Details of the Target

General Information of Target

Target ID LDTP13131
Target Name 7-dehydrocholesterol reductase (DHCR7)
Gene Name DHCR7
Gene ID 1717
Synonyms
D7SR; 7-dehydrocholesterol reductase; 7-DHC reductase; EC 1.3.1.21; Delta7-sterol reductase; Sterol Delta(7)-reductase; Sterol reductase SR-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLLAFLSLLALVLQETGTASLPRKERKRREEQMPREGDSFEVLPLRNDVLNPDNYGEVI
DLSNYEELTDYGDQLPEVKVTSLAPATSISPAKSTTAPGTPSSNPTMTRPTTAGLLLSSQ
PNHGLPTCLVCVCLGSSVYCDDIDLEDIPPLPRRTAYLYARFNRISRIRAEDFKGLTKLK
RIDLSNNLISSIDNDAFRLLHALQDLILPENQLEALPVLPSGIEFLDVRLNRLQSSGIQP
AAFRAMEKLQFLYLSDNLLDSIPGPLPLSLRSVHLQNNLIETMQRDVFCDPEEHKHTRRQ
LEDIRLDGNPINLSLFPSAYFCLPRLPIGRFT
Target Bioclass
Enzyme
Family
ERG4/ERG24 family
Subcellular location
Endoplasmic reticulum membrane
Function
7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway.
Uniprot ID
Q9UBM7
Ensemble ID
ENST00000355527.8
HGNC ID
HGNC:2860
ChEMBL ID
CHEMBL2169735

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.11  LDD0402  [1]
HDSF-alk
 Probe Info  		1.96  LDD0197  [2]
A-EBA
 Probe Info  		7.09  LDD0215  [3]
TH211
 Probe Info  		Y468(20.00); Y382(13.22); Y455(8.65); Y125(5.40)  LDD0260  [4]
C-Sul
 Probe Info  		3.98  LDD0066  [5]
YN-4
 Probe Info  		100.00  LDD0445  [6]
ONAyne
 Probe Info  		K358(0.70)  LDD0274  [7]
Probe 1
 Probe Info  		Y382(27.66); Y462(24.54); Y468(13.05)  LDD3495  [8]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [9]
BTD
 Probe Info  		C451(0.35)  LDD2091  [10]
EA-probe
 Probe Info  		N.A.  LDD0440  [11]
DBIA
 Probe Info  		C380(8.90); C368(18.76)  LDD0209  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		C368(0.00); C380(0.00)  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [16]
WYneO
 Probe Info  		N.A.  LDD0022  [16]
ENE
 Probe Info  		N.A.  LDD0006  [16]
IPM
 Probe Info  		C368(0.00); C380(0.00)  LDD0005  [16]
NHS
 Probe Info  		N.A.  LDD0010  [16]
SF
 Probe Info  		N.A.  LDD0028  [17]
STPyne
 Probe Info  		N.A.  LDD0009  [16]
VSF
 Probe Info  		N.A.  LDD0007  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [18]
W1
 Probe Info  		N.A.  LDD0236  [19]
AOyne
 Probe Info  		14.40  LDD0443  [20]
NAIA_5
 Probe Info  		C451(0.00); C368(0.00); C444(0.00); C118(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C041
 Probe Info  		7.21  LDD1741  [22]
C065
 Probe Info  		4.96  LDD1762  [22]
C094
 Probe Info  		28.25  LDD1785  [22]
C115
 Probe Info  		10.78  LDD1802  [22]
C140
 Probe Info  		10.13  LDD1822  [22]
C141
 Probe Info  		9.85  LDD1823  [22]
C160
 Probe Info  		10.41  LDD1840  [22]
C161
 Probe Info  		10.93  LDD1841  [22]
C171
 Probe Info  		8.63  LDD1851  [22]
C187
 Probe Info  		16.11  LDD1865  [22]
C194
 Probe Info  		8.51  LDD1870  [22]
C197
 Probe Info  		9.32  LDD1873  [22]
C200
