Details of the Target

General Information of Target

Target ID LDTP15648
Target Name BRI3-binding protein (BRI3BP)
Gene Name BRI3BP
Gene ID 140707
Synonyms
KG19; BRI3-binding protein; I3-binding protein; Cervical cancer 1 proto-oncogene-binding protein KG19; HCCRBP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQGTPGGGTRPGPSPVDRRTLLVFSFILAAALGQMNFTGDQVLRVLAKDEKQLSLLGDLE
GLKPQKVDFWRGPARPSLPVDMRVPFSELKDIKAYLESHGLAYSIMIKDIQVLLDEERQA
MAKSRRLERSTNSFSYSSYHTLEEIYSWIDNFVMEHSDIVSKIQIGNSFENQSILVLKFS
TGGSRHPAIWIDTGIHSREWITHATGIWTANKIVSDYGKDRVLTDILNAMDIFIELVTNP
DGFAFTHSMNRLWRKNKSIRPGIFCIGVDLNRNWKSGFGGNGSNSNPCSETYHGPSPQSE
PEVAAIVNFITAHGNFKALISIHSYSQMLMYPYGRLLEPVSNQRELYDLAKDAVEALYKV
HGIEYIFGSISTTLYVASGITVDWAYDSGIKYAFSFELRDTGQYGFLLPATQIIPTAQET
WMALRTIMEHTLNHPY
Target Bioclass
Transporter and channel
Subcellular location
Mitochondrion outer membrane
Function Involved in tumorigenesis and may function by stabilizing p53/TP53.
Uniprot ID
Q8WY22
Ensemble ID
ENST00000341446.9
HGNC ID
HGNC:14251

