Details of the Target

General Information of Target

Target ID LDTP06347
Target Name Rab GTPase-binding effector protein 1 (RABEP1)
Gene Name RABEP1
Gene ID 9135
Synonyms
RAB5EP; RABPT5; RABPT5A; Rab GTPase-binding effector protein 1; Rabaptin-4; Rabaptin-5; Rabaptin-5alpha; Renal carcinoma antigen NY-REN-17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED
AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV
LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR
MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ
LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK
ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT
PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE
KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV
LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV
SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK
ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE
EQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS
LERIRAILNDTKLTDINQLPET
Target Bioclass
Other
Family
Rabaptin family
Subcellular location
Cytoplasm
Function
Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium.
Uniprot ID
Q15276
Ensemble ID
ENST00000341923.10
HGNC ID
HGNC:17677

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.K683I .
AN3CA Deletion: p.K559NfsTer4 DBIA    Probe Info 
CHL1 SNV: p.T371S DBIA    Probe Info 
HCT15 SNV: p.A620T .
Ishikawa (Heraklio) 02 ER SNV: p.D672E DBIA    Probe Info 
SKMEL30 Deletion: p.K333_A338del DBIA    Probe Info 
SUDHL6 SNV: p.G5C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
SAA-alkyne
 Probe Info  		1.11  LDD0252  [1]
m-APA
 Probe Info  		13.38  LDD0403  [2]
BTD
 Probe Info  		C718(0.68)  LDD2125  [3]
NAIA_5
 Probe Info  		C718(20.00)  LDD2227  [4]
DA-P3
 Probe Info  		4.77  LDD0181  [5]
AHL-Pu-1
 Probe Info  		C350(20.00)  LDD0169  [6]
DBIA
 Probe Info  		C533(1.01); C536(1.01)  LDD0078  [7]
5E-2FA
 Probe Info  		H376(0.00); H594(0.00)  LDD2235  [8]
ATP probe
 Probe Info  		K282(0.00); K528(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C263(0.00); C734(0.00)  LDD0037  [10]
IPM
 Probe Info  		C533(0.00); C718(0.00); C350(0.00)  LDD2156  [11]
NHS
 Probe Info  		N.A.  LDD0010  [12]
STPyne
 Probe Info  		N.A.  LDD0009  [12]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Acrolein
 Probe Info  		C263(0.00); C718(0.00)  LDD0217  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
AOyne
 Probe Info  		12.90  LDD0443  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C263(2.38)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C350(20.00)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C533(0.85); C536(0.86)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C533(1.23); C536(1.23)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C533(0.86); C536(0.86)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C533(0.87); C536(0.87)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C533(0.92); C536(0.92)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C533(1.17); C536(1.17)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C533(1.02); C536(1.02)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C533(1.10); C536(1.10)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C533(1.23); C536(1.23)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C533(1.01); C536(1.01)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C533(1.10); C536(1.10)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C533(0.84); C536(0.84)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C533(1.31); C536(1.31)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C533(1.01); C536(1.01)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C533(0.96); C536(0.96)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C533(1.16); C536(1.16)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C533(1.10); C536(1.10)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C533(1.35); C536(1.35)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C533(1.56); C536(1.56)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C533(1.53); C536(1.53)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C533(1.18); C536(1.18)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C533(1.25); C536(1.25)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C533(1.29); C536(1.29)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C533(1.15); C536(1.15)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C533(0.92); C536(0.92)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C533(1.21); C536(1.21)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C533(1.19); C536(1.19)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C533(1.09); C536(1.09)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C533(1.12); C536(1.12)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C533(1.37); C536(1.37)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C533(1.48); C536(1.48)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C533(1.35); C536(1.35)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C533(2.20); C536(2.20)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C533(1.06); C536(1.06)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C533(2.95); C536(2.95)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C533(1.38); C536(1.38)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C533(1.19); C536(1.19)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C533(1.65); C536(1.65)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C533(1.68); C536(1.68)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C533(2.21); C536(2.21)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C533(1.36); C536(1.36)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C533(1.20); C536(1.20)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C533(2.08); C536(2.08)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C533(1.79); C536(1.79)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C533(1.21); C536(1.21)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C533(1.61); C536(1.61)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C533(1.69); C536(1.69)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C533(1.52); C536(1.52)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C536(1.60); C533(1.61)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C533(1.75); C536(1.77)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C533(1.18); C536(1.21)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C533(1.27); C536(1.29)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C533(1.34); C536(1.36)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C533(2.20); C536(2.22)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C533(2.06); C536(2.07)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C533(1.34); C536(1.34)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C533(1.35); C536(1.36)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C533(1.14); C536(1.15)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C533(2.41); C536(2.42)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C536(2.80); C533(2.81)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C533(1.49); C536(1.51)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C533(2.36); C536(2.37)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C533(1.01); C536(1.03)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C533(1.09); C536(1.13)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C533(0.99); C536(0.99)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C533(1.11); C536(1.11)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C533(1.13); C536(1.13)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C533(0.91); C536(0.95)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C533(1.08); C536(1.08)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C533(1.26); C536(1.26)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C533(1.07); C536(1.07)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C533(0.99); C536(0.99)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C533(0.98); C536(0.98)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C536(1.19); C533(1.22)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C536(1.46); C533(1.47)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C533(1.37); C536(1.37)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C533(1.33); C536(1.34)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C536(1.52); C533(1.58)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C533(0.89); C536(0.91)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C533(1.55); C536(1.57)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C536(1.46); C533(1.48)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C536(1.92); C533(1.99)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C536(1.81); C533(2.00)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C533(1.73); C536(1.74)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C533(0.75); C536(0.75)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C533(0.91); C536(0.91)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C533(0.90); C536(0.90)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C533(0.93); C536(0.93)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C533(1.06); C536(1.06)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C536(0.93); C533(0.93)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C533(1.26); C536(1.26)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C533(1.03); C536(1.03)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C533(0.99); C536(0.99)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C533(1.07); C536(1.07)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C533(1.05); C536(1.05)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C533(1.32); C536(1.32)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C533(1.16); C536(1.16)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C533(1.02); C536(1.02)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C533(1.10); C536(1.10)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C533(1.00); C536(1.00)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C536(0.88); C533(0.89)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C533(1.10); C536(1.10)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C533(1.09); C536(1.09)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C533(1.09); C536(1.09)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C533(0.99); C536(0.99)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C533(0.99); C536(0.99)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C533(0.93); C536(0.93)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C533(1.03); C536(1.03)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C533(1.45); C536(1.45)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C533(1.82); C536(1.82)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C533(1.46); C536(1.46)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C533(1.44); C536(1.44)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C533(1.47); C536(1.47)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C533(1.23); C536(1.23)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C533(1.51); C536(1.51)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C533(1.52); C536(1.52)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C533(1.61); C536(1.61)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C533(1.26); C536(1.26)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C533(1.11); C536(1.11)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C533(1.25); C536(1.25)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C533(1.12); C536(1.14)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C533(1.14); C536(1.14)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C533(1.24); C536(1.24)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C533(1.19); C536(1.23)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C533(1.02); C536(1.03)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C533(1.23); C536(1.34)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C533(1.83); C536(1.89)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C533(1.24); C536(1.30)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C533(1.55); C536(1.61)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C533(1.24); C536(1.30)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C533(1.70); C536(1.72)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C533(1.10); C536(1.13)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C533(1.21); C536(1.26)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C533(1.31); C536(1.31)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C533(1.03); C536(1.06)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C533(1.01); C536(1.06)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C533(1.45); C536(1.55)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C533(1.42); C536(1.42)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C533(1.41); C536(1.41)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C533(1.17); C536(1.17)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C533(1.10); C536(1.10)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C533(1.14); C536(1.14)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C533(1.19); C536(1.19)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C533(1.23); C536(1.23)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C533(1.19); C536(1.19)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C533(1.62); C536(1.62)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C533(1.38); C536(1.38)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C533(1.25); C536(1.25)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C533(1.11); C536(1.11)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C533(1.13); C536(1.13)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C533(1.53); C536(1.53)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C533(1.53); C536(1.53)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C533(1.69); C536(1.69)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C533(0.85); C536(0.85)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C533(1.13); C536(1.13)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C533(1.42); C536(1.42)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C533(2.06); C536(2.06)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 