 Probe Info  		8.69  LDD1876  [22]
C206
 Probe Info  		15.24  LDD1881  [22]
C219
 Probe Info  		9.19  LDD1893  [22]
C220
 Probe Info  		11.96  LDD1894  [22]
C221
 Probe Info  		5.43  LDD1895  [22]
C231
 Probe Info  		13.00  LDD1904  [22]
C270
 Probe Info  		7.26  LDD1940  [22]
C273
 Probe Info  		6.28  LDD1943  [22]
C276
 Probe Info  		6.96  LDD1946  [22]
C339
 Probe Info  		5.17  LDD2002  [22]
C349
 Probe Info  		9.92  LDD2010  [22]
C364
 Probe Info  		16.45  LDD2025  [22]
C419
 Probe Info  		10.48  LDD2074  [22]
C423
 Probe Info  		10.70  LDD2078  [22]
C425
 Probe Info  		7.06  LDD2080  [22]
VE-P
 Probe Info  		N.A.  LDD0396  [23]
OEA-DA
 Probe Info  		4.62  LDD0046  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C451(0.90)  LDD2112  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C451(0.82); C380(1.02)  LDD2117  [10]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C451(1.16)  LDD2152  [10]
 LDCM0214  AC1 HCT 116 C380(1.14)  LDD0531  [25]
 LDCM0215  AC10 HCT 116 C380(0.79)  LDD0532  [25]
 LDCM0216  AC100 HCT 116 C380(0.92)  LDD0533  [25]
 LDCM0217  AC101 HCT 116 C380(0.85)  LDD0534  [25]
 LDCM0218  AC102 HCT 116 C380(0.94)  LDD0535  [25]
 LDCM0219  AC103 HCT 116 C380(0.75)  LDD0536  [25]
 LDCM0220  AC104 HCT 116 C380(1.23)  LDD0537  [25]
 LDCM0221  AC105 HCT 116 C380(0.93)  LDD0538  [25]
 LDCM0222  AC106 HCT 116 C380(0.92)  LDD0539  [25]
 LDCM0223  AC107 HCT 116 C380(0.98)  LDD0540  [25]
 LDCM0224  AC108 HCT 116 C380(0.97)  LDD0541  [25]
 LDCM0225  AC109 HCT 116 C380(1.13)  LDD0542  [25]
 LDCM0226  AC11 HCT 116 C380(0.83)  LDD0543  [25]
 LDCM0227  AC110 HCT 116 C380(0.98)  LDD0544  [25]
 LDCM0228  AC111 HCT 116 C380(0.97)  LDD0545  [25]
 LDCM0229  AC112 HCT 116 C380(1.06)  LDD0546  [25]
 LDCM0230  AC113 HCT 116 C380(0.77)  LDD0547  [25]
 LDCM0231  AC114 HCT 116 C380(0.86)  LDD0548  [25]
 LDCM0232  AC115 HCT 116 C380(0.89)  LDD0549  [25]
 LDCM0233  AC116 HCT 116 C380(0.81)  LDD0550  [25]
 LDCM0234  AC117 HCT 116 C380(0.89)  LDD0551  [25]
 LDCM0235  AC118 HCT 116 C380(0.90)  LDD0552  [25]
 LDCM0236  AC119 HCT 116 C380(0.73)  LDD0553  [25]
 LDCM0237  AC12 HCT 116 C380(1.16)  LDD0554  [25]
 LDCM0238  AC120 HCT 116 C380(0.98)  LDD0555  [25]
 LDCM0239  AC121 HCT 116 C380(0.82)  LDD0556  [25]
 LDCM0240  AC122 HCT 116 C380(0.95)  LDD0557  [25]
 LDCM0241  AC123 HCT 116 C380(0.97)  LDD0558  [25]
 LDCM0242  AC124 HCT 116 C380(0.87)  LDD0559  [25]
 LDCM0243  AC125 HCT 116 C380(0.84)  LDD0560  [25]
 LDCM0244  AC126 HCT 116 C380(1.07)  LDD0561  [25]
 LDCM0245  AC127 HCT 116 C380(0.85)  LDD0562  [25]
 LDCM0246  AC128 HCT 116 C380(1.38)  LDD0563  [25]
 LDCM0247  AC129 HCT 116 C380(1.80)  LDD0564  [25]
 LDCM0249  AC130 HCT 116 C380(1.38)  LDD0566  [25]
 LDCM0250  AC131 HCT 116 C380(1.40)  LDD0567  [25]
 LDCM0251  AC132 HCT 116 C380(1.31)  LDD0568  [25]
