Details of the Target

General Information of Target

Target ID LDTP12507
Target Name Chromatin accessibility complex protein 1 (CHRAC1)
Gene Name CHRAC1
Gene ID 54108
Synonyms
CHRAC15; Chromatin accessibility complex protein 1; CHRAC-1; Chromatin accessibility complex 15 kDa protein; CHRAC-15; HuCHRAC15; DNA polymerase epsilon subunit p15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGK
RKTLNASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKTDSEEQD
KSRDEDNDEDEERLEEEEQNEEEEVDN
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.
Uniprot ID
Q9NRG0
Ensemble ID
ENST00000220913.10
HGNC ID
HGNC:13544

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K102(10.00)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C55(2.22)  LDD0169  [3]
DBIA
 Probe Info  		C55(1.51)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
TER-AC
 Probe Info  		N.A.  LDD0426  [9]
TPP-AC
 Probe Info  		N.A.  LDD0427  [9]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C210
 Probe Info  		38.85  LDD1884  [10]
C211
 Probe Info  		7.94  LDD1885  [10]
C213
 Probe Info  		14.93  LDD1887  [10]
C260
 Probe Info  		5.21  LDD1932  [10]
C275
 Probe Info  		9.65  LDD1945  [10]
C278
 Probe Info  		87.43  LDD1948  [10]
C311
 Probe Info  		7.26  LDD1978  [10]
C314
 Probe Info  		12.47  LDD1981  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C55(2.22)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C55(1.13)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C55(1.74)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C55(0.52)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C55(0.97)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C55(0.93)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C55(0.92)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C55(1.80)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C55(0.83)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C55(1.11)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C55(1.38)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C55(0.65)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C55(1.01)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C55(3.27)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C55(1.06)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C55(1.84)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C55(1.15)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C55(0.96)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C55(0.72)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C55(0.79)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C55(0.76)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C55(0.39)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C55(0.49)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C55(0.35)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C55(1.05)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C55(2.18)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C55(2.43)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C55(1.02)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C55(2.16)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C55(0.59)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C55(1.60)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C55(1.32)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C55(0.97)  LDD0562  [4]
 LDCM0259  AC14 HCT 116 C55(7.35)  LDD0576  [4]
 LDCM0263  AC143 HCT 116 C55(1.30)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C55(0.82)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C55(1.35)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C55(1.36)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C55(1.50)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C55(1.32)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C55(2.75)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C55(1.87)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C55(0.83)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C55(0.59)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C55(1.98)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C55(0.71)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C55(0.64)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C55(0.38)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C55(1.11)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C55(0.80)  LDD2161  [4]
 LDCM0276  AC17 HEK-293T C55(0.89)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C55(1.12)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C55(1.16)  LDD0876  [4]
 LDCM0279  AC2 HCT 116 C55(0.51)  LDD0596  [4]
 LDCM0280  AC20 HEK-293T C55(0.76)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C55(0.50)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C55(0.61)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C55(0.52)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C55(0.71)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C55(0.96)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C55(1.04)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C55(0.89)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C55(1.19)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C55(0.86)  LDD1528  [11]
 LDCM0290  AC3 HCT 116 C55(0.35)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C55(0.91)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C55(1.15)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C55(1.03)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C55(1.16)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C55(1.11)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C55(0.98)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C55(1.06)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C55(0.80)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C55(1.08)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C55(0.97)  LDD1539  [11]
 LDCM0301  AC4 HCT 116 C55(0.35)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C55(1.17)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C55(1.10)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C55(1.03)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C55(0.98)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C55(1.03)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C55(1.08)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C55(1.03)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C55(1.15)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C55(1.12)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C55(1.04)  LDD1550  [11]
 LDCM0312  AC5 HCT 116 C55(0.33)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C55(1.03)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C55(0.86)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C55(1.16)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C55(0.90)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C55(0.95)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C55(0.92)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C55(0.96)  LDD1558  [11]
