Details of the Target

General Information of Target

Target ID LDTP01055
Target Name 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2)
Gene Name PFKFB2
Gene ID 5208
Synonyms
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; PFK/FBPase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase; EC 2.7.1.105; Fructose-2,6-bisphosphatase; EC 3.1.3.46)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTR
YLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEE
NGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPE
RNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVY
YLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVW
TSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRY
PGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTI
FKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPR
NYSVGSRPLKPLSPLRAQDMQEGAD
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Phosphoglycerate mutase family
Function Synthesis and degradation of fructose 2,6-bisphosphate.
TTD ID
T20776
Uniprot ID
O60825
DrugMap ID
TTQYVKD
Ensemble ID
ENST00000367079.3
HGNC ID
HGNC:8873
ChEMBL ID
CHEMBL3421525

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.P494A DBIA    Probe Info 
KYM1 SNV: p.M500L DBIA    Probe Info 
MKN1 SNV: p.F453L DBIA    Probe Info 
UMUC3 SNV: p.P488L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.99  LDD0402  [1]
STPyne
 Probe Info  		K103(5.65); K86(10.00)  LDD0277  [2]
BTD
 Probe Info  		C105(1.28)  LDD2105  [3]
HHS-465
 Probe Info  		Y482(5.59)  LDD2237  [4]
DBIA
 Probe Info  		C430(1.06)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C397(0.00); C158(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C397(0.00); C415(0.00); C105(0.00); C430(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C397(0.00); C415(0.00); C105(0.00); C158(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
IPM
 Probe Info  		C105(0.00); C196(0.00)  LDD0005  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
AOyne
 Probe Info  		10.00  LDD0443  [10]
NAIA_5
 Probe Info  		C397(0.00); C415(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C28(1.35)  LDD1093  [5]
 LDCM0215  AC10 HCT 116 C105(1.07)  LDD0532  [5]
 LDCM0226  AC11 HCT 116 C105(1.03)  LDD0543  [5]
 LDCM0230  AC113 HCT 116 C430(1.15)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C430(0.96)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C430(1.06)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C430(1.12)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C430(1.08)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C430(0.95)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C430(1.36)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C105(0.93)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C430(1.23)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C430(1.07)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C430(1.08)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C430(1.22)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C430(1.06)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C430(1.15)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C430(1.05)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C430(1.08)  LDD0562  [5]
 LDCM0246  AC128 HEK-293T C415(0.57)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C415(0.85)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C415(0.64)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C415(0.55)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C415(0.91)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C415(0.92)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C415(0.84)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C415(0.77)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C415(0.83)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C415(1.02)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C415(1.52)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C415(0.80)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C105(0.98)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C415(0.83)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C415(1.04)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C415(0.80)  LDD0860  [5]
 LDCM0263  AC143 HCT 116 C105(1.23)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C105(1.02)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C105(1.05)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C105(1.23)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C105(1.04)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C105(1.90)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C105(1.87)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C105(0.99)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C105(1.39)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C105(1.26)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C105(1.21)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C105(1.63)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C105(1.04)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C105(1.31)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C105(1.10)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C105(1.24)  LDD2161  [5]
 LDCM0276  AC17 HEK-293T C430(0.95); C415(0.94); C105(0.96); C28(1.12)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C430(1.04); C415(0.98); C105(1.07); C28(0.86)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C430(1.00); C415(0.86); C105(1.12); C28(0.85)  LDD1517  [11]
 LDCM0279  AC2 PaTu 8988t C28(1.26)  LDD1158  [5]
 LDCM0280  AC20 HEK-293T C430(1.07); C415(0.88); C28(0.97); C158(0.97)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C430(1.01); C415(1.06); C105(1.02); C28(1.01)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C430(0.93); C415(1.01); C105(1.08); C28(1.07)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C430(0.93); C415(0.93); C105(1.05); C28(0.96)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C430(1.02); C105(1.07); C28(1.03); C158(1.04)  LDD1523  [11]
 LDCM0285  AC25 HCT 116 C105(1.07)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C105(1.28)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C105(1.27)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C105(1.20)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C105(1.12)  LDD0606  [5]
 LDCM0290  AC3 PaTu 8988t C28(1.20)  LDD1169  [5]
 LDCM0291  AC30 HCT 116 C105(1.27)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C105(1.22)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C105(1.48)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C105(1.33)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C105(1.41)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C430(0.91)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C430(0.91)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C430(0.91)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C430(1.07)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C430(1.07)  LDD0617  [5]
 LDCM0301  AC4 PaTu 8988t C28(1.19)  LDD1180  [5]
