Details of the Target

General Information of Target

Target ID LDTP00481
Target Name Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6)
Gene Name UBE2L6
Gene ID 9246
Synonyms
UBCH8; Ubiquitin/ISG15-conjugating enzyme E2 L6; EC 2.3.2.23; E2 ubiquitin-conjugating enzyme L6; Retinoic acid-induced gene B protein; RIG-B; UbcH8; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPE
YPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREP
LRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS
Target Bioclass
Enzyme
Family
Ubiquitin-conjugating enzyme family
Function
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.
Uniprot ID
O14933
Ensemble ID
ENST00000287156.9
HGNC ID
HGNC:12490

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 SNV: p.E106D .
NCIH2172 SNV: p.A140G .
SKMEL30 Substitution: p.R146Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K9(6.07)  LDD0277  [1]
NAIA_5
 Probe Info  		C86(1.13)  LDD2227  [2]
EA-probe
 Probe Info  		C98(0.91)  LDD2210  [3]
DBIA
 Probe Info  		C102(0.97); C86(0.92); C98(0.92)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
Compound 10
 Probe Info  		C102(0.00); C98(0.00)  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
IPM
 Probe Info  		N.A.  LDD2156  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C102(0.97)  LDD0531  [4]
 LDCM0215  AC10 PaTu 8988t C102(0.93)  LDD1094  [4]
 LDCM0216  AC100 PaTu 8988t C102(1.23)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C102(1.01)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C102(1.38)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C102(1.54)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C102(1.12)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C102(1.13)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C102(1.62)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C102(1.24)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C102(1.30)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C102(1.53)  LDD1104  [4]
 LDCM0226  AC11 PaTu 8988t C102(1.05)  LDD1105  [4]
 LDCM0227  AC110 PaTu 8988t C102(1.35)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C102(1.40)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C102(1.15)  LDD1108  [4]
 LDCM0230  AC113 PaTu 8988t C102(1.10)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C102(1.08)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C102(0.99)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C102(1.32)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C102(0.91)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C102(1.06)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C102(1.04)  LDD1115  [4]
 LDCM0237  AC12 PaTu 8988t C102(1.06)  LDD1116  [4]
 LDCM0238  AC120 PaTu 8988t C102(1.24)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C102(1.01)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C102(1.51)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C102(1.22)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C102(1.38)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C102(1.61)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C102(1.27)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C102(0.96)  LDD1124  [4]
 LDCM0259  AC14 PaTu 8988t C102(1.22)  LDD1138  [4]
 LDCM0270  AC15 PaTu 8988t C102(1.11)  LDD1149  [4]
 LDCM0276  AC17 HCT 116 C102(1.54)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C102(2.41)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C102(2.02)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C102(1.78)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C102(1.60)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C102(1.93)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C102(1.61)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C102(1.52)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C102(1.47)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C102(1.11)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C102(1.51)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C102(1.40)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C102(1.30)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C102(1.36)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C102(1.13)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C102(1.20)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C102(1.39)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C102(1.44)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C102(1.43)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C102(1.48)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C102(0.93)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C102(1.62)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C102(1.15)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C102(0.98)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C102(0.96)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C102(1.06)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C102(1.31)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C102(1.10)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C102(1.48)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C102(1.34)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C102(1.52)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C102(1.36)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C102(1.35)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C102(1.40)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C102(1.08)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C102(1.27)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C102(1.19)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C102(1.11)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C102(1.01)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C102(0.93)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C102(0.89)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C102(1.18)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C102(1.35)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C102(1.50)  LDD0636  [4]
 LDCM0320  AC57 PaTu 8988t C102(0.92)  LDD1199  [4]
 LDCM0321  AC58 PaTu 8988t C102(0.87)  LDD1200  [4]
 LDCM0322  AC59 PaTu 8988t C102(0.91)  LDD1201  [4]
