Details of the Target

General Information of Target

Target ID LDTP04434
Target Name Host cell factor 1 (HCFC1)
Gene Name HCFC1
Gene ID 3054
Synonyms
HCF1; HFC1; Host cell factor 1; HCF; HCF-1; C1 factor; CFF; VCAF; VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELH
VYNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEW
KRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRP
GSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIDTL
TWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLN
LDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLE
TEKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSV
PANPPKSPAPAAAAPAVQPLTQVGITLLPQAAPAPPTTTTIQVLPTVPGSSISVPTAART
QGVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSS
PQMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTMAVTPGTTTLPATVKVASSPV
MVSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKT
ITLVKSPISVPGGSALISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGT
ILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSPSTTKPGTTTIIKTIPMSAIITQ
AGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPG
QPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGGH
STSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQPTQV
TLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPGTVTLVCSNPPCET
HETGTTNTATTTVVANLGGHPQPTQVQFVCDRQEAAASLVTSTVGQQNGSVVRVCSNPPC
ETHETGTTNTATTATSNMAGQHGCSNPPCETHETGTTNTATTAMSSVGANHQRDARRACA
AGTPAVIRISVATGALEAAQGSKSQCQTRQTSATSTTMTVMATGAPCSAGPLLGPSMARE
PGGRSPAFVQLAPLSSKVRLSSPSIKDLPAGRHSHAVSTAAMTRSSVGAGEPRMAPVCES
LQGGSPSTTVTVTALEALLCPSATVTQVCSNPPCETHETGTTNTATTSNAGSAQRVCSNP
PCETHETGTTHTATTATSNGGTGQPEGGQQPPAGRPCETHQTTSTGTTMSVSVGALLPDA
TSSHRTVESGLEVAAAPSVTPQAGTALLAPFPTQRVCSNPPCETHETGTTHTATTVTSNM
SSNQDPPPAASDQGEVESTQGDSVNITSSSAITTTVSSTLTRAVTTVTQSTPVPGPSVPP
PEELQVSPGPRQQLPPRQLLQSASTALMGESAEVLSASQTPELPAAVDLSSTGEPSSGQE
SAGSAVVATVVVQPPPPTQSEVDQLSLPQELMAEAQAGTTTLMVTGLTPEELAVTAAAEA
AAQAAATEEAQALAIQAVLQAAQQAVMGTGEPMDTSEAAATVTQAELGHLSAEGQEGQAT
TIPIVLTQQELAALVQQQQLQEAQAQQQHHHLPTEALAPADSLNDPAIESNCLNELAGTV
PSTVALLPSTATESLAPSNTFVAPQPVVVASPAKLQAAATLTEVANGIESLGVKPDLPPP
PSKAPMKKENQWFDVGVIKGTNVMVTHYFLPPDDAVPSDDDLGTVPDYNQLKKQELQPGT
AYKFRVAGINACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKI
IEYSVYLAIQSSQAGGELKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAII
FRIAARNEKGYGPATQVRWLQETSKDSSGTKPANKRPMSSPEMKSAPKKSKADGQ
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Transcriptional coregulator. Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition. Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion. May negatively modulate transcriptional activity of FOXO3.; (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.
Uniprot ID
P51610
Ensemble ID
ENST00000310441.12
HGNC ID
HGNC:4839

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 SNV: p.Q1518K DBIA    Probe Info 
COLO792 SNV: p.P254S
Substitution: p.P1017F		 DBIA    Probe Info 
CORL23 SNV: p.G538V DBIA    Probe Info 
EFO27 SNV: p.R333C DBIA    Probe Info 
HCT15 SNV: p.R1986C DBIA    Probe Info 
HEC1 SNV: p.L1700P DBIA    Probe Info 
HT SNV: p.T738A DBIA    Probe Info 
HT115 SNV: p.G1787D DBIA    Probe Info 
IGR1 SNV: p.S1958F DBIA    Probe Info 
JURKAT SNV: p.T784M; p.Q1053E; p.G1300S Compound 10    Probe Info 
KNS42 SNV: p.G1038R; p.D1583H DBIA    Probe Info 
LNCaP clone FGC SNV: p.P1798L DBIA    Probe Info 
MDAMB436 SNV: p.P1766Q DBIA    Probe Info 
MELHO SNV: p.M1528I DBIA    Probe Info 
MEWO SNV: p.P1500L DBIA    Probe Info 
MFE319 SNV: p.E1789G; p.V1915M DBIA    Probe Info 
MOLT4 SNV: p.P435R; p.P439S IA-alkyne    Probe Info 
NCIH1048 SNV: p.T767A DBIA    Probe Info 
NCIH1155 SNV: p.F1829L DBIA    Probe Info 
NCIH1666 SNV: p.G1606W DBIA    Probe Info 
NUGC3 SNV: p.P985L DBIA    Probe Info 
OVCAR8 SNV: p.C149Y DBIA    Probe Info 
PF382 SNV: p.I1980V DBIA    Probe Info 
SUDHL6 Deletion: p.I1980del DBIA    Probe Info 
T24 SNV: p.A1353S DBIA    Probe Info 
TOV21G SNV: p.P985Q DBIA    Probe Info 
WM2664 Insertion: p.N378KfsTer24 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 40 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-9
 Probe Info  		5.76  LDD0393  [2]
TH211
 Probe Info  		Y268(6.76)  LDD0260  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K1853(6.67); K1863(7.70); K1884(5.88); K1989(3.70)  LDD0277  [5]
