
Synonyms
PEPP2; THG1; Rhox homeobox family member 2; Paired-like homeobox protein PEPP-2; Testis homeobox gene 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFPAQDALPRSGLNLKEEPLLPAGLGSVRSWMQGAGILDASTAAQSGVGLARAHFEKQPP
SNLRKSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGAEKTNNGIHYRLRLVYNNG
LRTEQDLYVRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDRKSCGNRNETPSD
PVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSK
HGRRARRLDPSEAATPCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELIT
PHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGCPGRFVYTALNEPTIDYGFQRLQKVIPRH
PGDPERLPKEVLLKRAADLAEALYGVPGSNQELLLKRAADVAEALYSTPRAPGPLAPLAP
SHPHPAVVGINAFSSPLAIAVGDATPGPEPGYARSCSSASPRGFAPSPGSQQSGYGGGLG
AGLGGYGAPGVAGLGVPGSPSFLNGSTATSPFAIMPSSPPLAAASSMSLPAAAPTTSVFS
FSPVNMISAVKQRSAFAPVLRPPSSPPQACPRAHGEGLPDQSFEDSDKFHSPARGLQGLA
YS
Target Bioclass
Transcription factor
Family
Paired-like homeobox family, PEPP subfamily
Subcellular location
Nucleus
Function Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.
Uniprot ID
Q9BQY4
Ensemble ID
ENST00000371388.5
HGNC ID
HGNC:30011

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
SAA-alkyne
 Probe Info  		1.12  LDD0252  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) Gamma-glutamylcyclotransferase family Q9BUX1
Inactive glycosyltransferase 25 family member 3 (CERCAM) Glycosyltransferase 25 family Q5T4B2
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Arylsulfatase A (ARSA) Sulfatase family P15289
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
Terminal nucleotidyltransferase 5C (TENT5C) TENT family Q5VWP2
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) . O60568
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Basic leucine zipper transcriptional factor ATF-like 3 (BATF3) BZIP family Q9NR55
Tissue-resident T-cell transcription regulator protein ZNF683 (ZNF683) Krueppel C2H2-type zinc-finger protein family Q8IZ20
Zinc finger and BTB domain-containing protein 32 (ZBTB32) Krueppel C2H2-type zinc-finger protein family Q9Y2Y4
Homeobox protein MSX-2 (MSX2) Msh homeobox family P35548
Homeobox protein Nkx-3.1 (NKX3-1) NK-3 homeobox family Q99801
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4
Homeobox protein VENTX (VENTX) . O95231
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) CEA family P40199
Other
Click To Hide/Show 33 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Beta-crystallin A3 (CRYBA1) Beta/gamma-crystallin family P05813
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 7-1 (KRTAP7-1) KRTAP type 7 family Q8IUC3
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Keratin-associated protein 13-4 (KRTAP13-4) PMG family Q3LI77
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Toll-interacting protein (TOLLIP) Tollip family Q9H0E2
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Ciliary microtubule inner protein 2A (CIMIP2A) UPF0605 family Q6J272
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
DAZ-associated protein 2 (DAZAP2) . Q15038
Disabled homolog 1 (DAB1) . O75553
Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) . Q8WVV9
Kelch domain-containing protein 7B (KLHDC7B) . Q96G42
LIM and SH3 domain protein 1 (LASP1) . Q14847
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
Proline-rich protein 34 (PRR34) . Q9NV39
RNA binding protein fox-1 homolog 2 (RBFOX2) . O43251
RNA-binding protein with multiple splicing (RBPMS) . Q93062
RNA-binding protein with multiple splicing 2 (RBPMS2) . Q6ZRY4
Telomerase protein component 1 (TEP1) . Q99973
Ubiquitin-associated protein 2 (UBAP2) . Q5T6F2
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5

References

1 Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.