Details of the Target

General Information of Target

Target ID LDTP12412
Target Name Reticulon-4 (RTN4)
Gene Name RTN4
Gene ID 57142
Synonyms
KIAA0886; NOGO; Reticulon-4; Foocen; Neurite outgrowth inhibitor; Nogo protein; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
HIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSF
CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRGLSTSFPIDGTFFNSWLAQSVQI
TAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRL
PAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPA
AGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRL
PGARPDAGMGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAE
EVVRMGVLAS
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function
Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities (Probable).; [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner.; [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation. Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. With isoform C, inhibits BACE1 activity and amyloid precursor protein processing.; [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions. With isoform B, inhibits BACE1 activity and amyloid precursor protein processing.
TTD ID
T70062
Uniprot ID
Q9NQC3
DrugMap ID
TT7YXGM
Ensemble ID
ENST00000317610.11
HGNC ID
HGNC:14085
ChEMBL ID
CHEMBL3712895

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Insertion: p.V100RfsTer36 DBIA    Probe Info 
AN3CA SNV: p.L49Q .
CAL78 SNV: p.D700A DBIA    Probe Info 
CCK81 Deletion: p.V670YfsTer4 DBIA    Probe Info 
CHL1 SNV: p.L788F DBIA    Probe Info 
HCC70 SNV: p.S1030L DBIA    Probe Info 
HT Insertion: p.P658TfsTer3 .
HT115 SNV: p.E30G .
MCC13 SNV: p.P598S DBIA    Probe Info 
MFE319 SNV: p.D761N DBIA    Probe Info 
MOLT4 SNV: p.F85L; p.V972I IA-alkyne    Probe Info 
SG231 SNV: p.V1039I DBIA    Probe Info 
SNU5 SNV: p.R91G DBIA    Probe Info 
SUPT1 Insertion: p.P658TfsTer3 DBIA    Probe Info 
TE10 SNV: p.S114L DBIA    Probe Info 
TGBC1TKB SNV: p.S129W DBIA    Probe Info 
VMRCRCW SNV: p.E56D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 60 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.52  LDD0402  [2]
HDSF-alk
 Probe Info  		2.94  LDD0197  [3]
P3
 Probe Info  		10.00  LDD0450  [4]
P8
 Probe Info  		10.00  LDD0451  [4]
A-EBA
 Probe Info  		3.71  LDD0215  [5]
EN219-alkyne
 Probe Info  		3.37  LDD0297  [6]
ILS-2
 Probe Info  		2.40  LDD0416  [7]
AZ-9
 Probe Info  		2.36  LDD0393  [8]
FBPP2
 Probe Info  		5.35  LDD0318  [9]
CHEMBL5175495
 Probe Info  		16.08  LDD0196  [10]
CY4
 Probe Info  		100.00  LDD0244  [11]
SAA-alkyne
 Probe Info  		1.11  LDD0252  [12]
TG42
 Probe Info  		12.20  LDD0043  [13]
W1
 Probe Info  		17.27  LDD0235  [14]
FBP2
 Probe Info  		5.99  LDD0317  [9]
TH211
 Probe Info  		Y1165(9.23); Y1076(5.68)  LDD0257  [15]
TH214
 Probe Info  		Y1091(20.00)  LDD0258  [15]
TH216
 Probe Info  		Y1091(20.00); Y1165(12.62)  LDD0259  [15]
YN-1
 Probe Info  		100.00  LDD0444  [16]
YN-4
 Probe Info  		100.00  LDD0445  [16]
ONAyne
 Probe Info  		K1066(0.18); K1174(0.92); K1179(1.07); K1183(6.55)  LDD0274  [17]
OPA-S-S-alkyne
 Probe Info  		K1104(1.32); K1066(3.40)  LDD3494  [18]
Alkylaryl probe 2
 Probe Info  		11.00  LDD0390  [19]
P13
 Probe Info  		6.04  LDD0203  [20]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [21]
THZ1-DTB
 Probe Info  		C1110(1.18)  LDD0460  [21]
Johansson_61
 Probe Info  		_(15.99)  LDD1489  [22]
YY4-yne
 Probe Info  		2.92  LDD0400  [23]
DA-P3
 Probe Info  		36.56  LDD0179  [24]
AHL-Pu-1
 Probe Info  		C1101(2.06)  LDD0170  [25]
HPAP
 Probe Info  		5.72  LDD0064  [26]
HHS-482
 Probe Info  		Y1076(0.19)  LDD0292  [27]
DBIA
 Probe Info  		C1101(1.77)  LDD0078  [28]
5E-2FA
 Probe Info  		N.A.  LDD2235  [29]
1d-yne
 Probe Info  		N.A.  LDD0358  [30]
4-Iodoacetamidophenylacetylene
 Probe Info  		C912(0.00); C1101(0.00)  LDD0038  [31]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [32]
Lodoacetamide azide
 Probe Info  		C912(0.00); C464(0.00); C1101(0.00)  LDD0037  [31]
ATP probe
 Probe Info  		K1183(0.00); K1171(0.00)  LDD0035  [33]
BTD
 Probe Info  		N.A.  LDD0004  [34]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [35]
NAIA_4
 Probe Info  		C699(0.00); C912(0.00); C1101(0.00)  LDD2226  [36]
NAIA_5
 Probe Info  		N.A.  LDD2224  [36]
TFBX
 Probe Info  		N.A.  LDD0027  [35]
WYneN
 Probe Info  		N.A.  LDD0021  [34]
WYneO
 Probe Info  		N.A.  LDD0022  [34]
Compound 10
 Probe Info  		N.A.  LDD2216  [37]
Compound 11
 Probe Info  		N.A.  LDD2213  [37]
ENE
 Probe Info  		N.A.  LDD0006  [34]
IPM
 Probe Info  		N.A.  LDD0005  [34]
PF-06672131
 Probe Info  		N.A.  LDD0017  [38]
PPMS
 Probe Info  		N.A.  LDD0008  [34]
STPyne
 Probe Info  		N.A.  LDD0009  [34]
VSF
 Probe Info  		N.A.  LDD0007  [34]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [39]
