Details of the Target

General Information of Target

Target ID LDTP05233
Target Name 55 kDa erythrocyte membrane protein (MPP1)
Gene Name MPP1
Gene ID 4354
Synonyms
DXS552E; EMP55; 55 kDa erythrocyte membrane protein; p55; Membrane protein, palmitoylated 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTLKASEGESGGSMHTALSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQ
VKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEI
NGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCK
EAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESAGLIPSPELQEWRVASMAQSAPSEAP
SCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKN
ALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFG
TKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKDSE
AIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWVY
Target Bioclass
Other
Family
MAGUK family
Subcellular location
Cell membrane
Function Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
Uniprot ID
Q00013
Ensemble ID
ENST00000369534.8
HGNC ID
HGNC:7219

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.K309T .
AN3CA SNV: p.R70Ter .
NCIH1666 SNV: p.K185N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K247(1.85); K29(5.88)  LDD0277  [2]
BTD
 Probe Info  		C179(1.54)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C242(2.01); C179(2.44)  LDD0168  [4]
HHS-482
 Probe Info  		Y331(1.20)  LDD0285  [5]
HHS-475
 Probe Info  		Y331(1.16)  LDD0264  [6]
HHS-465
 Probe Info  		Y331(10.00)  LDD2237  [7]
DBIA
 Probe Info  		C242(2.05); C94(1.46)  LDD0080  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C179(0.00); C94(0.00); C242(0.00); C454(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C179(0.00); C454(0.00); C242(0.00); C94(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C179(0.00); C454(0.00); C242(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
Compound 10
 Probe Info  		C179(0.00); C242(0.00); C94(0.00)  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
IPM
 Probe Info  		C242(0.00); C179(0.00)  LDD0005  [12]
TFBX
 Probe Info  		N.A.  LDD0148  [13]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		C242(0.00); C179(0.00); C94(0.00)  LDD0018  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C186
 Probe Info  		7.78  LDD1864  [16]
C219
 Probe Info  		13.27  LDD1893  [16]
C302
 Probe Info  		11.63  LDD1971  [16]
FFF probe11
 Probe Info  		8.52  LDD0472  [17]
FFF probe13
 Probe Info  		7.78  LDD0476  [17]
FFF probe3
 Probe Info  		12.36  LDD0465  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C179(1.17)  LDD2142  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C179(1.00)  LDD2152  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C179(1.10)  LDD2103  [3]
 LDCM0025  4SU-RNA HEK-293T C242(2.01); C179(2.44)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C179(2.19)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C242(1.23)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C242(1.52)  LDD0532  [8]
 LDCM0216  AC100 HEK-293T C179(0.97); C242(0.98)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C179(0.86); C242(0.85)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C179(0.97); C242(0.94)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C179(1.01); C242(1.16)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C179(0.96); C242(0.98)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C179(1.01); C242(0.86)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C179(0.96); C242(0.82)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C179(0.91); C242(1.03)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C179(1.01); C242(0.84)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C179(0.91); C242(0.96)  LDD0823  [8]
 LDCM0226  AC11 HCT 116 C242(1.18)  LDD0543  [8]
 LDCM0227  AC110 HEK-293T C179(0.96); C242(1.16)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C179(1.06); C242(0.89)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C179(0.93); C242(1.17)  LDD0827  [8]
 LDCM0230  AC113 HCT 116 C242(1.04)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C242(1.13)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C242(1.50)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C242(1.66)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C242(1.17)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C242(1.02)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C242(1.37)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C242(1.04)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C242(1.17)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C242(1.08)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C242(1.14)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C242(1.09)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C242(1.02)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C242(1.28)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C242(1.27)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C242(1.67)  LDD0562  [8]