 LDCM0252  AC133 HCT 116 C380(1.26)  LDD0569  [25]
 LDCM0253  AC134 HCT 116 C380(1.21)  LDD0570  [25]
 LDCM0254  AC135 HCT 116 C380(1.08)  LDD0571  [25]
 LDCM0255  AC136 HCT 116 C380(1.00)  LDD0572  [25]
 LDCM0256  AC137 HCT 116 C380(0.95)  LDD0573  [25]
 LDCM0257  AC138 HCT 116 C380(0.99)  LDD0574  [25]
 LDCM0258  AC139 HCT 116 C380(1.10)  LDD0575  [25]
 LDCM0259  AC14 HCT 116 C380(1.25)  LDD0576  [25]
 LDCM0260  AC140 HCT 116 C380(1.01)  LDD0577  [25]
 LDCM0261  AC141 HCT 116 C380(0.97)  LDD0578  [25]
 LDCM0262  AC142 HCT 116 C380(1.02)  LDD0579  [25]
 LDCM0263  AC143 HCT 116 C380(1.07)  LDD0580  [25]
 LDCM0264  AC144 HCT 116 C380(0.75)  LDD0581  [25]
 LDCM0265  AC145 HCT 116 C380(0.97)  LDD0582  [25]
 LDCM0266  AC146 HCT 116 C380(0.52)  LDD0583  [25]
 LDCM0267  AC147 HCT 116 C380(0.66)  LDD0584  [25]
 LDCM0268  AC148 HCT 116 C380(1.50)  LDD0585  [25]
 LDCM0269  AC149 HCT 116 C380(0.74)  LDD0586  [25]
 LDCM0270  AC15 HCT 116 C380(0.72)  LDD0587  [25]
 LDCM0271  AC150 HCT 116 C380(0.82)  LDD0588  [25]
 LDCM0272  AC151 HCT 116 C380(1.42)  LDD0589  [25]
 LDCM0273  AC152 HCT 116 C380(0.67)  LDD0590  [25]
 LDCM0274  AC153 HCT 116 C380(0.83)  LDD0591  [25]
 LDCM0621  AC154 HCT 116 C380(0.81)  LDD2158  [25]
 LDCM0622  AC155 HCT 116 C380(0.86)  LDD2159  [25]
 LDCM0623  AC156 HCT 116 C380(0.78)  LDD2160  [25]
 LDCM0624  AC157 HCT 116 C380(1.30)  LDD2161  [25]
 LDCM0276  AC17 HCT 116 C380(1.16)  LDD0593  [25]
 LDCM0277  AC18 HCT 116 C380(0.77)  LDD0594  [25]
 LDCM0278  AC19 HCT 116 C380(0.90)  LDD0595  [25]
 LDCM0279  AC2 HCT 116 C380(0.95)  LDD0596  [25]
 LDCM0280  AC20 HCT 116 C380(0.97)  LDD0597  [25]
 LDCM0281  AC21 HCT 116 C380(1.02)  LDD0598  [25]
 LDCM0282  AC22 HCT 116 C380(1.50)  LDD0599  [25]
 LDCM0283  AC23 HCT 116 C380(1.19)  LDD0600  [25]
 LDCM0284  AC24 HCT 116 C380(1.01)  LDD0601  [25]
 LDCM0285  AC25 HCT 116 C380(0.77)  LDD0602  [25]
 LDCM0286  AC26 HCT 116 C380(0.74)  LDD0603  [25]
 LDCM0287  AC27 HCT 116 C380(0.55)  LDD0604  [25]
 LDCM0288  AC28 HCT 116 C380(0.61)  LDD0605  [25]
 LDCM0289  AC29 HCT 116 C380(0.60)  LDD0606  [25]
 LDCM0290  AC3 HCT 116 C380(1.04)  LDD0607  [25]
 LDCM0291  AC30 HCT 116 C380(0.57)  LDD0608  [25]
 LDCM0292  AC31 HCT 116 C380(0.57)  LDD0609  [25]
 LDCM0293  AC32 HCT 116 C380(0.50)  LDD0610  [25]
 LDCM0294  AC33 HCT 116 C380(0.61)  LDD0611  [25]
 LDCM0295  AC34 HCT 116 C380(0.61)  LDD0612  [25]
 LDCM0296  AC35 HCT 116 C380(1.22)  LDD0613  [25]
 LDCM0297  AC36 HCT 116 C380(1.20)  LDD0614  [25]
 LDCM0298  AC37 HCT 116 C380(1.35)  LDD0615  [25]
 LDCM0299  AC38 HCT 116 C380(1.13)  LDD0616  [25]
 LDCM0300  AC39 HCT 116 C380(1.08)  LDD0617  [25]
 LDCM0301  AC4 HCT 116 C380(0.87)  LDD0618  [25]
 LDCM0302  AC40 HCT 116 C380(1.08)  LDD0619  [25]
 LDCM0303  AC41 HCT 116 C380(1.24)  LDD0620  [25]
