Target ID	LDTP03642
Target Name	Cytidine deaminase (CDA)
Gene Name	CDA
Gene ID	978
Synonyms	CDD; Cytidine deaminase; EC 3.5.4.5; Cytidine aminohydrolase
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP DGTYIVMTVQELLPSSFGPEDLQKTQ
Target Type	Clinical trial
Target Bioclass	Enzyme
Family	Cytidine and deoxycytidylate deaminase family
Function	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
TTD ID	T79027
Uniprot ID	P32320
DrugMap ID	TTQ12RK
Ensemble ID	ENST00000375071.4
HGNC ID	HGNC:1712
ChEMBL ID	CHEMBL4502

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
STPyne  Probe Info			K73(3.56); K80(3.14)	LDD0277	[1]
JZ128-DTB  Probe Info			N.A.	LDD0462	[2]
DBIA  Probe Info			C14(0.99); C8(0.99); C102(0.98); C99(0.98)	LDD0078	[3]
5E-2FA  Probe Info			N.A.	LDD2235	[4]
m-APA  Probe Info			N.A.	LDD2231	[4]
BTD  Probe Info			N.A.	LDD0004	[5]
IPM  Probe Info			N.A.	LDD0025	[6]
IA-alkyne  Probe Info			C14(0.00); C8(0.00); C31(0.00)	LDD0151	[7]
TFBX  Probe Info			N.A.	LDD0148	[6]
Phosphinate-6  Probe Info			N.A.	LDD0018	[8]
Acrolein  Probe Info			N.A.	LDD0217	[9]
HHS-465  Probe Info			Y124(0.00); Y116(0.00); Y79(0.00); K119(0.00)	LDD2240	[10]

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
Kambe_31  Probe Info			2.09	LDD0135	[11]

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0214	AC1	HCT 116	C14(1.33); C8(1.33); C21(1.23); C53(0.91)	LDD0531	[3]
LDCM0215	AC10	HCT 116	C14(1.42); C8(1.42); C21(1.28); C53(1.24)	LDD0532	[3]
LDCM0216	AC100	HCT 116	C14(0.86); C8(0.86); C21(0.81); C53(0.68)	LDD0533	[3]
LDCM0217	AC101	HCT 116	C14(0.94); C8(0.94); C21(0.89); C53(0.77)	LDD0534	[3]
LDCM0218	AC102	HCT 116	C14(0.88); C8(0.88); C21(0.86); C53(0.99)	LDD0535	[3]
LDCM0219	AC103	HCT 116	C14(1.20); C8(1.20); C21(0.90); C53(0.94)	LDD0536	[3]
LDCM0220	AC104	HCT 116	C14(1.11); C8(1.11); C21(0.89); C53(1.31)	LDD0537	[3]
LDCM0221	AC105	HCT 116	C14(1.02); C8(1.02); C21(0.86); C53(0.93)	LDD0538	[3]
LDCM0222	AC106	HCT 116	C14(0.99); C8(0.99); C21(0.83); C53(1.49)	LDD0539	[3]
LDCM0223	AC107	HCT 116	C14(1.15); C8(1.15); C21(0.83); C53(0.99)	LDD0540	[3]
LDCM0224	AC108	HCT 116	C14(0.80); C8(0.80); C21(0.81); C53(0.57)	LDD0541	[3]
LDCM0225	AC109	HCT 116	C14(0.87); C8(0.87); C21(0.99); C53(0.64)	LDD0542	[3]
LDCM0226	AC11	HCT 116	C14(1.42); C8(1.42); C21(1.28); C53(1.16)	LDD0543	[3]
LDCM0227	AC110	HCT 116	C14(0.81); C8(0.81); C21(0.99); C53(0.59)	LDD0544	[3]
LDCM0228	AC111	HCT 116	C14(0.86); C8(0.86); C21(0.87); C53(0.87)	LDD0545	[3]
LDCM0229	AC112	HCT 116	C14(0.91); C8(0.91); C21(1.09); C53(0.68)	LDD0546	[3]
LDCM0230	AC113	HCT 116	C14(1.03); C8(1.00); C21(0.99); C53(1.07)	LDD0547	[3]
LDCM0231	AC114	HCT 116	C14(1.27); C8(1.17); C21(1.05); C53(1.06)	LDD0548	[3]
LDCM0232	AC115	HCT 116	C14(1.35); C8(1.27); C21(1.18); C53(1.14)	LDD0549	[3]
LDCM0233	AC116	HCT 116	C14(1.90); C8(1.84); C21(1.70); C53(1.25)	LDD0550	[3]
LDCM0234	AC117	HCT 116	C14(1.19); C8(1.22); C21(1.18); C53(1.26)	LDD0551	[3]
LDCM0235	AC118	HCT 116	C14(1.15); C8(1.09); C21(1.08); C53(0.98)	LDD0552	[3]
LDCM0236	AC119	HCT 116	C14(1.11); C8(1.10); C21(1.20); C53(1.06)	LDD0553	[3]
LDCM0237	AC12	HCT 116	C14(1.07); C8(1.07); C21(1.06); C53(0.80)	LDD0554	[3]
LDCM0238	AC120	HCT 116	C14(1.16); C8(1.13); C21(1.12); C53(1.17)	LDD0555	[3]
LDCM0239	AC121	HCT 116	C14(1.10); C8(1.12); C21(1.03); C53(1.08)	LDD0556	[3]
LDCM0240	AC122	HCT 116	C14(1.08); C8(1.03); C21(1.03); C53(0.92)	LDD0557	[3]