 LDCM0246  AC128 HEK-293T C179(1.01); C242(0.97)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C179(1.08); C242(1.18)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C179(1.06); C242(1.14)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C179(1.03); C242(1.25)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C179(1.14); C242(1.27)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C179(1.14); C242(1.32)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C179(1.00); C242(1.30)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C179(1.26); C242(1.32)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C179(1.14); C242(1.18)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C179(1.20); C242(1.49)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C179(1.32); C242(1.41)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C179(1.20); C242(1.37)  LDD0856  [8]
 LDCM0259  AC14 HCT 116 C242(1.28)  LDD0576  [8]
 LDCM0260  AC140 HEK-293T C179(1.18); C242(1.27)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C179(1.16); C242(1.29)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C179(1.13); C242(1.42)  LDD0860  [8]
 LDCM0263  AC143 HCT 116 C242(1.18)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C242(1.29)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C242(1.26)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C242(1.20)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C242(1.11)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C242(1.61)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C242(1.35)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C242(1.14)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C242(1.11)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C242(1.19)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C242(1.25)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C242(1.87)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C242(1.27)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C242(1.26)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C242(1.03)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C242(1.06)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C242(0.89)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C242(1.30)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C242(1.03)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C242(1.07)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C242(1.00)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C242(1.11)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C242(0.92)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C242(1.06)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C242(1.18)  LDD0601  [8]
 LDCM0285  AC25 PaTu 8988t C242(0.93)  LDD1164  [8]
 LDCM0286  AC26 PaTu 8988t C242(1.10)  LDD1165  [8]
 LDCM0287  AC27 PaTu 8988t C242(1.07)  LDD1166  [8]
 LDCM0288  AC28 PaTu 8988t C242(0.88)  LDD1167  [8]
 LDCM0289  AC29 PaTu 8988t C242(1.05)  LDD1168  [8]
 LDCM0290  AC3 HCT 116 C242(1.29)  LDD0607  [8]
 LDCM0291  AC30 PaTu 8988t C242(1.03)  LDD1170  [8]
 LDCM0292  AC31 PaTu 8988t C242(0.81)  LDD1171  [8]
 LDCM0293  AC32 PaTu 8988t C242(1.06)  LDD1172  [8]
 LDCM0294  AC33 PaTu 8988t C242(1.08)  LDD1173  [8]
 LDCM0295  AC34 PaTu 8988t C242(0.93)  LDD1174  [8]
 LDCM0296  AC35 HCT 116 C242(1.22)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C242(1.11)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C242(0.81)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C242(1.06)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C242(1.23)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C242(1.46)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C242(1.21)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C242(1.00)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C242(0.95)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C242(0.97)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C242(1.05)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C242(1.09)  LDD0624  [8]
 LDCM0308  AC46 HEK-293T C179(1.15); C242(1.08)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C179(1.14); C242(0.93)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C179(1.09); C242(0.94)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C179(1.01); C242(1.05)  LDD0909  [8]
 LDCM0312  AC5 HCT 116 C242(1.26)  LDD0629  [8]
 LDCM0313  AC50 HEK-293T C179(0.98); C242(1.01)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C179(1.15); C242(1.02)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C179(1.09); C242(1.08)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C179(1.23); C242(0.97)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C179(1.23); C242(1.22)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C179(1.07); C242(1.21)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C179(1.05); C242(1.06)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C179(1.03); C242(0.99)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C179(0.92); C242(1.01)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C179(1.08); C242(1.02)  LDD0920  [8]
 LDCM0323  AC6 HCT 116 C242(1.06)  LDD0640  [8]
 LDCM0324  AC60 HEK-293T C179(0.81); C242(0.98)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C179(1.22); C242(1.07)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C179(1.19); C242(0.89)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C179(1.05); C242(1.08)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C179(1.06); C242(1.14)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C179(1.14); C242(1.04)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C179(1.08); C242(1.11)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C179(1.02); C242(1.07)  LDD0929  [8]