 LDCM0304  AC42 HCT 116 C380(1.00)  LDD0621  [25]
 LDCM0305  AC43 HCT 116 C380(1.17)  LDD0622  [25]
 LDCM0306  AC44 HCT 116 C380(1.18)  LDD0623  [25]
 LDCM0307  AC45 HCT 116 C380(1.07)  LDD0624  [25]
 LDCM0308  AC46 HCT 116 C380(1.05)  LDD0625  [25]
 LDCM0309  AC47 HCT 116 C380(1.04)  LDD0626  [25]
 LDCM0310  AC48 HCT 116 C380(1.17)  LDD0627  [25]
 LDCM0311  AC49 HCT 116 C380(0.91)  LDD0628  [25]
 LDCM0312  AC5 HCT 116 C380(0.92)  LDD0629  [25]
 LDCM0313  AC50 HCT 116 C380(0.87)  LDD0630  [25]
 LDCM0314  AC51 HCT 116 C380(2.11)  LDD0631  [25]
 LDCM0315  AC52 HCT 116 C380(0.95)  LDD0632  [25]
 LDCM0316  AC53 HCT 116 C380(0.89)  LDD0633  [25]
 LDCM0317  AC54 HCT 116 C380(0.89)  LDD0634  [25]
 LDCM0318  AC55 HCT 116 C380(0.89)  LDD0635  [25]
 LDCM0319  AC56 HCT 116 C380(0.87)  LDD0636  [25]
 LDCM0320  AC57 HCT 116 C380(0.60)  LDD0637  [25]
 LDCM0321  AC58 HCT 116 C380(0.76)  LDD0638  [25]
 LDCM0322  AC59 HCT 116 C380(0.53)  LDD0639  [25]
 LDCM0323  AC6 HCT 116 C380(0.77)  LDD0640  [25]
 LDCM0324  AC60 HCT 116 C380(0.51)  LDD0641  [25]
 LDCM0325  AC61 HCT 116 C380(0.92)  LDD0642  [25]
 LDCM0326  AC62 HCT 116 C380(0.55)  LDD0643  [25]
 LDCM0327  AC63 HCT 116 C380(0.56)  LDD0644  [25]
 LDCM0328  AC64 HCT 116 C380(0.71)  LDD0645  [25]
 LDCM0329  AC65 HCT 116 C380(0.66)  LDD0646  [25]
 LDCM0330  AC66 HCT 116 C380(0.74)  LDD0647  [25]
 LDCM0331  AC67 HCT 116 C380(0.66)  LDD0648  [25]
 LDCM0332  AC68 HCT 116 C380(0.72)  LDD0649  [25]
 LDCM0333  AC69 HCT 116 C380(0.83)  LDD0650  [25]
 LDCM0334  AC7 HCT 116 C380(0.81)  LDD0651  [25]
 LDCM0335  AC70 HCT 116 C380(0.71)  LDD0652  [25]
 LDCM0336  AC71 HCT 116 C380(0.83)  LDD0653  [25]
 LDCM0337  AC72 HCT 116 C380(0.76)  LDD0654  [25]
 LDCM0338  AC73 HCT 116 C380(0.79)  LDD0655  [25]
 LDCM0339  AC74 HCT 116 C380(0.85)  LDD0656  [25]
 LDCM0340  AC75 HCT 116 C380(0.77)  LDD0657  [25]
 LDCM0341  AC76 HCT 116 C380(0.76)  LDD0658  [25]
 LDCM0342  AC77 HCT 116 C380(0.65)  LDD0659  [25]
 LDCM0343  AC78 HCT 116 C380(0.89)  LDD0660  [25]
 LDCM0344  AC79 HCT 116 C380(0.70)  LDD0661  [25]
 LDCM0345  AC8 HCT 116 C380(0.78)  LDD0662  [25]
 LDCM0346  AC80 HCT 116 C380(0.91)  LDD0663  [25]
 LDCM0347  AC81 HCT 116 C380(1.05)  LDD0664  [25]
 LDCM0348  AC82 HCT 116 C380(0.80)  LDD0665  [25]
 LDCM0349  AC83 HCT 116 C380(0.57)  LDD0666  [25]
 LDCM0350  AC84 HCT 116 C380(0.57)  LDD0667  [25]
 LDCM0351  AC85 HCT 116 C380(0.99)  LDD0668  [25]
 LDCM0352  AC86 HCT 116 C380(0.69)  LDD0669  [25]
 LDCM0353  AC87 HCT 116 C380(0.90)  LDD0670  [25]
 LDCM0354  AC88 HCT 116 C380(0.64)  LDD0671  [25]
 LDCM0355  AC89 HCT 116 C380(0.64)  LDD0672  [25]
 LDCM0357  AC90 HCT 116 C380(1.27)  LDD0674  [25]
 LDCM0358  AC91 HCT 116 C380(0.63)  LDD0675  [25]
 LDCM0359  AC92 HCT 116 C380(0.63)  LDD0676  [25]
 LDCM0360  AC93 HCT 116 C380(0.64)  LDD0677  [25]
