Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment21  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 95 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03496  Protein PML (PML) C389 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C307 20.0
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) C138 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C71 8.3
 LDTP18123  Isochorismatase domain-containing protein 2 (ISOC2) C114 4.9
 LDTP10973  Thioredoxin, mitochondrial (TXN2) C90 4.3
 LDTP02502  Thioredoxin (TXN) C32 3.9
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) C258 2.8
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 2.7
 LDTP02223  Cathepsin B (CTSB) C211 2.6
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) C1224 2.2
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) C216 2.2
 LDTP08401  All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2) C71 2.1
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 2.0
 LDTP19669  Threonine synthase-like 1 (THNSL1) C324 2.0
 LDTP03000  General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) C342 2.0
 LDTP10320  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (TRMT61A) C209 2.0
 LDTP10982  Aconitate hydratase, mitochondrial (ACO2) C385 2.0
 LDTP15290  5'-nucleotidase domain-containing protein 3 (NT5DC3) C276 1.8
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.8
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C223 1.8
 LDTP15370  Pseudouridylate synthase RPUSD2 (RPUSD2) C246 1.8
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.7
 LDTP06320  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) C71 1.7
 LDTP00642  DNA-directed RNA polymerase I subunit RPA34 (POLR1G) C86 1.7
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.7
 LDTP18330  Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5) C392 1.6
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) C170 1.6
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C312 1.6
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.6
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.6
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 1.6
 LDTP09126  Probable aminopeptidase NPEPL1 (NPEPL1) C81 1.6
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 1.5
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) C317 1.5
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.5
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.5
 LDTP01055  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) C158 1.4
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.4
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.4
 LDTP10774  Elongation factor G, mitochondrial (GFM1) C153 1.4
 LDTP08254  Ubiquitin carboxyl-terminal hydrolase 48 (USP48) C39 1.4
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 1.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 1.4
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.3
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.3
 LDTP12539  DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) C130 1.3
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 1.3
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.3
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.2
 LDTP04438  Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) C340 1.2
 LDTP00479  Histone acetyltransferase type B catalytic subunit (HAT1) C101 1.2
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119 1.1
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C758 1.1
 LDTP04547  Nuclear pore complex protein Nup98-Nup96 (NUP98) C1312 1.1
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) C773 1.1
 LDTP16095  Ethylmalonyl-CoA decarboxylase (ECHDC1) C133 1.1
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C57 1.0
 LDTP04232  4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) C288 1.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 1.0
 LDTP08808  E3 SUMO-protein ligase PIAS4 (PIAS4) C326 1.0
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 1.0
 LDTP03937  Ubiquitin-like modifier-activating enzyme 7 (UBA7) C599 1.0
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 0.9
 LDTP05943  Myotubularin-related protein 1 (MTMR1) C117 0.9
 LDTP03258  Thymidylate kinase (DTYMK) C117 0.9
 LDTP06211  Caspase-8 (CASP8) C360 0.9
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 0.9
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) C205 0.9
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.9
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 0.9
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.9
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C114 0.9
 LDTP05954  GDP-L-fucose synthase (GFUS) C116 0.8
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 0.8
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 0.8
 LDTP04374  Dynamin-2 (DNM2) C27 0.8
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 0.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C54 0.8
 LDTP03770  Alpha-adducin (ADD1) C68 0.8
 LDTP06603  Cyclin-dependent kinase inhibitor 3 (CDKN3) C39 0.8
 LDTP15427  Ribonuclease P protein subunit p25-like protein (RPP25L) C131 0.8
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 0.8
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.7
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 0.7
 LDTP11617  Myotubularin-related protein 12 (MTMR12) C152 0.7