LDCM0241	AC123	HCT 116	C14(1.20); C8(1.12); C21(1.19); C53(0.90)	LDD0558	[3]
LDCM0242	AC124	HCT 116	C14(1.17); C8(1.09); C21(1.03); C53(1.24)	LDD0559	[3]
LDCM0243	AC125	HCT 116	C14(1.09); C8(1.10); C21(1.03); C53(0.95)	LDD0560	[3]
LDCM0244	AC126	HCT 116	C14(1.39); C8(1.34); C21(1.17); C53(1.35)	LDD0561	[3]
LDCM0245	AC127	HCT 116	C14(1.40); C8(1.32); C21(1.12); C53(1.31)	LDD0562	[3]
LDCM0246	AC128	HCT 116	C14(1.22); C8(1.17); C21(1.31); C53(1.11)	LDD0563	[3]
LDCM0247	AC129	HCT 116	C14(0.95); C8(0.90); C21(0.88); C53(0.90)	LDD0564	[3]
LDCM0249	AC130	HCT 116	C14(1.18); C8(1.17); C21(1.16); C53(0.98)	LDD0566	[3]
LDCM0250	AC131	HCT 116	C14(1.00); C8(0.97); C21(0.94); C53(0.82)	LDD0567	[3]
LDCM0251	AC132	HCT 116	C14(1.03); C8(0.99); C21(1.01); C53(0.61)	LDD0568	[3]
LDCM0252	AC133	HCT 116	C14(1.05); C8(1.03); C21(1.11); C53(0.71)	LDD0569	[3]
LDCM0253	AC134	HCT 116	C14(1.35); C8(1.33); C21(1.36); C53(0.81)	LDD0570	[3]
LDCM0254	AC135	HCT 116	C14(1.21); C8(1.18); C21(1.22); C53(0.75)	LDD0571	[3]
LDCM0255	AC136	HCT 116	C14(1.11); C8(1.11); C21(1.13); C53(0.72)	LDD0572	[3]
LDCM0256	AC137	HCT 116	C14(1.00); C8(0.97); C21(1.02); C53(0.69)	LDD0573	[3]
LDCM0257	AC138	HCT 116	C14(1.19); C8(1.15); C21(1.17); C53(0.76)	LDD0574	[3]
LDCM0258	AC139	HCT 116	C14(1.09); C8(1.07); C21(1.08); C53(0.80)	LDD0575	[3]
LDCM0259	AC14	HCT 116	C14(1.04); C8(1.04); C21(1.05); C53(1.26)	LDD0576	[3]
LDCM0260	AC140	HCT 116	C14(1.23); C8(1.18); C21(1.24); C53(0.77)	LDD0577	[3]
LDCM0261	AC141	HCT 116	C14(1.27); C8(1.22); C21(1.24); C53(0.83)	LDD0578	[3]
LDCM0262	AC142	HCT 116	C14(1.00); C8(1.03); C21(0.99); C53(0.59)	LDD0579	[3]
LDCM0263	AC143	HCT 116	C14(1.12); C8(1.12); C21(1.07); C53(0.91)	LDD0580	[3]
LDCM0264	AC144	HCT 116	C14(1.42); C8(1.42); C21(1.61); C59(1.65)	LDD0581	[3]
LDCM0265	AC145	HCT 116	C53(1.06); C14(1.18); C8(1.18); C59(1.20)	LDD0582	[3]
LDCM0266	AC146	HCT 116	C53(1.17); C59(1.19); C65(1.20); C14(1.46)	LDD0583	[3]
LDCM0267	AC147	HCT 116	C14(1.32); C8(1.32); C53(1.62); C59(1.68)	LDD0584	[3]
LDCM0268	AC148	HCT 116	C53(1.52); C59(1.62); C65(1.62); C14(1.95)	LDD0585	[3]
LDCM0269	AC149	HCT 116	C14(1.66); C8(1.66); C59(1.67); C65(1.68)	LDD0586	[3]
LDCM0270	AC15	HCT 116	C59(0.95); C65(0.95); C53(0.98); C21(1.15)	LDD0587	[3]
LDCM0271	AC150	HCT 116	C59(1.04); C65(1.05); C53(1.07); C14(1.11)	LDD0588	[3]
LDCM0272	AC151	HCT 116	C59(1.09); C65(1.10); C53(1.13); C14(1.24)	LDD0589	[3]
LDCM0273	AC152	HCT 116	C59(1.34); C65(1.35); C14(1.39); C8(1.39)	LDD0590	[3]
LDCM0274	AC153	HCT 116	C14(1.82); C8(1.82); C53(1.92); C65(2.06)	LDD0591	[3]
LDCM0621	AC154	HCT 116	C14(1.20); C8(1.20); C21(1.44); C53(1.34)	LDD2158	[3]
LDCM0622	AC155	HCT 116	C14(1.23); C8(1.23); C21(1.71); C53(1.25)	LDD2159	[3]
LDCM0623	AC156	HCT 116	C14(1.03); C8(1.03); C21(1.18); C53(1.25)	LDD2160	[3]
LDCM0624	AC157	HCT 116	C14(1.07); C8(1.07); C21(1.31); C53(1.20)	LDD2161	[3]
LDCM0276	AC17	HCT 116	C65(0.77); C53(0.95); C21(1.07); C59(1.14)	LDD0593	[3]
LDCM0277	AC18	HCT 116	C65(0.85); C53(1.23); C21(1.34); C14(1.50)	LDD0594	[3]
LDCM0278	AC19	HCT 116	C65(0.66); C53(0.95); C21(1.03); C14(1.07)	LDD0595	[3]
LDCM0279	AC2	HCT 116	C65(1.05); C59(1.06); C53(1.12); C21(1.23)	LDD0596	[3]
LDCM0280	AC20	HCT 116	C65(0.68); C53(0.81); C59(0.93); C21(1.10)	LDD0597	[3]
LDCM0281	AC21	HCT 116	C65(0.78); C53(0.81); C59(0.83); C21(1.06)	LDD0598	[3]
LDCM0282	AC22	HCT 116	C65(0.70); C53(0.86); C21(1.01); C59(1.01)	LDD0599	[3]
LDCM0283	AC23	HCT 116	C65(0.66); C53(0.88); C59(1.10); C21(1.47)	LDD0600	[3]