 LDCM0361  AC94 HCT 116 C380(1.10)  LDD0678  [25]
 LDCM0362  AC95 HCT 116 C380(0.84)  LDD0679  [25]
 LDCM0363  AC96 HCT 116 C380(0.79)  LDD0680  [25]
 LDCM0364  AC97 HCT 116 C380(0.64)  LDD0681  [25]
 LDCM0365  AC98 HCT 116 C380(0.84)  LDD0682  [25]
 LDCM0366  AC99 HCT 116 C380(0.79)  LDD0683  [25]
 LDCM0248  AKOS034007472 HCT 116 C380(1.03)  LDD0565  [25]
 LDCM0356  AKOS034007680 HCT 116 C380(0.95)  LDD0673  [25]
 LDCM0275  AKOS034007705 HCT 116 C380(0.85)  LDD0592  [25]
 LDCM0156  Aniline NCI-H1299 11.37  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C451(0.35)  LDD2091  [10]
 LDCM0108  Chloroacetamide HeLa C380(0.00); C368(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C380(3.33)  LDD2227  [21]
 LDCM0367  CL1 HCT 116 C380(1.09)  LDD0684  [25]
 LDCM0368  CL10 HCT 116 C380(0.92)  LDD0685  [25]
 LDCM0369  CL100 HCT 116 C380(0.90)  LDD0686  [25]
 LDCM0370  CL101 HCT 116 C380(0.80)  LDD0687  [25]
 LDCM0371  CL102 HCT 116 C380(0.91)  LDD0688  [25]
 LDCM0372  CL103 HCT 116 C380(0.99)  LDD0689  [25]
 LDCM0373  CL104 HCT 116 C380(1.23)  LDD0690  [25]
 LDCM0374  CL105 HCT 116 C380(0.91)  LDD0691  [25]
 LDCM0375  CL106 HCT 116 C380(0.87)  LDD0692  [25]
 LDCM0376  CL107 HCT 116 C380(0.73)  LDD0693  [25]
 LDCM0377  CL108 HCT 116 C380(0.85)  LDD0694  [25]
 LDCM0378  CL109 HCT 116 C380(0.74)  LDD0695  [25]
 LDCM0379  CL11 HCT 116 C380(0.86)  LDD0696  [25]
 LDCM0380  CL110 HCT 116 C380(1.26)  LDD0697  [25]
 LDCM0381  CL111 HCT 116 C380(1.01)  LDD0698  [25]
 LDCM0382  CL112 HCT 116 C380(0.81)  LDD0699  [25]
 LDCM0383  CL113 HCT 116 C380(0.55)  LDD0700  [25]
 LDCM0384  CL114 HCT 116 C380(0.72)  LDD0701  [25]
 LDCM0385  CL115 HCT 116 C380(0.59)  LDD0702  [25]
 LDCM0386  CL116 HCT 116 C380(0.70)  LDD0703  [25]
 LDCM0387  CL117 HCT 116 C380(1.24)  LDD0704  [25]
 LDCM0388  CL118 HCT 116 C380(1.10)  LDD0705  [25]
 LDCM0389  CL119 HCT 116 C380(1.06)  LDD0706  [25]
 LDCM0390  CL12 HCT 116 C380(0.86)  LDD0707  [25]
 LDCM0391  CL120 HCT 116 C380(1.20)  LDD0708  [25]
 LDCM0392  CL121 HCT 116 C380(0.72)  LDD0709  [25]
 LDCM0393  CL122 HCT 116 C380(1.07)  LDD0710  [25]
 LDCM0394  CL123 HCT 116 C380(0.85)  LDD0711  [25]
 LDCM0395  CL124 HCT 116 C380(0.83)  LDD0712  [25]
 LDCM0396  CL125 HCT 116 C380(0.67)  LDD0713  [25]
 LDCM0397  CL126 HCT 116 C380(0.59)  LDD0714  [25]
 LDCM0398  CL127 HCT 116 C380(0.66)  LDD0715  [25]
 LDCM0399  CL128 HCT 116 C380(0.55)  LDD0716  [25]
 LDCM0400  CL13 HCT 116 C380(0.87)  LDD0717  [25]
 LDCM0401  CL14 HCT 116 C380(0.75)  LDD0718  [25]
 LDCM0402  CL15 HCT 116 C380(1.14)  LDD0719  [25]
 LDCM0403  CL16 HCT 116 C380(0.56)  LDD0720  [25]
 LDCM0404  CL17 HCT 116 C380(0.59)  LDD0721  [25]
 LDCM0405  CL18 HCT 116 C380(0.57)  LDD0722  [25]
 LDCM0406  CL19 HCT 116 C380(0.54)  LDD0723  [25]
