Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment56  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 57 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02502  Thioredoxin (TXN) C32 1.5
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 1.4
 LDTP09200  FAD synthase (FLAD1) C499 1.3
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 1.3
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 1.3
 LDTP01055  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) C158 1.2
 LDTP06211  Caspase-8 (CASP8) C360 1.2
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 1.1
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.1
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.1
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 1.1
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) C138 1.1
 LDTP08401  All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2) C71 1.0
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.0
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 1.0
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.0
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 1.0
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) C170 1.0
 LDTP09126  Probable aminopeptidase NPEPL1 (NPEPL1) C81 1.0
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 1.0
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C758 1.0
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119 1.0
 LDTP04232  4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) C288 0.9
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 0.9
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 0.9
 LDTP16095  Ethylmalonyl-CoA decarboxylase (ECHDC1) C133 0.9
 LDTP12539  DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) C130 0.9
 LDTP03258  Thymidylate kinase (DTYMK) C163 0.9
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C312 0.9
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.9
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 0.9
 LDTP03786  Glutaredoxin-1 (GLRX) C23 0.9
 LDTP10320  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (TRMT61A) C209 0.9
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.9
 LDTP13527  Aspartyl aminopeptidase (DNPEP) C144 0.9
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 0.8
 LDTP18330  Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5) C392 0.8
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 0.8
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 0.8
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.8
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 0.8
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 0.8
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 0.8
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 0.8
 LDTP03770  Alpha-adducin (ADD1) C68 0.8
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.8
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 0.8
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 0.7
 LDTP03000  General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) C342 0.7
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C57 0.7
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 0.7
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 0.7
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) C216 0.7
Transporter and channel
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 3.9
 LDTP10642  Chloride intracellular channel protein 6 (CLIC6) C487 1.3
 LDTP05591  Nuclear cap-binding protein subunit 1 (NCBP1) C44 1.0
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 0.9
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 0.9
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 0.9
 LDTP04801  Gasdermin-D (GSDMD) C268 0.8
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 0.7
Transcription factor
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 1.2
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 1.0
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 0.9
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 0.8
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 0.8
Other
Click to Show/Hide to Show 54 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.4
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 1.3
 LDTP11235  Protein PAXX (PAXX) C180 1.3
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 1.3
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 1.3
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C439 1.2
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 1.2
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 1.2
 LDTP10864  Calponin-2 (CNN2) C164 1.2
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.2
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 1.2
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.2
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.2
 LDTP13705  LIM and calponin homology domains-containing protein 1 (LIMCH1) C140 1.1
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.1
 LDTP16117  Mediator of RNA polymerase II transcription subunit 9 (MED9) C139 1.1
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.1
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 1.1
 LDTP13580  Coronin-1C (CORO1C) C420 1.0
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 1.0
 LDTP01532  ZW10 interactor (ZWINT) C54 1.0
 LDTP04487  Cyclin-H (CCNH) C244 1.0
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 1.0
 LDTP12443  Anillin (ANLN) C712 1.0
 LDTP06330  Plectin (PLEC) C4574 1.0
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 0.9
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.9
 LDTP10613  Dedicator of cytokinesis protein 7 (DOCK7) C2125 0.9
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.9
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C645 0.9
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 0.9
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 0.9
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) C18 0.9
 LDTP13964  MOB-like protein phocein (MOB4) C134 0.9
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) C673 0.9
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 0.9
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 0.9
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C819 0.9
 LDTP04092  Crk-like protein (CRKL) C249 0.8
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 0.8
 LDTP12412  Reticulon-4 (RTN4) C1101 0.8
 LDTP05867  Treacle protein (TCOF1) C38 0.8
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 0.8
 LDTP15896  Ashwin (C2orf49) C10 0.8
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 0.8
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 0.8
 LDTP13906  Polymerase delta-interacting protein 2 (POLDIP2) C143 0.8
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 0.7
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) C391 0.7
 LDTP13622  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) C213 0.7
 LDTP12753  Succinate dehydrogenase assembly factor 2, mitochondrial (SDHAF2) C83 0.7
 LDTP17182  Uncharacterized protein C3orf38 (C3orf38) C308 0.7
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 0.7
 LDTP12883  Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A) C531 0.6

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.