 LDCM0332  AC68 HEK-293T C179(0.99); C242(0.83)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C179(1.05); C242(0.85)  LDD0931  [8]
 LDCM0334  AC7 HCT 116 C242(1.03)  LDD0651  [8]
 LDCM0335  AC70 HEK-293T C179(0.93); C242(0.94)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C179(0.90); C242(0.89)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C179(1.13); C242(1.05)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C179(1.06); C242(1.13)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C179(0.79); C242(0.87)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C179(0.94); C242(1.00)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C179(0.90); C242(0.85)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C179(0.95); C242(0.91)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C179(0.89); C242(0.89)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C179(0.85); C242(0.80)  LDD0942  [8]
 LDCM0345  AC8 HCT 116 C242(1.21)  LDD0662  [8]
 LDCM0346  AC80 HEK-293T C179(0.93); C242(0.94)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C179(0.92); C242(0.87)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C179(1.05); C242(0.90)  LDD0946  [8]
 LDCM0349  AC83 HEK-293T C242(1.13)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C242(1.30)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C242(1.38)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C242(1.36)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C242(1.32)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C242(1.47)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C242(1.55)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C242(1.36)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C242(1.13)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C242(1.29)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C242(1.19)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C242(1.57)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C242(1.34)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C242(1.31)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C242(1.54)  LDD0962  [8]
 LDCM0365  AC98 HEK-293T C179(0.89); C242(0.85)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C179(0.94); C242(0.94)  LDD0964  [8]
 LDCM0545  Acetamide MDA-MB-231 C179(0.60)  LDD2138  [3]
 LDCM0248  AKOS034007472 HCT 116 C242(1.03)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C242(1.10)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C242(1.75)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 12.27  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C179(0.68)  LDD2091  [3]
 LDCM0367  CL1 HCT 116 C242(0.70)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C242(0.79)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C242(1.16)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C242(1.08)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C242(1.05)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C242(1.15)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C242(1.10)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C242(1.15)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C242(1.14)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C242(1.01)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C242(1.32)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C242(1.02)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C242(0.97)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C242(1.27)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C242(0.89)  LDD0698  [8]
 LDCM0382  CL112 PaTu 8988t C242(1.09)  LDD1261  [8]
 LDCM0383  CL113 PaTu 8988t C242(0.88)  LDD1262  [8]
 LDCM0384  CL114 PaTu 8988t C242(1.04)  LDD1263  [8]
 LDCM0385  CL115 PaTu 8988t C242(0.95)  LDD1264  [8]
 LDCM0386  CL116 PaTu 8988t C242(0.84)  LDD1265  [8]
 LDCM0387  CL117 HCT 116 C242(1.43)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C242(1.33)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C242(1.08)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C242(1.09)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C242(0.94)  LDD0708  [8]
 LDCM0392  CL121 HEK-293T C179(1.01); C242(1.07)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C179(1.01); C242(1.14)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C179(1.04); C242(1.00)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C179(0.99); C242(0.94)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C179(0.90); C242(1.10)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C179(1.03); C242(1.02)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C179(1.02); C242(0.91)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C179(0.98); C242(1.03)  LDD0997  [8]