 LDTP00414  Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) C131 0.7
 LDTP02493  Serine/threonine-protein kinase A-Raf (ARAF) C597 0.7
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 0.7
 LDTP00481  Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) C98 0.7
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 0.6
 LDTP03401  Multifunctional protein CAD (CAD) C73 0.6
 LDTP07407  Desumoylating isopeptidase 1 (DESI1) C108 0.6
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 0.6
 LDTP05859  Integrin-linked protein kinase (ILK) C346 0.5
Transporter and channel
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 16.0
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 2.9
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) C100 2.2
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 1.8
 LDTP05591  Nuclear cap-binding protein subunit 1 (NCBP1) C44 1.3
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 1.3
 LDTP10642  Chloride intracellular channel protein 6 (CLIC6) C487 1.2
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.1
 LDTP01689  Chloride intracellular channel protein 3 (CLIC3) C22 1.0
 LDTP00501  Exportin-1 (XPO1) C528 0.8
 LDTP04801  Gasdermin-D (GSDMD) C268 0.7
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 0.7
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.6
 LDTP06475  Mothers against decapentaplegic homolog 2 (SMAD2) C81 1.3
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 1.1
 LDTP03280  COUP transcription factor 2 (NR2F2) C326 1.1
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 0.8
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 0.7
Other
Click to Show/Hide to Show 63 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 20.0
 LDTP06244  Nuclear mitotic apparatus protein 1 (NUMA1) C961 3.7
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 2.8
 LDTP03994  Condensin-2 complex subunit D3 (NCAPD3) C541 2.3
 LDTP12412  Reticulon-4 (RTN4) C1101 2.1
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.7
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 1.7
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C629 1.6
 LDTP12883  Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A) C531 1.6
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 1.5
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) C391 1.5
 LDTP15896  Ashwin (C2orf49) C10 1.5
 LDTP14215  Small ribosomal subunit protein mS40 (MRPS18B) C128 1.5
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.5
 LDTP16117  Mediator of RNA polymerase II transcription subunit 9 (MED9) C139 1.5
 LDTP05867  Treacle protein (TCOF1) C38 1.5
 LDTP04487  Cyclin-H (CCNH) C244 1.4
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C518 1.4
 LDTP18494  Tropomodulin-3 (TMOD3) C132 1.4
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.4
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.4
 LDTP09626  Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) C464 1.4
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.4
 LDTP12753  Succinate dehydrogenase assembly factor 2, mitochondrial (SDHAF2) C83 1.3
 LDTP13580  Coronin-1C (CORO1C) C420 1.3
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.1
 LDTP06362  Leucine-rich repeat-containing protein 41 (LRRC41) C297 1.1
 LDTP09650  LIM domain only protein 7 (LMO7) C228 1.1
 LDTP06046  Ribosome biogenesis protein BOP1 (BOP1) C404 1.1
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 1.0
 LDTP06330  Plectin (PLEC) C4574 1.0
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 1.0
 LDTP10864  Calponin-2 (CNN2) C164 0.9
 LDTP12571  LanC-like protein 2 (LANCL2) C187 0.9
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.9
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 0.9
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 0.9
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 0.9
 LDTP07205  Telomere-associated protein RIF1 (RIF1) C2298 0.9
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C645 0.9
 LDTP17182  Uncharacterized protein C3orf38 (C3orf38) C308 0.9
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 0.9
 LDTP04092  Crk-like protein (CRKL) C249 0.9
 LDTP13705  LIM and calponin homology domains-containing protein 1 (LIMCH1) C140 0.8
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 0.8
 LDTP01532  ZW10 interactor (ZWINT) C54 0.8
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 0.8
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 0.8
 LDTP07755  Dynamin-binding protein (DNMBP) C691 0.8
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 0.8
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 0.8
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 0.8
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 0.8
 LDTP10284  Multivesicular body subunit 12A (MVB12A) C231 0.7
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) C18 0.7
 LDTP10657  Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1) C900 0.7
 LDTP00229  Copper transport protein ATOX1 (ATOX1) C12 0.7
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C439 0.7
 LDTP10252  Elongator complex protein 4 (ELP4) C218 0.7
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 0.7
 LDTP14250  Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1) C51 0.6
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 0.5

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.