LDCM0284	AC24	HCT 116	C65(0.68); C53(0.78); C59(0.88); C21(0.98)	LDD0601	[3]
LDCM0285	AC25	HCT 116	C53(0.98); C65(0.98); C14(1.00); C8(1.02)	LDD0602	[3]
LDCM0286	AC26	HCT 116	C8(1.23); C14(1.23); C53(1.31); C65(1.31)	LDD0603	[3]
LDCM0287	AC27	HCT 116	C8(1.03); C14(1.08); C53(1.11); C65(1.11)	LDD0604	[3]
LDCM0288	AC28	HCT 116	C8(1.27); C14(1.27); C53(1.30); C65(1.30)	LDD0605	[3]
LDCM0289	AC29	HCT 116	C21(1.13); C53(1.16); C65(1.16); C8(1.18)	LDD0606	[3]
LDCM0290	AC3	HCT 116	C53(0.82); C65(0.87); C59(0.92); C21(1.17)	LDD0607	[3]
LDCM0291	AC30	HCT 116	C53(0.82); C65(0.82); C8(1.24); C14(1.25)	LDD0608	[3]
LDCM0292	AC31	HCT 116	C53(1.02); C65(1.02); C8(1.17); C14(1.19)	LDD0609	[3]
LDCM0293	AC32	HCT 116	C53(1.30); C65(1.30); C8(1.45); C14(1.49)	LDD0610	[3]
LDCM0294	AC33	HCT 116	C8(1.22); C53(1.28); C65(1.28); C14(1.31)	LDD0611	[3]
LDCM0295	AC34	HCT 116	C8(1.36); C14(1.42); C53(1.44); C65(1.44)	LDD0612	[3]
LDCM0296	AC35	HCT 116	C21(0.87); C14(0.95); C8(0.95); C53(1.01)	LDD0613	[3]
LDCM0297	AC36	HCT 116	C53(0.89); C65(0.89); C21(0.91); C14(1.03)	LDD0614	[3]
LDCM0298	AC37	HCT 116	C53(0.83); C65(0.83); C21(0.90); C14(0.91)	LDD0615	[3]
LDCM0299	AC38	HCT 116	C21(0.94); C14(1.02); C8(1.02); C53(1.19)	LDD0616	[3]
LDCM0300	AC39	HCT 116	C53(0.97); C65(0.97); C14(1.09); C8(1.09)	LDD0617	[3]
LDCM0301	AC4	HCT 116	C53(0.76); C65(0.98); C59(1.06); C21(1.33)	LDD0618	[3]
LDCM0302	AC40	HCT 116	C53(0.92); C65(0.92); C14(1.27); C8(1.27)	LDD0619	[3]
LDCM0303	AC41	HCT 116	C53(0.85); C65(0.85); C21(1.03); C14(1.18)	LDD0620	[3]
LDCM0304	AC42	HCT 116	C53(0.98); C65(0.98); C21(1.26); C14(1.38)	LDD0621	[3]
LDCM0305	AC43	HCT 116	C21(1.00); C53(1.01); C65(1.01); C14(1.14)	LDD0622	[3]
LDCM0306	AC44	HCT 116	C53(0.80); C65(0.80); C21(1.06); C14(1.10)	LDD0623	[3]
LDCM0307	AC45	HCT 116	C53(1.14); C65(1.14); C14(1.29); C8(1.29)	LDD0624	[3]
LDCM0308	AC46	HCT 116	C53(1.03); C65(1.03); C14(1.30); C8(1.30)	LDD0625	[3]
LDCM0309	AC47	HCT 116	C53(1.02); C65(1.02); C14(1.08); C8(1.08)	LDD0626	[3]
LDCM0310	AC48	HCT 116	C53(0.98); C65(0.98); C14(1.08); C8(1.08)	LDD0627	[3]
LDCM0311	AC49	HCT 116	C14(1.41); C8(1.41); C21(1.43); C53(1.47)	LDD0628	[3]
LDCM0312	AC5	HCT 116	C53(0.76); C65(1.03); C59(1.07); C21(1.33)	LDD0629	[3]
LDCM0313	AC50	HCT 116	C53(1.33); C65(1.33); C14(1.44); C8(1.44)	LDD0630	[3]
LDCM0314	AC51	HCT 116	C21(1.06); C53(1.07); C65(1.07); C14(1.09)	LDD0631	[3]
LDCM0315	AC52	HCT 116	C53(1.13); C65(1.13); C14(1.14); C8(1.14)	LDD0632	[3]
LDCM0316	AC53	HCT 116	C53(1.15); C65(1.15); C14(2.27); C8(2.27)	LDD0633	[3]
LDCM0317	AC54	HCT 116	C14(1.20); C8(1.20); C21(1.25); C53(1.31)	LDD0634	[3]
LDCM0318	AC55	HCT 116	C53(1.34); C65(1.34); C14(1.45); C8(1.45)	LDD0635	[3]
LDCM0319	AC56	HCT 116	C14(1.53); C8(1.53); C21(1.63); C53(1.78)	LDD0636	[3]
LDCM0320	AC57	HCT 116	C53(1.25); C65(1.25); C14(1.27); C8(1.27)	LDD0637	[3]
LDCM0321	AC58	HCT 116	C53(1.47); C65(1.47); C14(1.48); C8(1.48)	LDD0638	[3]
LDCM0322	AC59	HCT 116	C53(1.20); C65(1.20); C14(1.55); C8(1.55)	LDD0639	[3]
LDCM0323	AC6	HCT 116	C53(1.21); C59(1.26); C65(1.26); C14(1.41)	LDD0640	[3]
LDCM0324	AC60	HCT 116	C53(1.03); C65(1.03); C59(1.27); C14(1.42)	LDD0641	[3]
LDCM0325	AC61	HCT 116	C53(1.20); C65(1.20); C14(1.30); C8(1.30)	LDD0642	[3]
LDCM0326	AC62	HCT 116	C53(1.19); C65(1.19); C14(1.45); C8(1.45)	LDD0643	[3]
LDCM0327	AC63	HCT 116	C59(1.13); C53(1.19); C65(1.19); C14(1.36)	LDD0644	[3]
LDCM0328	AC64	HCT 116	C53(1.11); C65(1.11); C14(1.34); C8(1.34)	LDD0645	[3]
