Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment31  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cells (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 39 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 20.0
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 2.9
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 2.6
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 2.6
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 2.1
 LDTP00042  Probable ribonuclease ZC3H12D (ZC3H12D) C367 1.9
 LDTP00013  Ubiquitin-like modifier-activating enzyme 6 (UBA6) C347 1.9
 LDTP00481  Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) C98 1.9
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) C138 1.7
 LDTP02502  Thioredoxin (TXN) C32 1.7
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.7
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 1.4
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.4
 LDTP01220  Mitochondrial-processing peptidase subunit beta (PMPCB) C265 1.4
 LDTP07407  Desumoylating isopeptidase 1 (DESI1) C108 1.3
 LDTP08254  Ubiquitin carboxyl-terminal hydrolase 48 (USP48) C39 1.3
 LDTP01055  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) C158 1.3
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.3
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.3
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.2
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) C773 1.2
 LDTP05480  Amidophosphoribosyltransferase (PPAT) C100 1.2
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.2
 LDTP02852  Methylated-DNA--protein-cysteine methyltransferase (MGMT) C145 1.2
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.1
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.1
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.1
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C54 1.1
 LDTP03786  Glutaredoxin-1 (GLRX) C23 1.1
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.1
 LDTP04438  Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) C340 1.0
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 1.0
 LDTP03258  Thymidylate kinase (DTYMK) C163 1.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.0
 LDTP15370  Pseudouridylate synthase RPUSD2 (RPUSD2) C246 1.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.7
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.7
Transporter and channel
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 3.6
 LDTP04801  Gasdermin-D (GSDMD) C268 3.1
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 1.0
Transcription factor
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05362  Interferon regulatory factor 8 (IRF8) C306 2.0
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 1.9
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 1.6
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.1
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 0.8
Other
Click to Show/Hide to Show 23 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) C673 20.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C819 20.0
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C532 8.1
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 3.5
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 3.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 2.5
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 2.4
 LDTP05867  Treacle protein (TCOF1) C1298 2.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 2.0
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 2.0
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.8
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.6
 LDTP14250  Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1) C51 1.6
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.3
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.3
 LDTP10864  Calponin-2 (CNN2) C164 1.3
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 1.2
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.2
 LDTP13580  Coronin-1C (CORO1C) C420 1.1
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.1
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 1.0
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 0.9
 LDTP18494  Tropomodulin-3 (TMOD3) C132 0.7

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.