Details of the Target

General Information of Target

Target ID LDTP01141
Target Name E3 ubiquitin-protein ligase BRE1B (RNF40)
Gene Name RNF40
Gene ID 9810
Synonyms
BRE1B; KIAA0661; E3 ubiquitin-protein ligase BRE1B; BRE1-B; EC 2.3.2.27; 95 kDa retinoblastoma-associated protein; RBP95; RING finger protein 40; RING-type E3 ubiquitin transferase BRE1B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGPGNKRAAGDGGSGPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLA
ERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSS
APEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELE
LQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRL
QDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHL
AEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL
QGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATK
NSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN
REMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGV
SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPS
SRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELK
KAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKK
IADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLR
EKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQG
SLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREK
ESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVL
TKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRIYIS
Target Bioclass
Enzyme
Family
BRE1 family
Subcellular location
Nucleus
Function
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.; (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50.
Uniprot ID
O75150
Ensemble ID
ENST00000324685.11
HGNC ID
HGNC:16867

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.E70K DBIA    Probe Info 
C4II SNV: p.P584S DBIA    Probe Info 
CCK81 Deletion: p.G323AfsTer13 DBIA    Probe Info 
FUOV1 SNV: p.E613V DBIA    Probe Info 
MEWO Substitution: p.D218N DBIA    Probe Info 
NCIH2291 SNV: p.E276D DBIA    Probe Info 
NCIH23 SNV: p.G516A DBIA    Probe Info 
PC9 Substitution: p.P543L .
RBE SNV: p.K900R DBIA    Probe Info 
SHP77 SNV: p.E276D .
SNGM SNV: p.Q53R DBIA    Probe Info 
SW1116 SNV: p.H299Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K420(3.38); K517(6.30)  LDD0277  [2]
Probe 1
 Probe Info  		Y258(20.38); Y459(16.83)  LDD3495  [3]
BTD
 Probe Info  		C890(0.97)  LDD1700  [4]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [5]
AHL-Pu-1
 Probe Info  		C890(2.56)  LDD0169  [6]
HHS-475
 Probe Info  		Y258(0.74); Y928(13.17)  LDD0264  [7]
DBIA
 Probe Info  		C963(1.08); C968(1.08); C971(1.08); C890(0.93)  LDD0078  [8]
ATP probe
 Probe Info  		K498(0.00); K847(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C986(0.00); C890(0.00); C69(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C986(0.00); C890(0.00); C69(0.00); C210(0.00)  LDD0036  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C986(0.00); C890(0.00); C69(0.00); C210(0.00)  LDD0037  [10]
TFBX
 Probe Info  		C890(0.00); C951(0.00); C210(0.00)  LDD0027  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
Compound 11
 Probe Info  		N.A.  LDD2213  [13]
IPM
 Probe Info  		C951(0.00); C890(0.00)  LDD0005  [14]
VSF
 Probe Info  		N.A.  LDD0007  [14]
YN-1
 Probe Info  		D725(0.00); E724(0.00)  LDD0447  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Acrolein
 Probe Info  		C69(0.00); C950(0.00); C890(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
W1
 Probe Info  		N.A.  LDD0236  [18]
AOyne
 Probe Info  		14.00  LDD0443  [19]
NAIA_5
 Probe Info  		C986(0.00); C890(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C141
 Probe Info  		12.13  LDD1823  [21]
C163
 Probe Info  		8.06  LDD1843  [21]
C376
 Probe Info  		6.77  LDD2036  [21]
C414
 Probe Info  		11.55  LDD2070  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C890(0.87)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C210(0.87); C890(1.02)  LDD2112  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C210(1.10); C890(1.00)  LDD2152  [4]
 LDCM0025  4SU-RNA DM93 C111(4.35)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C890(2.56)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C890(1.01); C69(1.10); C948(0.83); C950(0.98)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C890(1.25); C948(0.74); C950(0.87); C951(0.68)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C890(1.17); C69(0.56); C948(0.37); C950(0.81)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C890(1.21); C69(0.54); C948(0.45); C950(0.88)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C890(1.15); C69(0.57); C948(0.46); C950(0.78)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C890(1.43); C69(0.93); C948(0.37); C950(0.95)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C890(1.05); C69(0.62); C948(0.36); C950(0.85)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C890(1.33); C69(0.57); C948(0.45); C950(0.86)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C890(1.23); C69(0.84); C948(0.42); C950(0.91)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C890(1.14); C69(0.67); C948(0.41); C950(0.86)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C890(1.39); C69(0.60); C948(0.45); C950(0.93)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C890(1.05); C69(0.70); C948(0.64); C950(0.79)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