 LDCM0323  AC6 PaTu 8988t C102(1.03)  LDD1202  [4]
 LDCM0324  AC60 PaTu 8988t C102(0.86)  LDD1203  [4]
 LDCM0325  AC61 PaTu 8988t C102(0.83)  LDD1204  [4]
 LDCM0326  AC62 PaTu 8988t C102(0.90)  LDD1205  [4]
 LDCM0327  AC63 PaTu 8988t C102(0.84)  LDD1206  [4]
 LDCM0328  AC64 PaTu 8988t C102(0.75)  LDD1207  [4]
 LDCM0329  AC65 PaTu 8988t C102(0.74)  LDD1208  [4]
 LDCM0330  AC66 PaTu 8988t C102(0.79)  LDD1209  [4]
 LDCM0331  AC67 PaTu 8988t C102(0.93)  LDD1210  [4]
 LDCM0332  AC68 PaTu 8988t C102(0.87)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C102(1.29)  LDD1212  [4]
 LDCM0334  AC7 PaTu 8988t C102(1.21)  LDD1213  [4]
 LDCM0335  AC70 PaTu 8988t C102(1.35)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C102(0.87)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C102(0.90)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C102(0.64)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C102(1.12)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C102(1.30)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C102(0.71)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C102(0.74)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C102(0.95)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C102(1.09)  LDD1223  [4]
 LDCM0345  AC8 PaTu 8988t C102(0.97)  LDD1224  [4]
 LDCM0346  AC80 PaTu 8988t C102(0.79)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C102(1.18)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C102(1.02)  LDD1227  [4]
 LDCM0365  AC98 PaTu 8988t C102(1.60)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C102(1.36)  LDD1245  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C102(0.88)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C102(1.15)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C102(1.02)  LDD1154  [4]
 LDCM0020  ARS-1620 HCC44 C102(0.97); C86(0.92); C98(0.92)  LDD0078  [4]
 LDCM0630  CCW28-3 231MFP C98(1.20)  LDD2214  [9]
 LDCM0632  CL-Sc Hep-G2 C86(1.13)  LDD2227  [2]
 LDCM0367  CL1 HCT 116 C102(1.02)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C102(1.83)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C102(1.31)  LDD0686  [4]
 LDCM0370  CL101 PaTu 8988t C102(0.84)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C102(0.87)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C102(1.08)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C102(0.97)  LDD1252  [4]
 LDCM0374  CL105 HCT 116 C102(2.23)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C102(2.21)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C102(1.88)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C102(2.04)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C102(1.48)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C102(1.05)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C102(2.12)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C102(1.74)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C102(1.21)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C102(1.52)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C102(1.17)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C102(1.35)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C102(1.26)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C102(1.89)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C102(1.10)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C102(1.03)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C102(1.58)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C102(1.31)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C102(0.63)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C102(2.51)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C102(1.15)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C102(2.28)  LDD0712  [4]
 LDCM0396  CL125 PaTu 8988t C102(0.90)  LDD1275  [4]
 LDCM0397  CL126 PaTu 8988t C102(0.75)  LDD1276  [4]
 LDCM0398  CL127 PaTu 8988t C102(0.96)  LDD1277  [4]
 LDCM0399  CL128 PaTu 8988t C102(0.89)  LDD1278  [4]
 LDCM0400  CL13 HCT 116 C102(2.47)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C102(1.74)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C102(2.65)  LDD0719  [4]
 LDCM0403  CL16 PaTu 8988t C102(1.23)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C102(1.23)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C102(1.22)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C102(1.45)  LDD1285  [4]
 LDCM0407  CL2 HCT 116 C102(1.01)  LDD0724  [4]
 LDCM0408  CL20 PaTu 8988t C102(1.33)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C102(1.44)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C102(1.47)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C102(1.74)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C102(1.44)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C102(1.25)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C102(1.31)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C102(1.58)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C102(1.45)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C102(1.52)  LDD1296  [4]
 LDCM0418  CL3 HCT 116 C102(1.14)  LDD0735  [4]
 LDCM0419  CL30 PaTu 8988t C102(1.66)  LDD1298  [4]
 LDCM0420  CL31 PaTu 8988t C102(0.82)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C102(0.99)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C102(1.13)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C102(1.04)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C102(1.22)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C102(1.13)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C102(1.17)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C102(1.23)  LDD1307  [4]
 LDCM0429  CL4 HCT 116 C102(1.10)  LDD0746  [4]
 LDCM0430  CL40 PaTu 8988t C102(1.10)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C102(1.17)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C102(1.88)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C102(1.48)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C102(1.31)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C102(1.24)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C102(1.32)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C102(1.21)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C102(1.38)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C102(1.36)  LDD1318  [4]