LDCM0329	AC65	HCT 116	C59(0.76); C53(0.90); C65(0.90); C14(1.53)	LDD0646	[3]
LDCM0330	AC66	HCT 116	C53(0.84); C65(0.84); C59(0.85); C14(1.50)	LDD0647	[3]
LDCM0331	AC67	HCT 116	C53(0.88); C65(0.88); C59(0.90); C14(1.79)	LDD0648	[3]
LDCM0332	AC68	HCT 116	C53(1.01); C14(1.11); C65(1.11); C21(1.14)	LDD0649	[3]
LDCM0333	AC69	HCT 116	C53(0.98); C65(1.08); C21(1.15); C59(1.17)	LDD0650	[3]
LDCM0334	AC7	HCT 116	C53(0.79); C59(0.94); C65(0.94); C21(1.44)	LDD0651	[3]
LDCM0335	AC70	HCT 116	C53(0.81); C65(0.98); C59(1.15); C21(1.25)	LDD0652	[3]
LDCM0336	AC71	HCT 116	C53(0.89); C65(0.96); C59(1.04); C21(1.18)	LDD0653	[3]
LDCM0337	AC72	HCT 116	C8(1.12); C53(1.12); C21(1.15); C14(1.15)	LDD0654	[3]
LDCM0338	AC73	HCT 116	C53(1.16); C65(1.25); C59(1.26); C21(1.55)	LDD0655	[3]
LDCM0339	AC74	HCT 116	C59(1.23); C53(1.24); C65(1.24); C21(1.52)	LDD0656	[3]
LDCM0340	AC75	HCT 116	C53(1.25); C65(1.34); C59(1.49); C14(2.41)	LDD0657	[3]
LDCM0341	AC76	HCT 116	C53(1.10); C65(1.12); C59(1.18); C21(1.24)	LDD0658	[3]
LDCM0342	AC77	HCT 116	C53(1.04); C65(1.08); C59(1.25); C21(1.44)	LDD0659	[3]
LDCM0343	AC78	HCT 116	C21(0.96); C53(0.97); C14(1.01); C8(1.04)	LDD0660	[3]
LDCM0344	AC79	HCT 116	C53(0.98); C65(1.07); C59(1.08); C21(1.11)	LDD0661	[3]
LDCM0345	AC8	HCT 116	C59(1.13); C65(1.13); C53(1.32); C21(1.32)	LDD0662	[3]
LDCM0346	AC80	HCT 116	C53(1.08); C65(1.14); C59(1.26); C14(1.37)	LDD0663	[3]
LDCM0347	AC81	HCT 116	C21(1.04); C53(1.05); C8(1.07); C14(1.08)	LDD0664	[3]
LDCM0348	AC82	HCT 116	C53(1.05); C65(1.10); C59(1.18); C21(1.79)	LDD0665	[3]
LDCM0349	AC83	HCT 116	C21(1.71); C14(1.71); C8(1.71); C53(1.74)	LDD0666	[3]
LDCM0350	AC84	HCT 116	C21(1.34); C14(1.37); C8(1.37); C53(1.49)	LDD0667	[3]
LDCM0351	AC85	HCT 116	C59(1.25); C53(1.26); C65(1.30); C21(1.31)	LDD0668	[3]
LDCM0352	AC86	HCT 116	C53(1.21); C59(1.25); C65(1.27); C14(1.37)	LDD0669	[3]
LDCM0353	AC87	HCT 116	C53(1.21); C65(1.31); C59(1.32); C21(1.34)	LDD0670	[3]
LDCM0354	AC88	HCT 116	C65(1.27); C53(1.28); C21(1.33); C14(1.35)	LDD0671	[3]
LDCM0355	AC89	HCT 116	C14(1.41); C8(1.41); C21(1.44); C53(1.50)	LDD0672	[3]
LDCM0357	AC90	HCT 116	C53(0.99); C65(0.99); C59(0.99); C21(1.12)	LDD0674	[3]
LDCM0358	AC91	HCT 116	C14(1.27); C8(1.27); C21(1.33); C53(1.64)	LDD0675	[3]
LDCM0359	AC92	HCT 116	C14(1.22); C8(1.22); C21(1.24); C53(1.49)	LDD0676	[3]
LDCM0360	AC93	HCT 116	C21(1.27); C53(1.28); C14(1.32); C8(1.32)	LDD0677	[3]
LDCM0361	AC94	HCT 116	C14(1.08); C8(1.08); C21(1.19); C53(1.45)	LDD0678	[3]
LDCM0362	AC95	HCT 116	C21(1.10); C14(1.14); C8(1.14); C53(1.41)	LDD0679	[3]
LDCM0363	AC96	HCT 116	C14(1.36); C8(1.36); C53(1.49); C59(1.56)	LDD0680	[3]
LDCM0364	AC97	HCT 116	C21(1.34); C14(1.38); C8(1.38); C53(1.93)	LDD0681	[3]
LDCM0365	AC98	HCT 116	C53(1.00); C21(1.41); C59(1.54); C65(1.54)	LDD0682	[3]
LDCM0366	AC99	HCT 116	C53(0.71); C14(1.02); C8(1.02); C59(1.23)	LDD0683	[3]
LDCM0248	AKOS034007472	HCT 116	C14(1.02); C8(1.02); C21(0.99); C53(0.95)	LDD0565	[3]
LDCM0356	AKOS034007680	HCT 116	C53(1.03); C59(1.08); C65(1.08); C21(1.24)	LDD0673	[3]
LDCM0275	AKOS034007705	HCT 116	C59(1.46); C65(1.46); C14(1.70); C8(1.70)	LDD0592	[3]
LDCM0020	ARS-1620	HCC44	C14(0.99); C8(0.99); C102(0.98); C99(0.98)	LDD0078	[3]
LDCM0367	CL1	HCT 116	C53(0.81); C65(0.81); C14(1.43); C8(1.43)	LDD0684	[3]
LDCM0368	CL10	HCT 116	C53(0.76); C65(0.76); C14(3.99); C8(3.99)	LDD0685	[3]
LDCM0369	CL100	HCT 116	C53(0.84); C65(0.98); C59(1.08); C21(2.31)	LDD0686	[3]