ONAyne
 Probe Info  		N.A.  LDD0273  [5]
Probe 1
 Probe Info  		Y106(21.58); Y111(20.03); Y208(13.53); Y1862(14.25)  LDD3495  [6]
P11
 Probe Info  		5.49  LDD0201  [7]
BTD
 Probe Info  		C326(2.29); C1166(1.17)  LDD1700  [8]
Sulforaphane-probe2
 Probe Info  		1.98  LDD0160  [9]
AHL-Pu-1
 Probe Info  		C227(2.56); C1166(3.41)  LDD0169  [10]
DBIA
 Probe Info  		C1166(8.03); C1139(20.67)  LDD0209  [11]
HHS-465
 Probe Info  		Y103(10.00)  LDD2237  [12]
5E-2FA
 Probe Info  		H825(0.00); H1907(0.00); H1970(0.00)  LDD2235  [13]
ATP probe
 Probe Info  		N.A.  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1139(0.00); C326(0.00); C149(0.00); C227(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C227(0.00); C149(0.00)  LDD0032  [16]
IPIAA_L
 Probe Info  		C1953(0.00); C149(0.00)  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C1139(0.00); C326(0.00); C149(0.00); C227(0.00)  LDD0037  [15]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [18]
NAIA_4
 Probe Info  		C227(0.00); C1050(0.00); C1139(0.00); C1872(0.00)  LDD2226  [19]
TFBX
 Probe Info  		N.A.  LDD0027  [18]
WYneN
 Probe Info  		C1166(0.00); C1139(0.00)  LDD0021  [20]
WYneO
 Probe Info  		N.A.  LDD0022  [20]
Compound 10
 Probe Info  		C1139(0.00); C1166(0.00); C1872(0.00); C1886(0.00)  LDD2216  [21]
Compound 11
 Probe Info  		C1139(0.00); C1872(0.00); C1886(0.00); C227(0.00)  LDD2213  [21]
ENE
 Probe Info  		C1872(0.00); C1886(0.00); C353(0.00)  LDD0006  [20]
IPM
 Probe Info  		C1139(0.00); C1166(0.00); C1886(0.00); C227(0.00)  LDD0005  [20]
NHS
 Probe Info  		K1989(0.00); K665(0.00)  LDD0010  [20]
PF-06672131
 Probe Info  		N.A.  LDD0017  [22]
SF
 Probe Info  		N.A.  LDD0028  [23]
VSF
 Probe Info  		C135(0.00); C1886(0.00)  LDD0007  [20]
Phosphinate-6
 Probe Info  		C1872(0.00); C1166(0.00); C1895(0.00); C1886(0.00)  LDD0018  [24]
1c-yne
 Probe Info  		K1989(0.00); K1901(0.00); K820(0.00); K665(0.00)  LDD0228  [25]
Acrolein
 Probe Info  		H258(0.00); C1872(0.00); C1895(0.00); C227(0.00)  LDD0217  [26]
Crotonaldehyde
 Probe Info  		C1872(0.00); C1895(0.00); C227(0.00)  LDD0219  [26]
Methacrolein
 Probe Info  		C326(0.00); C1872(0.00); C227(0.00); C1895(0.00)  LDD0218  [26]
W1
 Probe Info  		C1886(0.00); C1895(0.00); C352(0.00); C353(0.00)  LDD0236  [27]
AOyne
 Probe Info  		10.70  LDD0443  [28]
NAIA_5
 Probe Info  		C1139(0.00); C326(0.00); C149(0.00); C1872(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [29]
VE-P
 Probe Info  		N.A.  LDD0396  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C326(0.69)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C326(0.45)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1872(1.17)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C326(0.86); C135(1.54); C1872(0.55)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C326(1.19); C135(3.20); C1872(1.07)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C135(1.22)  LDD2103  [8]
 LDCM0025  4SU-RNA DM93 C1895(3.24)  LDD0170  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C227(2.56); C1166(3.41)  LDD0169  [10]
 LDCM0214  AC1 HEK-293T C1872(0.95); C1139(1.00); C227(0.98); C1187(1.08)  LDD1507  [31]
 LDCM0215  AC10 HEK-293T C135(1.22); C326(0.98); C1872(1.00); C1139(1.05)  LDD1508  [31]
 LDCM0226  AC11 HEK-293T C135(1.11); C1872(0.96); C1139(1.01); C227(0.89)  LDD1509  [31]
 LDCM0237  AC12 HEK-293T C135(1.10); C326(0.96); C1872(0.90); C1139(1.02)  LDD1510  [31]
 LDCM0259  AC14 HEK-293T C135(0.98); C326(0.97); C1872(0.80); C1139(1.05)  LDD1512  [31]
 LDCM0270  AC15 HEK-293T C135(1.26); C1872(0.92); C1139(0.97); C227(0.93)  LDD1513  [31]
 LDCM0276  AC17 HEK-293T C1872(1.00); C1139(1.05); C227(1.02); C1187(1.03)  LDD1515  [31]
 LDCM0277  AC18 HEK-293T C135(1.14); C326(1.17); C1872(0.97); C1139(0.98)  LDD1516  [31]
 LDCM0278  AC19 HEK-293T C135(1.30); C1872(1.49); C1139(1.68); C227(0.85)  LDD1517  [31]
 LDCM0279  AC2 HEK-293T C135(1.12); C326(1.06); C1872(1.04); C1139(1.00)  LDD1518  [31]
 LDCM0280  AC20 HEK-293T C135(1.06); C326(1.21); C1872(0.97); C1139(1.05)  LDD1519  [31]
 LDCM0281  AC21 HEK-293T C135(1.01); C326(1.01); C1872(1.00); C1139(1.01)  LDD1520  [31]
