Details of the Probe

General Information of Probe

Probe ID
LDPC0362
Probe Name
C115
Synonyms
Z4282859845
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 302.4
Lipid-water partition coefficient (xlogp) 2.4
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C17H26N4O
IUPAC Name
N-(1-but-3-enylpiperidin-4-yl)-3-(3-but-3-ynyldiazirin-3-yl)propanamide
Canonical SMILES
C=CCCN1CCC(CC1)NC(=O)CCC2(N=N2)CCC#C
InChI
InChI=1S/C17H26N4O/c1-3-5-10-17(19-20-17)11-7-16(22)18-15-8-13-21(14-9-15)12-6-4-2/h1,4,15H,2,5-14H2,(H,18,22)
InChIKey
JERBYBVUQRBQQB-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

56 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
5'-3' exonuclease PLD3 (PLD3) LDTP08476 5.43  LDD1802 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 5.43  LDD1802 
7-dehydrocholesterol reductase (DHCR7) LDTP13131 10.78  LDD1802 
7-dehydrocholesterol reductase (DHCR7) LDTP13131 10.78  LDD1802 
Alpha-galactosidase A (GLA) LDTP02141 7.78  LDD1802 
Alpha-galactosidase A (GLA) LDTP02141 7.78  LDD1802 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 5.74  LDD1802 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 5.74  LDD1802 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 7.16  LDD1802 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 7.16  LDD1802 
Bis(5'-adenosyl)-triphosphatase ENPP4 (ENPP4) LDTP14305 6.59  LDD1802 
Bis(5'-adenosyl)-triphosphatase ENPP4 (ENPP4) LDTP14305 6.59  LDD1802 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 17.39  LDD1802 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 17.39  LDD1802 
Carboxypeptidase D (CPD) LDTP01372 7.11  LDD1802 
Carboxypeptidase D (CPD) LDTP01372 7.11  LDD1802 
Delta(24)-sterol reductase (DHCR24) LDTP06375 5.78  LDD1802 
Delta(24)-sterol reductase (DHCR24) LDTP06375 5.78  LDD1802 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 7.11  LDD1802 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 7.11  LDD1802 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 12.64  LDD1802 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 12.64  LDD1802 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 12.73  LDD1802 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 12.73  LDD1802 
Lysosomal acid phosphatase (ACP2) LDTP02539 6.23  LDD1802 
Lysosomal acid phosphatase (ACP2) LDTP02539 6.23  LDD1802 
Lysosomal alpha-glucosidase (GAA) LDTP02486 7.57  LDD1802 
Lysosomal alpha-glucosidase (GAA) LDTP02486 7.57  LDD1802 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 5.90  LDD1802 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 5.90  LDD1802 
Lysosomal protective protein (CTSA) LDTP02505 5.31  LDD1802 
Lysosomal protective protein (CTSA) LDTP02505 5.31  LDD1802 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 12.64  LDD1802 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 12.64  LDD1802 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 18.38  LDD1802 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 18.38  LDD1802 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 8.88  LDD1802 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 8.88  LDD1802 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 6.59  LDD1802 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 6.59  LDD1802 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 7.73  LDD1802 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 7.73  LDD1802 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 6.19  LDD1802 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 6.19  LDD1802 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 7.21  LDD1802 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 7.21  LDD1802 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 14.62  LDD1802 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 14.62  LDD1802 
Ribonuclease T2 (RNASET2) LDTP00316 12.73  LDD1802 
Ribonuclease T2 (RNASET2) LDTP00316 12.73  LDD1802 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 8.40  LDD1802 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 8.40  LDD1802 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 11.47  LDD1802 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 11.47  LDD1802 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 18.38  LDD1802 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 18.38  LDD1802 
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⏷ Show the Full List of 56 Enzyme
38 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid-beta precursor protein (APP) LDTP02071 9.51  LDD1802 