Acrolein
 Probe Info  		C1101(0.00); H1164(0.00); H1158(0.00); H1098(0.00)  LDD0217  [40]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [40]
Crotonaldehyde
 Probe Info  		C1101(0.00); H1098(0.00); H1071(0.00)  LDD0219  [40]
Methacrolein
 Probe Info  		C1101(0.00); H1098(0.00)  LDD0218  [40]
AOyne
 Probe Info  		12.30  LDD0443  [41]
PAL-AfBPP Probe
Click To Hide/Show 134 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		6.68  LDD0398  [42]
C022
 Probe Info  		20.39  LDD1728  [43]
C026
 Probe Info  		5.70  LDD1732  [43]
C027
 Probe Info  		7.84  LDD1733  [43]
C040
 Probe Info  		32.00  LDD1740  [43]
C041
 Probe Info  		7.46  LDD1741  [43]
C049
 Probe Info  		9.92  LDD1747  [43]
C051
 Probe Info  		6.96  LDD1749  [43]
C053
 Probe Info  		10.56  LDD1751  [43]
C055
 Probe Info  		28.05  LDD1752  [43]
C056
 Probe Info  		44.02  LDD1753  [43]
C063
 Probe Info  		16.68  LDD1760  [43]
C064
 Probe Info  		6.50  LDD1761  [43]
C067
 Probe Info  		5.50  LDD1763  [43]
C070
 Probe Info  		15.78  LDD1766  [43]
C072
 Probe Info  		10.06  LDD1768  [43]
C082
 Probe Info  		7.57  LDD1774  [43]
C091
 Probe Info  		99.73  LDD1782  [43]
C092
 Probe Info  		99.73  LDD1783  [43]
C094
 Probe Info  		99.73  LDD1785  [43]
C095
 Probe Info  		7.01  LDD1786  [43]
C100
 Probe Info  		12.21  LDD1789  [43]
C106
 Probe Info  		29.24  LDD1793  [43]
C107
 Probe Info  		10.63  LDD1794  [43]
C108
 Probe Info  		8.82  LDD1795  [43]
C112
 Probe Info  		51.98  LDD1799  [43]
C130
 Probe Info  		8.40  LDD1812  [43]
C134
 Probe Info  		72.00  LDD1816  [43]
C135
 Probe Info  		18.90  LDD1817  [43]
C139
 Probe Info  		12.13  LDD1821  [43]
C141
 Probe Info  		19.56  LDD1823  [43]
C143
 Probe Info  		32.67  LDD1825  [43]
C153
 Probe Info  		26.72  LDD1834  [43]
C159
 Probe Info  		19.56  LDD1839  [43]
C160
 Probe Info  		19.43  LDD1840  [43]
C161
 Probe Info  		27.10  LDD1841  [43]
C163
 Probe Info  		11.31  LDD1843  [43]
C165
 Probe Info  		17.39  LDD1845  [43]
C166
 Probe Info  		12.82  LDD1846  [43]
C169
 Probe Info  		36.76  LDD1849  [43]
C186
 Probe Info  		9.71  LDD1864  [43]
C187
 Probe Info  		15.56  LDD1865  [43]
C196
 Probe Info  		9.99  LDD1872  [43]
C198
 Probe Info  		9.99  LDD1874  [43]
C201
 Probe Info  		99.73  LDD1877  [43]
C204
 Probe Info  		5.43  LDD1879  [43]
C205
 Probe Info  		5.03  LDD1880  [43]
C206
 Probe Info  		41.07  LDD1881  [43]
C207
 Probe Info  		26.72  LDD1882  [43]
C210
 Probe Info  		99.73  LDD1884  [43]
C218
 Probe Info  		60.55  LDD1892  [43]
C219
 Probe Info  		9.51  LDD1893  [43]
C220
 Probe Info  		33.59  LDD1894  [43]
C225
 Probe Info  		11.39  LDD1898  [43]
C226
 Probe Info  		9.58  LDD1899  [43]
C228
 Probe Info  		58.08  LDD1901  [43]
C229
 Probe Info  		9.13  LDD1902  [43]
C231
 Probe Info  		66.72  LDD1904  [43]
C232
 Probe Info  		45.25  LDD1905  [43]
C233
 Probe Info  		14.32  LDD1906  [43]
C234
 Probe Info  		6.87  LDD1907  [43]
C235
 Probe Info  		64.00  LDD1908  [43]
C238
 Probe Info  		18.13  LDD1911  [43]
C240
 Probe Info  		9.32  LDD1913  [43]
C243
 Probe Info  		20.25  LDD1916  [43]
C244
 Probe Info  		14.32  LDD1917  [43]
C246
 Probe Info  		35.51  LDD1919  [43]
C251
 Probe Info  		29.24  LDD1924  [43]
C252
 Probe Info  		25.99  LDD1925  [43]
C258
 Probe Info  		5.06  LDD1931  [43]
C264
 Probe Info  		35.26  LDD1935  [43]
C265
 Probe Info  		16.00  LDD1936  [43]
C270
 Probe Info  		6.92  LDD1940  [43]
C273
 Probe Info  		8.06  LDD1943  [43]
C277
 Probe Info  		13.74  LDD1947  [43]
C285
 Probe Info  		28.05  LDD1955  [43]
C287
 Probe Info  		17.27  LDD1957  [43]
C288
 Probe Info  		6.23  LDD1958  [43]
C289
 Probe Info  		65.34  LDD1959  [43]
C293
 Probe Info  		39.95  LDD1963  [43]
C296
 Probe Info  		27.28  LDD1966  [43]
C299
 Probe Info  		9.38  LDD1968  [43]
C305
 Probe Info  		10.85  LDD1974  [43]
C307
 Probe Info  		5.17  LDD1975  [43]
C310
 Probe Info  		24.59  LDD1977  [43]
C313
 Probe Info  		12.55  LDD1980  [43]
C314
 Probe Info  		13.74  LDD1981  [43]
C320
 Probe Info  		5.43  LDD1986  [43]
C322
 Probe Info  		9.85  LDD1988  [43]
C326
 Probe Info  		11.08  LDD1990  [43]
C338
 Probe Info  		10.78  LDD2001  [43]
C339
 Probe Info  		9.65  LDD2002  [43]
C343
 Probe Info  		21.41  LDD2005  [43]
C348
 Probe Info  		30.70  LDD2009  [43]
C349
 Probe Info  		41.36  LDD2010  [43]
C350
 Probe Info  		99.73  LDD2011  [43]
C355
 Probe Info  		24.93  LDD2016  [43]
C356
 Probe Info  		14.12  LDD2017  [43]
C357
 Probe Info  		6.11  LDD2018  [43]
C362
 Probe Info  		99.73  LDD2023  [43]
C363
 Probe Info  		45.57  LDD2024  [43]
C364
 Probe Info  		34.30  LDD2025  [43]
C366
 Probe Info  		16.56  LDD2027  [43]
C367
 Probe Info  		8.88  LDD2028  [43]
C373
 Probe Info  		5.24  LDD2033  [43]
C376
 Probe Info  		11.24  LDD2036  [43]
C378