C890(1.11); C948(0.72); C950(0.87); C951(0.65)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C890(1.25); C69(0.59); C948(0.54); C950(0.89)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C890(1.31); C69(0.54); C948(0.50); C950(1.09)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C890(1.35); C69(0.58); C948(0.37); C950(0.90)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C890(0.63); C210(1.65); C948(0.93); C950(0.88)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C890(0.82); C210(1.73); C948(0.81); C950(0.86)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C890(0.91); C210(1.05); C948(0.80); C950(0.90)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C890(0.96); C210(1.26); C948(0.82); C950(1.06)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C890(1.01); C210(1.05); C948(0.80); C950(0.91)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C890(0.97); C210(1.02); C948(0.84); C950(0.87)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C890(0.92); C210(1.42); C948(0.84); C950(0.91)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C890(1.12); C948(0.94); C950(1.02); C951(1.00)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C890(0.77); C210(1.15); C948(0.86); C950(0.89)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C890(1.17); C210(1.36); C948(0.81); C950(0.91)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C890(0.89); C210(1.18); C948(0.94); C950(0.88)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C890(0.63); C210(1.46); C948(0.91); C950(0.94)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C890(0.98); C210(1.32); C948(0.91); C950(0.98)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C890(0.76); C210(1.26); C948(0.85); C950(0.89)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C890(0.84); C210(1.25); C948(0.88); C950(1.02)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C890(0.80); C210(1.43); C948(0.82); C950(0.91)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C890(0.86); C948(0.58); C950(0.70); C951(0.58)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C890(1.16); C948(0.45); C950(0.66); C951(0.45)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C890(1.14); C948(0.52); C950(0.74); C951(0.52)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C890(0.97); C948(0.60); C950(0.80); C951(0.60)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C890(1.15); C948(0.53); C950(0.79); C951(0.53)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C890(1.06); C948(0.65); C950(0.75); C951(0.65)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C890(1.27); C948(0.43); C950(0.87); C951(0.43)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C890(1.35); C948(0.47); C950(0.74); C951(0.47)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C890(1.14); C948(0.53); C950(0.86); C951(0.53)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C890(1.11); C948(0.50); C950(0.86); C951(0.50)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C890(1.83); C948(0.30); C950(0.93); C951(0.30)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C890(1.46); C948(0.41); C950(0.93); C951(0.41)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C890(0.96); C948(0.83); C950(0.96); C951(0.77)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C890(2.17); C948(0.30); C950(0.84); C951(0.30)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C890(2.80); C948(0.31); C950(0.95); C951(0.31)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C890(1.58); C948(0.49); C950(0.85); C951(0.49)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C890(1.14); C111(1.39); C133(1.39); C968(0.89)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C133(0.70); C968(0.76); C971(0.85); C963(0.92)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C133(0.78); C968(0.81); C971(0.93); C890(0.96)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C968(0.72); C133(0.77); C111(0.79); C971(0.88)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C968(0.74); C111(0.81); C986(0.88); C971(0.91)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C133(0.54); C111(0.56); C968(1.00); C986(1.01)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C133(0.65); C111(0.86); C968(0.87); C971(1.00)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C951(0.78); C948(0.80); C963(0.84); C968(0.90)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C133(0.72); C111(0.76); C971(0.81); C890(0.91)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C133(0.60); C111(0.72); C971(0.97); C968(1.12)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C968(0.65); C111(0.91); C986(0.91); C890(0.92)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C111(0.59); C968(0.88); C971(0.90); C963(0.99)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C890(1.03); C111(0.87); C133(1.01); C950(1.28)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C890(1.21); C111(0.67); C133(0.68); C950(1.42)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C890(1.03); C111(1.00); C133(0.79); C950(1.08)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C890(0.93); C111(0.97); C133(0.90); C950(1.12)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C951(0.65); C948(0.72); C950(0.80); C971(0.81)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C210(0.45); C951(0.47); C968(0.58