Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C273  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 60 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 20.7
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 15.1
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 14.3
 LDTP01300  Cartilage-associated protein (CRTAP) 14.1
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 13.2
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 12.8
 LDTP02359  Heme oxygenase 1 (HMOX1) 12.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 12.6
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 11.6
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 11.3
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 11.2
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 11.1
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 10.9
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 10.9
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 10.3
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 10.3
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 9.3
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 9.0
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 8.9
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 8.9
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 8.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 8.6
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 8.6
 LDTP10329  Ceramide synthase 2 (CERS2) 7.9
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 7.7
 LDTP19851  Isochorismatase domain-containing protein 1 (ISOC1) 7.7
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 7.5
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 7.5
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 7.3
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 7.2
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 7.2
 LDTP11127  ADP-dependent glucokinase (ADPGK) 6.9
 LDTP02837  Beta-galactosidase (GLB1) 6.8
 LDTP06617  Ceramide glucosyltransferase (UGCG) 6.7
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 6.5
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 6.5
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 6.3
 LDTP13131  7-dehydrocholesterol reductase (DHCR7) 6.3
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 6.3
 LDTP05905  Acid ceramidase (ASAH1) 6.1
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 6.1
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 6.1
 LDTP06227  Prostaglandin reductase 1 (PTGR1) 6.0
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 5.8
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 5.7
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 5.7
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 5.7
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 5.5
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 5.4
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 5.4
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 5.3
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 5.3
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 5.3
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 5.2
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 5.1
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 5.1
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 5.1
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 5.0
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 5.0
 LDTP02868  Fumarylacetoacetase (FAH) 4.9
Transporter and channel
Click to Show/Hide to Show 48 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 34.8
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 18.4
 LDTP20002  Transmembrane protein 160 (TMEM160) 18.1
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 17.4
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 17.4
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 15.9
 LDTP15948  Transmembrane protein 126A (TMEM126A) 15.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 15.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 14.0
 LDTP16813  Tetraspanin-3 (TSPAN3) 13.8
 LDTP08881  Transmembrane protein 199 (TMEM199) 12.9
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 12.6
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 12.5
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 11.1
 LDTP12383  Protein GPR108 (GPR108) 10.9
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 10.8
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 10.1
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 9.7
 LDTP07236  Protein GPR107 (GPR107) 9.6
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 9.5
 LDTP05900  Metaxin-1 (MTX1) 9.4
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 9.0
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 8.9
 LDTP11213  Nucleoporin NDC1 (NDC1) 8.6
 LDTP11615  Protein tweety homolog 3 (TTYH3) 8.3
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 7.9
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.7
 LDTP15648  BRI3-binding protein (BRI3BP) 7.3
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 7.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 6.9
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 6.7
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 6.6
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 6.5
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 6.3
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 6.2
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 6.0
 LDTP01060  PRA1 family protein 2 (PRAF2) 5.8
 LDTP11245  Derlin-1 (DERL1) 5.7
 LDTP15000  Solute carrier family 35 member F1 (SLC35F1) 5.7
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 5.6
 LDTP04501  Importin subunit alpha-1 (KPNA2) 5.5
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 5.4
 LDTP09261  Major facilitator superfamily domain-containing protein 8 (MFSD8) 5.2
 LDTP09203  Nucleoporin Nup37 (NUP37) 5.2
 LDTP07667  Transmembrane protein 205 (TMEM205) 5.2
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 5.1
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 5.0
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 4.9
Other
Click to Show/Hide to Show 25 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 23.3
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 19.3
 LDTP00105  Protein unc-119 homolog B (UNC119B) 18.1
 LDTP14458  Tetraspanin-6 (TSPAN6) 14.0
 LDTP01522  Reticulon-3 (RTN3) 13.3
 LDTP18883  Protein CEBPZOS (CEBPZOS) 13.1
 LDTP14373  SAC3 domain-containing protein 1 (SAC3D1) 12.4
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 12.1
 LDTP11076  Apolipoprotein L2 (APOL2) 11.3
 LDTP05868  Protein unc-119 homolog A (UNC119) 10.3
 LDTP14939  Membralin (TMEM259) 8.1
 LDTP05160  Nucleobindin-2 (NUCB2) 8.1
 LDTP12412  Reticulon-4 (RTN4) 8.1
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 7.6
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 6.9
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 6.6
 LDTP10056  Protein FAM162A (FAM162A) 6.4
 LDTP01387  SEC14-like protein 2 (SEC14L2) 6.4
 LDTP16080  Protein FAM114A2 (FAM114A2) 6.1
 LDTP13086  Syntaxin-18 (STX18) 5.9
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 5.5
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 5.3
 LDTP00513  Plexin-B2 (PLXNB2) 5.2
 LDTP19963  TraB domain-containing protein (TRABD) 5.2
 LDTP08224  Protein LYRIC (MTDH) 5.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587