Details of the Probe

General Information of Probe

Probe ID
LDPC0362
Probe Name
C115
Synonyms
Z4282859845
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 302.4
Lipid-water partition coefficient (xlogp) 2.4
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C17H26N4O
IUPAC Name
N-(1-but-3-enylpiperidin-4-yl)-3-(3-but-3-ynyldiazirin-3-yl)propanamide
Canonical SMILES
C=CCCN1CCC(CC1)NC(=O)CCC2(N=N2)CCC#C
InChI
InChI=1S/C17H26N4O/c1-3-5-10-17(19-20-17)11-7-16(22)18-15-8-13-21(14-9-15)12-6-4-2/h1,4,15H,2,5-14H2,(H,18,22)
InChIKey
JERBYBVUQRBQQB-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

28 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
5'-3' exonuclease PLD3 (PLD3) LDTP08476 5.43  LDD1802 
7-dehydrocholesterol reductase (DHCR7) LDTP13131 10.78  LDD1802 
Alpha-galactosidase A (GLA) LDTP02141 7.78  LDD1802 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 5.74  LDD1802 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 7.16  LDD1802 
Bis(5'-adenosyl)-triphosphatase ENPP4 (ENPP4) LDTP14305 6.59  LDD1802 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 17.39  LDD1802 
Carboxypeptidase D (CPD) LDTP01372 7.11  LDD1802 
Delta(24)-sterol reductase (DHCR24) LDTP06375 5.78  LDD1802 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 7.11  LDD1802 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 12.64  LDD1802 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 12.73  LDD1802 
Lysosomal acid phosphatase (ACP2) LDTP02539 6.23  LDD1802 
Lysosomal alpha-glucosidase (GAA) LDTP02486 7.57  LDD1802 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 5.90  LDD1802 
Lysosomal protective protein (CTSA) LDTP02505 5.31  LDD1802 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 12.64  LDD1802 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 18.38  LDD1802 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 8.88  LDD1802 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 6.59  LDD1802 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 7.73  LDD1802 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 6.19  LDD1802 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 7.21  LDD1802 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 14.62  LDD1802 
Ribonuclease T2 (RNASET2) LDTP00316 12.73  LDD1802 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 8.40  LDD1802 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 11.47  LDD1802 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 18.38  LDD1802 
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⏷ Show the Full List of 28 Enzyme
19 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid-beta precursor protein (APP) LDTP02071 9.51  LDD1802 
Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 8.46  LDD1802 
Integral membrane protein 2B (ITM2B) LDTP13833 11.79  LDD1802 
Integral membrane protein 2C (ITM2C) LDTP12451 6.96  LDD1802 
Low-density lipoprotein receptor (LDLR) LDTP01829 11.08  LDD1802 
Lysosome membrane protein 2 (SCARB2) LDTP06034 8.22  LDD1802 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 4.96  LDD1802 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 5.66  LDD1802 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 5.39  LDD1802 
Prolow-density lipoprotein receptor-related protein 1 (LRP1) LDTP05538 7.21  LDD1802 
Prosaposin (PSAP) LDTP02215 12.13  LDD1802 
Protein tweety homolog 3 (TTYH3) LDTP11615 13.09  LDD1802 
Proton-coupled amino acid transporter 1 (SLC36A1) LDTP08016 7.57  LDD1802 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 5.54  LDD1802 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 7.26  LDD1802 
Sortilin (SORT1) LDTP10885 5.90  LDD1802 
Stomatin (STOM) LDTP03380 5.50  LDD1802 
Tetraspanin-3 (TSPAN3) LDTP16813 5.24  LDD1802 
Transferrin receptor protein 1 (TFRC) LDTP01969 9.99  LDD1802 
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⏷ Show the Full List of 19 Transporter and channel
1 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Neogenin (NEO1) LDTP09907 16.91  LDD1802 
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13 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid beta precursor like protein 2 (APLP2) LDTP05491 8.28  LDD1802 
C-type mannose receptor 2 (MRC2) LDTP13114 10.13  LDD1802 
Collectin-12 (COLEC12) LDTP07031 8.40  LDD1802 
Desmocollin-3 (DSC3) LDTP06154 4.99  LDD1802 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 6.82  LDD1802 
Galectin-3-binding protein (LGALS3BP) LDTP05558 7.89  LDD1802 
Ganglioside GM2 activator (GM2A) LDTP02927 6.28  LDD1802 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 5.06  LDD1802 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 9.38  LDD1802 
Seizure 6-like protein 2 (SEZ6L2) LDTP07703 25.11  LDD1802 
Tetraspanin-6 (TSPAN6) LDTP14458 4.99  LDD1802 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 8.46  LDD1802 
Trophoblast glycoprotein (TPBG) LDTP05960 5.10  LDD1802 
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⏷ Show the Full List of 13 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1802 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587