 Probe Info  		6.36  LDD2037  [43]
C380
 Probe Info  		5.21  LDD2039  [43]
C382
 Probe Info  		30.91  LDD2041  [43]
C383
 Probe Info  		10.70  LDD2042  [43]
C388
 Probe Info  		99.73  LDD2047  [43]
C390
 Probe Info  		75.06  LDD2049  [43]
C399
 Probe Info  		10.93  LDD2058  [43]
C403
 Probe Info  		33.36  LDD2061  [43]
C407
 Probe Info  		41.64  LDD2064  [43]
C409
 Probe Info  		5.39  LDD2066  [43]
C413
 Probe Info  		19.16  LDD2069  [43]
C419
 Probe Info  		11.63  LDD2074  [43]
C424
 Probe Info  		38.32  LDD2079  [43]
C426
 Probe Info  		27.28  LDD2081  [43]
C429
 Probe Info  		15.14  LDD2084  [43]
C431
 Probe Info  		26.91  LDD2086  [43]
FFF probe11
 Probe Info  		20.00  LDD0471  [44]
FFF probe13
 Probe Info  		20.00  LDD0475  [44]
FFF probe14
 Probe Info  		20.00  LDD0477  [44]
FFF probe15
 Probe Info  		7.40  LDD0478  [44]
FFF probe2
 Probe Info  		20.00  LDD0463  [44]
FFF probe3
 Probe Info  		20.00  LDD0464  [44]
FFF probe4
 Probe Info  		20.00  LDD0466  [44]
FFF probe7
 Probe Info  		20.00  LDD0483  [44]
JN0003
 Probe Info  		20.00  LDD0469  [44]
STS-1
 Probe Info  		N.A.  LDD0136  [45]
STS-2
 Probe Info  		N.A.  LDD0139  [45]
A-DA
 Probe Info  		2.59  LDD0143  [46]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1101(0.93)  LDD2142  [47]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1101(1.24)  LDD2112  [47]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C1101(0.82)  LDD2095  [47]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1101(1.24)  LDD2130  [47]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1101(0.99)  LDD2117  [47]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1101(1.11)  LDD2152  [47]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1101(1.10)  LDD2103  [47]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1101(0.96)  LDD2131  [47]
 LDCM0025  4SU-RNA DM93 C1101(2.06)  LDD0170  [25]
 LDCM0026  4SU-RNA+native RNA DM93 C1101(5.14)  LDD0171  [25]
 LDCM0214  AC1 HEK-293T C1101(1.29)  LDD0812  [28]
 LDCM0215  AC10 HEK-293T C1101(1.18)  LDD0813  [28]
 LDCM0226  AC11 HEK-293T C1101(1.02)  LDD0824  [28]
 LDCM0230  AC113 HEK-293T C1101(1.04)  LDD0828  [28]
 LDCM0231  AC114 HEK-293T C1101(1.16)  LDD0829  [28]
 LDCM0232  AC115 HEK-293T C1101(1.18)  LDD0830  [28]
 LDCM0233  AC116 HEK-293T C1101(1.00)  LDD0831  [28]
 LDCM0234  AC117 HEK-293T C1101(1.02)  LDD0832  [28]
 LDCM0235  AC118 HEK-293T C1101(0.94)  LDD0833  [28]
 LDCM0236  AC119 HEK-293T C1101(1.18)  LDD0834  [28]
 LDCM0237  AC12 HEK-293T C1101(1.12)  LDD0835  [28]
 LDCM0238  AC120 HEK-293T C1101(1.17)  LDD0836  [28]
 LDCM0239  AC121 HEK-293T C1101(0.95)  LDD0837  [28]
 LDCM0240  AC122 HEK-293T C1101(1.12)  LDD0838  [28]
 LDCM0241  AC123 HEK-293T C1101(1.11)  LDD0839  [28]
 LDCM0242  AC124 HEK-293T C1101(1.07)  LDD0840  [28]
 LDCM0243  AC125 HEK-293T C1101(1.19)  LDD0841  [28]
 LDCM0244  AC126 HEK-293T C1101(1.26)  LDD0842  [28]
 LDCM0245  AC127 HEK-293T C1101(1.44)  LDD0843  [28]
 LDCM0246  AC128 HEK-293T C1101(0.83)  LDD0844  [28]
 LDCM0247  AC129 HEK-293T C1101(0.85)  LDD0845  [28]
 LDCM0249  AC130 HEK-293T C1101(0.88)  LDD0847  [28]
 LDCM0250  AC131 HEK-293T C1101(0.87)  LDD0848  [28]
 LDCM0251  AC132 HEK-293T C1101(0.61)  LDD0849  [28]
 LDCM0252  AC133 HEK-293T C1101(0.98)  LDD0850  [28]
 LDCM0253  AC134 HEK-293T C1101(0.92)  LDD0851  [28]
 LDCM0254  AC135 HEK-293T C1101(0.88)  LDD0852  [28]
 LDCM0255  AC136 HEK-293T C1101(0.80)  LDD0853  [28]
 LDCM0256  AC137 HEK-293T C1101(1.12)  LDD0854  [28]
 LDCM0257  AC138 HEK-293T C1101(1.18)  LDD0855  [28]
 LDCM0258  AC139 HEK-293T C1101(0.91)  LDD0856  [28]
 LDCM0259  AC14 HEK-293T C1101(0.96)  LDD0857  [28]
 LDCM0260  AC140 HEK-293T C1101(0.91)  LDD0858  [28]
 LDCM0261  AC141 HEK-293T C1101(1.00)  LDD0859  [28]
 LDCM0262  AC142 HEK-293T C1101(0.92)  LDD0860  [28]
 LDCM0263  AC143 HCT 116 C1101(0.97)  LDD0580  [28]
 LDCM0264  AC144 HCT 116 C1101(1.05)  LDD0581  [28]
 LDCM0265  AC145 HCT 116 C1101(1.10)  LDD0582  [28]
 LDCM0266  AC146 HCT 116 C1101(0.89)  LDD0583  [28]
 LDCM0267  AC147 HCT 116 C1101(1.23)  LDD0584  [28]
 LDCM0268  AC148 HCT 116 C1101(0.89)  LDD0585  [28]
 LDCM0269  AC149 HCT 116 C1101(0.97)  LDD0586  [28]
 LDCM0270  AC15 HEK-293T C1101(0.95)  LDD0868  [28]
 LDCM0271  AC150 HCT 116 C1101(0.95)  LDD0588  [28]
 LDCM0272  AC151 HCT 116 C1101(0.92)  LDD0589  [28]
 LDCM0273  AC152 HCT 116 C1101(0.92)  LDD0590  [28]
 LDCM0274  AC153 HCT 116 C1101(0.69)  LDD0591  [28]
 LDCM0621  AC154 HCT 116 C1101(0.98)  LDD2158  [28]
 LDCM0622  AC155 HCT 116 C1101(0.75)  LDD2159  [28]
 LDCM0623  AC156 HCT 116 C1101(0.98)  LDD2160  [28]
 LDCM0624  AC157 HCT 116 C1101(0.92)  LDD2161  [28]
 LDCM0276  AC17 HCT 116 C1101(0.70)  LDD0593  [28]
 LDCM0277  AC18 HCT 116 C1101(0.61)  LDD0594  [28]
 LDCM0278  AC19 HCT 116 C1101(0.58)  LDD0595  [28]