LDCM0370	CL101	HCT 116	C59(1.12); C65(1.12); C53(1.15); C21(2.40)	LDD0687	[3]
LDCM0371	CL102	HCT 116	C53(0.92); C59(1.33); C65(1.33); C21(3.34)	LDD0688	[3]
LDCM0372	CL103	HCT 116	C59(1.22); C65(1.22); C53(1.77); C14(2.94)	LDD0689	[3]
LDCM0373	CL104	HCT 116	C53(0.88); C59(0.91); C65(0.91); C21(1.54)	LDD0690	[3]
LDCM0374	CL105	HCT 116	C65(0.58); C53(0.75); C59(0.92); C21(2.33)	LDD0691	[3]
LDCM0375	CL106	HCT 116	C65(0.61); C53(0.84); C59(1.07); C21(2.03)	LDD0692	[3]
LDCM0376	CL107	HCT 116	C65(0.61); C53(0.82); C59(1.03); C21(1.24)	LDD0693	[3]
LDCM0377	CL108	HCT 116	C65(0.58); C53(0.74); C59(0.90); C21(1.71)	LDD0694	[3]
LDCM0378	CL109	HCT 116	C65(0.66); C53(0.97); C59(1.28); C21(2.69)	LDD0695	[3]
LDCM0379	CL11	HCT 116	C53(1.09); C65(1.09); C14(2.94); C8(2.94)	LDD0696	[3]
LDCM0380	CL110	HCT 116	C65(0.52); C53(0.81); C59(1.10); C21(4.97)	LDD0697	[3]
LDCM0381	CL111	HCT 116	C65(0.63); C53(0.95); C59(1.26); C21(2.09)	LDD0698	[3]
LDCM0382	CL112	HCT 116	C53(0.90); C65(0.90); C21(4.12); C8(4.36)	LDD0699	[3]
LDCM0383	CL113	HCT 116	C53(1.05); C65(1.05); C8(1.33); C14(1.41)	LDD0700	[3]
LDCM0384	CL114	HCT 116	C53(1.03); C65(1.03); C21(4.58); C8(5.05)	LDD0701	[3]
LDCM0385	CL115	HCT 116	C53(1.30); C65(1.30); C21(2.29); C8(2.33)	LDD0702	[3]
LDCM0386	CL116	HCT 116	C53(0.93); C65(0.93); C14(1.30); C8(1.31)	LDD0703	[3]
LDCM0387	CL117	HCT 116	C53(1.27); C65(1.27); C21(3.25); C14(4.00)	LDD0704	[3]
LDCM0388	CL118	HCT 116	C53(0.91); C65(0.91); C21(1.07); C14(1.18)	LDD0705	[3]
LDCM0389	CL119	HCT 116	C14(1.05); C8(1.05); C21(1.10); C53(1.22)	LDD0706	[3]
LDCM0390	CL12	HCT 116	C53(1.20); C65(1.20); C14(1.99); C8(1.99)	LDD0707	[3]
LDCM0391	CL120	HCT 116	C53(0.86); C65(0.86); C21(1.02); C14(1.07)	LDD0708	[3]
LDCM0392	CL121	HCT 116	C53(1.13); C65(1.13); C14(4.73); C8(4.73)	LDD0709	[3]
LDCM0393	CL122	HCT 116	C53(0.76); C65(0.76); C14(1.31); C8(1.31)	LDD0710	[3]
LDCM0394	CL123	HCT 116	C53(0.60); C65(0.60); C14(4.44); C8(4.44)	LDD0711	[3]
LDCM0395	CL124	HCT 116	C53(1.24); C65(1.24); C14(3.01); C8(3.01)	LDD0712	[3]
LDCM0396	CL125	HCT 116	C59(0.88); C53(0.91); C65(0.91); C14(1.75)	LDD0713	[3]
LDCM0397	CL126	HCT 116	C59(0.73); C53(0.95); C65(0.95); C21(1.74)	LDD0714	[3]
LDCM0398	CL127	HCT 116	C59(0.75); C53(0.91); C65(0.91); C14(1.37)	LDD0715	[3]
LDCM0399	CL128	HCT 116	C53(1.51); C65(1.51); C14(1.51); C8(1.51)	LDD0716	[3]
LDCM0400	CL13	HCT 116	C53(1.31); C65(1.31); C14(1.39); C8(1.39)	LDD0717	[3]
LDCM0401	CL14	HCT 116	C53(0.97); C65(0.97); C14(1.69); C8(1.69)	LDD0718	[3]
LDCM0402	CL15	HCT 116	C53(0.85); C65(0.85); C21(1.81); C14(1.91)	LDD0719	[3]
LDCM0403	CL16	HCT 116	C53(0.94); C65(0.96); C59(1.03); C14(1.22)	LDD0720	[3]
LDCM0404	CL17	HCT 116	C53(0.88); C59(0.88); C65(0.92); C14(1.93)	LDD0721	[3]
LDCM0405	CL18	HCT 116	C59(0.94); C14(1.11); C8(1.11); C65(1.14)	LDD0722	[3]
LDCM0406	CL19	HCT 116	C65(1.19); C59(1.19); C14(1.21); C8(1.21)	LDD0723	[3]
LDCM0407	CL2	HCT 116	C53(0.98); C65(0.98); C21(1.16); C14(1.18)	LDD0724	[3]
LDCM0408	CL20	HCT 116	C14(1.17); C8(1.17); C21(1.35); C59(1.39)	LDD0725	[3]
LDCM0409	CL21	HCT 116	C59(1.34); C65(1.47); C53(1.59); C14(5.24)	LDD0726	[3]
LDCM0410	CL22	HCT 116	C59(1.19); C65(1.37); C53(1.43); C14(1.91)	LDD0727	[3]
LDCM0411	CL23	HCT 116	C14(1.18); C8(1.18); C59(1.29); C21(1.37)	LDD0728	[3]
LDCM0412	CL24	HCT 116	C14(1.36); C8(1.36); C21(1.67); C65(1.68)	LDD0729	[3]
LDCM0413	CL25	HCT 116	C14(2.30); C8(2.30); C21(2.75); C53(1.03)	LDD0730	[3]