 LDCM0407  CL2 HCT 116 C380(1.39)  LDD0724  [25]
 LDCM0408  CL20 HCT 116 C380(0.39)  LDD0725  [25]
 LDCM0409  CL21 HCT 116 C380(0.35)  LDD0726  [25]
 LDCM0410  CL22 HCT 116 C380(0.43)  LDD0727  [25]
 LDCM0411  CL23 HCT 116 C380(0.48)  LDD0728  [25]
 LDCM0412  CL24 HCT 116 C380(0.47)  LDD0729  [25]
 LDCM0413  CL25 HCT 116 C380(0.46)  LDD0730  [25]
 LDCM0414  CL26 HCT 116 C380(0.44)  LDD0731  [25]
 LDCM0415  CL27 HCT 116 C380(0.41)  LDD0732  [25]
 LDCM0416  CL28 HCT 116 C380(0.39)  LDD0733  [25]
 LDCM0417  CL29 HCT 116 C380(0.44)  LDD0734  [25]
 LDCM0418  CL3 HCT 116 C380(1.75)  LDD0735  [25]
 LDCM0419  CL30 HCT 116 C380(0.55)  LDD0736  [25]
 LDCM0420  CL31 HCT 116 C380(0.88)  LDD0737  [25]
 LDCM0421  CL32 HCT 116 C380(1.00)  LDD0738  [25]
 LDCM0422  CL33 HCT 116 C380(0.85)  LDD0739  [25]
 LDCM0423  CL34 HCT 116 C380(0.96)  LDD0740  [25]
 LDCM0424  CL35 HCT 116 C380(0.92)  LDD0741  [25]
 LDCM0425  CL36 HCT 116 C380(0.74)  LDD0742  [25]
 LDCM0426  CL37 HCT 116 C380(1.06)  LDD0743  [25]
 LDCM0428  CL39 HCT 116 C380(0.89)  LDD0745  [25]
 LDCM0429  CL4 HCT 116 C380(0.97)  LDD0746  [25]
 LDCM0430  CL40 HCT 116 C380(0.75)  LDD0747  [25]
 LDCM0431  CL41 HCT 116 C380(1.07)  LDD0748  [25]
 LDCM0432  CL42 HCT 116 C380(0.87)  LDD0749  [25]
 LDCM0433  CL43 HCT 116 C380(0.90)  LDD0750  [25]
 LDCM0434  CL44 HCT 116 C380(0.88)  LDD0751  [25]
 LDCM0435  CL45 HCT 116 C380(0.88)  LDD0752  [25]
 LDCM0436  CL46 HCT 116 C380(2.18)  LDD0753  [25]
 LDCM0437  CL47 HCT 116 C380(1.89)  LDD0754  [25]
 LDCM0438  CL48 HCT 116 C380(1.99)  LDD0755  [25]
 LDCM0439  CL49 HCT 116 C380(0.90)  LDD0756  [25]
 LDCM0440  CL5 HCT 116 C380(0.86)  LDD0757  [25]
 LDCM0441  CL50 HCT 116 C380(1.74)  LDD0758  [25]
 LDCM0442  CL51 HCT 116 C380(1.31)  LDD0759  [25]
 LDCM0443  CL52 HCT 116 C380(1.29)  LDD0760  [25]
 LDCM0444  CL53 HCT 116 C380(2.36)  LDD0761  [25]
 LDCM0445  CL54 HCT 116 C380(1.69)  LDD0762  [25]
 LDCM0446  CL55 HCT 116 C380(1.48)  LDD0763  [25]
 LDCM0447  CL56 HCT 116 C380(1.36)  LDD0764  [25]
 LDCM0448  CL57 HCT 116 C380(1.62)  LDD0765  [25]
 LDCM0449  CL58 HCT 116 C380(1.80)  LDD0766  [25]
 LDCM0450  CL59 HCT 116 C380(1.02)  LDD0767  [25]
 LDCM0451  CL6 HCT 116 C380(0.99)  LDD0768  [25]
 LDCM0452  CL60 HCT 116 C380(1.15)  LDD0769  [25]
 LDCM0453  CL61 HCT 116 C380(0.79)  LDD0770  [25]
 LDCM0454  CL62 HCT 116 C380(0.58)  LDD0771  [25]
 LDCM0455  CL63 HCT 116 C380(0.75)  LDD0772  [25]
 LDCM0456  CL64 HCT 116 C380(0.52)  LDD0773  [25]
 LDCM0457  CL65 HCT 116 C380(0.75)  LDD0774  [25]
 LDCM0458  CL66 HCT 116 C380(0.47)  LDD0775  [25]
 LDCM0459  CL67 HCT 116 C380(0.43)  LDD0776  [25]
 LDCM0460  CL68 HCT 116 C380(0.45)  LDD0777  [25]
 LDCM0461  CL69 HCT 116 C380(0.77)  LDD0778  [25]
 LDCM0462  CL7 HCT 116 C380(1.16)  LDD0779  [25]
 LDCM0463  CL70 HCT 116 C380(0.80)  LDD0780  [25]