 LDCM0440  CL5 HCT 116 C102(1.47)  LDD0757  [4]
 LDCM0441  CL50 PaTu 8988t C102(1.21)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C102(1.09)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C102(1.47)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C102(1.38)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C102(1.23)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C102(1.39)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C102(1.45)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C102(1.60)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C102(1.48)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C102(1.45)  LDD1329  [4]
 LDCM0451  CL6 HCT 116 C102(1.20)  LDD0768  [4]
 LDCM0452  CL60 PaTu 8988t C102(1.32)  LDD1331  [4]
 LDCM0453  CL61 HCT 116 C102(1.25)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C102(1.03)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C102(0.96)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C102(1.23)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C102(0.75)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C102(1.19)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C102(1.32)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C102(0.94)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C102(0.91)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C102(1.38)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C102(0.92)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C102(0.97)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C102(1.05)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C102(1.36)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C102(1.19)  LDD0784  [4]
 LDCM0469  CL76 PaTu 8988t C102(1.15)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C102(1.13)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C102(1.28)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C102(1.68)  LDD1351  [4]
 LDCM0473  CL8 HCT 116 C102(1.67)  LDD0790  [4]
 LDCM0474  CL80 PaTu 8988t C102(1.30)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C102(1.41)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C102(1.21)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C102(1.39)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C102(1.36)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C102(1.59)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C102(1.36)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C102(1.74)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C102(1.55)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C102(1.69)  LDD1362  [4]
 LDCM0484  CL9 HCT 116 C102(0.96)  LDD0801  [4]
 LDCM0485  CL90 PaTu 8988t C102(1.83)  LDD1364  [4]
 LDCM0486  CL91 HCT 116 C102(1.20)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C102(1.04)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C102(0.82)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C102(1.09)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C102(1.02)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C102(1.08)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C102(1.11)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C102(1.21)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C102(0.71)  LDD0811  [4]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C86, C98(4.29)  LDD0526  [10]
 LDCM0495  E2913 HEK-293T C102(1.32)  LDD1698  [11]
 LDCM0175  Ethacrynic acid HeLa C98(0.91)  LDD2210  [3]
 LDCM0625  F8 Ramos C102(0.69); 2.41; C98(1.60)  LDD2187  [12]
 LDCM0572  Fragment10 MDA-MB-231 C98(20.00)  LDD1465  [13]
 LDCM0573  Fragment11 Ramos C102(0.13); 2.03  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C102(0.63); 0.72  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C102(0.75); 1.08  LDD2192  [12]
 LDCM0576  Fragment14 MDA-MB-231 C98(2.48)  LDD1471  [13]
 LDCM0579  Fragment20 Ramos C102(0.46); 0.66  LDD2194  [12]
 LDCM0580  Fragment21 MDA-MB-231 C98(0.66)  LDD1473  [13]
 LDCM0582  Fragment23 Ramos C102(0.89); 1.16  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C102(0.91); 1.01  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C102(1.57); 1.16; C98(1.01)  LDD2198  [12]
 LDCM0587  Fragment29 Ramos C98(2.41)  LDD1476  [13]
 LDCM0588  Fragment30 Ramos C102(0.40); 1.04  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C98(1.85)  LDD1478  [13]
 LDCM0590  Fragment32 Ramos C102(0.68); 3.42  LDD2201  [12]
 LDCM0468  Fragment33 HCT 116 C102(0.94)  LDD0785  [4]
 LDCM0596  Fragment38 MDA-MB-231 C98(1.64)  LDD1480  [13]
 LDCM0566  Fragment4 MDA-MB-231 C98(3.01)  LDD1461  [13]
 LDCM0599  Fragment41 MDA-MB-231 C98(0.47)  LDD1481  [13]
 LDCM0603  Fragment45 MDA-MB-231 C98(20.00)  LDD1482  [13]
 LDCM0427  Fragment51 PaTu 8988t C102(1.79)  LDD1306  [4]
 LDCM0610  Fragment52 Ramos C102(0.32); 1.24  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C102(0.55); 0.67  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C102(0.77); 1.18; C98(1.51)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C98(2.78)  LDD1464  [13]
 LDCM0022  KB02 T cell C86(8.72); C98(0.00)  LDD1703  [10]
 LDCM0023  KB03 Ramos C102(0.58); 0.79; C98(0.94)  LDD2183  [12]
 LDCM0024  KB05 SK-MEL-2 C36(1.27)  LDD3425  [14]
 LDCM0131  RA190 MM1.R C86(1.40); C98(1.40); C102(1.22)  LDD0304  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable E3 ubiquitin-protein ligase DTX3 (DTX3) Deltex family Q8N9I9
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) RBR family Q9BYM8
E3 ubiquitin-protein ligase ARIH2 (ARIH2) RBR family O95376
E3 ubiquitin-protein ligase RNF144B (RNF144B) RBR family Q7Z419
E3 ubiquitin-protein ligase RNF19B (RNF19B) RBR family Q6ZMZ0
E3 ubiquitin-protein ligase Midline-1 (MID1) TRIM/RBCC family O15344
E3 ubiquitin-protein ligase TRIM62 (TRIM62) TRIM/RBCC family Q9BVG3
E3 ubiquitin-protein ligase TRIM8 (TRIM8) TRIM/RBCC family Q9BZR9
E3 ubiquitin-protein ligase RNF216 (RNF216) . Q9NWF9
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) WD repeat G protein beta family P62879
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
10 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.