 LDCM0279  AC2 HEK-293T C1101(0.90)  LDD0877  [28]
 LDCM0280  AC20 HCT 116 C1101(0.85)  LDD0597  [28]
 LDCM0281  AC21 HCT 116 C1101(0.73)  LDD0598  [28]
 LDCM0282  AC22 HCT 116 C1101(0.59)  LDD0599  [28]
 LDCM0283  AC23 HCT 116 C1101(1.05)  LDD0600  [28]
 LDCM0284  AC24 HCT 116 C1101(0.63)  LDD0601  [28]
 LDCM0285  AC25 HEK-293T C1101(1.03); C912(1.07); C559(1.02)  LDD1524  [48]
 LDCM0286  AC26 HEK-293T C1101(1.07); C464(0.96)  LDD1525  [48]
 LDCM0287  AC27 HEK-293T C1101(1.02)  LDD1526  [48]
 LDCM0288  AC28 HEK-293T C1101(1.07)  LDD1527  [48]
 LDCM0289  AC29 HEK-293T C1101(1.00); C464(0.94)  LDD1528  [48]
 LDCM0290  AC3 HEK-293T C1101(1.03)  LDD0888  [28]
 LDCM0291  AC30 HEK-293T C1101(1.03)  LDD1530  [48]
 LDCM0292  AC31 HEK-293T C1101(1.04); C464(1.07)  LDD1531  [48]
 LDCM0293  AC32 HEK-293T C1101(0.93)  LDD1532  [48]
 LDCM0294  AC33 HEK-293T C1101(1.07); C912(0.98); C559(0.93)  LDD1533  [48]
 LDCM0295  AC34 HEK-293T C1101(1.05); C464(1.05)  LDD1534  [48]
 LDCM0296  AC35 HEK-293T C1101(0.86)  LDD0894  [28]
 LDCM0297  AC36 HEK-293T C1101(0.66)  LDD0895  [28]
 LDCM0298  AC37 HEK-293T C1101(0.82)  LDD0896  [28]
 LDCM0299  AC38 HEK-293T C1101(0.72)  LDD0897  [28]
 LDCM0300  AC39 HEK-293T C1101(0.65)  LDD0898  [28]
 LDCM0301  AC4 HEK-293T C1101(1.00)  LDD0899  [28]
 LDCM0302  AC40 HEK-293T C1101(0.70)  LDD0900  [28]
 LDCM0303  AC41 HEK-293T C1101(1.02)  LDD0901  [28]
 LDCM0304  AC42 HEK-293T C1101(0.89)  LDD0902  [28]
 LDCM0305  AC43 HEK-293T C1101(1.01)  LDD0903  [28]
 LDCM0306  AC44 HEK-293T C1101(0.58)  LDD0904  [28]
 LDCM0307  AC45 HEK-293T C1101(0.77)  LDD0905  [28]
 LDCM0308  AC46 HEK-293T C1101(0.97)  LDD0906  [28]
 LDCM0309  AC47 HEK-293T C1101(1.01)  LDD0907  [28]
 LDCM0310  AC48 HEK-293T C1101(0.95)  LDD0908  [28]
 LDCM0311  AC49 HEK-293T C1101(1.00)  LDD0909  [28]
 LDCM0312  AC5 HEK-293T C1101(0.87)  LDD0910  [28]
 LDCM0313  AC50 HEK-293T C1101(0.92)  LDD0911  [28]
 LDCM0314  AC51 HEK-293T C1101(0.84)  LDD0912  [28]
 LDCM0315  AC52 HEK-293T C1101(0.78)  LDD0913  [28]
 LDCM0316  AC53 HEK-293T C1101(0.98)  LDD0914  [28]
 LDCM0317  AC54 HEK-293T C1101(0.80)  LDD0915  [28]
 LDCM0318  AC55 HEK-293T C1101(0.87)  LDD0916  [28]
 LDCM0319  AC56 HEK-293T C1101(0.95)  LDD0917  [28]
 LDCM0320  AC57 HEK-293T C1101(0.96); C912(1.05); C559(0.81)  LDD1559  [48]
 LDCM0321  AC58 HEK-293T C1101(0.93); C464(1.09)  LDD1560  [48]
 LDCM0322  AC59 HEK-293T C1101(0.90)  LDD1561  [48]
 LDCM0323  AC6 HEK-293T C1101(0.89)  LDD0921  [28]
 LDCM0324  AC60 HEK-293T C1101(0.98)  LDD1563  [48]
 LDCM0325  AC61 HEK-293T C1101(0.94); C464(0.93)  LDD1564  [48]
 LDCM0326  AC62 HEK-293T C1101(0.94)  LDD1565  [48]
 LDCM0327  AC63 HEK-293T C1101(0.94); C464(0.91)  LDD1566  [48]
 LDCM0328  AC64 HEK-293T C1101(0.90)  LDD1567  [48]
 LDCM0332  AC68 HCT 116 C1101(0.88)  LDD0649  [28]
 LDCM0333  AC69 HCT 116 C1101(0.66)  LDD0650  [28]
 LDCM0334  AC7 HEK-293T C1101(0.99)  LDD0932  [28]
 LDCM0335  AC70 HCT 116 C1101(0.64)  LDD0652  [28]
 LDCM0336  AC71 HCT 116 C1101(0.82)  LDD0653  [28]
 LDCM0337  AC72 HCT 116 C1101(0.99)  LDD0654  [28]
 LDCM0338  AC73 HCT 116 C1101(0.93)  LDD0655  [28]
 LDCM0339  AC74 HCT 116 C1101(0.84)  LDD0656  [28]
 LDCM0340  AC75 HCT 116 C1101(0.60)  LDD0657  [28]
 LDCM0341  AC76 HCT 116 C1101(0.76)  LDD0658  [28]
 LDCM0342  AC77 HCT 116 C1101(1.02)  LDD0659  [28]
 LDCM0343  AC78 HCT 116 C1101(0.90)  LDD0660  [28]
 LDCM0344  AC79 HCT 116 C1101(0.63)  LDD0661  [28]
 LDCM0345  AC8 HEK-293T C1101(0.81)  LDD0943  [28]
 LDCM0346  AC80 HCT 116 C1101(0.72)  LDD0663  [28]
 LDCM0347  AC81 HCT 116 C1101(0.81)  LDD0664  [28]
 LDCM0348  AC82 HCT 116 C1101(0.82)  LDD0665  [28]
 LDCM0349  AC83 HEK-293T C1101(1.07)  LDD0947  [28]
 LDCM0350  AC84 HEK-293T C1101(0.79)  LDD0948  [28]
 LDCM0351  AC85 HEK-293T C1101(0.81)  LDD0949  [28]
 LDCM0352  AC86 HEK-293T C1101(0.95)  LDD0950  [28]
 LDCM0353  AC87 HEK-293T C1101(0.83)  LDD0951  [28]
 LDCM0354  AC88 HEK-293T C1101(0.76)  LDD0952  [28]
 LDCM0355  AC89 HEK-293T C1101(0.73)  LDD0953  [28]
 LDCM0357  AC90 HEK-293T C1101(0.74)  LDD0955  [28]
 LDCM0358  AC91 HEK-293T C1101(0.93)  LDD0956  [28]
 LDCM0359  AC92 HEK-293T C1101(0.86)  LDD0957  [28]
 LDCM0360  AC93 HEK-293T C1101(0.88)  LDD0958  [28]
 LDCM0361  AC94 HEK-293T C1101(0.81)  LDD0959  [28]
 LDCM0362  AC95 HEK-293T C1101(0.81)  LDD0960  [28]
 LDCM0363  AC96 HEK-293T C1101(0.80)  LDD0961  [28]
 LDCM0364  AC97 HEK-293T C1101(1.17)  LDD0962  [28]
 LDCM0545  Acetamide MDA-MB-231 C1101(0.66)  LDD2138  [47]
 LDCM0520  AKOS000195272 MDA-MB-231 C1101(0.77)  LDD2113  [47]
 LDCM0248  AKOS034007472 HEK-293T C1101(0.94)  LDD0846  [28]
 LDCM0356  AKOS034007680 HEK-293T C1101(0.92)  LDD0954  [28]
 LDCM0275  AKOS034007705 HEK-293T C1101(0.79)  LDD0873  [28]