 LDCM0282  AC22 HEK-293T C135(0.96); C326(1.00); C1872(0.86); C1139(1.00)  LDD1521  [31]
 LDCM0283  AC23 HEK-293T C135(1.15); C1872(0.93); C1139(0.95); C227(0.96)  LDD1522  [31]
 LDCM0284  AC24 HEK-293T C135(1.15); C326(1.27); C1872(1.04); C1139(1.00)  LDD1523  [31]
 LDCM0285  AC25 HEK-293T C1872(1.01); C1139(1.05); C227(1.01); C1187(1.01)  LDD1524  [31]
 LDCM0286  AC26 HEK-293T C135(1.18); C326(1.03); C1872(1.07); C1139(1.03)  LDD1525  [31]
 LDCM0287  AC27 HEK-293T C135(1.04); C1872(1.06); C1139(1.03); C227(1.02)  LDD1526  [31]
 LDCM0288  AC28 HEK-293T C135(1.19); C326(1.02); C1872(0.99); C1139(1.03)  LDD1527  [31]
 LDCM0289  AC29 HEK-293T C135(1.09); C326(0.97); C1872(0.87); C1139(1.03)  LDD1528  [31]
 LDCM0290  AC3 HEK-293T C135(1.10); C1872(0.95); C1139(1.03); C227(0.90)  LDD1529  [31]
 LDCM0291  AC30 HEK-293T C135(1.08); C326(0.99); C1872(1.01); C1139(1.06)  LDD1530  [31]
 LDCM0292  AC31 HEK-293T C135(1.18); C1872(0.95); C1139(0.96); C227(0.95)  LDD1531  [31]
 LDCM0293  AC32 HEK-293T C135(1.09); C326(1.53); C1872(1.02); C1139(1.03)  LDD1532  [31]
 LDCM0294  AC33 HEK-293T C1872(1.02); C1139(1.02); C227(1.00); C1187(1.11)  LDD1533  [31]
 LDCM0295  AC34 HEK-293T C135(1.15); C326(1.09); C1872(1.07); C1139(1.04)  LDD1534  [31]
 LDCM0296  AC35 HEK-293T C135(1.20); C1872(1.02); C1139(0.99); C227(0.97)  LDD1535  [31]
 LDCM0297  AC36 HEK-293T C135(1.12); C326(1.09); C1872(0.93); C1139(1.00)  LDD1536  [31]
 LDCM0298  AC37 HEK-293T C135(0.98); C326(1.07); C1872(0.82); C1139(1.01)  LDD1537  [31]
 LDCM0299  AC38 HEK-293T C135(1.02); C326(0.99); C1872(0.90); C1139(0.99)  LDD1538  [31]
 LDCM0300  AC39 HEK-293T C135(1.12); C1872(0.99); C1139(1.00); C227(0.93)  LDD1539  [31]
 LDCM0301  AC4 HEK-293T C135(1.15); C326(1.16); C1872(0.87); C1139(1.03)  LDD1540  [31]
 LDCM0302  AC40 HEK-293T C135(1.09); C326(1.48); C1872(1.07); C1139(1.03)  LDD1541  [31]
 LDCM0303  AC41 HEK-293T C1872(0.97); C1139(1.04); C227(1.01); C1187(1.11)  LDD1542  [31]
 LDCM0304  AC42 HEK-293T C135(1.27); C326(1.02); C1872(1.04); C1139(1.11)  LDD1543  [31]
 LDCM0305  AC43 HEK-293T C135(1.22); C1872(0.93); C1139(0.96); C227(0.95)  LDD1544  [31]
 LDCM0306  AC44 HEK-293T C135(1.24); C326(1.16); C1872(0.98); C1139(1.01)  LDD1545  [31]
 LDCM0307  AC45 HEK-293T C135(0.96); C326(1.06); C1872(1.06); C1139(1.08)  LDD1546  [31]
 LDCM0308  AC46 HEK-293T C135(1.00); C326(0.92); C1872(0.96); C1139(1.05)  LDD1547  [31]
 LDCM0309  AC47 HEK-293T C135(1.22); C1872(0.93); C1139(0.96); C227(0.95)  LDD1548  [31]
 LDCM0310  AC48 HEK-293T C135(1.15); C326(1.20); C1872(1.00); C1139(1.08)  LDD1549  [31]
 LDCM0311  AC49 HEK-293T C1872(1.03); C1139(1.02); C227(1.02); C1187(1.14)  LDD1550  [31]
 LDCM0312  AC5 HEK-293T C135(0.99); C326(1.07); C1872(0.75); C1139(0.80)  LDD1551  [31]
 LDCM0313  AC50 HEK-293T C135(1.28); C326(1.11); C1872(1.06); C1139(1.00)  LDD1552  [31]
 LDCM0314  AC51 HEK-293T C135(1.11); C1872(1.00); C1139(0.97); C227(0.92)  LDD1553  [31]
 LDCM0315  AC52 HEK-293T C135(1.29); C326(1.21); C1872(0.86); C1139(1.03)  LDD1554  [31]
 LDCM0316  AC53 HEK-293T C135(1.01); C326(1.08); C1872(1.12); C1139(0.97)  LDD1555  [31]
 LDCM0317  AC54 HEK-293T C135(1.03); C326(1.00); C1872(0.98); C1139(1.02)  LDD1556  [31]
 LDCM0318  AC55 HEK-293T C135(1.17); C1872(0.91); C1139(1.00); C227(0.92)  LDD1557  [31]
 LDCM0319  AC56 HEK-293T C135(1.16); C326(1.03); C1872(0.96); C1139(1.02)  LDD1558  [31]
 LDCM0320  AC57 HEK-293T C1872(0.98); C1139(1.04); C227(1.06); C1187(1.16)  LDD1559  [31]
 LDCM0321  AC58 HEK-293T C135(1.17); C326(1.00); C1872(0.88); C1139(1.02)  LDD1560  [31]
 LDCM0322  AC59 HEK-293T C135(1.12); C1872(1.00); C1139(0.98); C227(0.92)  LDD1561  [31]
 LDCM0323  AC6 HEK-293T C135(1.01); C326(0.96); C1872(0.90); C1139(1.04)  LDD1562  [31]
 LDCM0324  AC60 HEK-293T C135(1.07); C326(0.97); C1872(0.86); C1139(1.01)  LDD1563  [31]
 LDCM0325  AC61 HEK-293T C135(1.00); C326(1.07); C1872(0.92); C1139(0.97)  LDD1564  [31]
 LDCM0326  AC62 HEK-293T C135(1.03); C326(0.97); C1872(0.86); C1139(1.06)  LDD1565  [31]
 LDCM0327  AC63 HEK-293T C135(1.17); C1872(0.97); C1139(1.00); C227(0.88)  LDD1566  [31]
 LDCM0328  AC64 HEK-293T C135(1.22); C326(1.00); C1872(1.13); C1139(1.03)  LDD1567  [31]
 LDCM0334  AC7 HEK-293T C135(1.07); C1872(0.95); C1139(0.94); C227(0.90)  LDD1568  [31]
