Details of the Target

General Information of Target

Target ID LDTP01372
Target Name Carboxypeptidase D (CPD)
Gene Name CPD
Gene ID 1362
Synonyms
Carboxypeptidase D; EC 3.4.17.22; Metallocarboxypeptidase D; gp180
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYH
EEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPD
AAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLP
SLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRA
LIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHP
IMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPAS
QLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFY
RLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTV
AIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYV
MEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRI
HLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMK
SYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPC
KNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQ
NRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTY
KITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTK
EFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLG
QSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPA
VTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAII
ENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSC
PNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADN
KRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNII
AIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIW
CICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH
Target Bioclass
Enzyme
Family
Peptidase M14 family
Subcellular location
Cell membrane
Uniprot ID
O75976
Ensemble ID
ENST00000225719.9
HGNC ID
HGNC:2301
ChEMBL ID
CHEMBL4523154

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.H33N DBIA    Probe Info 
CCK81 Insertion: p.A231RfsTer38 DBIA    Probe Info 
HCT116 SNV: p.C309Y DBIA    Probe Info 
HEPG2 Substitution: p.S280K .
HT SNV: p.L574R .
JURKAT SNV: p.R1041Ter .
KP4 SNV: p.E63K DBIA    Probe Info 
LS123 SNV: p.Y160Ter; p.R161H DBIA    Probe Info 
LS180 SNV: p.R87H DBIA    Probe Info 
MEWO SNV: p.W778Ter DBIA    Probe Info 
MFE296 SNV: p.L170M DBIA    Probe Info 
MFE319 SNV: p.H1174N .
MOLT4 SNV: p.D175N; p.E472D .
OVK18 SNV: p.A231S; p.Y611H DBIA    Probe Info 
RKO SNV: p.R1041Q DBIA    Probe Info 
RL952 SNV: p.G91D DBIA    Probe Info 
SKMEL5 SNV: p.Y437C DBIA    Probe Info 
SNGM Insertion: p.A231RfsTer38 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 2
 Probe Info  		20.00  LDD0391  [1]
FBPP2
 Probe Info  		7.23  LDD0318  [2]
STPyne
 Probe Info  		K1201(3.79); K1220(4.44); K1356(1.11); K281(10.00)  LDD0277  [3]
IPM
 Probe Info  		N.A.  LDD0241  [4]
m-APA
 Probe Info  		15.00  LDD0403  [5]
BTD
 Probe Info  		C1049(1.02)  LDD1700  [6]
Acrolein
 Probe Info  		N.A.  LDD0227  [7]
DBIA
 Probe Info  		C720(0.87); C195(0.87)  LDD0078  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
NHS
 Probe Info  		N.A.  LDD0010  [12]
NAIA_5
 Probe Info  		C1049(0.00); C1012(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C045
 Probe Info  		6.19  LDD1744  [13]
C073
 Probe Info  		5.74  LDD1769  [13]
C115
 Probe Info  		7.11  LDD1802  [13]
C149
 Probe Info  		9.78  LDD1830  [13]
C164
 Probe Info  		5.94  LDD1844  [13]
C170
 Probe Info  		36.00  LDD1850  [13]
C186
 Probe Info  		14.12  LDD1864  [13]
C197
 Probe Info  		12.21  LDD1873  [13]
C208
 Probe Info  		14.03  LDD1883  [13]
C221
 Probe Info  		7.06  LDD1895  [13]
C223
 Probe Info  		10.78  LDD1897  [13]
C229
 Probe Info  		7.06  LDD1902  [13]
C237
 Probe Info  		10.34  LDD1910  [13]
C281
 Probe Info  		10.93  LDD1951  [13]
C302
 Probe Info  		13.93  LDD1971  [13]
C310
 Probe Info  		19.56  LDD1977  [13]
C353
 Probe Info  		7.94  LDD2014  [13]
C355
 Probe Info  		22.63  LDD2016  [13]
C390
 Probe Info  		20.53  LDD2049  [13]
C425
 Probe Info  		10.20  LDD2080  [13]
FFF probe12
 Probe Info  		20.00  LDD0473  [14]
FFF probe9
 Probe Info  		20.00  LDD0470  [14]
STS-1
 Probe Info  		N.A.  LDD0136  [15]
STS-2
 Probe Info  		N.A.  LDD0138  [15]
Alk-rapa
 Probe Info  		2.36  LDD0213  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1049(0.67)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C720(0.66); C1049(0.84)  LDD2112  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1049(1.22)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C720(1.13); C1049(0.93)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1049(1.68)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C720(0.74)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1049(0.87)  LDD2132  [6]
 LDCM0214  AC1 HCT 116 C195(0.84); C720(0.58)  LDD0531  [8]
 LDCM0215  AC10 HEK-293T C582(1.06)  LDD0813  [8]
 LDCM0216  AC100 HCT 116 C720(0.82)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C720(0.81)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C720(0.93)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C720(0.94)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C720(0.94)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C720(0.96)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C720(0.74)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C720(0.73)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C720(0.67)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C720(1.22)  LDD0542  [8]
 LDCM0226  AC11 HEK-293T C582(0.90)  LDD0824  [8]
 LDCM0227  AC110 HCT 116 C720(0.93)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C720(0.81)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C720(0.74)  LDD0546  [8]
 LDCM0237  AC12 HEK-293T C582(0.89)  LDD0835  [8]
 LDCM0259  AC14 HEK-293T C582(1.12)  LDD0857  [8]