); C971(0.62)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C951(0.75); C948(0.79); C210(0.80); C950(0.89)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C963(0.60); C968(0.60); C971(0.60); C948(0.68)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C210(0.72); C948(0.78); C950(0.79); C951(0.87)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C950(0.72); C210(0.76); C948(0.77); C951(0.78)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C948(0.88); C210(0.89); C968(0.89); C950(0.92)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C948(0.70); C951(0.76); C968(0.82); C210(0.82)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C210(0.83); C951(0.92); C948(0.99); C986(1.05)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C210(0.69); C950(0.79); C968(0.81); C971(0.86)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C210(0.54); C963(0.66); C971(0.77); C986(0.82)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C210(0.65); C963(0.67); C971(0.76); C986(0.79)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C968(0.63); C963(0.63); C971(0.64); C210(0.71)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C210(0.74); C986(0.82); C963(0.88); C971(0.90)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C963(0.63); C968(0.63); C971(0.63); C948(0.70)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C210(0.60); C963(0.61); C986(0.67); C971(0.73)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C210(0.55); C963(0.75); C986(0.78); C968(0.78)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C963(0.53); C210(0.56); C971(0.67); C968(0.71)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C210(0.59); C963(0.70); C971(0.76); C968(0.79)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C986(0.56); C963(0.57); C210(0.64); C971(0.68)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C963(0.80); C986(0.87); C968(0.88); C971(0.88)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C948(0.71); C950(0.86); C968(0.90); C971(0.90)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C963(0.75); C968(0.82); C971(0.82); C948(0.89)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C968(0.87); C971(0.87); C948(0.91); C963(1.00)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C963(0.50); C968(0.59); C971(0.59); C210(0.93)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C963(0.51); C968(0.51); C971(0.51); C948(0.64)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C963(0.81); C968(0.95); C971(0.95); C890(1.11)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C963(0.77); C948(0.79); C968(0.84); C971(0.84)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C968(0.76); C971(0.76); C963(0.80); C948(0.81)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C963(0.61); C968(0.88); C971(0.88); C210(0.93)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C948(0.84); C968(0.89); C971(0.89); C950(0.89)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C963(0.79); C968(0.85); C971(0.85); C948(0.88)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C890(0.93); C948(0.98); C111(0.98); C133(0.98)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C971(0.90); C968(0.91); C948(0.93); C890(0.93)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C890(0.77); C963(0.97); C968(0.97); C971(1.03)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C111(0.70); C133(0.70); C986(0.83); C948(0.85)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C963(0.33); C968(0.33); C971(0.33); C948(0.64)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C111(0.90); C133(0.90); C890(0.93); C948(1.04)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C890(0.86); C111(1.00); C133(1.00); C968(1.04)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C111(0.78); C133(0.78); C968(0.85); C948(0.86)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C948(0.78); C950(0.79); C986(0.83); C968(0.99)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C111(0.61); C133(0.61); C890(0.84); C986(0.88)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C948(0.94); C111(1.00); C133(1.00); C950(1.00)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C890(0.89); C948(1.11); C950(1.14); C986(1.39)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C948(0.71); C950(0.71); C951(0.75); C986(0.91)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C948(0.60); C950(0.60); C951(0.70); C963(1.20)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C948(0.70); C950(0.70); C951(0.70); C963(0.88)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C951(0.77); C948(0.85); C963(0.89); C950(0.97)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C951(0.66); C948(0.67); C950(0.67); C963(1.05)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C948(0.71); C950(0.71); C951(0.81); C986(1.08)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C948(0.67); C950(0.67); C951(0.81); C963(0.83)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C951(0.67); C948(0.70); C950(0.70); C963(0.83)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C948(0.57); C950(0.57); C951(0.64); C963(0.86)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C948(0.54); C950(0.54); C951(0.71); C986(0.73)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C948(0.55); C950(0.55); C951(0.60); C986(0.65)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