 LDCM0345  AC8 HEK-293T C135(1.02); C326(1.20); C1872(1.16); C1139(1.07)  LDD1569  [31]
 LDCM0545  Acetamide MDA-MB-231 C1872(0.32)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C326(0.89); C135(1.81); C353(0.94)  LDD2113  [8]
 LDCM0248  AKOS034007472 HEK-293T C135(0.99); C326(0.96); C1872(0.78); C1139(1.16)  LDD1511  [31]
 LDCM0356  AKOS034007680 HEK-293T C1872(0.99); C1139(1.03); C227(1.01); C1187(1.08)  LDD1570  [31]
 LDCM0275  AKOS034007705 HEK-293T C135(1.21); C326(1.05); C1872(0.99); C1139(0.99)  LDD1514  [31]
 LDCM0156  Aniline NCI-H1299 C1139(0.00); C1872(0.00); C227(0.00); C1886(0.00)  LDD0404  [1]
 LDCM0498  BS-3668 MDA-MB-231 C135(0.40); C1872(0.50)  LDD2091  [8]
 LDCM0088  C45 HEK-293T 5.49  LDD0201  [7]
 LDCM0630  CCW28-3 231MFP C1886(1.22); C227(1.19)  LDD2214  [32]
 LDCM0108  Chloroacetamide HeLa C227(0.00); C1872(0.00); H258(0.00); C352(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C326(2.12); C1139(1.16); C227(0.57)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C135(1.08); C326(1.03); C1872(0.91); C1139(0.95)  LDD1571  [31]
 LDCM0368  CL10 HEK-293T C135(0.97); C326(0.76); C1872(1.01); C1139(1.13)  LDD1572  [31]
 LDCM0369  CL100 HEK-293T C326(0.99); C1872(0.96); C1139(1.01); C227(0.94)  LDD1573  [31]
 LDCM0370  CL101 HEK-293T C135(1.01); C326(0.96); C1872(0.96); C1139(1.04)  LDD1574  [31]
 LDCM0371  CL102 HEK-293T C135(1.13); C1872(0.99); C1139(1.03); C227(0.89)  LDD1575  [31]
 LDCM0372  CL103 HEK-293T C135(1.06); C326(1.05); C1872(1.06); C1139(1.03)  LDD1576  [31]
 LDCM0373  CL104 HEK-293T C326(1.07); C1872(0.89); C1139(1.01); C227(0.98)  LDD1577  [31]
 LDCM0374  CL105 HEK-293T C135(0.96); C326(0.97); C1872(1.02); C1139(0.98)  LDD1578  [31]
 LDCM0375  CL106 HEK-293T C135(1.09); C1872(1.00); C1139(0.96); C227(0.94)  LDD1579  [31]
 LDCM0376  CL107 HEK-293T C135(1.13); C326(1.04); C1872(1.05); C1139(0.97)  LDD1580  [31]
 LDCM0377  CL108 HEK-293T C326(0.99); C1872(1.06); C1139(0.99); C227(1.01)  LDD1581  [31]
 LDCM0378  CL109 HEK-293T C135(1.07); C326(0.85); C1872(1.03); C1139(0.93)  LDD1582  [31]
 LDCM0379  CL11 HEK-293T C135(0.90); C1872(0.77); C1139(1.18); C227(0.87)  LDD1583  [31]
 LDCM0380  CL110 HEK-293T C135(0.99); C1872(1.02); C1139(1.00); C227(0.92)  LDD1584  [31]
 LDCM0381  CL111 HEK-293T C135(0.97); C326(1.06); C1872(1.04); C1139(0.98)  LDD1585  [31]
 LDCM0382  CL112 HEK-293T C326(0.90); C1872(1.01); C1139(1.04); C227(0.98)  LDD1586  [31]
 LDCM0383  CL113 HEK-293T C135(1.11); C326(0.97); C1872(0.95); C1139(1.06)  LDD1587  [31]
 LDCM0384  CL114 HEK-293T C135(1.06); C1872(0.98); C1139(0.99); C227(0.84)  LDD1588  [31]
 LDCM0385  CL115 HEK-293T C135(1.12); C326(1.09); C1872(1.07); C1139(0.98)  LDD1589  [31]
 LDCM0386  CL116 HEK-293T C326(0.99); C1872(1.01); C1139(0.98); C227(0.98)  LDD1590  [31]
 LDCM0387  CL117 HEK-293T C135(1.15); C326(1.04); C1872(1.02); C1139(1.01)  LDD1591  [31]
 LDCM0388  CL118 HEK-293T C135(1.15); C1872(1.10); C1139(1.12); C227(0.92)  LDD1592  [31]
 LDCM0389  CL119 HEK-293T C135(1.20); C326(1.03); C1872(1.03); C1139(0.97)  LDD1593  [31]
 LDCM0390  CL12 HEK-293T C135(0.97); C326(0.84); C1872(0.90); C1139(1.22)  LDD1594  [31]
 LDCM0391  CL120 HEK-293T C326(0.89); C1872(0.95); C1139(1.07); C227(0.97)  LDD1595  [31]
 LDCM0392  CL121 HEK-293T C135(1.13); C326(0.89); C1872(0.99); C1139(1.03)  LDD1596  [31]
 LDCM0393  CL122 HEK-293T C135(1.14); C1872(0.96); C1139(1.00); C227(0.87)  LDD1597  [31]
 LDCM0394  CL123 HEK-293T C135(0.97); C326(0.63); C1872(1.02); C1139(0.93)  LDD1598  [31]
 LDCM0395  CL124 HEK-293T C326(0.96); C1872(0.99); C1139(1.00); C227(0.92)  LDD1599  [31]
 LDCM0396  CL125 HEK-293T C135(1.09); C326(1.02); C1872(1.01); C1139(0.98)  LDD1600  [31]
 LDCM0397  CL126 HEK-293T C135(1.04); C1872(1.04); C1139(1.01); C227(0.90)  LDD1601  [31]
 LDCM0398  CL127 HEK-293T C135(1.04); C326(1.07); C1872(1.02); C1139(0.96)  LDD1602  [31]
 LDCM0399  CL128 HEK-293T C326(1.01); C1872(0.98); C1139(1.03); C227(0.99)  LDD1603  [31]
 LDCM0400  CL13 HEK-293T C135(1.06); C326(1.04); C1872(1.03); C1139(1.12)  LDD1604  [31]
 LDCM0401  CL14 HEK-293T C135(1.23); C1872(0.88); C1139(0.97); C227(0.89)  LDD1605  [31]
 LDCM0402  CL15 HEK-293T C135(0.97); C326(1.00); C1872(1.07); C1139(0.94)  LDD1606  [31]