LDCM0414	CL26	HCT 116	C14(1.22); C8(1.22); C21(1.26); C53(1.16)	LDD0731	[3]
LDCM0415	CL27	HCT 116	C14(1.21); C8(1.21); C21(1.33); C53(1.30)	LDD0732	[3]
LDCM0416	CL28	HCT 116	C14(1.84); C8(1.84); C21(2.05); C53(1.28)	LDD0733	[3]
LDCM0417	CL29	HCT 116	C14(1.12); C8(1.12); C21(1.35); C53(1.39)	LDD0734	[3]
LDCM0418	CL3	HCT 116	C14(1.13); C8(1.13); C21(1.23); C53(0.97)	LDD0735	[3]
LDCM0419	CL30	HCT 116	C14(0.97); C8(0.97); C21(1.18); C53(1.37)	LDD0736	[3]
LDCM0420	CL31	HCT 116	C14(1.72); C8(1.72); C21(1.72); C53(1.21)	LDD0737	[3]
LDCM0421	CL32	HCT 116	C14(1.44); C8(1.44); C21(1.40); C53(0.88)	LDD0738	[3]
LDCM0422	CL33	HCT 116	C14(3.77); C8(3.77); C21(3.67); C53(0.70)	LDD0739	[3]
LDCM0423	CL34	HCT 116	C14(1.84); C8(1.84); C21(1.76); C53(0.96)	LDD0740	[3]
LDCM0424	CL35	HCT 116	C14(1.65); C8(1.65); C21(1.64); C53(1.38)	LDD0741	[3]
LDCM0425	CL36	HCT 116	C14(1.94); C8(1.94); C21(1.89); C53(0.95)	LDD0742	[3]
LDCM0426	CL37	HCT 116	C14(2.39); C8(2.39); C21(2.37); C53(0.97)	LDD0743	[3]
LDCM0428	CL39	HCT 116	C14(2.15); C8(2.15); C21(2.15); C53(1.05)	LDD0745	[3]
LDCM0429	CL4	HCT 116	C14(1.85); C8(1.85); C21(1.88); C53(1.02)	LDD0746	[3]
LDCM0430	CL40	HCT 116	C14(2.58); C8(2.58); C21(2.43); C53(1.08)	LDD0747	[3]
LDCM0431	CL41	HCT 116	C14(1.75); C8(1.75); C21(1.66); C53(0.94)	LDD0748	[3]
LDCM0432	CL42	HCT 116	C14(5.87); C8(5.87); C21(5.82); C53(0.98)	LDD0749	[3]
LDCM0433	CL43	HCT 116	C14(1.60); C8(1.60); C21(1.60); C53(1.02)	LDD0750	[3]
LDCM0434	CL44	HCT 116	C14(1.99); C8(1.99); C21(1.99); C53(0.93)	LDD0751	[3]
LDCM0435	CL45	HCT 116	C14(2.57); C8(2.57); C21(2.57); C53(0.98)	LDD0752	[3]
LDCM0436	CL46	HCT 116	C14(1.28); C8(1.24); C21(1.85); C53(0.69)	LDD0753	[3]
LDCM0437	CL47	HCT 116	C14(1.38); C8(1.34); C21(1.47); C53(0.59)	LDD0754	[3]
LDCM0438	CL48	HCT 116	C14(1.07); C8(1.08); C21(1.21); C53(0.55)	LDD0755	[3]
LDCM0439	CL49	HCT 116	C14(1.18); C8(1.18); C21(1.13); C53(0.61)	LDD0756	[3]
LDCM0440	CL5	HCT 116	C14(0.99); C8(0.99); C21(1.02); C53(1.27)	LDD0757	[3]
LDCM0441	CL50	HCT 116	C14(2.21); C8(2.22); C21(1.75); C53(0.71)	LDD0758	[3]
LDCM0442	CL51	HCT 116	C14(1.50); C8(1.46); C21(2.77); C53(0.83)	LDD0759	[3]
LDCM0443	CL52	HCT 116	C14(1.53); C8(1.31); C21(2.10); C53(0.90)	LDD0760	[3]
LDCM0444	CL53	HCT 116	C14(1.46); C8(1.44); C21(1.35); C53(1.12)	LDD0761	[3]
LDCM0445	CL54	HCT 116	C14(1.07); C8(1.02); C21(1.41); C53(0.61)	LDD0762	[3]
LDCM0446	CL55	HCT 116	C14(0.98); C8(0.93); C21(1.17); C53(0.66)	LDD0763	[3]
LDCM0447	CL56	HCT 116	C14(1.39); C8(1.39); C21(1.27); C53(0.70)	LDD0764	[3]
LDCM0448	CL57	HCT 116	C14(1.47); C8(1.46); C21(1.56); C53(0.77)	LDD0765	[3]
LDCM0449	CL58	HCT 116	C14(1.09); C8(1.01); C21(1.29); C53(0.79)	LDD0766	[3]
LDCM0450	CL59	HCT 116	C14(1.11); C8(1.11); C21(1.10); C53(0.72)	LDD0767	[3]
LDCM0451	CL6	HCT 116	C14(2.41); C8(2.41); C21(2.70); C53(0.93)	LDD0768	[3]
LDCM0452	CL60	HCT 116	C14(1.34); C8(1.32); C21(1.37); C53(0.56)	LDD0769	[3]
LDCM0453	CL61	HCT 116	C14(1.20); C8(1.26); C21(1.26); C53(0.66)	LDD0770	[3]
LDCM0454	CL62	HCT 116	C14(1.33); C8(1.38); C21(1.43); C53(0.80)	LDD0771	[3]
LDCM0455	CL63	HCT 116	C14(1.63); C8(1.68); C21(1.75); C53(0.84)	LDD0772	[3]
LDCM0456	CL64	HCT 116	C14(2.26); C8(2.37); C21(2.38); C53(0.90)	LDD0773	[3]
LDCM0457	CL65	HCT 116	C14(1.05); C8(1.11); C21(1.08); C53(0.84)	LDD0774	[3]
LDCM0458	CL66	HCT 116	C14(2.24); C8(2.31); C21(2.58); C53(0.97)	LDD0775	[3]
LDCM0459	CL67	HCT 116	C14(1.22); C8(1.31); C21(1.27); C53(0.88)	LDD0776	[3]