C948(0.59); C950(0.59); C986(0.63); C951(0.72)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C968(0.83); C963(0.87); C971(0.87); C69(0.88)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C69(0.80); C890(0.89); C950(0.92); C951(0.92)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C963(0.61); C951(0.72); C948(0.81); C968(0.88)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C951(0.81); C986(0.82); C69(0.84); C968(0.88)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C69(0.73); C890(0.95); C986(1.00); C963(1.01)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C69(0.75); C968(0.86); C963(0.94); C971(0.94)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C968(1.00); C69(1.02); C963(1.03); C971(1.03)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C968(0.91); C69(0.92); C963(0.99); C971(0.99)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C968(1.08); C963(1.10); C971(1.10); C950(1.19)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C69(0.82); C951(0.95); C968(0.97); C963(0.98)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C968(0.76); C963(0.90); C971(0.90); C951(0.93)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C968(0.86); C963(0.89); C971(0.89); C69(0.95)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C968(0.76); C963(0.85); C971(0.85); C69(0.95)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C963(0.63); C986(0.70); C951(0.74); C948(0.75)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C69(0.89); C951(0.93); C968(0.97); C963(1.01)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C968(0.80); C963(0.85); C971(0.85); C69(0.90)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C69(0.85); C963(1.02); C971(1.02); C968(1.04)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C986(0.80); C963(0.84); C971(0.84); C968(0.88)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C986(0.67); C948(0.75); C963(0.93); C971(0.93)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C986(0.69); C948(0.94); C963(1.03); C971(1.03)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C948(0.83); C986(0.86); C950(0.96); C963(0.96)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C951(0.87); C968(0.95); C963(0.95); C971(0.95)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C986(0.75); C948(0.82); C950(0.85); C963(0.90)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C986(0.90); C950(0.91); C948(0.91); C963(0.93)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C963(0.85); C971(0.85); C950(0.98); C968(1.00)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C948(0.84); C986(0.85); C950(0.95); C963(1.20)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C963(0.81); C971(0.81); C986(0.82); C948(0.82)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C986(0.68); C963(0.75); C971(0.75); C948(0.80)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C986(0.65); C963(0.84); C971(0.84); C948(0.98)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C948(0.91); C951(0.92); C963(1.16); C971(1.16)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C986(0.83); C948(0.89); C950(1.01); C963(1.08)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C986(0.65); C948(0.85); C963(0.93); C971(0.93)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C951(0.26); C948(0.38); C963(0.61); C971(0.61)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C951(0.41); C948(0.58); C963(0.61); C971(0.61)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C890(1.09); C948(1.07); C950(1.11); C951(1.05)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C963(0.58); C951(0.74); C948(0.78); C950(0.88)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C951(0.65); C948(0.71); C963(0.72); C968(0.92)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 12.03  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C963(1.08); C968(1.08); C971(1.08); C890(0.93)  LDD0078  [8]
 LDCM0108  Chloroacetamide HeLa C890(0.00); C69(0.00); C210(0.00); H229(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C890(0.49)  LDD2227  [20]
 LDCM0367  CL1 HCT 116 C948(0.85); C951(0.85); C69(0.86); C111(0.89)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C69(1.09); C950(1.14); C963(1.16); C971(1.16)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C963(0.55); C968(0.55); C971(0.55); C948(0.67)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C951(0.74); C948(0.79); C950(0.87); C890(0.89)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C951(1.04); C948(1.06); C950(1.07); C890(1.10)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C890(0.93); C948(0.94); C950(0.95); C951(1.02)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C963(0.76); C986(0.93); C948(1.01); C950(1.06)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C951(0.49); C948(0.55); C950(0.62); C968(0.66)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C951(0.50); C948(0.58); C950(0.65); C968(0.74)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C951(0.39); C948(0.40); C968(0.56); C971(0.58)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C951(0.38); C948(0.42); C950(0.51); C968(0.63)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C951(0.60); C948(0.61); C950(0.71); C210(0.75)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C948(0.74); C951(0.74); C950(0.85); C986(1.