 LDCM0403  CL16 HEK-293T C326(1.09); C1872(0.85); C1139(0.94); C227(0.95)  LDD1607  [31]
 LDCM0404  CL17 HEK-293T C1872(0.86); C1139(1.04); C227(0.93); C1187(1.16)  LDD1608  [31]
 LDCM0405  CL18 HEK-293T C135(1.20); C326(1.00); C1872(0.82); C1139(1.04)  LDD1609  [31]
 LDCM0406  CL19 HEK-293T C135(1.17); C1872(0.81); C1139(0.99); C227(0.85)  LDD1610  [31]
 LDCM0407  CL2 HEK-293T C135(0.92); C1872(0.84); C1139(1.01); C227(0.87)  LDD1611  [31]
 LDCM0408  CL20 HEK-293T C135(1.07); C326(0.91); C1872(0.80); C1139(1.02)  LDD1612  [31]
 LDCM0409  CL21 HEK-293T C135(0.98); C326(0.81); C1872(0.76); C1139(1.17)  LDD1613  [31]
 LDCM0410  CL22 HEK-293T C135(0.95); C326(0.91); C1872(0.85); C1139(1.10)  LDD1614  [31]
 LDCM0411  CL23 HEK-293T C135(1.05); C1872(0.86); C1139(1.14); C227(0.90)  LDD1615  [31]
 LDCM0412  CL24 HEK-293T C135(0.86); C326(1.00); C1872(0.79); C1139(1.19)  LDD1616  [31]
 LDCM0413  CL25 HEK-293T C135(0.97); C326(0.91); C1872(0.96); C1139(0.89)  LDD1617  [31]
 LDCM0414  CL26 HEK-293T C135(1.03); C1872(0.96); C1139(0.98); C227(0.92)  LDD1618  [31]
 LDCM0415  CL27 HEK-293T C135(1.05); C326(1.11); C1872(1.01); C1139(0.96)  LDD1619  [31]
 LDCM0416  CL28 HEK-293T C326(0.81); C1872(0.95); C1139(0.96); C227(0.93)  LDD1620  [31]
 LDCM0417  CL29 HEK-293T C1872(1.02); C1139(1.03); C227(0.98); C1187(1.12)  LDD1621  [31]
 LDCM0418  CL3 HEK-293T C135(1.02); C326(0.89); C1872(1.02); C1139(0.93)  LDD1622  [31]
 LDCM0419  CL30 HEK-293T C135(1.07); C326(0.94); C1872(0.84); C1139(1.02)  LDD1623  [31]
 LDCM0420  CL31 HEK-293T C135(1.10); C1872(1.03); C1139(1.10); C227(0.94)  LDD1624  [31]
 LDCM0421  CL32 HEK-293T C135(1.19); C326(0.76); C1872(0.86); C1139(1.04)  LDD1625  [31]
 LDCM0422  CL33 HEK-293T C135(0.98); C326(0.91); C1872(0.90); C1139(0.93)  LDD1626  [31]
 LDCM0423  CL34 HEK-293T C135(1.02); C326(0.81); C1872(0.93); C1139(1.10)  LDD1627  [31]
 LDCM0424  CL35 HEK-293T C135(1.08); C1872(1.06); C1139(1.17); C227(1.03)  LDD1628  [31]
 LDCM0425  CL36 HEK-293T C135(0.96); C326(1.19); C1872(0.93); C1139(1.14)  LDD1629  [31]
 LDCM0426  CL37 HEK-293T C135(0.90); C326(1.10); C1872(0.86); C1139(0.90)  LDD1630  [31]
 LDCM0428  CL39 HEK-293T C135(1.11); C326(1.08); C1872(0.98); C1139(0.94)  LDD1632  [31]
 LDCM0429  CL4 HEK-293T C326(0.87); C1872(0.95); C1139(0.97); C227(0.95)  LDD1633  [31]
 LDCM0430  CL40 HEK-293T C326(1.12); C1872(0.95); C1139(0.98); C227(0.98)  LDD1634  [31]
 LDCM0431  CL41 HEK-293T C1872(1.06); C1139(1.02); C227(1.00); C1187(1.06)  LDD1635  [31]
 LDCM0432  CL42 HEK-293T C135(1.07); C326(1.15); C1872(0.90); C1139(1.08)  LDD1636  [31]
 LDCM0433  CL43 HEK-293T C135(1.08); C1872(0.98); C1139(1.04); C227(0.89)  LDD1637  [31]
 LDCM0434  CL44 HEK-293T C135(1.19); C326(0.95); C1872(0.92); C1139(1.07)  LDD1638  [31]
 LDCM0435  CL45 HEK-293T C135(0.98); C326(0.67); C1872(1.01); C1139(1.11)  LDD1639  [31]
 LDCM0436  CL46 HEK-293T C135(1.05); C326(0.91); C1872(0.81); C1139(1.10)  LDD1640  [31]
 LDCM0437  CL47 HEK-293T C135(1.18); C1872(0.91); C1139(1.17); C227(0.96)  LDD1641  [31]
 LDCM0438  CL48 HEK-293T C135(1.03); C326(1.08); C1872(1.13); C1139(1.21)  LDD1642  [31]
 LDCM0439  CL49 HEK-293T C135(1.11); C326(1.24); C1872(0.81); C1139(1.00)  LDD1643  [31]
 LDCM0440  CL5 HEK-293T C1872(0.87); C1139(0.99); C227(0.99); C1187(1.07)  LDD1644  [31]
 LDCM0441  CL50 HEK-293T C135(0.99); C1872(0.79); C1139(1.04); C227(0.87)  LDD1645  [31]
 LDCM0443  CL52 HEK-293T C326(0.95); C1872(0.83); C1139(1.04); C227(0.97)  LDD1646  [31]
 LDCM0444  CL53 HEK-293T C1872(0.95); C1139(1.05); C227(0.89); C1187(1.12)  LDD1647  [31]
 LDCM0445  CL54 HEK-293T C135(1.14); C326(0.79); C1872(0.83); C1139(1.25)  LDD1648  [31]
 LDCM0446  CL55 HEK-293T C135(1.19); C1872(0.90); C1139(1.03); C227(0.91)  LDD1649  [31]
 LDCM0447  CL56 HEK-293T C135(1.20); C326(1.15); C1872(0.89); C1139(1.13)  LDD1650  [31]
 LDCM0448  CL57 HEK-293T C135(1.00); C326(0.87); C1872(0.80); C1139(1.44)  LDD1651  [31]
 LDCM0449  CL58 HEK-293T C135(0.97); C326(0.95); C1872(0.78); C1139(1.06)  LDD1652  [31]
 LDCM0450  CL59 HEK-293T C135(1.06); C1872(0.85); C1139(1.12); C227(0.95)  LDD1653  [31]
 LDCM0451  CL6 HEK-293T C135(1.05); C326(1.00); C1872(0.80); C1139(1.24)  LDD1654  [31]
