Details of the Target

General Information of Target

Target ID LDTP04438
Target Name Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1)
Gene Name ALDH5A1
Gene ID 7915
Synonyms
SSADH; Succinate-semialdehyde dehydrogenase, mitochondrial; EC 1.2.1.24; Aldehyde dehydrogenase family 5 member A1; NAD(+)-dependent succinic semialdehyde dehydrogenase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR
TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER
SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH
TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL
AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV
KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF
AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFF
EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWR
VAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
Target Type
Successful
Target Bioclass
Enzyme
Family
Aldehyde dehydrogenase family
Subcellular location
Mitochondrion
Function Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
TTD ID
T13259
Uniprot ID
P51649
DrugMap ID
TTJUWVB
Ensemble ID
ENST00000348925.2
HGNC ID
HGNC:408
ChEMBL ID
CHEMBL1911

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FTC133 SNV: p.A324D DBIA    Probe Info 
MCC26 SNV: p.Q477H DBIA    Probe Info 
NCIH1703 Deletion: p.S208VfsTer3 DBIA    Probe Info 
NUGC3 SNV: p.R514Ter DBIA    Probe Info 
REH SNV: p.L158F DBIA    Probe Info 
SNU1 SNV: p.E152D .
UMUC3 SNV: p.S83R DBIA    Probe Info 
WM793 Substitution: p.Q345L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.49  LDD0402  [1]
Alkylaryl probe 3
 Probe Info  		6.62  LDD0381  [2]
W1
 Probe Info  		21.79  LDD0235  [3]
TH211
 Probe Info  		Y519(20.00)  LDD0260  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
Probe 1
 Probe Info  		Y175(29.36); Y519(53.57)  LDD3495  [6]
DBIA
 Probe Info  		C110(0.95); C285(1.50); C515(0.89); C544(0.86)  LDD3312  [7]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [8]
Acrolein
 Probe Info  		N.A.  LDD0222  [9]
ATP probe
 Probe Info  		K387(0.00); K391(0.00); K262(0.00); K265(0.00)  LDD0199  [10]
N1
 Probe Info  		D274(0.00); T273(0.00)  LDD0245  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C110(0.00); C272(0.00); C502(0.00); C93(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C110(0.00); C93(0.00)  LDD0032  [13]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C110(0.00); C272(0.00); C93(0.00); C434(0.00)  LDD0037  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
Compound 11
 Probe Info  		N.A.  LDD2213  [16]
ENE
 Probe Info  		N.A.  LDD0006  [17]
IPM
 Probe Info  		N.A.  LDD0005  [17]
TFBX
 Probe Info  		C272(0.00); C110(0.00)  LDD0148  [15]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
AOyne
 Probe Info  		4.70  LDD0443  [19]
NAIA_5