 LDCM0302  AC40 HCT 116 C430(1.00)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C430(0.91)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C430(0.92)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C430(1.16)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C430(0.88)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C430(0.85)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C430(1.18)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C430(1.11)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C430(1.09)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C430(1.05)  LDD0628  [5]
 LDCM0312  AC5 PaTu 8988t C28(1.24)  LDD1191  [5]
 LDCM0313  AC50 HCT 116 C430(0.99)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C430(1.05)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C430(1.22)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C430(1.07)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C430(1.10)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C430(1.00)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C430(0.91)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C430(1.06)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C430(0.90)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C430(0.81)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C105(1.16)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C430(0.94)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C430(0.93)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C430(1.01)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C430(1.03)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C430(0.88)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C430(1.05)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C430(1.31)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C430(0.71)  LDD0648  [5]
 LDCM0334  AC7 HCT 116 C105(1.07)  LDD0651  [5]
 LDCM0345  AC8 HCT 116 C105(1.17)  LDD0662  [5]
 LDCM0349  AC83 HCT 116 C430(1.14)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C430(0.91)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C430(1.12)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C430(1.27)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C430(1.21)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C430(0.92)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C430(1.10)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C430(1.20)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C430(0.98)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C430(1.13)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C430(0.98)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C430(1.24)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C430(1.19)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C430(1.06)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C430(1.13)  LDD0681  [5]
 LDCM0248  AKOS034007472 HCT 116 C105(0.93)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C105(0.95)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C105(1.26)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 12.90  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C430(1.06)  LDD0078  [5]
 LDCM0632  CL-Sc Hep-G2 C105(3.13); C105(0.94)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C105(0.98)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C105(1.11)  LDD0685  [5]
 LDCM0369  CL100 PaTu 8988t C28(1.04)  LDD1248  [5]
 LDCM0370  CL101 HCT 116 C105(1.11)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C105(0.91)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C105(0.90)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C105(1.04)  LDD0690  [5]
 LDCM0374  CL105 HEK-293T C430(0.96); C415(1.10); C105(0.91); C28(0.94)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C430(0.98); C415(1.11); C105(1.07); C28(0.95)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C430(1.01); C415(0.91); C105(0.99); C28(1.10)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C430(1.05); C105(1.00); C28(1.11); C158(0.98)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C430(0.97); C415(1.02); C105(1.05); C28(1.18)  LDD1582  [11]
 LDCM0379  CL11 HCT 116 C105(0.91)  LDD0696  [5]
 LDCM0380  CL110 HEK-293T C430(0.82); C415(1.30); C105(1.01); C28(0.89)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C430(0.85); C415(1.07); C105(0.97); C28(1.07)  LDD1585  [11]
 LDCM0382  CL112 HCT 116 C105(0.92)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C105(1.30)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C105(1.08)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C105(1.11)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C105(1.29)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C430(1.12)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C430(1.17)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C430(1.22)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C105(1.23)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C430(1.03)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C430(1.26)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C430(0.98)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C430(0.97)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C430(1.01)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C430(1.00)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C430(0.85)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C430(0.86)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C430(0.99)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C105(1.06)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C105(1.08)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C105(0.96)  LDD0719  [5]
 LDCM0403  CL16 HEK-293T C430(0.97); C105(1.04); C28(1.13); C158(0.91)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C430(0.65); C415(1.38); C105(1.47); C28(0.90)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C430(1.09); C415(0.91); C105(1.06); C28(0.93)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C430(1.01); C415(1.06); C105(1.08); C28(0.96)  LDD1610  [11]
 LDCM0407  CL2 HCT 116 C105(1.00)  LDD0724  [5]
 LDCM0408  CL20 HEK-293T C430(1.00); C415(1.06); C28(1.03); C158(1.04)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C430(0.79); C415(1.28); C105(1.06); C28(1.24)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C430(0.91); C415(1.11); C105(1.11); C28(1.12)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C430(0.93); C415(1.08); C105(1.12); C28(1.18)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C430(0.94); C105(1.17); C28(1.15); C158(0.98)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C430(0.95); C415(0.97); C105(1.01); C28(1.09)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C430(0.95); C415(1.13); C105(1.02); C28(0.93)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C430(1.08); C415(1.05); C105(1.06); C28(0.91)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C430(0.96); C105(1.05); C28(1.07); C158(1.07)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C430(1.01); C415(0.88); C105(1.03); C28(1.04)  LDD1621  [11]
 LDCM0418  CL3 HCT 116 C105(0.96)  LDD0735  [5]
 LDCM0419  CL30 HEK-293T C430(1.04); C415(1.01); C105(1.06); C28(0.81)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C430(1.02); C415(1.19); C105(1.02); C28(1.04)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C430(1.00); C415(1.05); C28(0.99); C158(1.05)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C430(0.65); C415(1.32); C105(1.22); C28(1.00)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C430(0.85); C415(1.30); C105(1.22); C28(0.89)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C430(0.96); C415(1.06); C105(1.11); C28(1.00)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C430(0.92); C105(1.14); C28(1.23); C158(1.13)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C430(0.97); C415(0.92); C105(0.95); C28(1.00)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C430(0.91); C415(0.99); C105(1.10); C28(1.21)  LDD1632  [11]