13.38  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C533(1.01); C536(1.01)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C718(20.00)  LDD2227  [4]
 LDCM0367  CL1 HCT 116 C533(0.87); C536(0.92)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C533(1.38); C536(1.48)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C533(0.88); C536(0.89)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C533(1.49); C536(1.49)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C533(1.02); C536(1.02)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C533(1.16); C536(1.16)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C533(1.15); C536(1.15)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C533(1.27); C536(1.27)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C533(1.46); C536(1.46)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C533(1.41); C536(1.41)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C533(1.42); C536(1.42)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C533(1.20); C536(1.20)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C533(1.59); C536(1.62)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C533(1.26); C536(1.26)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C533(1.15); C536(1.15)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C536(0.96); C533(0.97)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C533(1.60); C536(1.66)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C533(1.25); C536(1.25)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C533(1.36); C536(1.38)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C536(1.39); C533(1.41)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C533(2.03); C536(2.03)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C533(1.07); C536(1.07)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C533(1.09); C536(1.09)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C533(1.88); C536(2.03)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C533(0.96); C536(0.96)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C533(1.06); C536(1.06)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C533(1.02); C536(1.02)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C533(1.03); C536(1.03)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C533(1.01); C536(1.01)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C533(1.00); C536(1.00)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C533(1.26); C536(1.26)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C533(1.01); C536(1.01)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C533(1.91); C536(1.91)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C536(1.33); C533(1.35)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C533(1.10); C536(1.14)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C536(1.23); C533(1.26)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C536(1.19); C533(1.32)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C536(1.06); C533(1.13)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C536(1.17); C533(1.29)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C536(1.23); C533(1.39)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C533(0.90); C536(0.93)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C536(1.40); C533(1.65)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C536(1.63); C533(1.84)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C536(2.99); C533(3.79)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C536(1.41); C533(1.58)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C533(2.19); C536(1.62)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C533(1.91); C536(1.65)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C533(1.60); C536(1.45)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C533(1.59); C536(1.36)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C533(1.85); C536(1.53)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C533(1.84); C536(1.52)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C533(0.96); C536(1.04)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C533(1.39); C536(1.17)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C533(1.10); C536(1.09)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C533(0.92); C536(0.92)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C533(0.82); C536(0.82)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C533(0.84); C536(0.84)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C533(1.02); C536(1.02)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C533(0.83); C536(0.83)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C533(1.05); C536(1.05)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C533(0.85); C536(0.85)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C533(0.99); C536(1.03)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C533(0.93); C536(0.93)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C533(0.92); C536(0.92)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C533(0.90); C536(0.90)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C533(0.90); C536(0.90)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C533(0.93); C536(0.93)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C533(0.91); C536(0.91)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C533(0.75); C536(0.75)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C533(0.81); C536(0.81)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C533(0.76); C536(0.76)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C533(0.72); C536(0.72)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C533(1.04); C536(1.17)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C533(0.76); C536(0.76)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C533(0.77); C536(0.77)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C533(0.83); C536(0.83)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