Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment34  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 70 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP02733  Pyruvate kinase PKM (PKM) C423 20.0
 LDTP02502  Thioredoxin (TXN) C32 1.5
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 1.3
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 1.2
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.1
 LDTP05373  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) C680 1.1
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.0
 LDTP13147  Cathepsin Z (CTSZ) C173 1.0
 LDTP01005  Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) C691 1.0
 LDTP05289  AMP deaminase 2 (AMPD2) C107 1.0
 LDTP02223  Cathepsin B (CTSB) C319 1.0
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 1.0
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.0
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 0.9
 LDTP03642  Cytidine deaminase (CDA) C14 0.9
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 0.9
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 0.9
 LDTP04424  Galactokinase (GALK1) C182 0.9
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 0.9
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 0.9
 LDTP02223  Cathepsin B (CTSB) C211 0.9
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 0.9
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 0.9
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 0.9
 LDTP03786  Glutaredoxin-1 (GLRX) C23 0.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 0.9
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 0.9
 LDTP02672  Elongation factor 2 (EEF2) C136 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.9
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.8
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 0.8
 LDTP05859  Integrin-linked protein kinase (ILK) C346 0.8
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 0.8
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 0.8
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.8
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 0.8
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.8
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 0.8
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 0.8
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 0.8
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 0.8
 LDTP03400  Deoxycytidine kinase (DCK) C9 0.8
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 0.8
 LDTP02672  Elongation factor 2 (EEF2) C41 0.8
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 0.8
 LDTP13147  Cathepsin Z (CTSZ) C92 0.8
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 0.8
 LDTP04374  Dynamin-2 (DNM2) C27 0.8
 LDTP04689  Adenosine kinase (ADK) C353 0.8
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 0.8
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 0.8
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.7
 LDTP10386  ERO1-like protein alpha (ERO1A) C37 0.7
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 0.7
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 0.7
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 0.7
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 0.7
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 0.7
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 0.7
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 0.7
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.7
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C414 0.6
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 0.6
Transporter and channel
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04801  Gasdermin-D (GSDMD) C268 1.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 0.9
 LDTP00501  Exportin-1 (XPO1) C34 0.8
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 0.8
 LDTP04707  Protein SEC13 homolog (SEC13) C187 0.8
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 0.8
 LDTP01574  Importin-7 (IPO7) C757 0.7
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.9
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 0.9
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 0.8
Other
Click to Show/Hide to Show 41 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 2.6
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.3
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.2
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 1.2
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) C235 1.2
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.2
 LDTP10864  Calponin-2 (CNN2) C164 1.1
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 1.1
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.1
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 1.1
 LDTP10864  Calponin-2 (CNN2) C215 1.0
 LDTP10700  KH domain-containing RNA-binding protein QKI (QKI) C35 1.0
 LDTP02205  Tubulin beta chain (TUBB) C239 1.0
 LDTP00202  AH receptor-interacting protein (AIP) C122 1.0
 LDTP05867  Treacle protein (TCOF1) C1298 0.9
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 0.9
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 0.9
 LDTP02205  Tubulin beta chain (TUBB) C354 0.9
 LDTP13964  MOB-like protein phocein (MOB4) C134 0.9
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 0.8
 LDTP12412  Reticulon-4 (RTN4) C1101 0.8
 LDTP05233  55 kDa erythrocyte membrane protein (MPP1) C179 0.8
 LDTP12737  BRISC and BRCA1-A complex member 1 (BABAM1) C222 0.8
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 0.8
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 0.8
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 0.8
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 0.8
 LDTP13580  Coronin-1C (CORO1C) C420 0.8
 LDTP02692  Plastin-3 (PLS3) C33 0.8
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.8
 LDTP01532  ZW10 interactor (ZWINT) C54 0.8
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) C108 0.8
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.7
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.7
 LDTP12571  LanC-like protein 2 (LANCL2) C187 0.7
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 0.7
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 0.7
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.6
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 0.5
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 0.5

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.