 Probe Info  		C110(0.00); C272(0.00); C93(0.00); C259(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C215
 Probe Info  		7.01  LDD1889  [21]
C218
 Probe Info  		16.91  LDD1892  [21]
C220
 Probe Info  		11.55  LDD1894  [21]
C287
 Probe Info  		12.21  LDD1957  [21]
C355
 Probe Info  		25.11  LDD2016  [21]
C420
 Probe Info  		11.96  LDD2075  [21]
STS-1
 Probe Info  		N.A.  LDD0137  [22]
STS-2
 Probe Info  		N.A.  LDD0138  [22]
VE-P
 Probe Info  		N.A.  LDD0396  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C93(0.92); C502(1.02); C272(0.98); C110(0.92)  LDD1507  [24]
 LDCM0215  AC10 HEK-293T C93(0.96); C502(0.92); C272(0.97); C110(0.93)  LDD1508  [24]
 LDCM0226  AC11 HEK-293T C93(0.93); C502(0.98); C272(0.89); C110(1.01)  LDD1509  [24]
 LDCM0237  AC12 HEK-293T C93(1.03); C502(0.93); C110(0.92); C4(0.98)  LDD1510  [24]
 LDCM0259  AC14 HEK-293T C93(1.08); C502(1.00); C272(1.06); C110(0.92)  LDD1512  [24]
 LDCM0270  AC15 HEK-293T C93(0.99); C502(1.05); C272(1.11); C110(0.92)  LDD1513  [24]
 LDCM0276  AC17 HEK-293T C93(0.95); C502(1.02); C272(0.96); C110(0.90)  LDD1515  [24]
 LDCM0277  AC18 HEK-293T C93(0.97); C502(0.99); C272(0.97); C110(0.93)  LDD1516  [24]
 LDCM0278  AC19 HEK-293T C93(0.74); C502(0.92); C272(0.93); C110(0.96)  LDD1517  [24]
 LDCM0279  AC2 HEK-293T C93(1.06); C502(0.96); C272(0.93); C110(1.07)  LDD1518  [24]
 LDCM0280  AC20 HEK-293T C93(1.14); C502(0.83); C110(0.97); C4(1.05)  LDD1519  [24]
 LDCM0281  AC21 HEK-293T C93(0.95); C502(0.97); C259(1.21); C272(1.06)  LDD1520  [24]
 LDCM0282  AC22 HEK-293T C93(0.96); C502(0.95); C272(0.92); C110(0.91)  LDD1521  [24]
 LDCM0283  AC23 HEK-293T C93(1.04); C502(0.94); C272(0.95); C110(0.97)  LDD1522  [24]
 LDCM0284  AC24 HEK-293T C93(0.91); C502(0.98); C272(0.94); C110(1.01)  LDD1523  [24]
 LDCM0285  AC25 HEK-293T C93(0.91); C502(1.01); C272(1.00); C110(1.01)  LDD1524  [24]
 LDCM0286  AC26 HEK-293T C93(1.07); C502(0.96); C272(0.97); C110(1.01)  LDD1525  [24]
 LDCM0287  AC27 HEK-293T C93(0.99); C502(1.07); C272(0.96); C110(0.99)  LDD1526  [24]
 LDCM0288  AC28 HEK-293T C93(1.12); C502(0.92); C110(0.95); C4(1.13)  LDD1527  [24]
 LDCM0289  AC29 HEK-293T C93(0.98); C502(1.02); C259(1.21); C272(1.11)  LDD1528  [24]
 LDCM0290  AC3 HEK-293T C93(0.96); C502(0.99); C272(0.99); C110(0.97)  LDD1529  [24]
 LDCM0291  AC30 HEK-293T C93(1.13); C502(1.07); C272(1.04); C110(0.98)  LDD1530  [24]
 LDCM0292  AC31 HEK-293T C93(0.95); C502(0.96); C272(1.03); C110(1.01)  LDD1531  [24]
 LDCM0293  AC32 HEK-293T C93(1.11); C502(1.01); C272(1.04); C110(1.04)  LDD1532  [24]
 LDCM0294  AC33 HEK-293T C93(1.02); C502(1.01); C272(1.04); C110(0.86)  LDD1533  [24]
 LDCM0295  AC34 HEK-293T C93(1.06); C502(0.93); C272(0.99); C110(0.98)  LDD1534  [24]
 LDCM0296  AC35 HEK-293T C93(0.97); C502(0.94); C272(0.93); C110(1.02)  LDD1535  [24]
 LDCM0297  AC36 HEK-293T C93(1.11); C502(0.92); C110(0.96); C4(1.02)  LDD1536  [24]