LDCM0460	CL68	HCT 116	C14(1.65); C8(1.69); C21(1.60); C53(0.69)	LDD0777	[3]
LDCM0461	CL69	HCT 116	C14(1.68); C8(1.70); C21(1.56); C53(0.92)	LDD0778	[3]
LDCM0462	CL7	HCT 116	C14(1.34); C8(1.34); C21(1.62); C53(1.03)	LDD0779	[3]
LDCM0463	CL70	HCT 116	C14(1.19); C8(1.16); C21(1.12); C53(0.86)	LDD0780	[3]
LDCM0464	CL71	HCT 116	C14(3.52); C8(3.63); C21(3.45); C53(0.63)	LDD0781	[3]
LDCM0465	CL72	HCT 116	C14(1.06); C8(1.09); C21(1.11); C53(0.72)	LDD0782	[3]
LDCM0466	CL73	HCT 116	C14(1.93); C8(1.97); C21(2.06); C53(0.78)	LDD0783	[3]
LDCM0467	CL74	HCT 116	C14(2.02); C8(2.12); C21(2.00); C53(0.90)	LDD0784	[3]
LDCM0469	CL76	HCT 116	C14(1.21); C8(1.21); C21(1.16); C53(0.83)	LDD0786	[3]
LDCM0470	CL77	HCT 116	C14(2.78); C8(2.92); C21(2.77); C53(0.68)	LDD0787	[3]
LDCM0471	CL78	HCT 116	C14(1.74); C8(1.69); C21(1.62); C53(0.90)	LDD0788	[3]
LDCM0472	CL79	HCT 116	C14(1.49); C8(1.64); C21(1.60); C53(1.07)	LDD0789	[3]
LDCM0473	CL8	HCT 116	C14(12.99); C8(12.99); C21(11.06); C53(1.32)	LDD0790	[3]
LDCM0474	CL80	HCT 116	C14(1.09); C8(1.19); C21(1.17); C53(1.06)	LDD0791	[3]
LDCM0475	CL81	HCT 116	C14(1.22); C8(1.46); C21(1.44); C53(1.12)	LDD0792	[3]
LDCM0476	CL82	HCT 116	C14(1.72); C8(2.06); C21(1.94); C53(1.15)	LDD0793	[3]
LDCM0477	CL83	HCT 116	C14(2.21); C8(2.31); C21(2.28); C53(0.89)	LDD0794	[3]
LDCM0478	CL84	HCT 116	C14(4.02); C8(5.60); C21(5.06); C53(0.94)	LDD0795	[3]
LDCM0479	CL85	HCT 116	C14(1.33); C8(1.55); C21(1.51); C53(0.83)	LDD0796	[3]
LDCM0480	CL86	HCT 116	C14(1.28); C8(1.50); C21(1.48); C53(0.79)	LDD0797	[3]
LDCM0481	CL87	HCT 116	C14(2.02); C8(2.22); C21(2.16); C53(0.89)	LDD0798	[3]
LDCM0482	CL88	HCT 116	C14(1.39); C8(1.58); C21(1.49); C53(1.27)	LDD0799	[3]
LDCM0483	CL89	HCT 116	C14(1.86); C8(2.21); C21(2.02); C53(1.19)	LDD0800	[3]
LDCM0484	CL9	HCT 116	C14(1.33); C8(1.33); C21(1.44); C53(1.03)	LDD0801	[3]
LDCM0485	CL90	HCT 116	C14(3.45); C8(3.60); C21(3.37); C53(0.64)	LDD0802	[3]
LDCM0486	CL91	HCT 116	C14(1.49); C8(1.49); C21(1.39); C53(0.85)	LDD0803	[3]
LDCM0487	CL92	HCT 116	C14(1.88); C8(1.88); C21(1.65); C53(0.88)	LDD0804	[3]
LDCM0488	CL93	HCT 116	C14(1.18); C8(1.18); C21(1.11); C53(0.79)	LDD0805	[3]
LDCM0489	CL94	HCT 116	C14(3.23); C8(3.23); C21(2.98); C53(0.82)	LDD0806	[3]
LDCM0490	CL95	HCT 116	C14(6.16); C8(6.16); C21(5.50); C53(1.22)	LDD0807	[3]
LDCM0491	CL96	HCT 116	C14(4.36); C8(4.36); C21(3.83); C53(0.79)	LDD0808	[3]
LDCM0492	CL97	HCT 116	C14(3.68); C8(3.68); C21(3.75); C53(0.91)	LDD0809	[3]
LDCM0493	CL98	HCT 116	C14(2.08); C8(2.08); C21(1.89); C53(1.21)	LDD0810	[3]
LDCM0494	CL99	HCT 116	C14(2.45); C8(2.45); C21(2.43); C53(0.74)	LDD0811	[3]
LDCM0573	Fragment11	MDA-MB-231	C14(20.00)	LDD1391	[12]
LDCM0575	Fragment13	MDA-MB-231	C14(2.99)	LDD1395	[12]
LDCM0576	Fragment14	MDA-MB-231	C14(10.25)	LDD1397	[12]
LDCM0577	Fragment15	MDA-MB-231	C14(1.15)	LDD1399	[12]
LDCM0579	Fragment20	MDA-MB-231	C14(2.83)	LDD1402	[12]
LDCM0582	Fragment23	MDA-MB-231	C14(0.63)	LDD1408	[12]
LDCM0584	Fragment25	MDA-MB-231	C14(1.06)	LDD1411	[12]
LDCM0578	Fragment27	MDA-MB-231	C14(0.48)	LDD1401	[12]
LDCM0587	Fragment29	MDA-MB-231	C14(1.21)	LDD1417	[12]
LDCM0589	Fragment31	MDA-MB-231	C14(6.01)	LDD1421	[12]
LDCM0468	Fragment33	HCT 116	C14(1.62); C8(1.67); C21(1.58); C53(0.72)	LDD0785	[3]
LDCM0592	Fragment34	MDA-MB-231	C14(0.92)	LDD1427	[12]
LDCM0596	Fragment38	MDA-MB-231	C14(1.24)	LDD1433	[12]
LDCM0566	Fragment4	MDA-MB-231	C14(20.00)	LDD1378	[12]
LDCM0599	Fragment41	MDA-MB-231	C14(2.61)	LDD1438	[12]
