Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment22  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 89 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 5.3
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 2.2
 LDTP03786  Glutaredoxin-1 (GLRX) C23 2.1
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 2.0
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.9
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.9
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 1.8
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.7
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 1.7
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 1.7
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) C205 1.6
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.6
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.6
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.6
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.6
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.6
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 1.5
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 1.3
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 1.3
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 1.3
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C414 1.3
 LDTP06603  Cyclin-dependent kinase inhibitor 3 (CDKN3) C39 1.3
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.3
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 1.2
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 1.2
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 1.2
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.1
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 1.1
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) C2267 1.1
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.1
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.1
 LDTP03806  ADP-ribosylation factor-like protein 3 (ARL3) C174 1.1
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.1
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.0
 LDTP05289  AMP deaminase 2 (AMPD2) C107 1.0
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.0
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 1.0
 LDTP05992  Bleomycin hydrolase (BLMH) C73 1.0
 LDTP04424  Galactokinase (GALK1) C182 0.9
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 0.9
 LDTP12166  Ras-related GTP-binding protein C (RRAGC) C377 0.9
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 0.9
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 0.9
 LDTP10929  Cell cycle checkpoint control protein RAD9A (RAD9A) C114 0.9
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 0.9
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 0.9
 LDTP02672  Elongation factor 2 (EEF2) C41 0.8
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 0.8
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.8
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 0.8
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C100 0.8
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.8
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 0.8
 LDTP09446  Ribonuclease H2 subunit C (RNASEH2C) C34 0.8
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 0.8
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 0.7
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 0.7
 LDTP03400  Deoxycytidine kinase (DCK) C9 0.7
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.7
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 0.7
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 0.7
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.7
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 0.7
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 0.7
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 0.7
 LDTP04374  Dynamin-2 (DNM2) C27 0.7
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 0.7
 LDTP03400  Deoxycytidine kinase (DCK) C45 0.7
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.7
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.6
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.6
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.6
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 0.6
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 0.6
 LDTP04689  Adenosine kinase (ADK) C353 0.6
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 0.6
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.5
 LDTP02502  Thioredoxin (TXN) C32 0.5
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C147 0.4
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 0.4
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 0.4
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 0.4
 LDTP02672  Elongation factor 2 (EEF2) C136 0.3
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 0.3
Transporter and channel
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 3.4
 LDTP04707  Protein SEC13 homolog (SEC13) C187 2.0
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 2.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 1.5
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 0.8
 LDTP04801  Gasdermin-D (GSDMD) C268 0.8
 LDTP13661  Sorting nexin-6 (SNX6) C264 0.8
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 0.7
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 0.7
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 0.6
Transcription factor
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 2.0
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.5
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.2
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 1.1
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 1.0
 LDTP02016  Glucocorticoid receptor (NR3C1) C302 0.9
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.7
Other
Click to Show/Hide to Show 57 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) C235 20.0
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 2.6
 LDTP04092  Crk-like protein (CRKL) C249 2.2
 LDTP03244  Cofilin-1 (CFL1) C80 1.7
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.6
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.4
 LDTP14195  FH1/FH2 domain-containing protein 1 (FHOD1) C502 1.3
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 1.2
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.2
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.2
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.2
 LDTP13580  Coronin-1C (CORO1C) C420 1.1
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 1.1
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.1
 LDTP00202  AH receptor-interacting protein (AIP) C122 1.1
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.0
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 1.0
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 1.0
 LDTP12412  Reticulon-4 (RTN4) C1101 1.0
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 1.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.0
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.0
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 1.0
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.0
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 1.0
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 0.9
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 0.9
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 0.9
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 0.9
 LDTP05867  Treacle protein (TCOF1) C38 0.9
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.9
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 0.9
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 0.9
 LDTP10864  Calponin-2 (CNN2) C164 0.9
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 0.8
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 0.8
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 0.8
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 0.8
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 0.8
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 0.8
 LDTP02205  Tubulin beta chain (TUBB) C354 0.8
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 0.8
 LDTP10864  Calponin-2 (CNN2) C215 0.8
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 0.8
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 0.8
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 0.8
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 0.7
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 0.7
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.7
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.6
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 0.6
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.6
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 0.6
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) C253 0.4
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.4
 LDTP02205  Tubulin beta chain (TUBB) C239 0.4

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.