 LDCM0452  CL60 HEK-293T C135(0.98); C326(1.05); C1872(0.89); C1139(1.21)  LDD1655  [31]
 LDCM0453  CL61 HEK-293T C135(0.98); C326(1.10); C1872(0.82); C1139(1.00)  LDD1656  [31]
 LDCM0454  CL62 HEK-293T C135(1.11); C1872(0.93); C1139(1.03); C227(0.91)  LDD1657  [31]
 LDCM0455  CL63 HEK-293T C135(1.13); C326(1.15); C1872(1.04); C1139(0.96)  LDD1658  [31]
 LDCM0456  CL64 HEK-293T C326(0.76); C1872(0.86); C1139(1.04); C227(0.90)  LDD1659  [31]
 LDCM0457  CL65 HEK-293T C1872(0.87); C1139(1.03); C227(1.00); C1187(1.19)  LDD1660  [31]
 LDCM0458  CL66 HEK-293T C135(1.10); C326(1.08); C1872(0.86); C1139(1.04)  LDD1661  [31]
 LDCM0459  CL67 HEK-293T C135(1.21); C1872(0.91); C1139(1.01); C227(0.97)  LDD1662  [31]
 LDCM0460  CL68 HEK-293T C135(1.10); C326(0.92); C1872(0.89); C1139(1.09)  LDD1663  [31]
 LDCM0461  CL69 HEK-293T C135(1.00); C326(0.87); C1872(0.80); C1139(1.13)  LDD1664  [31]
 LDCM0462  CL7 HEK-293T C135(1.12); C1872(0.91); C1139(1.00); C227(0.88)  LDD1665  [31]
 LDCM0463  CL70 HEK-293T C135(1.00); C326(0.89); C1872(0.89); C1139(1.06)  LDD1666  [31]
 LDCM0464  CL71 HEK-293T C135(1.13); C1872(0.88); C1139(1.13); C227(0.96)  LDD1667  [31]
 LDCM0465  CL72 HEK-293T C135(0.97); C326(0.94); C1872(0.95); C1139(1.21)  LDD1668  [31]
 LDCM0466  CL73 HEK-293T C135(1.01); C326(0.96); C1872(0.88); C1139(0.94)  LDD1669  [31]
 LDCM0467  CL74 HEK-293T C135(1.06); C1872(0.85); C1139(1.03); C227(0.87)  LDD1670  [31]
 LDCM0469  CL76 HEK-293T C326(1.06); C1872(0.97); C1139(0.97); C227(0.97)  LDD1672  [31]
 LDCM0470  CL77 HEK-293T C1872(0.99); C1139(1.10); C227(0.99); C1187(1.06)  LDD1673  [31]
 LDCM0471  CL78 HEK-293T C135(1.11); C326(1.16); C1872(0.90); C1139(1.00)  LDD1674  [31]
 LDCM0472  CL79 HEK-293T C135(1.20); C1872(0.94); C1139(0.97); C227(0.85)  LDD1675  [31]
 LDCM0473  CL8 HEK-293T C135(0.98); C326(0.98); C1872(0.87); C1139(1.25)  LDD1676  [31]
 LDCM0474  CL80 HEK-293T C135(1.19); C326(0.91); C1872(0.82); C1139(0.99)  LDD1677  [31]
 LDCM0475  CL81 HEK-293T C135(1.01); C326(0.99); C1872(0.86); C1139(1.05)  LDD1678  [31]
 LDCM0476  CL82 HEK-293T C135(1.04); C326(0.93); C1872(0.85); C1139(1.09)  LDD1679  [31]
 LDCM0477  CL83 HEK-293T C135(1.16); C1872(0.97); C1139(1.09); C227(0.90)  LDD1680  [31]
 LDCM0478  CL84 HEK-293T C135(1.01); C326(1.05); C1872(0.94); C1139(1.18)  LDD1681  [31]
 LDCM0479  CL85 HEK-293T C135(0.97); C326(1.46); C1872(0.85); C1139(0.94)  LDD1682  [31]
 LDCM0480  CL86 HEK-293T C135(0.95); C1872(0.86); C1139(1.02); C227(0.86)  LDD1683  [31]
 LDCM0481  CL87 HEK-293T C135(1.06); C326(1.07); C1872(1.01); C1139(0.97)  LDD1684  [31]
 LDCM0482  CL88 HEK-293T C326(1.14); C1872(0.89); C1139(1.02); C227(0.97)  LDD1685  [31]
 LDCM0483  CL89 HEK-293T C1872(0.88); C1139(0.98); C227(1.00); C1187(1.09)  LDD1686  [31]
 LDCM0484  CL9 HEK-293T C135(0.97); C326(0.77); C1872(0.79); C1139(1.11)  LDD1687  [31]
 LDCM0485  CL90 HEK-293T C135(1.00); C326(1.04); C1872(0.80); C1139(1.62)  LDD1688  [31]
 LDCM0486  CL91 HEK-293T C135(1.18); C1872(0.85); C1139(0.98); C227(0.84)  LDD1689  [31]
 LDCM0487  CL92 HEK-293T C135(1.12); C326(1.00); C1872(0.83); C1139(1.04)  LDD1690  [31]
 LDCM0488  CL93 HEK-293T C135(1.02); C326(0.76); C1872(0.87); C1139(0.95)  LDD1691  [31]
 LDCM0489  CL94 HEK-293T C135(0.92); C326(0.82); C1872(0.86); C1139(1.13)  LDD1692  [31]
 LDCM0490  CL95 HEK-293T C135(1.00); C1872(1.03); C1139(1.47); C227(0.90)  LDD1693  [31]
 LDCM0491  CL96 HEK-293T C135(0.91); C326(0.98); C1872(0.83); C1139(1.12)  LDD1694  [31]
 LDCM0492  CL97 HEK-293T C135(0.97); C326(0.81); C1872(0.98); C1139(1.00)  LDD1695  [31]
 LDCM0493  CL98 HEK-293T C135(1.01); C1872(0.95); C1139(1.04); C227(0.87)  LDD1696  [31]
 LDCM0494  CL99 HEK-293T C135(0.96); C326(1.06); C1872(1.07); C1139(1.02)  LDD1697  [31]
 LDCM0495  E2913 HEK-293T C135(1.12); C326(1.19); C1872(1.01); C1139(1.00)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C135(2.45); C1139(1.76); C1886(1.11); C227(1.10)  LDD1702  [8]
 LDCM0625  F8 Ramos C326(1.31); C227(2.08); C1139(0.97); C149(0.79)  LDD2187  [33]
 LDCM0572  Fragment10 MDA-MB-231 C1872(1.51)  LDD1465  [34]
 LDCM0573  Fragment11 MDA-MB-231 C1872(0.54)  LDD1467  [34]
 LDCM0574  Fragment12 Ramos C326(0.31); C227(0.69); C1139(1.03); C149(0.39)  LDD2191  [33]