 LDCM0298  AC37 HEK-293T C93(0.94); C502(1.07); C259(1.08); C272(1.00)  LDD1537  [24]
 LDCM0299  AC38 HEK-293T C93(1.06); C502(1.02); C272(1.07); C110(0.92)  LDD1538  [24]
 LDCM0300  AC39 HEK-293T C93(1.00); C502(1.00); C272(1.05); C110(0.95)  LDD1539  [24]
 LDCM0301  AC4 HEK-293T C93(0.96); C502(0.95); C110(1.00); C4(1.02)  LDD1540  [24]
 LDCM0302  AC40 HEK-293T C93(1.10); C502(1.00); C272(1.01); C110(1.01)  LDD1541  [24]
 LDCM0303  AC41 HEK-293T C93(0.99); C502(0.98); C272(0.99); C110(0.94)  LDD1542  [24]
 LDCM0304  AC42 HEK-293T C93(0.93); C502(0.88); C272(1.01); C110(1.01)  LDD1543  [24]
 LDCM0305  AC43 HEK-293T C93(0.89); C502(0.94); C272(0.92); C110(1.01)  LDD1544  [24]
 LDCM0306  AC44 HEK-293T C93(1.08); C502(0.96); C110(0.99); C4(1.03)  LDD1545  [24]
 LDCM0307  AC45 HEK-293T C93(0.93); C502(1.07); C259(1.00); C272(1.01)  LDD1546  [24]
 LDCM0308  AC46 HEK-293T C93(1.06); C502(1.07); C272(1.08); C110(1.01)  LDD1547  [24]
 LDCM0309  AC47 HEK-293T C93(1.04); C502(0.90); C272(0.96); C110(0.99)  LDD1548  [24]
 LDCM0310  AC48 HEK-293T C93(0.97); C502(0.95); C272(1.00); C110(1.03)  LDD1549  [24]
 LDCM0311  AC49 HEK-293T C93(0.84); C502(1.01); C272(1.06); C110(1.04)  LDD1550  [24]
 LDCM0312  AC5 HEK-293T C93(0.95); C502(0.98); C259(1.00); C272(1.09)  LDD1551  [24]
 LDCM0313  AC50 HEK-293T C93(0.93); C502(0.99); C272(0.94); C110(1.08)  LDD1552  [24]
 LDCM0314  AC51 HEK-293T C93(1.08); C502(0.97); C272(0.93); C110(1.12)  LDD1553  [24]
 LDCM0315  AC52 HEK-293T C93(1.04); C502(0.91); C110(0.83); C4(1.08)  LDD1554  [24]
 LDCM0316  AC53 HEK-293T C93(0.92); C502(0.99); C259(1.25); C272(0.97)  LDD1555  [24]
 LDCM0317  AC54 HEK-293T C93(0.93); C502(0.91); C272(0.97); C110(1.01)  LDD1556  [24]
 LDCM0318  AC55 HEK-293T C93(1.02); C502(0.88); C272(0.90); C110(0.98)  LDD1557  [24]
 LDCM0319  AC56 HEK-293T C93(0.94); C502(1.01); C272(0.90); C110(1.00)  LDD1558  [24]
 LDCM0320  AC57 HEK-293T C93(0.93); C502(1.02); C272(0.99); C110(0.90)  LDD1559  [24]
 LDCM0321  AC58 HEK-293T C93(1.07); C502(0.96); C272(0.98); C110(0.95)  LDD1560  [24]
 LDCM0322  AC59 HEK-293T C93(0.93); C502(0.96); C272(0.95); C110(1.12)  LDD1561  [24]
 LDCM0323  AC6 HEK-293T C93(0.97); C502(1.22); C272(1.10); C110(1.01)  LDD1562  [24]
 LDCM0324  AC60 HEK-293T C93(1.09); C502(0.93); C110(1.01); C4(1.14)  LDD1563  [24]
 LDCM0325  AC61 HEK-293T C93(0.92); C502(0.99); C259(1.21); C272(0.95)  LDD1564  [24]
 LDCM0326  AC62 HEK-293T C93(0.97); C502(0.96); C272(0.92); C110(0.99)  LDD1565  [24]
 LDCM0327  AC63 HEK-293T C93(0.97); C502(0.87); C272(1.05); C110(0.98)  LDD1566  [24]
 LDCM0328  AC64 HEK-293T C93(1.03); C502(0.89); C272(0.97); C110(1.11)  LDD1567  [24]
 LDCM0334  AC7 HEK-293T C93(1.03); C502(0.99); C272(1.02); C110(1.05)  LDD1568  [24]
 LDCM0345  AC8 HEK-293T C93(0.87); C502(0.93); C272(1.02); C110(1.08)  LDD1569  [24]