 LDCM0263  AC143 HCT 116 C195(0.82)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C195(0.70)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C195(1.03)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C195(0.75)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C195(0.67)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C195(0.79)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C195(0.73)  LDD0586  [8]
 LDCM0270  AC15 HEK-293T C582(1.18)  LDD0868  [8]
 LDCM0271  AC150 HCT 116 C195(0.67)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C195(0.71)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C195(0.58)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C195(0.91)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C195(0.76)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C195(0.59)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C195(0.79)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C195(0.92)  LDD2161  [8]
 LDCM0276  AC17 PaTu 8988t C195(0.94)  LDD1155  [8]
 LDCM0277  AC18 PaTu 8988t C195(0.92)  LDD1156  [8]
 LDCM0278  AC19 PaTu 8988t C195(1.09)  LDD1157  [8]
 LDCM0279  AC2 HCT 116 C720(0.70); C195(0.94)  LDD0596  [8]
 LDCM0280  AC20 PaTu 8988t C195(1.19)  LDD1159  [8]
 LDCM0281  AC21 PaTu 8988t C195(1.30)  LDD1160  [8]
 LDCM0282  AC22 PaTu 8988t C195(1.09)  LDD1161  [8]
 LDCM0283  AC23 PaTu 8988t C195(0.94)  LDD1162  [8]
 LDCM0284  AC24 PaTu 8988t C195(0.99)  LDD1163  [8]
 LDCM0285  AC25 HEK-293T C195(0.95); C720(1.00); C309(1.03)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C720(1.08); C309(1.00)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C720(1.10); C309(1.26)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C720(1.12); C309(1.11)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C720(1.00); C309(0.96)  LDD1528  [17]
 LDCM0290  AC3 HCT 116 C720(0.51); C195(0.70)  LDD0607  [8]
 LDCM0291  AC30 HEK-293T C720(1.08); C309(1.03)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C720(1.04); C309(1.05)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C720(1.05); C309(0.99)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C195(1.02); C720(1.05); C309(1.11)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C720(1.14); C309(0.95)  LDD1534  [17]
 LDCM0296  AC35 HCT 116 C195(0.81)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C195(0.96)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C195(0.90)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C195(1.07)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C195(1.06)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C720(0.51); C195(0.95)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C195(1.09)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C195(1.26)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C195(1.19)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C195(1.63)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C195(0.88)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C195(0.91)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C720(0.89)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C720(1.11)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C720(0.81)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C720(1.14)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C720(0.53); C195(0.85)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C720(0.78)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C720(0.90)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C720(0.81)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C720(0.67)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C720(0.73)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C720(0.75)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C720(0.76)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C195(1.06)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C195(1.06)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C195(0.99)  LDD0639  [8]
 LDCM0323  AC6 HEK-293T C582(0.75)  LDD0921  [8]
 LDCM0324  AC60 HCT 116 C195(1.02)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C195(0.93)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C195(1.02)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C195(1.07)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C195(1.06)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C195(1.44)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C195(0.97)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C195(1.12)  LDD0648  [8]
 LDCM0334  AC7 HEK-293T C582(0.95)  LDD0932  [8]
 LDCM0345  AC8 HEK-293T C582(0.93)  LDD0943  [8]
 LDCM0349  AC83 HCT 116 C195(0.58)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C195(0.45)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C195(0.64)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C195(1.17)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C195(1.10)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C195(0.44)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C195(0.76)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C195(1.97)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C195(0.47)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C195(0.59)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C195(0.59)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C195(0.68)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C195(0.71)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C195(0.80)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C195(0.50)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C720(0.77)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C720(0.78)  LDD0683  [8]
 LDCM0545  Acetamide MDA-MB-231 C1049(0.34)  LDD2138  [6]
 LDCM0248  AKOS034007472 HEK-293T C582(0.79)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C582(1.21)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C582(1.05)  LDD0873  [8]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [5]