 LDCM0575  Fragment13 MDA-MB-231 C1872(1.04)  LDD1469  [34]
 LDCM0576  Fragment14 MDA-MB-231 C1872(1.10)  LDD1471  [34]
 LDCM0579  Fragment20 Ramos C326(0.69); C227(2.12); C1139(0.94); 0.49  LDD2194  [33]
 LDCM0580  Fragment21 Ramos C326(0.69); C227(0.95); C1139(0.98); C149(0.64)  LDD2195  [33]
 LDCM0582  Fragment23 Ramos C326(0.36); C227(0.78); C1139(1.33); 0.42  LDD2196  [33]
 LDCM0578  Fragment27 Ramos C326(1.47); C227(1.04); C1139(0.97)  LDD2197  [33]
 LDCM0586  Fragment28 Ramos C326(0.67); C227(1.27); C1139(1.00); 1.22  LDD2198  [33]
 LDCM0588  Fragment30 Ramos C326(1.20); C227(0.73); C1139(1.38); 1.13  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C326(1.60); C227(1.12); C1139(1.23); 1.21  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C326(0.52); C227(0.63); C1139(2.83); C149(0.47)  LDD2201  [33]
 LDCM0468  Fragment33 HEK-293T C135(1.08); C326(0.94); C1872(1.03); C1139(0.91)  LDD1671  [31]
 LDCM0596  Fragment38 MDA-MB-231 C1872(1.28)  LDD1480  [34]
 LDCM0566  Fragment4 Ramos C326(0.90); C227(1.18); C1139(1.03); 1.13  LDD2184  [33]
 LDCM0599  Fragment41 MDA-MB-231 C1872(0.47)  LDD1481  [34]
 LDCM0427  Fragment51 HEK-293T C135(1.07); C1872(0.90); C1139(1.03); C227(0.91)  LDD1631  [31]
 LDCM0610  Fragment52 Ramos C326(1.58); C227(0.63); C1139(1.15); 3.68  LDD2204  [33]
 LDCM0614  Fragment56 Ramos C326(2.17); C227(0.83); C1139(1.52); C149(1.26)  LDD2205  [33]
 LDCM0569  Fragment7 Ramos C326(0.53); C227(0.73); C1139(1.51); 0.80  LDD2186  [33]
 LDCM0571  Fragment9 Ramos C1872(1.02)  LDD1464  [34]
 LDCM0107  IAA HeLa H258(0.00); C1895(0.00)  LDD0221  [26]
 LDCM0022  KB02 MDA-MB-231 C1872(4.07)  LDD1460  [34]
 LDCM0023  KB03 Jurkat C1166(8.03); C1139(20.67)  LDD0209  [11]
 LDCM0024  KB05 COLO792 C149(3.33); C227(2.32); C135(2.57); C1916(5.58)  LDD3310  [35]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C135(1.61)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C326(0.66); C135(0.87); C1872(0.62)  LDD2121  [8]
 LDCM0109  NEM HeLa H258(0.00); H203(0.00); H140(0.00); H1235(0.00)  LDD0223  [26]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1139(0.34)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C135(1.14)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C326(1.16); C1139(1.06)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C326(0.92); C135(2.93); C1139(0.87)  LDD2093  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C326(0.26)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C326(0.97); C1872(0.65)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C326(0.67); C135(0.72)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C326(1.15); C1166(0.72); C1872(0.99); C1139(0.82)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C326(0.37); C135(0.40); C1166(0.59)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C326(1.22); C1166(1.40); C1872(1.23)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C326(0.56); C135(0.83)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C326(1.59)  LDD2105  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C326(0.83); C135(1.57); C1872(0.77); C1139(0.68)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C326(0.39)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C326(0.46); C135(1.78); C1166(0.40); C1872(0.51)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C326(0.85); C135(2.37); C1872(0.80)  LDD2111  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C326(0.46); C1166(0.58); C1872(0.58)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C326(0.67)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1166(1.07)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C326(1.31); C135(1.37); C1872(1.82)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C326(0.58); C1872(1.01)  LDD2120  