 LDCM0400  CL13 HCT 116 C242(1.10)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C242(0.81)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C242(1.00)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C242(0.98)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C242(1.08)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C242(1.21)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C242(1.29)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C242(0.87)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C242(1.29)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C242(1.28)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C242(1.86)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C242(1.26)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C242(1.49)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C242(1.18)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C242(0.93)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C242(1.32)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C242(0.98)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C242(1.20)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C242(0.72)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C242(1.06)  LDD0736  [8]
 LDCM0420  CL31 HEK-293T C179(0.96); C242(1.01)  LDD1018  [8]
 LDCM0421  CL32 HEK-293T C179(0.84); C242(0.89)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C179(4.60); C242(1.18)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C179(0.97); C242(0.99)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C179(1.05); C242(0.95)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C179(1.06); C242(0.95)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C179(1.06); C242(0.98)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C179(1.37); C242(1.04)  LDD1026  [8]
 LDCM0429  CL4 HCT 116 C242(1.15)  LDD0746  [8]
 LDCM0430  CL40 HEK-293T C179(1.01); C242(0.94)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C179(1.02); C242(1.08)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C179(0.95); C242(1.02)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C179(1.18); C242(1.03)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C179(1.00); C242(1.10)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C179(1.19); C242(0.96)  LDD1033  [8]
 LDCM0436  CL46 HEK-293T C179(0.69); C242(1.37)  LDD1034  [8]
 LDCM0437  CL47 HEK-293T C179(0.96); C242(1.20)  LDD1035  [8]
 LDCM0438  CL48 HEK-293T C179(0.93); C242(1.10)  LDD1036  [8]
 LDCM0439  CL49 HEK-293T C179(1.04); C242(1.12)  LDD1037  [8]
 LDCM0440  CL5 HCT 116 C242(1.15)  LDD0757  [8]
 LDCM0441  CL50 HEK-293T C179(1.43); C242(1.20)  LDD1039  [8]
 LDCM0442  CL51 HEK-293T C179(0.99); C242(1.30)  LDD1040  [8]
 LDCM0443  CL52 HEK-293T C179(0.98); C242(1.01)  LDD1041  [8]
 LDCM0444  CL53 HEK-293T C179(0.87); C242(1.52)  LDD1042  [8]
 LDCM0445  CL54 HEK-293T C179(1.14); C242(0.99)  LDD1043  [8]
 LDCM0446  CL55 HEK-293T C179(0.86); C242(1.36)  LDD1044  [8]
 LDCM0447  CL56 HEK-293T C179(1.00); C242(0.92)  LDD1045  [8]
 LDCM0448  CL57 HEK-293T C179(0.75); C242(1.25)  LDD1046  [8]
 LDCM0449  CL58 HEK-293T C179(0.98); C242(1.11)  LDD1047  [8]
 LDCM0450  CL59 HEK-293T C179(1.03); C242(1.13)  LDD1048  [8]
 LDCM0451  CL6 HCT 116 C242(0.81)  LDD0768  [8]
 LDCM0452  CL60 HEK-293T C179(1.07); C242(1.15)  LDD1050  [8]
 LDCM0453  CL61 HEK-293T C179(1.19); C242(1.08)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C179(1.28); C242(1.01)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C179(0.74); C242(1.02)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C179(0.86); C242(1.32)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C179(0.80); C242(1.07)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C179(0.94); C242(0.98)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C179(0.95); C242(1.13)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C179(1.88); C242(0.99)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C179(1.11); C242(0.92)  LDD1059  [8]
 LDCM0462  CL7 HCT 116 C242(1.10)  LDD0779  [8]
 LDCM0463  CL70 HEK-293T C179(1.94); C242(1.06)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C179(1.26); C242(1.04)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C179(1.12); C242(1.02)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C179(1.65); C242(1.04)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C179(1.40); C242(1.18)  LDD1065  [8]
 LDCM0469  CL76 HEK-293T C242(0.97)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C242(0.87)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C242(0.90)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C242(1.12)  LDD1070  [8]
 LDCM0473  CL8 HCT 116 C242(0.94)  LDD0790  [8]
 LDCM0474  CL80 HEK-293T C242(1.01)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C242(0.92)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C242(0.91)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C242(0.87)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C242(0.93)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C242(0.97)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C242(1.06)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C242(1.11)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C242(1.29)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C242(1.10)  LDD1081  [8]
 LDCM0484  CL9 HCT 116 C242(0.82)  LDD0801  [8]
 LDCM0485  CL90 HEK-293T C242(1.14)  LDD1083  [8]