 LDCM0248  AKOS034007472 HEK-293T C93(0.94); C502(1.00); C259(1.07); C272(1.01)  LDD1511  [24]
 LDCM0356  AKOS034007680 HEK-293T C93(0.92); C502(1.03); C272(1.02); C110(0.91)  LDD1570  [24]
 LDCM0275  AKOS034007705 HEK-293T C93(0.99); C502(1.01); C272(0.99); C110(1.00)  LDD1514  [24]
 LDCM0156  Aniline NCI-H1299 9.69  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HEK-293T C93(1.24); C502(1.02); C259(1.09); C272(1.23)  LDD1571  [24]
 LDCM0368  CL10 HEK-293T C93(0.93); C502(1.29); C272(1.18); C110(0.53)  LDD1572  [24]
 LDCM0369  CL100 HEK-293T C93(0.94); C502(1.02); C259(0.97); C272(1.12)  LDD1573  [24]
 LDCM0370  CL101 HEK-293T C93(0.96); C502(0.97); C259(0.99); C272(1.07)  LDD1574  [24]
 LDCM0371  CL102 HEK-293T C93(0.93); C502(1.08); C259(0.92); C272(1.06)  LDD1575  [24]
 LDCM0372  CL103 HEK-293T C93(0.98); C502(0.97); C272(1.04); C110(0.92)  LDD1576  [24]
 LDCM0373  CL104 HEK-293T C93(1.09); C502(0.95); C259(0.94); C272(1.05)  LDD1577  [24]
 LDCM0374  CL105 HEK-293T C93(0.97); C502(0.84); C259(0.93); C272(1.11)  LDD1578  [24]
 LDCM0375  CL106 HEK-293T C93(0.98); C502(1.04); C259(1.21); C272(1.09)  LDD1579  [24]
 LDCM0376  CL107 HEK-293T C93(0.96); C502(0.92); C272(1.02); C110(1.00)  LDD1580  [24]
 LDCM0377  CL108 HEK-293T C93(1.18); C502(1.05); C259(1.01); C272(1.23)  LDD1581  [24]
 LDCM0378  CL109 HEK-293T C93(1.08); C502(1.02); C259(1.12); C272(1.12)  LDD1582  [24]
 LDCM0379  CL11 HEK-293T C93(1.23); C502(1.43); C272(1.48); C110(0.66)  LDD1583  [24]
 LDCM0380  CL110 HEK-293T C93(0.96); C502(1.11); C259(0.94); C272(1.08)  LDD1584  [24]
 LDCM0381  CL111 HEK-293T C93(1.08); C502(1.21); C272(1.18); C110(0.90)  LDD1585  [24]
 LDCM0382  CL112 HEK-293T C93(1.00); C502(0.98); C259(0.96); C272(0.92)  LDD1586  [24]
 LDCM0383  CL113 HEK-293T C93(0.97); C502(0.80); C259(1.14); C272(1.08)  LDD1587  [24]
 LDCM0384  CL114 HEK-293T C93(0.98); C502(1.06); C259(1.19); C272(0.97)  LDD1588  [24]
 LDCM0385  CL115 HEK-293T C93(1.04); C502(1.09); C272(1.17); C110(0.94)  LDD1589  [24]
 LDCM0386  CL116 HEK-293T C93(1.12); C502(0.94); C259(1.02); C272(0.90)  LDD1590  [24]
 LDCM0387  CL117 HEK-293T C93(0.96); C502(0.90); C259(1.11); C272(0.96)  LDD1591  [24]
 LDCM0388  CL118 HEK-293T C93(0.84); C502(1.00); C259(1.03); C272(0.98)  LDD1592  [24]
 LDCM0389  CL119 HEK-293T C93(0.90); C502(1.15); C272(1.04); C110(0.94)  LDD1593  [24]
 LDCM0390  CL12 HEK-293T C93(0.92); C502(0.97); C272(1.09); C110(0.69)  LDD1594  [24]
 LDCM0391  CL120 HEK-293T C93(1.06); C502(0.92); C259(0.94); C272(1.03)  LDD1595  [24]
 LDCM0392  CL121 HEK-293T C93(0.98); C502(0.88); C259(0.99); C272(0.96)  LDD1596  [24]
 LDCM0393  CL122 HEK-293T C93(0.92); C502(0.99); C259(0.99); C272(1.05)  LDD1597  [24]
 LDCM0394  CL123 HEK-293T C93(1.05); C502(1.19); C272(1.26); C110(0.95)  LDD1598  [24]