 LDCM0020  ARS-1620 HCC44 C720(0.87); C195(0.87)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C720(0.22); C1049(0.54)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C1321(0.11)  LDD2214  [18]
 LDCM0367  CL1 HCT 116 C720(0.94)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C720(0.80)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C720(0.79); C195(0.90)  LDD0686  [8]
 LDCM0370  CL101 HEK-293T C582(1.11)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C582(1.29)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C582(1.02)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C582(0.99)  LDD0971  [8]
 LDCM0374  CL105 PaTu 8988t C195(1.05)  LDD1253  [8]
 LDCM0375  CL106 PaTu 8988t C195(0.93)  LDD1254  [8]
 LDCM0376  CL107 PaTu 8988t C195(1.01)  LDD1255  [8]
 LDCM0377  CL108 PaTu 8988t C195(0.97)  LDD1256  [8]
 LDCM0378  CL109 PaTu 8988t C195(1.05)  LDD1257  [8]
 LDCM0379  CL11 HCT 116 C720(0.73)  LDD0696  [8]
 LDCM0380  CL110 PaTu 8988t C195(1.01)  LDD1259  [8]
 LDCM0381  CL111 PaTu 8988t C195(0.93)  LDD1260  [8]
 LDCM0382  CL112 HEK-293T C720(1.16); C309(1.11)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C720(0.92); C309(1.12)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C720(1.30); C309(1.01)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C720(1.01); C309(0.97)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C720(1.05); C309(1.07)  LDD1590  [17]
 LDCM0387  CL117 HCT 116 C195(1.10)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C195(1.13)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C195(1.41)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C720(0.89)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C195(1.26)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C720(0.75)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C720(0.72)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C720(0.69)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C720(0.88)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C195(1.21)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C195(0.77)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C195(1.13)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C195(1.01)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C720(0.87)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C720(0.78)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C720(0.65)  LDD0719  [8]
 LDCM0403  CL16 HEK-293T C582(0.86)  LDD1001  [8]
 LDCM0404  CL17 HCT 116 C195(0.98)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C195(1.17)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C195(1.01)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C720(1.04)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C195(1.11)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C195(1.05)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C195(0.83)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C195(0.72)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C195(0.92)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C195(1.00)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C195(1.03)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C195(1.02)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C195(1.32)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C195(0.98)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C720(0.91)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C195(1.09)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C195(1.03)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C195(0.99)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C195(1.01)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C195(0.79)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C195(0.94)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C195(1.08)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C195(0.83)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C195(1.15)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C720(0.72)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C195(0.80)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C195(1.19)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C195(1.02)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C195(0.97)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C195(0.91)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C195(1.04)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C195(1.34)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C195(1.26)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C195(0.89)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C195(1.11)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C720(0.75)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C195(1.26)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C195(1.06)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C195(1.26)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C195(0.92)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C195(1.23)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C195(1.06)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C195(1.08)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C195(1.01)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C195(1.27)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C195(1.12)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C720(0.60)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C195(1.14)  LDD0769  [8]
 LDCM0453  CL61 HEK-293T C582(0.92)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C582(1.07)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C582(1.07)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C582(1.21)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C582(1.33)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C582(1.70)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C582(1.36)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C582(1.41)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C582(1.08)  LDD1059  [8]