23)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C948(0.49); C951(0.49); C968(0.68); C950(0.70)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C948(0.50); C951(0.60); C210(0.66); C968(0.73)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C963(0.64); C986(0.78); C210(0.82); C971(0.82)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C210(0.51); C963(0.58); C986(0.62); C971(0.63)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C963(0.70); C210(0.70); C986(0.81); C968(0.86)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C210(0.61); C963(0.65); C968(0.69); C971(0.69)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C210(0.62); C963(0.63); C971(0.65); C968(0.67)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C963(0.73); C986(0.84); C968(0.93); C971(0.93)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C963(0.66); C968(0.81); C971(0.81); C210(0.94)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C963(0.78); C968(0.79); C971(0.79); C210(1.01)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C948(0.91); C951(0.91); C950(1.02); C890(1.20)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C963(0.70); C968(0.79); C971(0.79); C210(1.02)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C210(1.02); C950(1.08); C948(1.15); C890(1.20)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C986(0.79); C968(0.89); C948(0.93); C111(0.93)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C948(0.74); C950(0.75); C963(0.77); C968(0.80)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C948(0.80); C950(0.87); C968(1.03); C986(1.03)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C948(0.67); C950(0.67); C951(0.68); C963(0.91)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C948(0.54); C950(0.54); C951(0.63); C963(0.84)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C948(0.76); C950(0.76); C951(0.98); C963(1.02)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C948(0.63); C950(0.63); C951(0.73); C963(1.00)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C948(0.86); C951(0.86); C950(1.05); C890(1.19)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C948(0.80); C951(0.80); C950(1.01); C69(1.06)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C948(0.94); C951(0.94); C69(1.01); C963(1.02)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C950(0.84); C948(0.85); C210(0.89); C986(0.92)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C111(0.63); C133(0.63); C951(0.78); C948(0.81)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C890(1.00); C951(1.02); C210(1.04); C950(1.13)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C950(0.83); C948(0.92); C210(1.01); C951(1.04)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C111(0.78); C133(0.78); C69(0.88); C950(1.03)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C950(0.76); C948(0.79); C210(0.85); C951(1.02)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C950(0.71); C210(0.88); C986(0.91); C948(0.95)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C951(0.88); C948(0.98); C950(1.09); C210(1.16)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C951(0.78); C210(0.87); C948(0.92); C986(1.06)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C890(1.32); C111(3.51); C133(3.51); C210(1.25)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C890(1.33); C111(4.99); C133(4.99); C210(0.72)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C890(1.53); C111(1.85); C133(1.85); C210(0.95)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C890(1.10); C111(2.08); C133(2.08); C210(0.88)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C890(1.36); C111(2.51); C133(2.51); C210(1.16)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C890(1.34); C111(2.34); C133(2.34); C210(1.23)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C890(0.93); C111(1.48); C133(1.48); C69(0.95)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C890(1.25); C111(1.64); C133(1.64); C210(0.90)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C890(1.54); C111(1.20); C133(1.20); C210(0.77)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C890(1.27); C111(1.53); C133(1.53); C210(1.10)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C890(1.48); C111(1.68); C133(1.68); C210(0.58)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C890(1.08); C111(0.71); C133(0.71); C210(0.59)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C890(1.08); C111(0.99); C133(0.99); C210(0.84)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C890(1.12); C111(1.21); C133(1.21); C210(0.67)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C890(1.14); C111(3.52); C133(3.52); C210(0.75)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C890(1.05); C111(1.30); C133(1.30); C210(0.66)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C890(1.15); C111(3.88); C133(3.88); C69(0.98)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C890(2.47); C111(1.55); C133(1.55); C210(0.70)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C890(1.21); C111(1.03); C133(1.03); C210(0.70)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C890(0.92); C111(1.50); C133(1.50); C210(0.81)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C890(0.99); C111(1.51); C133(1.51); C210(1.02)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