 LDCM0464  CL71 HCT 116 C380(0.56)  LDD0781  [25]
 LDCM0465  CL72 HCT 116 C380(0.52)  LDD0782  [25]
 LDCM0466  CL73 HCT 116 C380(0.62)  LDD0783  [25]
 LDCM0467  CL74 HCT 116 C380(0.43)  LDD0784  [25]
 LDCM0469  CL76 HCT 116 C380(0.87)  LDD0786  [25]
 LDCM0470  CL77 HCT 116 C380(1.05)  LDD0787  [25]
 LDCM0471  CL78 HCT 116 C380(0.65)  LDD0788  [25]
 LDCM0472  CL79 HCT 116 C380(0.62)  LDD0789  [25]
 LDCM0473  CL8 HCT 116 C380(0.92)  LDD0790  [25]
 LDCM0474  CL80 HCT 116 C380(0.80)  LDD0791  [25]
 LDCM0475  CL81 HCT 116 C380(0.63)  LDD0792  [25]
 LDCM0476  CL82 HCT 116 C380(0.71)  LDD0793  [25]
 LDCM0477  CL83 HCT 116 C380(0.71)  LDD0794  [25]
 LDCM0478  CL84 HCT 116 C380(0.71)  LDD0795  [25]
 LDCM0479  CL85 HCT 116 C380(0.74)  LDD0796  [25]
 LDCM0480  CL86 HCT 116 C380(1.05)  LDD0797  [25]
 LDCM0481  CL87 HCT 116 C380(0.64)  LDD0798  [25]
 LDCM0482  CL88 HCT 116 C380(0.67)  LDD0799  [25]
 LDCM0483  CL89 HCT 116 C380(0.72)  LDD0800  [25]
 LDCM0484  CL9 HCT 116 C380(0.91)  LDD0801  [25]
 LDCM0485  CL90 HCT 116 C380(1.07)  LDD0802  [25]
 LDCM0486  CL91 HCT 116 C380(0.89)  LDD0803  [25]
 LDCM0487  CL92 HCT 116 C380(0.98)  LDD0804  [25]
 LDCM0488  CL93 HCT 116 C380(1.13)  LDD0805  [25]
 LDCM0489  CL94 HCT 116 C380(1.15)  LDD0806  [25]
 LDCM0490  CL95 HCT 116 C380(0.78)  LDD0807  [25]
 LDCM0491  CL96 HCT 116 C380(1.05)  LDD0808  [25]
 LDCM0492  CL97 HCT 116 C380(0.99)  LDD0809  [25]
 LDCM0493  CL98 HCT 116 C380(0.69)  LDD0810  [25]
 LDCM0494  CL99 HCT 116 C380(0.75)  LDD0811  [25]
 LDCM0495  E2913 HEK-293T C380(0.89); C118(1.13); C444(1.02); C209(1.33)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C380(0.58)  LDD1702  [10]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [11]
 LDCM0625  F8 Ramos C380(1.67)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C380(1.89)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C380(0.17); C444(20.00)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C380(1.97)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C380(1.14)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C380(2.75); C444(3.57)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C380(2.41)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C380(1.12)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C380(0.58)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C380(0.99)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C380(0.59); C444(0.69)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C380(1.29)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C380(1.02)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C380(1.23)  LDD2201  [27]
 LDCM0468  Fragment33 HCT 116 C380(0.52)  LDD0785  [25]
 LDCM0596  Fragment38 Ramos C380(2.19)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C380(2.09)  LDD2184  [27]