 LDCM0486  CL91 HCT 116 C242(1.24)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C242(1.24)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C242(1.18)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C242(1.30)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C242(1.44)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C242(1.20)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C242(1.00)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C242(1.12)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C242(1.20)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C94(1.18); C179(1.02); C242(0.99); C454(1.26)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C179(2.84)  LDD1702  [3]
 LDCM0572  Fragment10 MDA-MB-231 C179(4.17)  LDD1389  [19]
 LDCM0576  Fragment14 MDA-MB-231 C179(0.97)  LDD1397  [19]
 LDCM0581  Fragment22 MDA-MB-231 C179(1.25)  LDD1406  [19]
 LDCM0584  Fragment25 MDA-MB-231 C179(1.08)  LDD1411  [19]
 LDCM0578  Fragment27 MDA-MB-231 C179(0.70)  LDD1401  [19]
 LDCM0588  Fragment30 MDA-MB-231 C179(0.95)  LDD1419  [19]
 LDCM0589  Fragment31 MDA-MB-231 C179(2.30)  LDD1421  [19]
 LDCM0590  Fragment32 MDA-MB-231 C179(13.06)  LDD1423  [19]
 LDCM0468  Fragment33 HEK-293T C179(1.46); C242(1.14)  LDD1066  [8]
 LDCM0592  Fragment34 MDA-MB-231 C179(0.83)  LDD1427  [19]
 LDCM0596  Fragment38 MDA-MB-231 C179(0.84)  LDD1433  [19]
 LDCM0566  Fragment4 MDA-MB-231 C179(2.01)  LDD1378  [19]
 LDCM0599  Fragment41 MDA-MB-231 C179(2.03)  LDD1438  [19]
 LDCM0604  Fragment46 MDA-MB-231 C179(1.10)  LDD1445  [19]
 LDCM0427  Fragment51 HEK-293T C179(0.88); C242(0.99)  LDD1025  [8]
 LDCM0614  Fragment56 MDA-MB-231 C179(0.75)  LDD1458  [19]
 LDCM0116  HHS-0101 DM93 Y331(1.16)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y331(1.23)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y331(1.44)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y331(0.90)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y331(1.38)  LDD0268  [6]
 LDCM0123  JWB131 DM93 Y331(1.20)  LDD0285  [5]
 LDCM0124  JWB142 DM93 Y331(2.07)  LDD0286  [5]
 LDCM0126  JWB150 DM93 Y331(2.97)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y331(1.44)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y331(0.10)  LDD0290  [5]
 LDCM0129  JWB202 DM93 Y331(0.88)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y331(0.79)  LDD0292  [5]
 LDCM0022  KB02 HCT 116 C242(2.05); C94(1.46)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C242(1.36); C94(1.89)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C242(2.18); C94(1.44)  LDD0082  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C179(0.80)  LDD2121  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C179(0.88)  LDD2089  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C179(0.81)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C179(1.00)  LDD2094  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C179(0.69)  LDD2098  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C179(0.99)  LDD2104  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C179(1.63)  LDD2105  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C179(1.02)  LDD2106  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C179(0.92)  LDD2108  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C179(0.94)  LDD2120  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C179(0.80)  LDD2123  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C179(0.60); C94(0.77)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C179(0.50)  LDD2129  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C179(1.03)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C179(0.90)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C179(1.54)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C179(0.63)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C179(0.61)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C179(1.25)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C179(3.66)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C179(0.86)  LDD2146  [3]
 LDCM0131  RA190 MM1.R C242(1.40); C454(1.07); C179(1.07)  LDD0304  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NRZ7
ATP-binding cassette sub-family C member 4 (ABCC4) ABCC family O15439
Alkaline ceramidase 1 (ACER1) Alkaline ceramidase family Q8TDN7
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
DNA-directed primase/polymerase protein (PRIMPOL) Eukaryotic-type primase small subunit family Q96LW4
Aspartyl aminopeptidase (DNPEP) Peptidase M18 family Q9ULA0
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit mu (AP2M1) Adaptor complexes medium subunit family Q96CW1
Membrane progestin receptor beta (PAQR8) ADIPOR family Q8TEZ7
Gamma-secretase subunit APH-1A (APH1A) APH-1 family Q96BI3
Derlin-2 (DERL2) Derlin family Q9GZP9
Solute carrier family 35 member E1 (SLC35E1) TPT transporter family Q96K37
Optineurin (OPTN) . Q96CV9
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G protein-coupled receptor associated sorting protein 3 (GPRASP3) GPRASP family Q6PI77
Zinc finger protein 639 (ZNF639) Krueppel C2H2-type zinc-finger protein family Q9UID6
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
Protein reprimo (RPRM) Reprimo family Q9NS64
Synaptogyrin-3 (SYNGR3) Synaptogyrin family O43761
Protein UXT (UXT) UXT family Q9UBK9
Gelsolin (GSN) Villin/gelsolin family P06396
Kelch-like protein 12 (KLHL12) . Q53G59

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
20 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.