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C326(0.79); C135(1.72); C1166(0.69); C1872(0.61)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C326(0.47)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C326(0.84); C1872(0.59); C1139(0.80)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C326(0.40); C1872(1.15)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C326(0.73); C1166(0.52); C1872(0.67)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C326(0.46); C135(1.11); C1872(1.20)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C326(1.01); C135(1.96); C1166(0.75)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C326(0.62); C1166(1.16)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C326(0.53); C135(1.69)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C326(1.20); C135(3.35); C1872(0.95)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C326(0.86); C135(1.50); C1166(0.66); C1872(0.87)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C326(0.86); C135(1.81); C1872(0.75)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C326(2.29); C1166(1.17)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C326(0.84); C1872(0.59); C1139(0.41)  LDD2140  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C326(0.56); C1872(1.13)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C326(1.94); C135(0.64); C1872(3.64)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C326(0.77)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C326(0.75); C135(1.03)  LDD2146  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C135(2.74)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C326(0.37); C1872(1.08)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C135(0.66); C1872(0.56); C1139(0.25)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C326(0.27)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C135(1.87)  LDD2153  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C227(1.01)  LDD2206  [36]
 LDCM0628  OTUB2-COV-1 HEK-293T C135(1.20); C227(0.80); C1872(0.73); C1139(0.70)  LDD2207  [36]
 LDCM0131  RA190 MM1.R C1139(2.24); C1872(1.36); C1886(1.31); C1895(1.31)  LDD0304  [37]
 LDCM0170  Structure8 Ramos 7.08  LDD0433  [38]
 LDCM0003  Sulforaphane MDA-MB-231 1.98  LDD0160  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SETD1A (SETD1A) Class V-like SAM-binding methyltransferase superfamily O15047
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) Glycosyltransferase 41 family O15294
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Histone deacetylase 2 (HDAC2) Histone deacetylase family Q92769
Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1) Peptidase C12 family Q92560
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) Sirtuin family Q96EB6
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L) . Q9UBL3
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CREB/ATF bZIP transcription factor (CREBZF) BZIP family Q9NS37
Cyclic AMP-responsive element-binding protein 3 (CREB3) BZIP family O43889
GA-binding protein alpha chain (GABPA) ETS family Q06546
Zinc finger and BTB domain-containing protein 17 (ZBTB17) Krueppel C2H2-type zinc-finger protein family Q13105
Transcription factor Sp1 (SP1) Sp1 C2H2-type zinc-finger protein family P08047
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
THAP domain-containing protein 11 (THAP11) THAP11 family Q96EK4
Forkhead box protein O3 (FOXO3) . O43524
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sin3 histone deacetylase corepressor complex component SDS3 (SUDS3) SDS3 family Q9H7L9
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964
Four and a half LIM domains protein 2 (FHL2) . Q14192
GA-binding protein subunit beta-1 (GABPB1) . Q06547
Host cell factor 1 (HCFC1) . P51610
Paired amphipathic helix protein Sin3a (SIN3A) . Q96ST3

References

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3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
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13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
22 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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28 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
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Mass spectrometry data entry: PXD044402
32 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
34 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
35 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
36 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
37 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
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