C533(0.82); C536(0.82)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C533(0.82); C536(0.82)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C533(0.71); C536(0.71)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C533(0.90); C536(0.90)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C533(0.90); C536(0.90)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C533(0.73); C536(0.73)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C533(0.82); C536(0.82)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C533(1.14); C536(1.18)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C533(0.76); C536(0.76)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C533(1.01); C536(0.93)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C533(0.99); C536(0.98)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C533(1.03); C536(0.96)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C533(1.18); C536(1.00)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C533(1.02); C536(0.86)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C533(1.22); C536(0.94)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C533(1.12); C536(0.97)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C533(1.11); C536(0.94)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C533(1.06); C536(1.10)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C533(1.39); C536(1.44)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C533(1.06); C536(1.00)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C533(0.99); C536(0.85)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C533(1.07); C536(1.16)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C533(1.08); C536(0.98)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C533(1.15); C536(1.05)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C533(1.12); C536(1.12)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C533(0.96); C536(0.96)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C533(1.15); C536(1.15)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C533(1.63); C536(1.63)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C533(1.60); C536(1.58)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C533(0.93); C536(0.93)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C533(1.35); C536(1.35)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C533(2.08); C536(2.08)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C533(1.71); C536(1.71)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C533(2.23); C536(2.23)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C533(1.18); C536(1.18)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C533(0.98); C536(0.98)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C533(1.35); C536(1.35)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C533(1.53); C536(1.53)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C533(2.59); C536(2.59)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C533(1.18); C536(1.16)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C533(0.73); C536(0.73)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C533(1.07); C536(1.12)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C533(0.87); C536(0.90)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C533(0.87); C536(0.89)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C533(0.96); C536(0.97)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C533(0.97); C536(1.00)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C533(1.04); C536(1.08)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C533(0.92); C536(0.94)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C533(0.89); C536(0.88)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C533(0.97); C536(0.96)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C718(0.98); C263(0.93); C350(1.00); C734(0.98)  LDD1698  [15]
 LDCM0468  Fragment33 HCT 116 C533(1.01); C536(1.01)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C533(1.19); C536(1.19)  LDD0744  [7]
 LDCM0022  KB02 HCT 116 C533(1.58); C536(1.58)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C533(1.24); C536(1.24)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C533(1.40); C536(1.40)  LDD0082  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C718(0.68)  LDD2125  [3]
 LDCM0029  Quercetin HEK-293T 4.77  LDD0181  [5]
 LDCM0021  THZ1 HCT 116 C533(1.20); C536(1.20)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-acetyltransferase ESCO2 (ESCO2) Acetyltransferase family Q56NI9
Methionine adenosyltransferase 2 subunit beta (MAT2B) DTDP-4-dehydrorhamnose reductase family Q9NZL9
E3 ubiquitin-protein ligase pellino homolog 2 (PELI2) Pellino family Q9HAT8
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
Cyclin-dependent kinase-like 3 (CDKL3) CMGC Ser/Thr protein kinase family Q8IVW4
Tensin-4 (TNS4) PTEN phosphatase protein family Q8IZW8
Ras-related protein Rab-4A (RAB4A) Rab family P20338
Ras-related protein Rab-4B (RAB4B) Rab family P61018
BRCA1-associated RING domain protein 1 (BARD1) . Q99728
RING finger protein 39 (RNF39) . Q9H2S5
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit gamma-1 (AP1G1) Adaptor complexes large subunit family O43747
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
ADP-ribosylation factor-binding protein GGA1 (GGA1) GGA protein family Q9UJY5
ADP-ribosylation factor-binding protein GGA3 (GGA3) GGA protein family Q9NZ52
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Zinc finger protein 512B (ZNF512B) Krueppel C2H2-type zinc-finger protein family Q96KM6
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Teashirt homolog 2 (TSHZ2) Teashirt C2H2-type zinc-finger protein family Q9NRE2
Upstream-binding factor 1-like protein 1 (UBTFL1) . P0CB47
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit gamma-like 2 (AP1G2) Adaptor complexes large subunit family O75843
Parafibromin (CDC73) CDC73 family Q6P1J9
Cilia- and flagella-associated protein 53 (CFAP53) CFAP53 family Q96M91
Protein FAM50B (FAM50B) FAM50 family Q9Y247
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
ADP-ribosylation factor-binding protein GGA2 (GGA2) GGA protein family Q9UJY4
SNW domain-containing protein 1 (SNW1) SNW family Q13573
U3 small nucleolar RNA-associated protein 14 homolog C (UTP14C) UTP14 family Q5TAP6
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) . Q13155
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Elongin-A (ELOA) . Q14241
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Microspherule protein 1 (MCRS1) . Q96EZ8
Outer dynein arm-docking complex subunit 3 (ODAD3) . A5D8V7
Steroidogenic acute regulatory protein, mitochondrial (STAR) . P49675
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395

References

1 Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402