 LDCM0395  CL124 HEK-293T C93(1.10); C502(0.98); C259(1.05); C272(0.99)  LDD1599  [24]
 LDCM0396  CL125 HEK-293T C93(1.03); C502(0.82); C259(1.03); C272(0.96)  LDD1600  [24]
 LDCM0397  CL126 HEK-293T C93(0.93); C502(1.10); C259(1.01); C272(1.11)  LDD1601  [24]
 LDCM0398  CL127 HEK-293T C93(0.89); C502(1.05); C272(1.03); C110(1.06)  LDD1602  [24]
 LDCM0399  CL128 HEK-293T C93(1.09); C502(0.95); C259(1.02); C272(0.98)  LDD1603  [24]
 LDCM0400  CL13 HEK-293T C93(0.98); C502(0.95); C259(1.12); C272(0.98)  LDD1604  [24]
 LDCM0401  CL14 HEK-293T C93(1.02); C502(1.54); C259(1.37); C272(1.34)  LDD1605  [24]
 LDCM0402  CL15 HEK-293T C93(0.86); C502(1.19); C272(1.03); C110(0.78)  LDD1606  [24]
 LDCM0403  CL16 HEK-293T C93(1.03); C502(0.94); C259(1.05); C272(1.00)  LDD1607  [24]
 LDCM0404  CL17 HEK-293T C93(0.92); C502(1.11); C272(1.05); C110(0.69)  LDD1608  [24]
 LDCM0405  CL18 HEK-293T C93(1.01); C502(0.96); C272(0.98); C110(0.71)  LDD1609  [24]
 LDCM0406  CL19 HEK-293T C93(0.86); C502(1.11); C272(1.04); C110(0.80)  LDD1610  [24]
 LDCM0407  CL2 HEK-293T C93(1.09); C502(1.90); C259(1.10); C272(1.54)  LDD1611  [24]
 LDCM0408  CL20 HEK-293T C93(1.04); C502(1.14); C110(0.68); C4(1.33)  LDD1612  [24]
 LDCM0409  CL21 HEK-293T C93(0.95); C502(1.07); C259(1.83); C272(0.97)  LDD1613  [24]
 LDCM0410  CL22 HEK-293T C93(1.23); C502(1.35); C272(1.33); C110(0.66)  LDD1614  [24]
 LDCM0411  CL23 HEK-293T C93(1.04); C502(1.08); C272(1.07); C110(0.67)  LDD1615  [24]
 LDCM0412  CL24 HEK-293T C93(1.19); C502(1.08); C272(1.08); C110(0.75)  LDD1616  [24]
 LDCM0413  CL25 HEK-293T C93(1.10); C502(0.85); C259(1.05); C272(0.99)  LDD1617  [24]
 LDCM0414  CL26 HEK-293T C93(0.94); C502(0.99); C259(1.02); C272(1.07)  LDD1618  [24]
 LDCM0415  CL27 HEK-293T C93(0.89); C502(0.95); C272(1.00); C110(0.78)  LDD1619  [24]
 LDCM0416  CL28 HEK-293T C93(1.09); C502(0.97); C259(1.08); C272(0.97)  LDD1620  [24]
 LDCM0417  CL29 HEK-293T C93(0.86); C502(0.99); C272(1.13); C110(0.76)  LDD1621  [24]
 LDCM0418  CL3 HEK-293T C93(1.05); C502(1.13); C272(1.15); C110(0.79)  LDD1622  [24]
 LDCM0419  CL30 HEK-293T C93(0.85); C502(1.07); C272(1.02); C110(0.80)  LDD1623  [24]
 LDCM0420  CL31 HEK-293T C93(0.88); C502(1.26); C272(1.10); C110(0.81)  LDD1624  [24]
 LDCM0421  CL32 HEK-293T C93(0.99); C502(1.08); C110(0.68); C4(1.19)  LDD1625  [24]
 LDCM0422  CL33 HEK-293T C93(0.85); C502(0.98); C259(1.73); C272(1.03)  LDD1626  [24]
 LDCM0423  CL34 HEK-293T C93(1.16); C502(1.28); C272(1.27); C110(0.68)  LDD1627  [24]
 LDCM0424  CL35 HEK-293T C93(1.08); C502(1.02); C272(1.04); C110(0.73)  LDD1628  [24]
 LDCM0425  CL36 HEK-293T C93(0.49); C502(1.31); C272(1.04); C110(0.75)  LDD1629  [24]
 LDCM0426  CL37 HEK-293T C93(0.89); C502(0.95); C259(1.00); C272(0.92)  LDD1630  [24]
 LDCM0428  CL39 HEK-293T C93(1.03); C502(1.43); C272(1.20); C110(0.92)  LDD1632  [24]