 LDCM0429  CL4 HCT 116 C105(0.96)  LDD0746  [5]
 LDCM0430  CL40 HEK-293T C430(1.07); C105(1.13); C28(1.19); C158(0.91)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C430(0.95); C415(1.03); C105(1.02); C28(1.01)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C430(1.11); C415(1.00); C105(1.13); C28(0.93)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C430(1.02); C415(0.99); C105(1.05); C28(0.98)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C430(0.86); C415(0.93); C28(1.05); C158(1.17)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C430(0.80); C415(1.31); C105(1.23); C28(1.07)  LDD1639  [11]
 LDCM0436  CL46 HCT 116 C105(1.03)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C105(1.22)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C105(1.20)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C105(1.35)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C105(0.97)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C105(1.10)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C105(1.08)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C105(1.21)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C105(1.09)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C105(0.97)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C105(0.84)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C105(0.91)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C105(0.96)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C105(0.90)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C105(1.11)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C105(1.07)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C105(1.13)  LDD0769  [5]
 LDCM0453  CL61 HEK-293T C430(1.00); C415(0.95); C105(0.99); C28(1.01)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C430(1.07); C415(1.00); C105(1.04); C28(0.98)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C430(1.06); C415(0.86); C105(1.03); C28(0.90)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C430(0.92); C105(1.03); C28(1.18); C158(1.06)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C430(0.93); C415(0.88); C105(1.10); C28(1.12)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C430(0.96); C415(1.02); C105(1.11); C28(0.95)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C430(1.04); C415(1.01); C105(1.17); C28(0.96)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C430(0.89); C415(0.94); C28(0.94); C158(1.13)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C430(0.89); C415(1.16); C105(1.19); C28(1.03)  LDD1664  [11]
 LDCM0462  CL7 HCT 116 C105(1.11)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C430(0.92); C415(0.97); C105(1.17); C28(1.00)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C430(0.88); C415(1.14); C105(1.11); C28(1.20)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C430(0.88); C105(1.12); C28(1.10); C158(1.06)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C430(0.88); C415(1.15); C105(1.18); C28(1.09)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C430(1.00); C415(0.94); C105(1.05); C28(0.87)  LDD1670  [11]
 LDCM0469  CL76 HCT 116 C105(0.90); C430(1.11)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C105(0.96); C430(0.83)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C105(0.89); C430(0.84)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C105(1.00); C430(1.05)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C105(0.96)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C105(1.11); C430(0.99)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C105(0.92); C430(1.03)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C105(0.89); C430(1.10)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C105(0.95); C430(0.93)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C105(0.96); C430(0.97)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C105(0.89); C430(0.99)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C105(0.93); C430(1.00)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C105(1.02); C430(1.03)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C105(0.96); C430(0.98)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C105(1.05); C430(0.86)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C105(1.13)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C105(0.93); C430(1.04)  LDD0802  [5]
 LDCM0486  CL91 PaTu 8988t C28(0.96)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C28(1.21)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C28(1.11)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C28(1.20)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C28(1.40)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C28(1.14)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C28(1.15)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C28(1.47)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C28(1.25)  LDD1373  [5]
 LDCM0495  E2913 HEK-293T C430(1.03); C415(0.99); C105(1.26); C28(0.93)  LDD1698  [11]
 LDCM0625  F8 Ramos C105(2.83)  LDD2187  [12]
 LDCM0572  Fragment10 MDA-MB-231 C158(0.74)  LDD1465  [13]
 LDCM0573  Fragment11 Ramos C105(0.00)  LDD2190  [12]
 LDCM0574  Fragment12 MDA-MB-231 C158(0.75)  LDD1468  [13]
 LDCM0575  Fragment13 Ramos C158(0.90)  LDD1470  [13]
 LDCM0576  Fragment14 MDA-MB-231 C158(1.51)  LDD1471  [13]
 LDCM0579  Fragment20 Ramos C105(1.23)  LDD2194  [12]
 LDCM0580  Fragment21 MDA-MB-231 C158(1.43)  LDD1473  [13]
 LDCM0582  Fragment23 Ramos C105(0.73)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C105(1.14)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C105(2.14)  LDD2198  [12]
 LDCM0587  Fragment29 Ramos C158(0.90)  LDD1476  [13]
 LDCM0588  Fragment30 Ramos C105(0.53)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C158(1.29)  LDD1478  [13]
 LDCM0468  Fragment33 HEK-293T C430(0.95); C415(1.04); C105(1.04); C28(0.90)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C105(0.67)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C105(0.74)  LDD2184  [12]
 LDCM0599  Fragment41 MDA-MB-231 C158(0.66)  LDD1481  [13]
 LDCM0603  Fragment45 MDA-MB-231 C158(1.33)  LDD1482  [13]
 LDCM0427  Fragment51 MDA-MB-231 C158(0.89)  LDD1483  [13]
 LDCM0610  Fragment52 Ramos C105(0.62)  LDD2204  [12]
 LDCM0614  Fragment56 MDA-MB-231 C158(1.17)  LDD1484  [13]
 LDCM0569  Fragment7 Ramos C105(0.72)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C158(1.77)  LDD1464  [13]
 LDCM0022  KB02 HCT 116 C430(1.10)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C430(1.15)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C430(2.43)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0224  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C105(1.28)  LDD2105  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C105(0.25)  LDD2150  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C28(0.81)  LDD2207  [14]
 LDCM0131  RA190 MM1.R C158(1.15)  LDD0304  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.