Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment50  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 91 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 20.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 20.0
 LDTP03642  Cytidine deaminase (CDA) C14 20.0
 LDTP03681  DNA replication licensing factor MCM5 (MCM5) C482 20.0
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 20.0
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 20.0
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 20.0
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 20.0
 LDTP04689  Adenosine kinase (ADK) C353 14.4
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 9.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 9.2
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 7.3
 LDTP02502  Thioredoxin (TXN) C32 6.4
 LDTP02198  Cathepsin D (CTSD) C117 6.2
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 6.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 3.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 3.7
 LDTP09912  DNA repair protein RAD50 (RAD50) C1296 3.2
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 3.2
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 3.1
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 3.1
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 3.1
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 2.7
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 2.6
 LDTP02672  Elongation factor 2 (EEF2) C41 2.5
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 2.4
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 2.4
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 2.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 2.4
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 2.4
 LDTP05289  AMP deaminase 2 (AMPD2) C107 2.3
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 2.3
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 2.3
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 2.2
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) C308 2.2
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 2.2
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 2.2
 LDTP03644  Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) C120 2.2
 LDTP13147  Cathepsin Z (CTSZ) C173 2.2
 LDTP02223  Cathepsin B (CTSB) C319 2.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 2.1
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 2.1
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 2.0
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 2.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 2.0
 LDTP02911  Calpain-2 catalytic subunit (CAPN2) C640 2.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.9
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.8
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 1.8
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.8
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.8
 LDTP03496  Protein PML (PML) C389 1.8
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.8
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.7
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.6
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 1.6
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 1.6
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.6
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) C2267 1.6
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.5
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.5
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 1.5
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 1.5
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C147 1.4
 LDTP13147  Cathepsin Z (CTSZ) C92 1.4
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.4
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.4
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.3
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.3
 LDTP04374  Dynamin-2 (DNM2) C27 1.3
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.3
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.3
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 1.3
 LDTP02672  Elongation factor 2 (EEF2) C136 1.3
 LDTP13080  GMP reductase 2 (GMPR2) C186 1.2
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 1.2
 LDTP08135  E3 ubiquitin-protein ligase HUWE1 (HUWE1) C4367 1.1
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.1
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 1.1
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.1
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.1
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 1.1
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.0
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.0
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 0.9
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 0.8
 LDTP05992  Bleomycin hydrolase (BLMH) C73 0.8
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 0.6
Transporter and channel
Click to Show/Hide to Show 15 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04801  Gasdermin-D (GSDMD) C268 20.0
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 20.0
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 20.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 5.6
 LDTP04707  Protein SEC13 homolog (SEC13) C187 4.9
 LDTP04662  Exportin-2 (CSE1L) C842 3.9
 LDTP00196  Unconventional myosin-Ic (MYO1C) C802 2.6
 LDTP13661  Sorting nexin-6 (SNX6) C264 2.0
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.8
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 1.5
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 1.3
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.3
 LDTP00501  Exportin-1 (XPO1) C34 1.2
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 0.8
 LDTP01574  Importin-7 (IPO7) C757 0.8
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 2.8
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 2.3
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 1.5
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.4
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.0
 LDTP10756  Nucleus accumbens-associated protein 1 (NACC1) C416 0.3
Other
Click to Show/Hide to Show 79 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 20.0
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 20.0
 LDTP13088  Protein IMPACT (IMPACT) C195 20.0
 LDTP12412  Reticulon-4 (RTN4) C1101 20.0
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 20.0
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 8.8
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 6.6
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 5.3
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 5.1
 LDTP08238  Kinectin (KTN1) C303 4.6
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 4.5
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 4.4
 LDTP06681  Inverted formin-2 (INF2) C332 4.2
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 4.1
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 4.0
 LDTP05867  Treacle protein (TCOF1) C38 3.8
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 3.8
 LDTP04092  Crk-like protein (CRKL) C249 3.6
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 3.4
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C280 3.4
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 3.3
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 3.2
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 3.2
 LDTP12638  Protein lin-7 homolog C (LIN7C) C47 2.9
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) C781 2.7
 LDTP02205  Tubulin beta chain (TUBB) C239 2.6
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 2.5
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 2.5
 LDTP03620  Protein S100-A11 (S100A11) C91 2.4
 LDTP04363  Serpin H1 (SERPINH1) C156 2.4
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 2.4
 LDTP10864  Calponin-2 (CNN2) C164 2.3
 LDTP00202  AH receptor-interacting protein (AIP) C122 2.3
 LDTP11235  Protein PAXX (PAXX) C180 2.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 2.3
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 2.3
 LDTP06362  Leucine-rich repeat-containing protein 41 (LRRC41) C297 2.3
 LDTP13705  LIM and calponin homology domains-containing protein 1 (LIMCH1) C140 2.2
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 2.2
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 2.1
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 2.1
 LDTP18494  Tropomodulin-3 (TMOD3) C132 2.0
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 2.0
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 2.0
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 1.9
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.8
 LDTP10864  Calponin-2 (CNN2) C215 1.8
 LDTP02205  Tubulin beta chain (TUBB) C354 1.8
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.7
 LDTP12443  Anillin (ANLN) C712 1.7
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 1.7
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 1.6
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.6
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.6
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2) C843 1.6
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.6
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.6
 LDTP10613  Dedicator of cytokinesis protein 7 (DOCK7) C2125 1.5
 LDTP14337  Protein strawberry notch homolog 1 (SBNO1) C445 1.5
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.5
 LDTP06330  Plectin (PLEC) C3110 1.5
 LDTP13580  Coronin-1C (CORO1C) C420 1.4
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.3
 LDTP10700  KH domain-containing RNA-binding protein QKI (QKI) C35 1.3
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 1.3
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 1.3
 LDTP13580  Coronin-1C (CORO1C) C456 1.3
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.2
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.2
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) C108 1.1
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.1
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 1.1
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 1.1
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 1.1
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 1.1
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.1
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 1.0
 LDTP02631  Alpha-actinin-1 (ACTN1) C370 0.9
 LDTP03244  Cofilin-1 (CFL1) C80 0.7

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.