 LDCM0429  CL4 HEK-293T C93(1.07); C502(1.24); C259(1.06); C272(1.22)  LDD1633  [24]
 LDCM0430  CL40 HEK-293T C93(0.98); C502(0.96); C259(0.91); C272(0.96)  LDD1634  [24]
 LDCM0431  CL41 HEK-293T C93(0.93); C502(1.01); C272(0.98); C110(0.82)  LDD1635  [24]
 LDCM0432  CL42 HEK-293T C93(1.06); C502(1.10); C272(1.05); C110(0.88)  LDD1636  [24]
 LDCM0433  CL43 HEK-293T C93(1.06); C502(1.22); C272(1.23); C110(0.81)  LDD1637  [24]
 LDCM0434  CL44 HEK-293T C93(1.05); C502(1.04); C110(0.63); C4(1.16)  LDD1638  [24]
 LDCM0435  CL45 HEK-293T C93(0.88); C502(1.39); C259(1.35); C272(1.36)  LDD1639  [24]
 LDCM0436  CL46 HEK-293T C93(1.09); C502(1.34); C272(1.33); C110(0.69)  LDD1640  [24]
 LDCM0437  CL47 HEK-293T C93(1.15); C502(1.06); C272(1.14); C110(0.70)  LDD1641  [24]
 LDCM0438  CL48 HEK-293T C93(0.98); C502(1.11); C272(1.01); C110(0.79)  LDD1642  [24]
 LDCM0439  CL49 HEK-293T C93(0.91); C502(0.97); C259(1.14); C272(1.12)  LDD1643  [24]
 LDCM0440  CL5 HEK-293T C93(1.09); C502(1.16); C272(1.13); C110(0.78)  LDD1644  [24]
 LDCM0441  CL50 HEK-293T C93(0.99); C502(1.07); C259(1.01); C272(1.12)  LDD1645  [24]
 LDCM0443  CL52 HEK-293T C93(1.07); C502(0.98); C259(0.97); C272(1.10)  LDD1646  [24]
 LDCM0444  CL53 HEK-293T C93(0.87); C502(1.12); C272(1.03); C110(0.69)  LDD1647  [24]
 LDCM0445  CL54 HEK-293T C93(1.15); C502(1.00); C272(1.26); C110(0.64)  LDD1648  [24]
 LDCM0446  CL55 HEK-293T C93(1.09); C502(1.06); C272(0.94); C110(0.79)  LDD1649  [24]
 LDCM0447  CL56 HEK-293T C93(0.93); C502(1.09); C110(0.67); C4(1.14)  LDD1650  [24]
 LDCM0448  CL57 HEK-293T C93(0.97); C502(1.22); C259(1.49); C272(1.11)  LDD1651  [24]
 LDCM0449  CL58 HEK-293T C93(0.99); C502(1.32); C272(1.45); C110(0.59)  LDD1652  [24]
 LDCM0450  CL59 HEK-293T C93(1.08); C502(1.03); C272(1.05); C110(0.67)  LDD1653  [24]
 LDCM0451  CL6 HEK-293T C93(1.10); C502(1.07); C272(1.01); C110(0.68)  LDD1654  [24]
 LDCM0452  CL60 HEK-293T C93(1.16); C502(1.23); C272(1.16); C110(0.74)  LDD1655  [24]
 LDCM0453  CL61 HEK-293T C93(0.95); C502(0.84); C259(0.93); C272(1.01)  LDD1656  [24]
 LDCM0454  CL62 HEK-293T C93(0.99); C502(1.38); C259(1.10); C272(1.29)  LDD1657  [24]
 LDCM0455  CL63 HEK-293T C93(0.95); C502(1.03); C272(0.95); C110(0.89)  LDD1658  [24]
 LDCM0456  CL64 HEK-293T C93(1.16); C502(0.99); C259(0.90); C272(1.05)  LDD1659  [24]
 LDCM0457  CL65 HEK-293T C93(1.11); C502(1.06); C272(1.06); C110(0.85)  LDD1660  [24]
 LDCM0458  CL66 HEK-293T C93(0.97); C502(1.06); C272(1.00); C110(0.77)  LDD1661  [24]
 LDCM0459  CL67 HEK-293T C93(0.88); C502(1.09); C272(0.91); C110(0.81)  LDD1662  [24]
 LDCM0460  CL68 HEK-293T C93(1.10); C502(1.17); C110(0.70); C4(1.19)  LDD1663  [24]
 LDCM0461  CL69 HEK-293T C93(1.05); C502(1.39); C259(1.69); C272(1.41)  LDD1664  [24]
 LDCM0462  CL7 HEK-293T C93(0.79); C502(1.10); C272(1.19); C110(0.76)  LDD1665  [24]