 LDCM0320  AC57 HCT 116 C55(0.57)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C55(1.43)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C55(1.02)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C55(1.94)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C55(2.25)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C55(0.91)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C55(0.92)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C55(1.53)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C55(1.18)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C55(0.99)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C55(1.03)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C55(1.47)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C55(1.73)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C55(1.32)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C55(1.92)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C55(0.21)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C55(0.50)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C55(0.22)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C55(0.33)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C55(0.53)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C55(0.81)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C55(0.59)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C55(1.99)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C55(0.76)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C55(0.54)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C55(1.79)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C55(0.58)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C55(0.40)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C55(0.42)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C55(1.67)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C55(1.98)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C55(1.78)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C55(1.98)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C55(1.01)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C55(1.80)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C55(1.67)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C55(0.58)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C55(1.94)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C55(1.18)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C55(1.33)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C55(1.17)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C55(1.11)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C55(1.23)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C55(1.33)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C55(0.72)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C55(0.63)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C55(1.37)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C55(1.85)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C55(2.79)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 13.51  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C55(1.51)  LDD0078  [4]
 LDCM0630  CCW28-3 231MFP C55(2.91)  LDD2214  [12]
 LDCM0367  CL1 HEK-293T C55(1.23)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C55(1.39)  LDD1572  [11]
 LDCM0369  CL100 HCT 116 C55(0.75)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C55(11.52)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C55(12.25)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C55(7.60)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C55(6.64)  LDD0690  [4]
 LDCM0374  CL105 HEK-293T C55(0.58)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C55(1.17)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C55(0.67)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C55(0.89)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C55(0.52)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C55(1.18)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C55(0.68)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C55(0.36)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C55(1.18)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C55(1.04)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C55(1.27)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C55(0.91)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C55(1.30)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C55(1.05)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C55(1.08)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C55(0.86)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C55(0.85)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C55(0.97)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C55(1.10)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C55(1.14)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C55(0.97)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C55(1.10)  LDD1599  [11]
 LDCM0396  CL125 HCT 116 C55(0.93)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C55(0.86)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C55(1.65)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C55(1.03)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C55(1.44)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C55(1.06)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C55(0.94)  LDD1606  [11]
 LDCM0403  CL16 HCT 116 C55(0.77)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C55(0.60)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C55(1.13)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C55(0.67)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C55(1.01)  LDD1611  [11]
 LDCM0408  CL20 HCT 116 C55(1.48)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C55(1.84)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C55(2.68)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C55(1.82)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C55(1.28)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C55(0.97)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C55(0.98)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C55(0.82)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C55(1.25)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C55(1.63)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C55(0.93)  LDD1622  [11]
 LDCM0419  CL30 HCT 116 C55(1.36)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C55(0.27)  LDD0737  [4]