Amyloid-beta precursor protein (APP) LDTP02071 9.51  LDD1802 
Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 8.46  LDD1802 
Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 8.46  LDD1802 
Integral membrane protein 2B (ITM2B) LDTP13833 11.79  LDD1802 
Integral membrane protein 2B (ITM2B) LDTP13833 11.79  LDD1802 
Integral membrane protein 2C (ITM2C) LDTP12451 6.96  LDD1802 
Integral membrane protein 2C (ITM2C) LDTP12451 6.96  LDD1802 
Low-density lipoprotein receptor (LDLR) LDTP01829 11.08  LDD1802 
Low-density lipoprotein receptor (LDLR) LDTP01829 11.08  LDD1802 
Lysosome membrane protein 2 (SCARB2) LDTP06034 8.22  LDD1802 
Lysosome membrane protein 2 (SCARB2) LDTP06034 8.22  LDD1802 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 4.96  LDD1802 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 4.96  LDD1802 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 5.66  LDD1802 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 5.66  LDD1802 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 5.39  LDD1802 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 5.39  LDD1802 
Prolow-density lipoprotein receptor-related protein 1 (LRP1) LDTP05538 7.21  LDD1802 
Prolow-density lipoprotein receptor-related protein 1 (LRP1) LDTP05538 7.21  LDD1802 
Prosaposin (PSAP) LDTP02215 12.13  LDD1802 
Prosaposin (PSAP) LDTP02215 12.13  LDD1802 
Protein tweety homolog 3 (TTYH3) LDTP11615 13.09  LDD1802 
Protein tweety homolog 3 (TTYH3) LDTP11615 13.09  LDD1802 
Proton-coupled amino acid transporter 1 (SLC36A1) LDTP08016 7.57  LDD1802 
Proton-coupled amino acid transporter 1 (SLC36A1) LDTP08016 7.57  LDD1802 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 5.54  LDD1802 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 5.54  LDD1802 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 7.26  LDD1802 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 7.26  LDD1802 
Sortilin (SORT1) LDTP10885 5.90  LDD1802 
Sortilin (SORT1) LDTP10885 5.90  LDD1802 
Stomatin (STOM) LDTP03380 5.50  LDD1802 
Stomatin (STOM) LDTP03380 5.50  LDD1802 
Tetraspanin-3 (TSPAN3) LDTP16813 5.24  LDD1802 
Tetraspanin-3 (TSPAN3) LDTP16813 5.24  LDD1802 
Transferrin receptor protein 1 (TFRC) LDTP01969 9.99  LDD1802 
Transferrin receptor protein 1 (TFRC) LDTP01969 9.99  LDD1802 
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⏷ Show the Full List of 38 Transporter and channel
2 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Neogenin (NEO1) LDTP09907 16.91  LDD1802 
Neogenin (NEO1) LDTP09907 16.91  LDD1802 
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26 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid beta precursor like protein 2 (APLP2) LDTP05491 8.28  LDD1802 
Amyloid beta precursor like protein 2 (APLP2) LDTP05491 8.28  LDD1802 
C-type mannose receptor 2 (MRC2) LDTP13114 10.13  LDD1802 
C-type mannose receptor 2 (MRC2) LDTP13114 10.13  LDD1802 
Collectin-12 (COLEC12) LDTP07031 8.40  LDD1802 
Collectin-12 (COLEC12) LDTP07031 8.40  LDD1802 
Desmocollin-3 (DSC3) LDTP06154 4.99  LDD1802 
Desmocollin-3 (DSC3) LDTP06154 4.99  LDD1802 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 6.82  LDD1802 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 6.82  LDD1802 
Galectin-3-binding protein (LGALS3BP) LDTP05558 7.89  LDD1802 
Galectin-3-binding protein (LGALS3BP) LDTP05558 7.89  LDD1802 
Ganglioside GM2 activator (GM2A) LDTP02927 6.28  LDD1802 
Ganglioside GM2 activator (GM2A) LDTP02927 6.28  LDD1802 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 5.06  LDD1802 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 5.06  LDD1802 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 9.38  LDD1802 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 9.38  LDD1802 
Seizure 6-like protein 2 (SEZ6L2) LDTP07703 25.11  LDD1802 
Seizure 6-like protein 2 (SEZ6L2) LDTP07703 25.11  LDD1802 
Tetraspanin-6 (TSPAN6) LDTP14458 4.99  LDD1802 
Tetraspanin-6 (TSPAN6) LDTP14458 4.99  LDD1802 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 8.46  LDD1802 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 8.46  LDD1802 
Trophoblast glycoprotein (TPBG) LDTP05960 5.10  LDD1802 
Trophoblast glycoprotein (TPBG) LDTP05960 5.10  LDD1802 
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⏷ Show the Full List of 26 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1802 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587