Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment11  Competitor Info 
Competitor Concentration 100 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 80 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03786  Glutaredoxin-1 (GLRX) C23 20.0
 LDTP02502  Thioredoxin (TXN) C32 13.0
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) C138 9.2
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 4.3
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 4.1
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 3.7
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 3.4
 LDTP03163  Sterol carrier protein 2 (SCP2) C94 3.3
 LDTP03163  Sterol carrier protein 2 (SCP2) C307 2.9
 LDTP10973  Thioredoxin, mitochondrial (TXN2) C90 2.7
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C57 2.2
 LDTP10785  Ubiquitin carboxyl-terminal hydrolase 28 (USP28) C171 2.2
 LDTP12627  Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (DECR2) C22 2.1
 LDTP03163  Sterol carrier protein 2 (SCP2) C71 2.0
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) C216 1.9
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.8
 LDTP09200  FAD synthase (FLAD1) C499 1.6
 LDTP00013  Ubiquitin-like modifier-activating enzyme 6 (UBA6) C347 1.6
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 1.5
 LDTP15290  5'-nucleotidase domain-containing protein 3 (NT5DC3) C276 1.4
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 1.4
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.4
 LDTP13980  Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2) C105 1.3
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 1.3
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 1.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.2
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.2
 LDTP14155  Serine/threonine-protein kinase MRCK beta (CDC42BPB) C1517 1.2
 LDTP02223  Cathepsin B (CTSB) C211 1.1
 LDTP01141  E3 ubiquitin-protein ligase BRE1B (RNF40) C890 1.1
 LDTP18330  Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5) C392 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.1
 LDTP16095  Ethylmalonyl-CoA decarboxylase (ECHDC1) C133 1.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.0
 LDTP08401  All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2) C71 1.0
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C223 1.0
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C758 1.0
 LDTP01220  Mitochondrial-processing peptidase subunit beta (PMPCB) C265 1.0
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 1.0
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 1.0
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 0.9
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) C317 0.9
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) C773 0.9
 LDTP03770  Alpha-adducin (ADD1) C68 0.9
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 0.9
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 0.9
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 0.9
 LDTP18123  Isochorismatase domain-containing protein 2 (ISOC2) C114 0.9
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.8
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 0.8
 LDTP13719  Ubiquitin carboxyl-terminal hydrolase 22 (USP22) C171 0.8
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 0.8
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 0.8
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 0.8
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 0.8
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C114 0.8
 LDTP00479  Histone acetyltransferase type B catalytic subunit (HAT1) C101 0.8
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 0.8
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119 0.7
 LDTP03000  General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) C342 0.7
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.7
 LDTP04374  Dynamin-2 (DNM2) C27 0.7
 LDTP07407  Desumoylating isopeptidase 1 (DESI1) C108 0.7
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 0.7
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.7
 LDTP12313  Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (ALG13) C86 0.7
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 0.6
 LDTP06320  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) C71 0.6
 LDTP05289  AMP deaminase 2 (AMPD2) C107 0.6
 LDTP05859  Integrin-linked protein kinase (ILK) C346 0.6
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 0.6
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.6
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 0.6
 LDTP03496  Protein PML (PML) C389 0.5
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) C436 0.5
 LDTP03400  Deoxycytidine kinase (DCK) C9 0.5
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C54 0.3
 LDTP03258  Thymidylate kinase (DTYMK) C163 0.2
Transporter and channel
Click to Show/Hide to Show 15 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 17.7
 LDTP10642  Chloride intracellular channel protein 6 (CLIC6) C487 3.1
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 2.5
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.9
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 1.4
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 1.3
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 1.3
 LDTP05591  Nuclear cap-binding protein subunit 1 (NCBP1) C44 1.1
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) C100 1.0
 LDTP13498  Nuclear pore complex protein Nup50 (NUP50) C151 1.0
 LDTP05252  Clathrin heavy chain 1 (CLTC) C870 0.9
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 0.8
 LDTP00501  Exportin-1 (XPO1) C528 0.7
 LDTP04801  Gasdermin-D (GSDMD) C268 0.7
 LDTP02735  G2/mitotic-specific cyclin-B1 (CCNB1) C238 0.7
Transcription factor
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 7.6
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.2
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 1.1
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 1.0
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 1.0
 LDTP03280  COUP transcription factor 2 (NR2F2) C326 0.9
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 0.7
Other
Click to Show/Hide to Show 70 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 20.0
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 20.0
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) C391 3.0
 LDTP12800  Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) C22 2.3
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.8
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 1.7
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 1.6
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 1.4
 LDTP07205  Telomere-associated protein RIF1 (RIF1) C2298 1.3
 LDTP09650  LIM domain only protein 7 (LMO7) C228 1.3
 LDTP04487  Cyclin-H (CCNH) C244 1.3
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 1.3
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 1.2
 LDTP01532  ZW10 interactor (ZWINT) C54 1.2
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.2
 LDTP12753  Succinate dehydrogenase assembly factor 2, mitochondrial (SDHAF2) C83 1.1
 LDTP15896  Ashwin (C2orf49) C10 1.1
 LDTP06330  Plectin (PLEC) C4574 1.1
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.1
 LDTP05867  Treacle protein (TCOF1) C38 1.1
 LDTP12412  Reticulon-4 (RTN4) C1101 1.1
 LDTP06362  Leucine-rich repeat-containing protein 41 (LRRC41) C297 1.1
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C645 1.0
 LDTP13705  LIM and calponin homology domains-containing protein 1 (LIMCH1) C140 1.0
 LDTP08094  Wings apart-like protein homolog (WAPL) C160 1.0
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.0
 LDTP00306  Pescadillo homolog (PES1) C272 1.0
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 1.0
 LDTP17182  Uncharacterized protein C3orf38 (C3orf38) C308 1.0
 LDTP06276  MAD2L1-binding protein (MAD2L1BP) C124 1.0
 LDTP12443  Anillin (ANLN) C712 0.9
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 0.9
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 0.9
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 0.9
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 0.9
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 0.9
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C439 0.9
 LDTP13580  Coronin-1C (CORO1C) C420 0.9
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 0.9
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 0.9
 LDTP09626  Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) C464 0.9
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 0.9
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 0.9
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 0.8
 LDTP05867  Treacle protein (TCOF1) C1298 0.8
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C518 0.8
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.8
 LDTP14215  Small ribosomal subunit protein mS40 (MRPS18B) C128 0.8
 LDTP12571  LanC-like protein 2 (LANCL2) C187 0.8
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C819 0.8
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) C18 0.8
 LDTP12963  Ankycorbin (RAI14) C973 0.8
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 0.8
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 0.8
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 0.7
 LDTP00229  Copper transport protein ATOX1 (ATOX1) C12 0.7
 LDTP10284  Multivesicular body subunit 12A (MVB12A) C231 0.7
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 0.7
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.6
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 0.6
 LDTP10864  Calponin-2 (CNN2) C164 0.6
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 0.6
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C629 0.6
 LDTP04434  Host cell factor 1 (HCFC1) C1872 0.5
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C72 0.5
 LDTP18494  Tropomodulin-3 (TMOD3) C132 0.5
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) C235 0.5
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 0.5
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 0.4
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 0.4

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.