 LDCM0156  Aniline NCI-H1299 11.92  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C1101(1.77)  LDD0078  [28]
 LDCM0083  Avasimibe A-549 2.59  LDD0143  [46]
 LDCM0199  BPK-21 T cell C1101(9.76)  LDD0517  [49]
 LDCM0200  BPK-25 T cell C1101(9.13)  LDD0516  [49]
 LDCM0498  BS-3668 MDA-MB-231 C1101(0.55)  LDD2091  [47]
 LDCM0088  C45 HEK-293T 6.04  LDD0203  [20]
 LDCM0630  CCW28-3 231MFP C1101(1.59)  LDD2214  [50]
 LDCM0108  Chloroacetamide HeLa C1101(0.00); H1164(0.00); H1158(0.00); H1071(0.00)  LDD0222  [40]
 LDCM0367  CL1 HEK-293T C1101(1.31); C912(0.90)  LDD1571  [48]
 LDCM0368  CL10 HEK-293T C1101(7.73)  LDD1572  [48]
 LDCM0369  CL100 HEK-293T C1101(1.01)  LDD0967  [28]
 LDCM0370  CL101 HEK-293T C1101(0.94)  LDD0968  [28]
 LDCM0371  CL102 HEK-293T C1101(0.92)  LDD0969  [28]
 LDCM0372  CL103 HEK-293T C1101(0.82)  LDD0970  [28]
 LDCM0373  CL104 HEK-293T C1101(0.92)  LDD0971  [28]
 LDCM0374  CL105 HCT 116 C1101(0.73)  LDD0691  [28]
 LDCM0375  CL106 HCT 116 C1101(0.64)  LDD0692  [28]
 LDCM0376  CL107 HCT 116 C1101(0.66)  LDD0693  [28]
 LDCM0377  CL108 HCT 116 C1101(0.61)  LDD0694  [28]
 LDCM0378  CL109 HCT 116 C1101(0.93)  LDD0695  [28]
 LDCM0379  CL11 HEK-293T C1101(1.37); C464(0.92)  LDD1583  [48]
 LDCM0380  CL110 HCT 116 C1101(1.10)  LDD0697  [28]
 LDCM0381  CL111 HCT 116 C1101(1.25)  LDD0698  [28]
 LDCM0382  CL112 HEK-293T C1101(1.08)  LDD1586  [48]
 LDCM0383  CL113 HEK-293T C1101(0.86); C912(0.97)  LDD1587  [48]
 LDCM0384  CL114 HEK-293T C1101(1.93)  LDD1588  [48]
 LDCM0385  CL115 HEK-293T C1101(1.00); C464(1.12)  LDD1589  [48]
 LDCM0386  CL116 HEK-293T C1101(0.95)  LDD1590  [48]
 LDCM0387  CL117 HEK-293T C1101(0.80)  LDD0985  [28]
 LDCM0388  CL118 HEK-293T C1101(0.84)  LDD0986  [28]
 LDCM0389  CL119 HEK-293T C1101(0.61)  LDD0987  [28]
 LDCM0390  CL12 HEK-293T C1101(1.17)  LDD1594  [48]
 LDCM0391  CL120 HEK-293T C1101(0.83)  LDD0989  [28]
 LDCM0392  CL121 HEK-293T C1101(0.96)  LDD0990  [28]
 LDCM0393  CL122 HEK-293T C1101(0.87)  LDD0991  [28]
 LDCM0394  CL123 HEK-293T C1101(0.96)  LDD0992  [28]
 LDCM0395  CL124 HEK-293T C1101(0.88)  LDD0993  [28]
 LDCM0396  CL125 HEK-293T C1101(0.85); C912(0.95)  LDD1600  [48]
 LDCM0397  CL126 HEK-293T C1101(1.03)  LDD1601  [48]
 LDCM0398  CL127 HEK-293T C1101(0.81); C464(0.95)  LDD1602  [48]
 LDCM0399  CL128 HEK-293T C1101(0.79)  LDD1603  [48]
 LDCM0400  CL13 HEK-293T C1101(0.94); C912(0.89)  LDD1604  [48]
 LDCM0401  CL14 HEK-293T C1101(0.99)  LDD1605  [48]
 LDCM0402  CL15 HEK-293T C1101(2.29); C464(1.16)  LDD1606  [48]
 LDCM0403  CL16 HEK-293T C1101(0.93)  LDD1607  [48]
 LDCM0404  CL17 HCT 116 C1101(1.97)  LDD0721  [28]
 LDCM0405  CL18 HCT 116 C1101(0.81)  LDD0722  [28]
 LDCM0406  CL19 HCT 116 C1101(1.10)  LDD0723  [28]
 LDCM0407  CL2 HEK-293T C1101(1.01)  LDD1611  [48]
 LDCM0408  CL20 HCT 116 C1101(1.12)  LDD0725  [28]
 LDCM0409  CL21 HCT 116 C1101(1.52)  LDD0726  [28]
 LDCM0410  CL22 HCT 116 C1101(1.19)  LDD0727  [28]
 LDCM0411  CL23 HCT 116 C1101(1.38)  LDD0728  [28]
 LDCM0412  CL24 HCT 116 C1101(0.80)  LDD0729  [28]
 LDCM0413  CL25 HCT 116 C1101(1.59)  LDD0730  [28]
 LDCM0414  CL26 HCT 116 C1101(0.97)  LDD0731  [28]
 LDCM0415  CL27 HCT 116 C1101(0.84)  LDD0732  [28]
 LDCM0416  CL28 HCT 116 C1101(0.93)  LDD0733  [28]
 LDCM0417  CL29 HCT 116 C1101(0.98)  LDD0734  [28]
 LDCM0418  CL3 HEK-293T C1101(1.17); C464(0.79)  LDD1622  [48]
 LDCM0419  CL30 HCT 116 C1101(1.11)  LDD0736  [28]
 LDCM0420  CL31 HCT 116 C1101(0.90)  LDD0737  [28]
 LDCM0421  CL32 HEK-293T C1101(0.84)  LDD1019  [28]
 LDCM0422  CL33 HEK-293T C1101(0.93)  LDD1020  [28]
 LDCM0423  CL34 HEK-293T C1101(0.86)  LDD1021  [28]
 LDCM0424  CL35 HEK-293T C1101(0.86)  LDD1022  [28]
 LDCM0425  CL36 HEK-293T C1101(0.90)  LDD1023  [28]
 LDCM0426  CL37 HEK-293T C1101(0.76)  LDD1024  [28]
 LDCM0428  CL39 HEK-293T C1101(0.77)  LDD1026  [28]
 LDCM0429  CL4 HEK-293T C1101(1.18)  LDD1633  [48]
 LDCM0430  CL40 HEK-293T C1101(0.67)  LDD1028  [28]
 LDCM0431  CL41 HEK-293T C1101(0.88)  LDD1029  [28]
 LDCM0432  CL42 HEK-293T C1101(0.85)  LDD1030  [28]
 LDCM0433  CL43 HEK-293T C1101(0.75)  LDD1031  [28]
 LDCM0434  CL44 HEK-293T C1101(0.67)  LDD1032  [28]
 LDCM0435  CL45 HEK-293T C1101(0.75)  LDD1033  [28]
 LDCM0436  CL46 HEK-293T C1101(1.04)  LDD1034  [28]
 LDCM0437  CL47 HEK-293T C1101(0.97)  LDD1035  [28]
 LDCM0438  CL48 HEK-293T C1101(0.87)  LDD1036  [28]
 LDCM0439  CL49 HEK-293T C1101(1.00)  LDD1037  [28]
 LDCM0440  CL5 HEK-293T C1101(0.92); C912(1.25); C559(1.09)  LDD1644  [48]
 LDCM0441  CL50 HEK-293T C1101(1.09)  LDD1039  [28]
 LDCM0442  CL51 HEK-293T C1101(0.96)  LDD1040  [28]
 LDCM0443  CL52 HEK-293T C1101(1.06)  LDD1041  [28]
 LDCM0444  CL53 HEK-293T C1101(1.04)  LDD1042  [28]
 LDCM0445  CL54 HEK-293T C1101(1.06)  LDD1043  [28]
 LDCM0446  CL55 HEK-293T C1101(1.03)  LDD1044  [28]
 LDCM0447  CL56 HEK-293T C1101(0.92)  LDD1045  [28]