 LDCM0463  CL70 HEK-293T C93(1.03); C502(1.18); C272(1.06); C110(0.64)  LDD1666  [24]
 LDCM0464  CL71 HEK-293T C93(1.12); C502(0.99); C272(1.02); C110(0.73)  LDD1667  [24]
 LDCM0465  CL72 HEK-293T C93(1.09); C502(1.17); C272(1.11); C110(0.73)  LDD1668  [24]
 LDCM0466  CL73 HEK-293T C93(0.82); C502(0.83); C259(1.06); C272(0.89)  LDD1669  [24]
 LDCM0467  CL74 HEK-293T C93(1.00); C502(1.12); C259(0.93); C272(1.04)  LDD1670  [24]
 LDCM0469  CL76 HEK-293T C93(1.10); C502(1.06); C259(1.21); C272(1.28)  LDD1672  [24]
 LDCM0470  CL77 HEK-293T C93(0.98); C502(1.08); C272(1.16); C110(0.82)  LDD1673  [24]
 LDCM0471  CL78 HEK-293T C93(0.99); C502(1.12); C272(0.98); C110(0.83)  LDD1674  [24]
 LDCM0472  CL79 HEK-293T C93(0.92); C502(1.17); C272(1.12); C110(0.84)  LDD1675  [24]
 LDCM0473  CL8 HEK-293T C93(0.96); C502(0.94); C110(0.46); C4(1.27)  LDD1676  [24]
 LDCM0474  CL80 HEK-293T C93(1.11); C502(1.24); C110(0.78); C4(1.31)  LDD1677  [24]
 LDCM0475  CL81 HEK-293T C93(1.01); C502(1.09); C259(1.67); C272(1.20)  LDD1678  [24]
 LDCM0476  CL82 HEK-293T C93(1.07); C502(1.12); C272(1.11); C110(0.71)  LDD1679  [24]
 LDCM0477  CL83 HEK-293T C93(1.15); C502(1.01); C272(1.13); C110(0.74)  LDD1680  [24]
 LDCM0478  CL84 HEK-293T C93(0.99); C502(0.09); C272(1.05); C110(0.74)  LDD1681  [24]
 LDCM0479  CL85 HEK-293T C93(0.96); C502(0.88); C259(1.01); C272(0.98)  LDD1682  [24]
 LDCM0480  CL86 HEK-293T C93(0.91); C502(1.04); C259(0.98); C272(1.01)  LDD1683  [24]
 LDCM0481  CL87 HEK-293T C93(0.85); C502(1.08); C272(0.99); C110(1.00)  LDD1684  [24]
 LDCM0482  CL88 HEK-293T C93(1.07); C502(1.01); C259(0.99); C272(1.03)  LDD1685  [24]
 LDCM0483  CL89 HEK-293T C93(0.98); C502(1.06); C272(1.16); C110(0.87)  LDD1686  [24]
 LDCM0484  CL9 HEK-293T C93(0.99); C502(1.28); C259(1.35); C272(1.40)  LDD1687  [24]
 LDCM0485  CL90 HEK-293T C93(0.89); C502(1.06); C272(0.99); C110(0.72)  LDD1688  [24]
 LDCM0486  CL91 HEK-293T C93(0.88); C502(1.09); C272(0.98); C110(0.92)  LDD1689  [24]
 LDCM0487  CL92 HEK-293T C93(1.01); C502(1.15); C110(0.79); C4(1.08)  LDD1690  [24]
 LDCM0488  CL93 HEK-293T C93(0.95); C502(1.24); C259(1.22); C272(1.13)  LDD1691  [24]
 LDCM0489  CL94 HEK-293T C93(1.07); C502(1.36); C272(1.42); C110(0.76)  LDD1692  [24]
 LDCM0490  CL95 HEK-293T C93(0.90); C502(0.86); C272(0.91); C110(0.64)  LDD1693  [24]
 LDCM0491  CL96 HEK-293T C93(0.96); C502(0.87); C272(1.10); C110(0.77)  LDD1694  [24]
 LDCM0492  CL97 HEK-293T C93(0.87); C502(0.88); C259(1.11); C272(1.08)  LDD1695  [24]
 LDCM0493  CL98 HEK-293T C93(0.96); C502(1.29); C259(0.97); C272(1.40)  LDD1696  [24]
 LDCM0494  CL99 HEK-293T C93(0.99); C502(1.36); C272(1.23); C110(1.01)  LDD1697  [24]
 LDCM0495  E2913 HEK-293T C93(1.34); C502(1.73); C272(1.59); C110(0.87)  LDD1698  [24]
 LDCM0625  F8 Ramos C272(1.46); C531(0.92); C110(0.49); 2.14  LDD2187  [25]