 LDCM0462  CL7 HCT 116 C720(0.69)  LDD0779  [8]
 LDCM0463  CL70 HEK-293T C582(1.21)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C582(1.24)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C582(1.00)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C582(1.67)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C582(1.97)  LDD1065  [8]
 LDCM0469  CL76 PaTu 8988t C195(0.98)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C195(1.01)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C195(1.08)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C195(0.95)  LDD1351  [8]
 LDCM0473  CL8 HCT 116 C720(0.85)  LDD0790  [8]
 LDCM0474  CL80 PaTu 8988t C195(0.99)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C195(1.19)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C195(0.89)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C195(1.39)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C195(1.03)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C195(1.36)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C195(1.12)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C195(1.09)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C195(1.14)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C195(1.10)  LDD1362  [8]
 LDCM0484  CL9 HCT 116 C720(0.70)  LDD0801  [8]
 LDCM0485  CL90 PaTu 8988t C195(1.14)  LDD1364  [8]
 LDCM0486  CL91 HCT 116 C195(0.95); C720(1.01)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C195(0.94); C720(1.36)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C195(1.02); C720(0.91)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C195(0.78); C720(0.81)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C195(0.74); C720(0.94)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C195(0.92); C720(0.70)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C195(0.89); C720(0.84)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C195(1.06); C720(0.47)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C195(0.83); C720(0.43)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C720(1.01); C309(1.04)  LDD1698  [17]
 LDCM0468  Fragment33 HEK-293T C582(1.76)  LDD1066  [8]
 LDCM0427  Fragment51 HCT 116 C195(0.79)  LDD0744  [8]
 LDCM0022  KB02 HEK-293T C195(1.06); C720(0.88); C309(0.94)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C195(1.30); C720(1.02); C309(0.96)  LDD1497  [17]
 LDCM0024  KB05 COLO792 C720(2.57)  LDD3310  [19]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C720(0.85)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1049(0.49)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0227  [7]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C720(0.39); C1049(0.91)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C720(0.93); C1049(0.83)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C720(0.65)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1049(0.53)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C720(1.05)  LDD2094  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1049(1.02)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1049(0.68)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C720(0.77); C1049(0.72)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1049(0.96)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1049(0.97)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1049(1.10)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C720(1.21); C1049(0.83)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C720(0.80); C1049(0.78)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1049(0.69)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C720(0.92); C1049(0.56)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C1049(2.25)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1049(0.89)  LDD2111  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1049(0.68)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1049(1.04)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1049(2.11)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1049(0.86)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C720(0.93); C1049(0.60)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C720(0.65); C1049(0.60)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C720(1.08); C1049(0.98)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C720(0.85)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C720(0.95); C1049(0.56)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1049(0.43)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1049(0.41)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C720(0.52); C1049(0.39)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C720(1.26); C1049(0.93)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C720(1.26); C1049(0.93)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1049(1.02)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C720(0.58); C1049(0.60)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C720(0.50); C1049(0.58)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1049(1.13)  LDD2143  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C1049(2.16)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C720(0.74); C1049(0.65)  LDD2146  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C720(0.53); C1049(0.33)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C720(1.35)  LDD2153  [6]
 LDCM0099  Phenelzine MDA-MB-231 15.00  LDD0392  [1]
 LDCM0090  Rapamycin JHH-7 2.36  LDD0213  [16]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanidinoethylmercaptosuccinic Acid . DB04489

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840