Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C163  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 89 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03540  Heme oxygenase 2 (HMOX2) 37.5
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 29.4
 LDTP02837  Beta-galactosidase (GLB1) 28.8
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 25.8
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 23.8
 LDTP00697  Cytochrome b5 type B (CYB5B) 21.3
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 21.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 19.3
 LDTP05905  Acid ceramidase (ASAH1) 19.2
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 18.4
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 17.5
 LDTP02359  Heme oxygenase 1 (HMOX1) 16.9
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 16.9
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 16.4
 LDTP06511  Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH) 15.6
 LDTP02505  Lysosomal protective protein (CTSA) 13.8
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 13.7
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 12.7
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 12.5
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 12.4
 LDTP01329  Lathosterol oxidase (SC5D) 11.9
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 11.5
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 11.2
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 10.8
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 10.6
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 10.6
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 10.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 10.5
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 10.3
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 10.1
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 10.0
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 9.8
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 9.8
 LDTP10329  Ceramide synthase 2 (CERS2) 9.7
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 9.7
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 9.6
 LDTP02264  Asparagine synthetase [glutamine-hydrolyzing] (ASNS) 9.6
 LDTP01769  Dihydrofolate reductase (DHFR) 9.4
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 9.3
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 9.1
 LDTP11127  ADP-dependent glucokinase (ADPGK) 8.9
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 8.9
 LDTP01300  Cartilage-associated protein (CRTAP) 8.8
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 8.6
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 8.6
 LDTP01141  E3 ubiquitin-protein ligase BRE1B (RNF40) 8.1
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 7.8
 LDTP04243  Fatty acid synthase (FASN) 7.7
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 7.7
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 7.7
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 7.6
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 7.4
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) 7.2
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 7.1
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 7.0
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 7.0
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 6.9
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 6.8
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 6.5
 LDTP03794  Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) 6.5
 LDTP12163  Calcyclin-binding protein (CACYBP) 6.5
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 6.4
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 6.4
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 6.4
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 6.3
 LDTP04209  Casein kinase I isoform alpha (CSNK1A1) 6.2
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 6.2
 LDTP00988  Protein O-GlcNAcase (OGA) 6.2
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 6.1
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 6.1
 LDTP13986  Vesicle transport protein GOT1B (GOLT1B) 6.1
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 6.1
 LDTP03900  ADP-ribosylation factor-like protein 1 (ARL1) 6.1
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 6.1
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 6.0
 LDTP06142  Squalene monooxygenase (SQLE) 6.0
 LDTP03024  Plasma membrane calcium-transporting ATPase 1 (ATP2B1) 6.0
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 5.9
 LDTP09155  Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) 5.9
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 5.9
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 5.9
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 5.9
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 5.9
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 5.8
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 5.8
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) 5.8
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 5.7
 LDTP08512  Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCAT) 5.6
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 5.6
Transporter and channel
Click to Show/Hide to Show 69 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 36.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 28.6
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 25.8
 LDTP16813  Tetraspanin-3 (TSPAN3) 23.4
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 22.3
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 21.7
 LDTP05900  Metaxin-1 (MTX1) 17.9
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 17.5
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 17.4
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 17.0
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 16.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 16.0
