Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment13  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 66 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) C66 20.0
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) C138 20.0
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 13.1
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 10.3
 LDTP02502  Thioredoxin (TXN) C32 7.9
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 6.2
 LDTP03163  Sterol carrier protein 2 (SCP2) C71 4.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 3.5
 LDTP18123  Isochorismatase domain-containing protein 2 (ISOC2) C114 2.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 2.1
 LDTP10320  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (TRMT61A) C209 2.1
 LDTP18330  Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5) C392 2.0
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) C1224 1.9
 LDTP06320  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) C71 1.6
 LDTP02223  Cathepsin B (CTSB) C211 1.6
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) C258 1.6
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.6
 LDTP15290  5'-nucleotidase domain-containing protein 3 (NT5DC3) C276 1.5
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.5
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 1.4
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 1.4
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 1.4
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 1.3
 LDTP19669  Threonine synthase-like 1 (THNSL1) C324 1.3
 LDTP03496  Protein PML (PML) C389 1.3
 LDTP00013  Ubiquitin-like modifier-activating enzyme 6 (UBA6) C347 1.3
 LDTP00642  DNA-directed RNA polymerase I subunit RPA34 (POLR1G) C86 1.3
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) C317 1.3
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 1.3
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.3
 LDTP08401  All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2) C71 1.2
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) C170 1.2
 LDTP06211  Caspase-8 (CASP8) C360 1.2
 LDTP04547  Nuclear pore complex protein Nup98-Nup96 (NUP98) C1312 1.2
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.2
 LDTP15427  Ribonuclease P protein subunit p25-like protein (RPP25L) C131 1.2
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 1.1
 LDTP04438  Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) C340 1.1
 LDTP16095  Ethylmalonyl-CoA decarboxylase (ECHDC1) C133 1.1
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119 1.1
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.1
 LDTP03000  General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) C342 1.1
 LDTP03770  Alpha-adducin (ADD1) C68 1.1
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C114 1.1
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) C436 1.0
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.0
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C758 1.0
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.0
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.0
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 1.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.9
 LDTP00479  Histone acetyltransferase type B catalytic subunit (HAT1) C101 0.9
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.9
 LDTP14092  Protein phosphatase methylesterase 1 (PPME1) C381 0.9
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 0.9
 LDTP12313  Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (ALG13) C86 0.9
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) C773 0.8
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.8
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 0.8
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 0.7
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C312 0.7
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 0.7
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 0.7
 LDTP05859  Integrin-linked protein kinase (ILK) C346 0.7
 LDTP03258  Thymidylate kinase (DTYMK) C117 0.6
Transporter and channel
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 20.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 2.3
 LDTP10642  Chloride intracellular channel protein 6 (CLIC6) C487 1.9
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) C100 1.6
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 1.5
 LDTP02735  G2/mitotic-specific cyclin-B1 (CCNB1) C238 1.3
 LDTP00501  Exportin-1 (XPO1) C528 1.1
 LDTP05591  Nuclear cap-binding protein subunit 1 (NCBP1) C44 1.0
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 1.0
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 1.0
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 2.4
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 1.2
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 1.1
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.1
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.0
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 1.0
Other
Click to Show/Hide to Show 57 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06244  Nuclear mitotic apparatus protein 1 (NUMA1) C961 2.2
 LDTP09650  LIM domain only protein 7 (LMO7) C228 2.0
 LDTP17802  Glutathione S-transferase C-terminal domain-containing protein (GSTCD) C140 1.8
 LDTP15896  Ashwin (C2orf49) C10 1.6
 LDTP05772  FAS-associated death domain protein (FADD) C98 1.6
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.6
 LDTP07755  Dynamin-binding protein (DNMBP) C691 1.6
 LDTP13622  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) C213 1.6
 LDTP05867  Treacle protein (TCOF1) C38 1.6
 LDTP06362  Leucine-rich repeat-containing protein 41 (LRRC41) C297 1.6
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 1.5
 LDTP00229  Copper transport protein ATOX1 (ATOX1) C12 1.5
 LDTP00306  Pescadillo homolog (PES1) C272 1.4
 LDTP06330  Plectin (PLEC) C4574 1.4
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 1.4
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.3
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C645 1.3
 LDTP12443  Anillin (ANLN) C712 1.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 1.2
 LDTP10252  Elongator complex protein 4 (ELP4) C218 1.2
 LDTP10657  Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1) C900 1.2
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.2
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) C18 1.2
 LDTP15861  Acyl-CoA-binding domain-containing protein 6 (ACBD6) C267 1.1
 LDTP16117  Mediator of RNA polymerase II transcription subunit 9 (MED9) C139 1.1
 LDTP13705  LIM and calponin homology domains-containing protein 1 (LIMCH1) C140 1.1
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 1.1
 LDTP17182  Uncharacterized protein C3orf38 (C3orf38) C308 1.1
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 1.1
 LDTP06046  Ribosome biogenesis protein BOP1 (BOP1) C404 1.1
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 1.1
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.1
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.1
 LDTP11235  Protein PAXX (PAXX) C180 1.1
 LDTP13580  Coronin-1C (CORO1C) C420 1.1
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.1
 LDTP04434  Host cell factor 1 (HCFC1) C1872 1.0
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 1.0
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 1.0
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.0
 LDTP04487  Cyclin-H (CCNH) C244 1.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C629 1.0
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 1.0
 LDTP10864  Calponin-2 (CNN2) C164 0.9
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 0.9
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 0.9
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 0.9
 LDTP01532  ZW10 interactor (ZWINT) C54 0.8
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 0.8
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.8
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 0.7
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 0.7
 LDTP04594  Protein transport protein Sec24C (SEC24C) C78 0.7
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 0.7
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 0.7
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 0.6

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.