 LDCM0572  Fragment10 MDA-MB-231 C340(13.35)  LDD1465  [26]
 LDCM0573  Fragment11 Ramos C272(1.83); C531(0.93); C110(0.06)  LDD2190  [25]
 LDCM0574  Fragment12 MDA-MB-231 C340(20.00)  LDD1468  [26]
 LDCM0575  Fragment13 MDA-MB-231 C340(1.12)  LDD1469  [26]
 LDCM0576  Fragment14 MDA-MB-231 C340(0.73)  LDD1471  [26]
 LDCM0579  Fragment20 Ramos C272(0.39); C531(0.52); C110(0.46); 1.62  LDD2194  [25]
 LDCM0580  Fragment21 MDA-MB-231 C340(1.21)  LDD1473  [26]
 LDCM0582  Fragment23 Ramos C272(0.80); C531(0.82); C110(1.03); 1.00  LDD2196  [25]
 LDCM0578  Fragment27 MDA-MB-231 C340(0.92)  LDD1474  [26]
 LDCM0586  Fragment28 Ramos C272(0.71); C110(2.59); 2.96; C93(0.52)  LDD2198  [25]
 LDCM0587  Fragment29 Ramos C340(1.00)  LDD1476  [26]
 LDCM0588  Fragment30 Ramos C272(1.05); C531(0.80); C110(0.98); 0.77  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C340(1.04)  LDD1478  [26]
 LDCM0590  Fragment32 Ramos C272(0.86); C531(0.56); C110(0.52)  LDD2201  [25]
 LDCM0468  Fragment33 MDA-MB-231 C340(0.93)  LDD1479  [26]
 LDCM0596  Fragment38 Ramos C272(0.76); C531(0.86); C110(1.08); 0.54  LDD2203  [25]
 LDCM0566  Fragment4 MDA-MB-231 C340(1.01)  LDD1461  [26]
 LDCM0603  Fragment45 MDA-MB-231 C340(2.42)  LDD1482  [26]
 LDCM0427  Fragment51 HEK-293T C93(0.95); C502(1.42); C259(1.24); C272(1.43)  LDD1631  [24]
 LDCM0610  Fragment52 Ramos C272(1.24); C531(0.90); C110(1.77)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C272(1.28); C531(0.79); C110(1.12); 1.12  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C272(0.43); C531(0.76); C110(0.76); 1.24  LDD2186  [25]
 LDCM0570  Fragment8 MDA-MB-231 C340(2.71)  LDD1462  [26]
 LDCM0571  Fragment9 Ramos C340(1.47)  LDD1464  [26]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [8]
 LDCM0022  KB02 MDA-MB-231 C340(1.94)  LDD1460  [26]
 LDCM0023  KB03 Jurkat C340(7.09); C340,C342(4.16)  LDD0315  [13]
 LDCM0024  KB05 HMCB C110(0.95); C285(1.50); C515(0.89); C544(0.86)  LDD3312  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C340(0.92); C340(0.91)  LDD2206  [27]
 LDCM0628  OTUB2-COV-1 HEK-293T C340(0.74)  LDD2207  [27]
 LDCM0131  RA190 MM1.R C340(1.30)  LDD0304  [28]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Chlormerodrin Small molecular drug D06EMT
Nadh Small molecular drug DB00157
Succinic Acid Small molecular drug D06VNK
Valproic Acid Small molecular drug DB00313
Sodium Oxybate . DB09072
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-(4-hydroxyphenyl)Prop-2-en-1-one Small molecular drug D0L7RB
Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
T83193 Small molecular drug D0B5YS

References

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2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
23 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
28 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.