 LDCM0421  CL32 HEK-293T C55(1.42)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C55(2.09)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C55(1.25)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C55(1.00)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C55(1.09)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C55(0.88)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C55(1.52)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C55(1.22)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C55(1.16)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C55(1.38)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C55(2.02)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C55(1.37)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C55(1.05)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C55(0.86)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C55(0.86)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C55(0.93)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C55(0.71)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C55(1.20)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C55(1.02)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C55(1.15)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C55(1.48)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C55(0.56)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C55(0.58)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C55(1.22)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C55(1.16)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C55(0.85)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C55(1.08)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C55(0.94)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C55(1.24)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C55(1.12)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C55(1.52)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C55(1.09)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C55(0.77)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C55(1.78)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C55(1.02)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C55(1.35)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C55(1.15)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C55(3.13)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C55(7.02)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C55(2.71)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C55(1.08)  LDD1665  [11]
 LDCM0463  CL70 HCT 116 C55(1.55)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C55(1.86)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C55(3.79)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C55(2.95)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C55(2.70)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C55(1.73)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C55(1.72)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C55(0.79)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C55(1.58)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C55(1.21)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C55(1.79)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C55(1.21)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C55(0.87)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C55(1.17)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C55(3.20)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C55(1.95)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C55(2.23)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C55(1.51)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C55(2.91)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C55(0.71)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C55(1.15)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C55(1.70)  LDD1083  [4]
 LDCM0486  CL91 HCT 116 C55(3.57)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C55(5.81)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C55(0.33)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C55(1.13)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C55(1.28)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C55(0.69)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C55(1.38)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C55(1.20)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C55(0.93)  LDD0811  [4]
 LDCM0634  CY-0357 Hep-G2 C55(3.14)  LDD2228  [7]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C55(9.16)  LDD0513  [13]
 LDCM0495  E2913 HEK-293T C55(1.06)  LDD1698  [11]
 LDCM0572  Fragment10 MDA-MB-231 C55(1.75)  LDD1389  [14]
 LDCM0573  Fragment11 MDA-MB-231 C55(9.44)  LDD1391  [14]
 LDCM0574  Fragment12 MDA-MB-231 C55(20.00)  LDD1393  [14]
 LDCM0575  Fragment13 MDA-MB-231 C55(2.18)  LDD1395  [14]
 LDCM0576  Fragment14 MDA-MB-231 C55(1.84)  LDD1397  [14]
 LDCM0579  Fragment20 MDA-MB-231 C55(1.78)  LDD1402  [14]
 LDCM0580  Fragment21 MDA-MB-231 C55(4.87)  LDD1404  [14]
 LDCM0581  Fragment22 Ramos C55(1.05)  LDD1407  [14]
 LDCM0583  Fragment24 Ramos C55(1.66)  LDD1410  [14]
 LDCM0578  Fragment27 MDA-MB-231 C55(0.87)  LDD1401  [14]
 LDCM0586  Fragment28 MDA-MB-231 C55(2.57)  LDD1415  [14]
 LDCM0587  Fragment29 MDA-MB-231 C55(0.60)  LDD1417  [14]
 LDCM0588  Fragment30 Ramos C55(3.35)  LDD1420  [14]
 LDCM0589  Fragment31 Ramos C55(1.98)  LDD1422  [14]
 LDCM0590  Fragment32 MDA-MB-231 C55(20.00)  LDD1423  [14]
 LDCM0468  Fragment33 HCT 116 C55(1.26)  LDD0785  [4]
 LDCM0596  Fragment38 MDA-MB-231 C55(1.21)  LDD1433  [14]
 LDCM0566  Fragment4 MDA-MB-231 C55(4.06)  LDD1378  [14]
 LDCM0598  Fragment40 MDA-MB-231 C55(0.91)  LDD1436  [14]
 LDCM0599  Fragment41 Ramos C55(12.21)  LDD1439  [14]
 LDCM0600  Fragment42 Ramos C55(1.00)  LDD1440  [14]
 LDCM0601  Fragment43 MDA-MB-231 C55(20.00)  LDD1441  [14]
 LDCM0603  Fragment45 MDA-MB-231 C55(20.00)  LDD1444  [14]
 LDCM0604  Fragment46 MDA-MB-231 C55(1.15)  LDD1445  [14]
 LDCM0605  Fragment47 MDA-MB-231 C55(3.06)  LDD1446  [14]
 LDCM0427  Fragment51 HEK-293T C55(0.67)  LDD1025  [4]
 LDCM0610  Fragment52 MDA-MB-231 C55(0.89)  LDD1452  [14]
 LDCM0611  Fragment53 MDA-MB-231 C55(0.85)  LDD1454  [14]
 LDCM0614  Fragment56 MDA-MB-231 C55(0.60)  LDD1458  [14]
 LDCM0568  Fragment6 MDA-MB-231 C55(1.65)  LDD1382  [14]
 LDCM0569  Fragment7 MDA-MB-231 C55(1.09)  LDD1383  [14]
 LDCM0570  Fragment8 Ramos C55(1.27)  LDD1386  [14]
 LDCM0571  Fragment9 MDA-MB-231 C55(1.05)  LDD1387  [14]
 LDCM0022  KB02 HCT 116 C55(20.00)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C55(2.51)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C55(4.60)  LDD0082  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C55(0.13)  LDD2206  [15]
 LDCM0628  OTUB2-COV-1 HEK-293T C55(0.85)  LDD2207  [15]
 LDCM0131  RA190 MM1.R C55(1.36)  LDD0304  [16]
 LDCM0170  Structure8 Ramos 13.91  LDD0433  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
DNA polymerase epsilon subunit 3 (POLE3) . Q9NRF9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
13 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
14 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
16 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
17 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.