 LDCM0427  Fragment51 HCT 116 C380(0.76)  LDD0744  [25]
 LDCM0610  Fragment52 Ramos C380(1.20)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C380(1.60)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C380(2.32)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C380(2.95)  LDD2188  [27]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [9]
 LDCM0022  KB02 HEK-293T C444(1.23); C380(0.86)  LDD1492  [26]
 LDCM0023  KB03 Jurkat C380(8.90); C368(18.76)  LDD0209  [12]
 LDCM0024  KB05 COLO792 C380(1.07)  LDD3310  [28]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C451(0.71)  LDD2092  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C451(0.55)  LDD2093  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C380(1.51)  LDD2099  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C451(0.94)  LDD2101  [10]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C451(1.37)  LDD2105  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C451(0.84); C380(0.98)  LDD2107  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C451(0.68); C380(0.75)  LDD2109  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C380(1.07)  LDD2111  [10]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C451(0.69)  LDD2114  [10]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C380(1.14)  LDD2119  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C451(0.43); C380(1.19)  LDD2123  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C380(0.86)  LDD2125  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C451(0.64)  LDD2127  [10]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C451(0.59)  LDD2134  [10]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C380(0.56)  LDD2135  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C451(1.09); C380(1.27)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C368(0.46)  LDD2137  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C451(0.46); C380(0.96)  LDD2140  [10]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C451(1.20)  LDD2143  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C380(1.62)  LDD2144  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C451(0.46)  LDD2146  [10]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C451(0.62)  LDD2148  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C368(0.92)  LDD2206  [29]
 LDCM0628  OTUB2-COV-1 HEK-293T C380(1.18); C368(1.02); C368(0.72)  LDD2207  [29]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

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2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
23 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
24 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
25 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
29 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.