 LDCM0448  CL57 HEK-293T C1101(1.00)  LDD1046  [28]
 LDCM0449  CL58 HEK-293T C1101(0.91)  LDD1047  [28]
 LDCM0450  CL59 HEK-293T C1101(0.98)  LDD1048  [28]
 LDCM0451  CL6 HEK-293T C1101(1.57); C464(1.01)  LDD1654  [48]
 LDCM0452  CL60 HEK-293T C1101(1.17)  LDD1050  [28]
 LDCM0453  CL61 HEK-293T C1101(0.87); C912(1.09)  LDD1656  [48]
 LDCM0454  CL62 HEK-293T C1101(0.99)  LDD1657  [48]
 LDCM0455  CL63 HEK-293T C1101(0.91); C464(0.93)  LDD1658  [48]
 LDCM0456  CL64 HEK-293T C1101(1.21)  LDD1659  [48]
 LDCM0457  CL65 HEK-293T C1101(1.06); C912(1.14); C559(1.03)  LDD1660  [48]
 LDCM0458  CL66 HEK-293T C1101(1.07); C464(1.07)  LDD1661  [48]
 LDCM0459  CL67 HEK-293T C1101(1.02)  LDD1662  [48]
 LDCM0460  CL68 HEK-293T C1101(1.13)  LDD1663  [48]
 LDCM0461  CL69 HEK-293T C1101(1.23); C464(0.94)  LDD1664  [48]
 LDCM0462  CL7 HEK-293T C1101(1.05)  LDD1665  [48]
 LDCM0463  CL70 HEK-293T C1101(1.16)  LDD1666  [48]
 LDCM0464  CL71 HEK-293T C1101(1.13); C464(1.07)  LDD1667  [48]
 LDCM0465  CL72 HEK-293T C1101(1.04)  LDD1668  [48]
 LDCM0466  CL73 HEK-293T C1101(1.24); C912(1.05)  LDD1669  [48]
 LDCM0467  CL74 HEK-293T C1101(0.97)  LDD1670  [48]
 LDCM0469  CL76 HEK-293T C1101(0.93)  LDD1672  [48]
 LDCM0470  CL77 HEK-293T C1101(1.49); C912(1.34); C559(0.82)  LDD1673  [48]
 LDCM0471  CL78 HEK-293T C1101(0.94); C464(0.97)  LDD1674  [48]
 LDCM0472  CL79 HEK-293T C1101(1.00)  LDD1675  [48]
 LDCM0473  CL8 HEK-293T C1101(5.55)  LDD1676  [48]
 LDCM0474  CL80 HEK-293T C1101(0.95)  LDD1677  [48]
 LDCM0475  CL81 HEK-293T C1101(0.98); C464(0.94)  LDD1678  [48]
 LDCM0476  CL82 HEK-293T C1101(1.12)  LDD1679  [48]
 LDCM0477  CL83 HEK-293T C1101(1.36); C464(1.01)  LDD1680  [48]
 LDCM0478  CL84 HEK-293T C1101(1.24)  LDD1681  [48]
 LDCM0479  CL85 HEK-293T C1101(0.82); C912(0.94)  LDD1682  [48]
 LDCM0480  CL86 HEK-293T C1101(0.79)  LDD1683  [48]
 LDCM0481  CL87 HEK-293T C1101(0.84); C464(1.16)  LDD1684  [48]
 LDCM0482  CL88 HEK-293T C1101(0.78)  LDD1685  [48]
 LDCM0483  CL89 HEK-293T C1101(0.87); C912(1.09); C559(0.95)  LDD1686  [48]
 LDCM0484  CL9 HEK-293T C1101(1.19); C464(0.99)  LDD1687  [48]
 LDCM0485  CL90 HEK-293T C1101(5.59); C464(0.91)  LDD1688  [48]
 LDCM0486  CL91 HEK-293T C1101(1.20)  LDD1084  [28]
 LDCM0487  CL92 HEK-293T C1101(1.03)  LDD1085  [28]
 LDCM0488  CL93 HEK-293T C1101(0.88)  LDD1086  [28]
 LDCM0489  CL94 HEK-293T C1101(1.13)  LDD1087  [28]
 LDCM0490  CL95 HEK-293T C1101(0.91)  LDD1088  [28]
 LDCM0491  CL96 HEK-293T C1101(0.95)  LDD1089  [28]
 LDCM0492  CL97 HEK-293T C1101(0.87)  LDD1090  [28]
 LDCM0493  CL98 HEK-293T C1101(1.11)  LDD1091  [28]
 LDCM0494  CL99 HEK-293T C1101(0.99)  LDD1092  [28]
 LDCM0189  Compound 16 HEK-293T 58.82  LDD0492  [44]
 LDCM0185  Compound 17 HEK-293T 9.76  LDD0512  [44]
 LDCM0184  Compound 20 HEK-293T 6.59  LDD0503  [44]
 LDCM0191  Compound 21 HEK-293T 4.88  LDD0493  [44]
 LDCM0186  Compound 31 HEK-293T 5.33  LDD0506  [44]
 LDCM0187  Compound 32 HEK-293T 132.33  LDD0507  [44]
 LDCM0190  Compound 34 HEK-293T 37.04  LDD0497  [44]
 LDCM0192  Compound 35 HEK-293T 7.55  LDD0491  [44]
 LDCM0193  Compound 36 HEK-293T 5.49  LDD0511  [44]
 LDCM0194  Compound 37 HEK-293T 42.55  LDD0498  [44]
 LDCM0196  Compound 39 HEK-293T 4.69  LDD0496  [44]
 LDCM0197  Compound 40 HEK-293T 8.00  LDD0495  [44]
 LDCM0027  Dopamine HEK-293T 36.56  LDD0179  [24]
 LDCM0495  E2913 HEK-293T C1101(1.00); C464(0.84)  LDD1698  [48]
 LDCM0202  EV-93 T cell C1101(15.97)  LDD0527  [49]
 LDCM0203  EV-96 T cell C1101(4.00)  LDD0522  [49]
 LDCM0204  EV-97 T cell C1101(14.00)  LDD0525  [49]
 LDCM0625  F8 Ramos C1101(0.99)  LDD2187  [51]
 LDCM0572  Fragment10 MDA-MB-231 C1101(11.86)  LDD1389  [22]
 LDCM0573  Fragment11 MDA-MB-231 C1101(1.08)  LDD1467  [22]
 LDCM0574  Fragment12 Ramos C1101(20.00)  LDD1394  [22]
 LDCM0575  Fragment13 MDA-MB-231 C1101(3.93)  LDD1395  [22]
 LDCM0576  Fragment14 MDA-MB-231 C1101(3.74)  LDD1397  [22]
 LDCM0579  Fragment20 MDA-MB-231 C1101(5.63)  LDD1402  [22]
 LDCM0580  Fragment21 MDA-MB-231 C1101(8.56)  LDD1404  [22]
 LDCM0581  Fragment22 MDA-MB-231 C1101(1.08)  LDD1406  [22]
 LDCM0582  Fragment23 MDA-MB-231 C1101(3.16)  LDD1408  [22]
 LDCM0578  Fragment27 MDA-MB-231 C1101(0.91)  LDD1401  [22]
 LDCM0586  Fragment28 MDA-MB-231 C1101(1.40)  LDD1415  [22]
 LDCM0587  Fragment29 MDA-MB-231 C1101(0.95)  LDD1417  [22]
 LDCM0588  Fragment30 MDA-MB-231 C1101(1.60)  LDD1419  [22]
 LDCM0589  Fragment31 MDA-MB-231 C1101(20.00)  LDD1421  [22]
 LDCM0590  Fragment32 MDA-MB-231 C1101(20.00)  LDD1423  [22]
 LDCM0468  Fragment33 MDA-MB-231 C1101(1.21)  LDD1425  [22]
 LDCM0592  Fragment34 MDA-MB-231 C1101(0.84)  LDD1427  [22]
 LDCM0593  Fragment35 MDA-MB-231 C1101(1.38)  LDD1429  [22]
 LDCM0594  Fragment36 MDA-MB-231 C1101(2.64)  LDD1431  [22]
 LDCM0596  Fragment38 MDA-MB-231 C1101(7.50)  LDD1433  [22]