LDCM0604	Fragment46	MDA-MB-231	C14(1.06)	LDD1445	[12]
LDCM0605	Fragment47	MDA-MB-231	C14(1.97)	LDD1446	[12]
LDCM0608	Fragment50	MDA-MB-231	C14(20.00)	LDD1449	[12]
LDCM0427	Fragment51	HCT 116	C14(4.61); C8(4.61); C21(4.55); C53(1.09)	LDD0744	[3]
LDCM0610	Fragment52	MDA-MB-231	C14(0.98)	LDD1452	[12]
LDCM0568	Fragment6	MDA-MB-231	C14(0.73)	LDD1382	[12]
LDCM0569	Fragment7	MDA-MB-231	C14(1.61)	LDD1383	[12]
LDCM0570	Fragment8	MDA-MB-231	C14(12.09)	LDD1385	[12]
LDCM0571	Fragment9	MDA-MB-231	C14(1.66)	LDD1387	[12]
LDCM0107	IAA	HeLa	H35(0.00); C59(0.00)	LDD0221	[9]
LDCM0179	JZ128	PC-3	N.A.	LDD0462	[2]
LDCM0079	kambe_cp64	PC-3	2.09	LDD0135	[11]
LDCM0022	KB02	HCT 116	C8(20.00); C21(20.00); C14(20.00)	LDD0080	[3]
LDCM0023	KB03	HCT 116	C8(3.27); C21(3.27); C14(3.27)	LDD0081	[3]
LDCM0024	KB05	HCT 116	C8(20.00); C21(20.00); C14(20.00)	LDD0082	[3]
LDCM0109	NEM	HeLa	N.A.	LDD0232	[9]
LDCM0021	THZ1	HCT 116	C14(1.24); C21(1.24); C8(1.24)	LDD2173	[3]

Protein name				Family	Uniprot ID
Cytidine deaminase (CDA)				Cytidine and deoxycytidylate deaminase family	P32320
Probable inactive tRNA-specific adenosine deaminase-like protein 3 (ADAT3)				Cytidine and deoxycytidylate deaminase family	Q96EY9
Protein N-terminal glutamine amidohydrolase (NTAQ1)				NTAQ1 family	Q96HA8
Proteasome subunit alpha type-1 (PSMA1)				Peptidase T1A family	P25786
E3 ubiquitin-protein ligase LNX (LNX1)				.	Q8TBB1

Protein name				Family	Uniprot ID
Arrestin domain-containing protein 3 (ARRDC3)				Arrestin family	Q96B67
Syntenin-1 (SDCBP)				.	O00560

Protein name				Family	Uniprot ID
Zinc finger and BTB domain-containing protein 24 (ZBTB24)				Krueppel C2H2-type zinc-finger protein family	O43167
Forkhead box protein N1 (FOXN1)				.	O15353

Protein name				Family	Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L)				DDIT4 family	Q96D03
Golgi reassembly-stacking protein 2 (GORASP2)				GORASP family	Q9H8Y8
Protein INCA1 (INCA1)				INCA family	Q0VD86
Keratin-associated protein 6-1 (KRTAP6-1)				KRTAP type 6 family	Q3LI64
Keratin-associated protein 8-1 (KRTAP8-1)				KRTAP type 8 family	Q8IUC2
Fibronectin type III domain-containing protein 11 (FNDC11)				.	Q9BVV2
Pleckstrin homology domain-containing family B member 2 (PLEKHB2)				.	Q96CS7

Drug Name				Drug Type	External ID
Azacitidine				Small molecular drug	DB00928
Capecitabine				Small molecular drug	DB01101
Cytarabine				Small molecular drug	DB00987
Decitabine				Small molecular drug	DB01262
Gemcitabine				Small molecular drug	DB00441
Cedazuridine				.	DB15694

Drug Name				Drug Type	External ID
Tetrahydrouridine				Small molecular drug	D0I5OR

Drug Name				Drug Type	External ID
1-beta-ribofuranosyl-13-diazepinone				.	DB03185

1	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
2	A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
3	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4	Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print. Mass spectrometry data entry: PXD042377
5	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
7	Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
8	DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22. Mass spectrometry data entry: PXD033004
9	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10	Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6. Mass spectrometry data entry: PXD038010
11	Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
12	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.