C890(0.98); C111(1.78); C133(1.78); C210(0.82)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C890(0.93); C111(3.13); C133(3.13); C210(0.72)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C890(1.39); C111(0.65); C133(0.65); C948(0.97)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C890(1.02); C111(0.42); C133(0.42); C948(1.16)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C890(0.93); C111(0.78); C133(0.78); C948(0.98)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C890(0.83); C111(5.12); C133(5.12); C948(1.01)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C890(1.06); C111(1.31); C133(1.31); C69(1.14)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C890(0.88); C111(4.09); C133(4.09); C948(1.25)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C890(0.94); C111(0.80); C133(0.80); C948(1.26)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C890(1.25); C111(0.71); C133(0.71); C948(1.09)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C890(1.16); C111(0.77); C133(0.77); C948(0.87)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C890(1.06); C111(2.67); C133(2.67); C948(0.90)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C890(1.14); C111(0.51); C133(0.51); C948(0.96)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C890(1.08); C111(0.67); C133(0.67); C948(0.89)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C890(1.15); C111(0.92); C133(0.92); C948(1.30)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C890(1.07); C111(0.71); C133(0.71); C948(1.05)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C890(0.99); C111(0.71); C133(0.71); C948(1.44)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C890(1.16); C111(1.78); C133(1.78); C69(0.95)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C890(1.28); C111(1.07); C133(1.07); C948(1.12)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C890(1.36); C111(1.00); C133(1.00); C210(0.76)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C890(1.25); C111(1.22); C133(1.22); C210(1.05)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C890(0.95); C111(1.29); C133(1.29); C210(1.28)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C890(1.01); C111(2.41); C133(2.41); C210(0.75)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C890(1.01); C111(1.07); C133(1.07); C210(0.99)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C890(1.03); C111(1.98); C133(1.98); C210(0.68)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C890(1.04); C111(0.91); C133(0.91); C210(0.70)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C890(1.35); C111(1.78); C133(1.78); C210(0.78)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C890(1.32); C111(1.58); C133(1.58); C210(1.08)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C890(1.08); C111(2.72); C133(2.72); C69(1.40)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C890(1.10); C111(1.54); C133(1.54); C210(1.16)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C890(1.20); C111(1.35); C133(1.35); C210(0.85)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C890(1.14); C111(0.90); C133(0.90); C210(1.20)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C890(1.11); C111(2.68); C133(2.68); C210(0.57)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C890(0.98); C111(1.06); C133(1.06); C210(0.73)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C890(1.17); C948(1.18); C950(1.14); C951(1.19)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C890(1.04); C948(1.13); C950(1.01); C951(1.58)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C890(1.04); C948(1.07); C950(0.93); C951(1.33)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C890(1.27); C948(1.06); C950(0.94); C951(1.52)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C890(1.63); C111(2.01); C133(2.01); C69(1.20)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C890(1.01); C948(1.58); C950(1.23); C951(2.32)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C890(1.14); C948(1.21); C950(1.05); C951(1.76)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C890(0.93); C948(1.13); C950(1.01); C951(1.62)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C890(1.14); C948(0.97); C950(0.90); C951(1.25)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C890(1.16); C948(0.91); C950(0.86); C951(1.11)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C890(1.11); C948(0.92); C950(0.90); C951(1.05)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C890(1.04); C948(1.03); C950(0.85); C951(1.57)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C890(1.58); C948(1.04); C950(0.95); C951(1.16)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C890(0.88); C948(0.93); C950(0.93); C951(1.13)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C890(0.93); C948(1.11); C950(1.05); C951(1.51)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C890(1.41); C111(1.16); C133(1.16); C69(1.29)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C890(1.66); C948(1.11); C950(1.26); C951(1.09)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C890(1.04); C69(1.24); C948(0.84); C950(1.27)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C890(0.87); C69(1.17); C948(0.77); C950(0.89)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C890(0.80); C69(0.74); C948(0.88); C950(1.08)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C890(1.24); C69(1.03); C948(0.78); C950(1.08)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C890(1.54); C69(1.28); C948(0.81); C950(0.84)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C890(0.77); C69(0.92); C948(0.69); C950(0.93)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C890(0.89); C69(1.34); C948(0.75); C950(0.93)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C890(1.36); C69(1.31); C948(0.64); C950(1.16)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C890(1.43); C69(1.65); C948(0.73); C950(1.11)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C69(0.93); C890(0.89); C986(0.97); C950(0.84)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C890(6.39); C950(0.99)  LDD1702  [4]