 LDCM0566  Fragment4 MDA-MB-231 C1101(11.88)  LDD1378  [22]
 LDCM0599  Fragment41 MDA-MB-231 C1101(1.35)  LDD1438  [22]
 LDCM0600  Fragment42 Ramos C1101(0.98)  LDD1440  [22]
 LDCM0601  Fragment43 Ramos C1101(10.94)  LDD1442  [22]
 LDCM0602  Fragment44 MDA-MB-231 C1101(0.72)  LDD1443  [22]
 LDCM0603  Fragment45 MDA-MB-231 C1101(20.00)  LDD1444  [22]
 LDCM0604  Fragment46 MDA-MB-231 C1101(1.36)  LDD1445  [22]
 LDCM0606  Fragment48 MDA-MB-231 C1101(1.76)  LDD1447  [22]
 LDCM0607  Fragment49 MDA-MB-231 C1101(11.17)  LDD1448  [22]
 LDCM0608  Fragment50 MDA-MB-231 C1101(20.00)  LDD1449  [22]
 LDCM0427  Fragment51 HEK-293T C1101(0.86)  LDD1025  [28]
 LDCM0610  Fragment52 Ramos C1101(3.89)  LDD2204  [51]
 LDCM0611  Fragment53 MDA-MB-231 C1101(1.38)  LDD1454  [22]
 LDCM0612  Fragment54 MDA-MB-231 C1101(1.06)  LDD1456  [22]
 LDCM0613  Fragment55 MDA-MB-231 C1101(1.02)  LDD1457  [22]
 LDCM0614  Fragment56 MDA-MB-231 C1101(0.93)  LDD1458  [22]
 LDCM0616  Fragment61 Jurkat _(15.99)  LDD1489  [22]
 LDCM0617  Fragment63-S Jurkat _(11.94)  LDD1490  [22]
 LDCM0569  Fragment7 Ramos C1101(8.18)  LDD2186  [51]
 LDCM0570  Fragment8 MDA-MB-231 C1101(1.54)  LDD1385  [22]
 LDCM0571  Fragment9 MDA-MB-231 C1101(15.03)  LDD1387  [22]
 LDCM0107  IAA HeLa H1164(0.00); H1158(0.00); C1101(0.00); H1098(0.00)  LDD0221  [40]
 LDCM0130  JWB211 DM93 Y1076(0.19)  LDD0292  [27]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [21]
 LDCM0022  KB02 Ramos 14.77  LDD0431  [52]
 LDCM0023  KB03 Jurkat C1101(4.76)  LDD0315  [32]
 LDCM0024  KB05 COLO792 C464(0.86); C895(4.05)  LDD3310  [53]
 LDCM0169  KB63 Ramos 10.70  LDD0432  [52]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1101(1.24)  LDD2102  [47]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1101(0.82)  LDD2121  [47]
 LDCM0109  NEM HeLa H1098(0.00); H1164(0.00); H1158(0.00); H1071(0.00)  LDD0223  [40]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1101(0.83)  LDD2089  [47]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C1101(2.01)  LDD2090  [47]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1101(1.16)  LDD2092  [47]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1101(1.50)  LDD2093  [47]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1101(1.54)  LDD2094  [47]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1101(0.74)  LDD2096  [47]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1101(1.03)  LDD2097  [47]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1101(1.54)  LDD2098  [47]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1101(0.92)  LDD2099  [47]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1101(1.82)  LDD2100  [47]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1101(0.95)  LDD2101  [47]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1101(1.57)  LDD2104  [47]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1101(1.53)  LDD2105  [47]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1101(1.57)  LDD2106  [47]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1101(0.76)  LDD2107  [47]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1101(0.68)  LDD2108  [47]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1101(0.87)  LDD2109  [47]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C1101(5.25)  LDD2110  [47]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1101(1.05)  LDD2111  [47]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1101(1.19)  LDD2114  [47]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1101(0.52)  LDD2115  [47]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C1101(1.07)  LDD2116  [47]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1101(1.39)  LDD2118  [47]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1101(2.34)  LDD2119  [47]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1101(0.75)  LDD2120  [47]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1101(0.97)  LDD2122  [47]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1101(0.88)  LDD2123  [47]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1101(1.21)  LDD2124  [47]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1101(0.85)  LDD2125  [47]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1101(3.08)  LDD2126  [47]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1101(1.28)  LDD2127  [47]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1101(0.75)  LDD2128  [47]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1101(1.00)  LDD2129  [47]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1101(0.72)  LDD2133  [47]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1101(0.99)  LDD2135  [47]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1101(1.47)  LDD2136  [47]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1101(0.90)  LDD2137  [47]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1101(1.50)  LDD1700  [47]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1101(0.83)  LDD2140  [47]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1101(0.56)  LDD2141  [47]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1101(0.96)  LDD2143  [47]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1101(2.06)  LDD2144  [47]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C1101(9.33)  LDD2145  [47]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1101(0.85)  LDD2146  [47]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C1101(2.44)  LDD2147  [47]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1101(0.58)  LDD2148  [47]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C1101(1.15)  LDD2149  [47]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1101(0.66)  LDD2150  [47]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1101(3.69)  LDD2153  [47]
 LDCM0627  NUDT7-COV-1 HEK-293T C1101(0.30); C1101(0.07)  LDD2206  [54]
 LDCM0628  OTUB2-COV-1 HEK-293T C1101(1.08); C1101(0.49)  LDD2207  [54]
 LDCM0014  Panhematin hPBMC 5.72  LDD0064  [26]
 LDCM0099  Phenelzine HEK-293T 11.00  LDD0390  [19]
 LDCM0131  RA190 MM1.R C1101(6.15)  LDD0304  [55]
 LDCM0084  Ro 48-8071 A-549 2.84  LDD0145  [46]
 LDCM0021  THZ1 HeLa S3 C1110(1.18)  LDD0460  [21]
 LDCM0110  W12 Hep-G2 C1101(10.39)  LDD0237  [14]
 LDCM0111  W14 Hep-G2 C1101(12.24)  LDD0238  [14]
 LDCM0112  W16 Hep-G2 C1101(0.60)  LDD0239  [14]
 LDCM0113  W17 Hep-G2 H1098(8.42); C1101(8.50)  LDD0240  [14]
 LDCM0154  YY4 T cell 2.92  LDD0400  [23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atlastin-1 (ATL1) GB1/RHD3 GTPase family Q8WXF7
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Sorting nexin-15 (SNX15) Sorting nexin family Q9NRS6
Ceramide transfer protein (CERT1) . Q9Y5P4
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Synaptotagmin-16 (SYT16) Synaptotagmin family Q17RD7
Cytoplasmic protein NCK2 (NCK2) . O43639
Zinc finger FYVE domain-containing protein 21 (ZFYVE21) . Q9BQ24

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ati-355 Antibody D0M0WM

References

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Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
4 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
5 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
6 Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15. doi: 10.1016/j.chembiol.2021.01.005. Epub 2021 Jan 28.
7 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
10 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
11 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
12 Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.
13 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
16 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
17 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
18 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
19 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
20 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
21 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
22 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
23 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
24 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
25 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
26 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
27 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
28 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
29 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
30 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
31 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
32 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
33 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
34 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
35 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
36 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
37 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
38 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
39 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
40 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
41 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
42 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
43 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
44 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
45 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
46 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
47 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
48 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
49 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840
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