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 15.7
 LDTP11615  Protein tweety homolog 3 (TTYH3) 15.1
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 15.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 14.4
 LDTP09288  Vang-like protein 1 (VANGL1) 14.4
 LDTP12383  Protein GPR108 (GPR108) 14.3
 LDTP08881  Transmembrane protein 199 (TMEM199) 14.0
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 13.9
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 13.2
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 12.9
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 12.7
 LDTP20002  Transmembrane protein 160 (TMEM160) 12.7
 LDTP02215  Prosaposin (PSAP) 11.8
 LDTP07236  Protein GPR107 (GPR107) 11.6
 LDTP15648  BRI3-binding protein (BRI3BP) 11.2
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 11.2
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 10.7
 LDTP15948  Transmembrane protein 126A (TMEM126A) 10.6
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 9.8
 LDTP11213  Nucleoporin NDC1 (NDC1) 9.8
 LDTP04501  Importin subunit alpha-1 (KPNA2) 9.8
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 9.7
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 9.6
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 9.1
 LDTP09949  Transportin-1 (TNPO1) 8.8
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 8.4
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 8.2
 LDTP13262  Signal recognition particle subunit SRP68 (SRP68) 8.2
 LDTP16190  Protein FAM8A1 (FAM8A1) 8.1
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 8.1
 LDTP10065  Transmembrane protein 230 (TMEM230) 7.9
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 7.7
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 7.6
 LDTP13201  Vesicle transport through interaction with t-SNAREs homolog 1B (VTI1B) 7.6
 LDTP03380  Stomatin (STOM) 7.3
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 7.1
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 7.1
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 6.9
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 6.9
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 6.8
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 6.6
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 6.5
 LDTP11245  Derlin-1 (DERL1) 6.5
 LDTP01295  Nuclear pore complex protein Nup155 (NUP155) 6.5
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 6.1
 LDTP00592  Surfeit locus protein 4 (SURF4) 6.1
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 6.0
 LDTP07058  Transmembrane protein 201 (TMEM201) 6.0
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 5.9
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 5.9
 LDTP09515  Importin-4 (IPO4) 5.9
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 5.9
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.9
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 5.8
 LDTP05780  Syntaxin-5 (STX5) 5.8
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 5.7
 LDTP10343  Vacuole membrane protein 1 (VMP1) 5.6
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05572  Leukocyte surface antigen CD47 (CD47) 5.7
Other
Click to Show/Hide to Show 50 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 33.4
 LDTP01522  Reticulon-3 (RTN3) 28.6
 LDTP11076  Apolipoprotein L2 (APOL2) 25.1
 LDTP00105  Protein unc-119 homolog B (UNC119B) 23.8
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 20.0
 LDTP05160  Nucleobindin-2 (NUCB2) 17.6
 LDTP14458  Tetraspanin-6 (TSPAN6) 17.6
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 16.3
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 15.5
 LDTP13086  Syntaxin-18 (STX18) 15.5
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 14.3
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 13.6
 LDTP11140  Peroxiredoxin-like 2A (PRXL2A) 13.4
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 12.8
 LDTP05375  Nucleobindin-1 (NUCB1) 12.2
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 12.0
 LDTP12412  Reticulon-4 (RTN4) 11.3
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 11.2
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) 11.2
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 10.9
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 10.8
 LDTP05868  Protein unc-119 homolog A (UNC119) 10.7
 LDTP16080  Protein FAM114A2 (FAM114A2) 10.3
 LDTP02973  DNA repair protein XRCC1 (XRCC1) 10.1
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 9.7
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 9.2
 LDTP00859  Synaptogyrin-2 (SYNGR2) 9.1
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 8.5
 LDTP08594  Negative elongation factor C/D (NELFCD) 8.2
 LDTP19963  TraB domain-containing protein (TRABD) 7.8
 LDTP18272  Transmembrane protein 209 (TMEM209) 7.4
 LDTP07476  RAD50-interacting protein 1 (RINT1) 7.3
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 6.7
 LDTP08224  Protein LYRIC (MTDH) 6.6
 LDTP10304  Sororin (CDCA5) 6.5
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 6.3
 LDTP02927  Ganglioside GM2 activator (GM2A) 6.2
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L) 6.2
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 6.2
 LDTP18467  LYR motif-containing protein 2 (LYRM2) 6.2
 LDTP06373  Mitochondrial import receptor subunit TOM20 homolog (TOMM20) 6.1
 LDTP12830  U3 small nucleolar RNA-associated protein 6 homolog (UTP6) 6.1
 LDTP16006  Optic atrophy 3 protein (OPA3) 6.0
 LDTP16173  Disco-interacting protein 2 homolog B (DIP2B) 5.9
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 5.9
 LDTP10056  Protein FAM162A (FAM162A) 5.9
 LDTP06868  Angiomotin (AMOT) 5.8
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 5.8
 LDTP04947  DDB1- and CUL4-associated factor 7 (DCAF7) 5.8
 LDTP11326  FUN14 domain-containing protein 2 (FUNDC2) 5.7

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587