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K229(5.73)  LDD0277  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
PAL-AfBPP Probe
Click To Hide/Show 115 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		8.57  LDD1714  [3]
C007
 Probe Info  		5.35  LDD1716  [3]
C010
 Probe Info  		5.82  LDD1719  [3]
C017
 Probe Info  		11.96  LDD1725  [3]
C022
 Probe Info  		33.82  LDD1728  [3]
C026
 Probe Info  		5.62  LDD1732  [3]
C040
 Probe Info  		39.95  LDD1740  [3]
C041
 Probe Info  		11.88  LDD1741  [3]
C049
 Probe Info  		7.11  LDD1747  [3]
C053
 Probe Info  		9.13  LDD1751  [3]
C055
 Probe Info  		41.64  LDD1752  [3]
C056
 Probe Info  		88.65  LDD1753  [3]
C063
 Probe Info  		20.97  LDD1760  [3]
C064
 Probe Info  		9.38  LDD1761  [3]
C067
 Probe Info  		6.63  LDD1763  [3]
C070
 Probe Info  		34.54  LDD1766  [3]
C071
 Probe Info  		8.11  LDD1767  [3]
C072
 Probe Info  		18.25  LDD1768  [3]
C082
 Probe Info  		7.67  LDD1774  [3]
C087
 Probe Info  		7.46  LDD1779  [3]
C100
 Probe Info  		22.78  LDD1789  [3]
C106
 Probe Info  		99.73  LDD1793  [3]
C107
 Probe Info  		17.15  LDD1794  [3]
C108
 Probe Info  		25.99  LDD1795  [3]
C112
 Probe Info  		88.03  LDD1799  [3]
C130
 Probe Info  		8.63  LDD1812  [3]
C134
 Probe Info  		99.73  LDD1816  [3]
C135
 Probe Info  		36.76  LDD1817  [3]
C138
 Probe Info  		5.58  LDD1820  [3]
C139
 Probe Info  		14.12  LDD1821  [3]
C140
 Probe Info  		9.78  LDD1822  [3]
C141
 Probe Info  		15.89  LDD1823  [3]
C143
 Probe Info  		34.06  LDD1825  [3]
C153
 Probe Info  		33.82  LDD1834  [3]
C159
 Probe Info  		9.99  LDD1839  [3]
C160
 Probe Info  		7.21  LDD1840  [3]
C161
 Probe Info  		16.80  LDD1841  [3]
C163
 Probe Info  		11.24  LDD1843  [3]
C165
 Probe Info  		14.62  LDD1845  [3]
C166
 Probe Info  		7.89  LDD1846  [3]
C177
 Probe Info  		11.39  LDD1856  [3]
C178
 Probe Info  		61.39  LDD1857  [3]
C210
 Probe Info  		68.59  LDD1884  [3]
C215
 Probe Info  		6.32  LDD1889  [3]
C216
 Probe Info  		9.38  LDD1890  [3]
C217
 Probe Info  		9.19  LDD1891  [3]
C218
 Probe Info  		99.73  LDD1892  [3]
C219
 Probe Info  		18.38  LDD1893  [3]
C220
 Probe Info  		99.73  LDD1894  [3]
C225
 Probe Info  		11.39  LDD1898  [3]
C226
 Probe Info  		12.04  LDD1899  [3]
C228
 Probe Info  		94.35  LDD1901  [3]
C229
 Probe Info  		16.68  LDD1902  [3]
C231
 Probe Info  		83.29  LDD1904  [3]
C232
 Probe Info  		99.73  LDD1905  [3]
C233
 Probe Info  		26.72  LDD1906  [3]
C234
 Probe Info  		16.56  LDD1907  [3]
C235
 Probe Info  		99.73  LDD1908  [3]
C238
 Probe Info  		21.41  LDD1911  [3]
C240
 Probe Info  		8.69  LDD1913  [3]
C243
 Probe Info  		17.75  LDD1916  [3]
C244
 Probe Info  		15.45  LDD1917  [3]
C246
 Probe Info  		22.63  LDD1919  [3]
C249
 Probe Info  		13.00  LDD1922  [3]
C258
 Probe Info  		5.46  LDD1931  [3]
C264
 Probe Info  		47.18  LDD1935  [3]
C265
 Probe Info  		18.64  LDD1936  [3]
C270
 Probe Info  		7.57  LDD1940  [3]
C273
 Probe Info  		7.26  LDD1943  [3]
C277
 Probe Info  		22.01  LDD1947  [3]
C278
 Probe Info  		99.73  LDD1948  [3]
C280
 Probe Info  		12.30  LDD1950  [3]
C282
 Probe Info  		44.63  LDD1952  [3]
C284
 Probe Info  		50.21  LDD1954  [3]
C285
 Probe Info  		99.73  LDD1955  [3]
C287
 Probe Info  		39.67  LDD1957  [3]
C288
 Probe Info  		19.56  LDD1958  [3]
C289
 Probe Info  		99.73  LDD1959  [3]
C290
 Probe Info  		6.45  LDD1960  [3]
C293
 Probe Info  		73.52  LDD1963  [3]
C296
 Probe Info  		47.18  LDD1966  [3]
C299
 Probe Info  		15.78  LDD1968  [3]
C305
 Probe Info  		21.26  LDD1974  [3]
C307
 Probe Info  		6.59  LDD1975  [3]
C310
 Probe Info  		15.67  LDD1977  [3]
C313
 Probe Info  		21.56  LDD1980  [3]
C314
 Probe Info  		34.06  LDD1981  [3]
C317
 Probe Info  		8.88  LDD1983  [3]
C322
 Probe Info  		8.34  LDD1988  [3]
C326
 Probe Info  		15.35  LDD1990  [3]
C338
 Probe Info  		14.32  LDD2001  [3]
C339
 Probe Info  		15.56  LDD2002  [3]
C343
 Probe Info  		33.13  LDD2005  [3]
C355
 Probe Info  		56.49  LDD2016  [3]
C356
 Probe Info  		16.80  LDD2017  [3]
C357
 Probe Info  		7.73  LDD2018  [3]
C362
 Probe Info  		99.73  LDD2023  [3]
C363
 Probe Info  		19.43  LDD2024  [3]
C364
 Probe Info  		28.84  LDD2025  [3]
C366
 Probe Info  		8.94  LDD2027  [3]
C383
 Probe Info  		14.83  LDD2042  [3]
C386
 Probe Info  		7.62  LDD2045  [3]
C388
 Probe Info  		99.73  LDD2047  [3]
C397
 Probe Info  		11.71  LDD2056  [3]
C399
 Probe Info  		21.86  LDD2058  [3]
C403
 Probe Info  		62.25  LDD2061  [3]
C407
 Probe Info  		53.08  LDD2064  [3]
C424
 Probe Info  		8.46  LDD2079  [3]
C426
 Probe Info  		17.15  LDD2081  [3]
FFF probe11
 Probe Info  		20.00  LDD0471  [4]
JN0003
 Probe Info  		20.00  LDD0469  [4]
STS-2
 Probe Info  		N.A.  LDD0138  [5]
BD-F
 Probe Info  		D100(0.00); L99(0.00); D105(0.00)  LDD0024  [6]
LD-F
 Probe Info  		T96(0.00); L99(0.00); L98(0.00); V101(0.00)  LDD0015  [6]
OEA-DA
 Probe Info  		20.00  LDD0046  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
LETM1 domain-containing protein 1 (LETMD1) . Q6P1Q0
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane protein BRI3 (BRI3) BRI3 family O95415

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
4 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
5 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
6 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
7 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570