 LDCM0625  F8 Ramos C890(1.17)  LDD2187  [23]
 LDCM0572  Fragment10 MDA-MB-231 C890(4.21)  LDD1465  [5]
 LDCM0573  Fragment11 MDA-MB-231 C890(1.13)  LDD1467  [5]
 LDCM0574  Fragment12 Ramos C890(0.59)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C890(1.08)  LDD2192  [23]
 LDCM0576  Fragment14 MDA-MB-231 C890(1.07)  LDD1471  [5]
 LDCM0579  Fragment20 Ramos C890(0.73)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C890(0.77)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C890(0.79)  LDD2196  [23]
 LDCM0578  Fragment27 MDA-MB-231 C890(1.20)  LDD1474  [5]
 LDCM0586  Fragment28 Ramos C890(0.67)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C890(1.09)  LDD2199  [23]
 LDCM0589  Fragment31 MDA-MB-231 C890(0.68)  LDD1477  [5]
 LDCM0590  Fragment32 Ramos C890(2.80)  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C890(1.38); C111(1.34); C133(1.34); C210(0.89)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C890(0.56)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C890(1.12)  LDD2184  [23]
 LDCM0599  Fragment41 MDA-MB-231 C890(1.26)  LDD1481  [5]
 LDCM0427  Fragment51 HCT 116 C890(7.14); C111(1.96); C133(1.96); C210(0.96)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C890(0.77)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C890(0.92)  LDD2205  [23]
 LDCM0617  Fragment63-S Jurkat _(5.54)  LDD1490  [5]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [5]
 LDCM0571  Fragment9 Ramos C890(0.92)  LDD2188  [23]
 LDCM0116  HHS-0101 DM93 Y258(0.74); Y928(13.17)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y258(2.45)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y258(11.10)  LDD0266  [7]
 LDCM0120  HHS-0701 DM93 Y258(4.69)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HCT 116 C890(12.58); C950(1.17)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C890(1.68); C950(1.00)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C890(4.62); C950(1.05)  LDD0082  [8]
 LDCM0169  KB63 Ramos 9.51  LDD0432  [24]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C890(1.00)  LDD2090  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C890(0.76)  LDD2096  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C890(0.69)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C210(0.40); C890(0.94)  LDD2100  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C890(0.99)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C890(0.67); C69(0.71)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C890(0.58)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C890(0.37)  LDD2109  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C210(0.44)  LDD2114  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C210(0.94)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C890(0.52)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C890(1.05)  LDD2126  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C210(0.64)  LDD2128  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C69(0.71)  LDD2136  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C890(0.97)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C890(0.52)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C890(0.56)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C210(1.67)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C210(1.04); C890(0.72)  LDD2146  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C210(1.01)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C890(1.88)  LDD2153  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C950(3.19)  LDD2206  [25]
 LDCM0628  OTUB2-COV-1 HEK-293T C950(0.41)  LDD2207  [25]
 LDCM0131  RA190 MM1.R C890(1.67)  LDD0304  [26]
 LDCM0021  THZ1 HCT 116 C950(1.20); C890(1.09); C986(1.03); C69(0.96)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase BRE1A (RNF20) BRE1 family Q5VTR2
Dual specificity phosphatase 29 (DUSP29) Protein-tyrosine phosphatase family Q68J44
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Nuclear cap-binding protein subunit 1 (NCBP1) NCBP1 family Q09161
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin-like protein 2 (AMOTL2) Angiomotin family Q9Y2J4
Retinoblastoma-associated protein (RB1) Retinoblastoma protein (RB) family P06400
Swi5-dependent recombination DNA repair protein 1 homolog (SFR1) SFR1/MEI5 family Q86XK3
Zinc finger CCHC domain-containing protein 12 (ZCCHC12) ZCCHC12 family Q6PEW1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
25 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
26 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.