Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C302  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 45 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02223  Cathepsin B (CTSB) 31.6
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 24.1
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 19.0
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 18.6
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 17.4
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 15.0
 LDTP14801  Di-N-acetylchitobiase (CTBS) 14.5
 LDTP02141  Alpha-galactosidase A (GLA) 13.9
 LDTP01372  Carboxypeptidase D (CPD) 13.9
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 13.6
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 12.7
 LDTP00316  Ribonuclease T2 (RNASET2) 12.4
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 12.0
 LDTP05561  Lactadherin (MFGE8) 11.9
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 11.7
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 10.6
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 10.5
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 10.0
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 9.6
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 9.5
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 9.3
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 9.1
 LDTP02539  Lysosomal acid phosphatase (ACP2) 8.7
 LDTP02837  Beta-galactosidase (GLB1) 8.5
 LDTP00282  Beta-mannosidase (MANBA) 8.3
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 8.1
 LDTP13751  Exonuclease 1 (EXO1) 8.1
 LDTP10888  Legumain (LGMN) 8.1
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 8.0
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 7.7
 LDTP02260  Beta-glucuronidase (GUSB) 6.7
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 6.6
 LDTP02505  Lysosomal protective protein (CTSA) 6.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 6.5
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 6.4
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 6.3
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 6.1
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 6.1
 LDTP17633  Beta-galactosidase-1-like protein 2 (GLB1L2) 5.7
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 5.6
 LDTP05905  Acid ceramidase (ASAH1) 5.3
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 5.3
 LDTP09984  Phosphorylase b kinase regulatory subunit beta (PHKB) 5.2
 LDTP16025  Ketosamine-3-kinase (FN3KRP) 5.2
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 5.1
Transporter and channel
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02215  Prosaposin (PSAP) 21.3
 LDTP10885  Sortilin (SORT1) 15.0
 LDTP12451  Integral membrane protein 2C (ITM2C) 14.5
 LDTP02071  Amyloid-beta precursor protein (APP) 13.2
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 13.1
 LDTP02586  Cation-independent mannose-6-phosphate receptor (IGF2R) 11.6
 LDTP01829  Low-density lipoprotein receptor (LDLR) 11.5
 LDTP05538  Prolow-density lipoprotein receptor-related protein 1 (LRP1) 11.3
 LDTP01969  Transferrin receptor protein 1 (TFRC) 8.6
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 8.5
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 8.1
 LDTP11615  Protein tweety homolog 3 (TTYH3) 7.0
 LDTP00592  Surfeit locus protein 4 (SURF4) 6.8
 LDTP00433  Neuropilin-1 (NRP1) 6.7
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 6.4
 LDTP06275  Lysosomal-associated transmembrane protein 4A (LAPTM4A) 5.7
 LDTP01427  Slit homolog 2 protein (SLIT2) 5.6
 LDTP03380  Stomatin (STOM) 5.5
Immunoglobulin
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14203  Junctional adhesion molecule A (F11R) 6.8
 LDTP02040  HLA class I histocompatibility antigen, A alpha chain (HLA-A) 5.7
 LDTP02491  HLA class I histocompatibility antigen, C alpha chain (HLA-C) 5.3
Other
Click to Show/Hide to Show 25 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01279  Protein CREG1 (CREG1) 15.7
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 15.2
 LDTP01075  Protein CutA (CUTA) 12.0
 LDTP05233  55 kDa erythrocyte membrane protein (MPP1) 11.6
 LDTP13114  C-type mannose receptor 2 (MRC2) 11.2
 LDTP07031  Collectin-12 (COLEC12) 10.7
 LDTP15623  Neuferricin (CYB5D2) 10.3
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 10.3
 LDTP02927  Ganglioside GM2 activator (GM2A) 9.8
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 9.6
 LDTP06097  Reticulocalbin-2 (RCN2) 8.8
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 8.6
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 8.3
 LDTP05960  Trophoblast glycoprotein (TPBG) 7.5
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 7.3
 LDTP09787  Nicastrin (NCSTN) 7.1
 LDTP09920  Golgi apparatus protein 1 (GLG1) 6.4
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 6.2
 LDTP00887  Calumenin (CALU) 6.1
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 5.9
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 5.7
 LDTP14458  Tetraspanin-6 (TSPAN6) 5.7
 LDTP01362  Survival of motor neuron-related-splicing factor 30 (SMNDC1) 5.5
 LDTP03775  RNA-binding protein FUS (FUS) 5.4
 LDTP05160  Nucleobindin-2 (NUCB2) 5.2

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587