Details of the Target

General Information of Target

Target ID LDTP10418
Target Name Mannose-1-phosphate guanyltransferase alpha (GMPPA)
Gene Name GMPPA
Gene ID 29926
Synonyms
Mannose-1-phosphate guanyltransferase alpha; GDP-mannose pyrophosphorylase A; GMPP-alpha; GTP-mannose-1-phosphate guanylyltransferase alpha
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAAGLVAVAAAAEYSGTVASGGNLPGVHCGPSSGAGPGFGPGSWSRSLDRALEEAAVTG
VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI
PEAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDV
SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNKITTIPVCYRNL
RHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDYDRRPLGFGSCHEEL
YSSRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGS
LVVTNGGVEHDLDQIDYIDSCTAEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISHEGSP
VKPVAIREFQKTEDMRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTR
REAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQH
TDDSALCMSLSGLNQVGCAATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAA
IQRNQPQRPESFLFRAGVRAETNKGHASPLPPSAAPTTDSTDSITGQNSRQREEELELID
QLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRR
NVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAVTVQALLELAPPKQQQHQLSAV
Target Bioclass
Enzyme
Family
Transferase hexapeptide repeat family
Subcellular location
Cytoplasm
Function May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose.
Uniprot ID
Q96IJ6
Ensemble ID
ENST00000313597.10
HGNC ID
HGNC:22923

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 Deletion: p.A274GfsTer37 DBIA    Probe Info 
COLO678 Deletion: p.A274GfsTer37 DBIA    Probe Info 
HCT15 SNV: p.P48S; p.A367T .
HUH1 SNV: p.F186L DBIA    Probe Info 
ICC9 SNV: p.R412Ter DBIA    Probe Info 
LN229 SNV: p.F76L DBIA    Probe Info 
MCC13 SNV: p.E396K DBIA    Probe Info 
MFE319 Insertion: p.L89PfsTer28; p.V311GfsTer5 DBIA    Probe Info 
NCIH716 Deletion: p.A274GfsTer37 .
SW1116 SNV: p.A87T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y288(9.48)  LDD0257  [2]
STPyne
 Probe Info  		K13(8.25); K408(10.00)  LDD0277  [3]
DBIA
 Probe Info  		C442(2.41)  LDD3312  [4]
AHL-Pu-1
 Probe Info  		C389(2.87)  LDD0169  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
5E-2FA
 Probe Info  		H407(0.00); H97(0.00)  LDD2235  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		C389(0.00); C335(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C389(0.00); C118(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
IPM
 Probe Info  		N.A.  LDD0005  [13]
NHS
 Probe Info  		N.A.  LDD0010  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C389(2.87)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C389(0.89); C118(1.23); C154(1.05)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C389(0.92); C118(0.99); C335(1.05); C154(1.04)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C389(0.93); C118(1.00); C335(1.04); C154(1.13)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C389(1.00); C118(1.03); C154(1.04)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C389(0.93); C118(1.36)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C389(1.00); C118(0.99); C154(0.98)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C389(0.99); C118(1.07); C154(0.86)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C389(0.94); C118(1.02); C335(0.99); C154(1.00)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C389(0.82); C118(0.79); C335(0.97); C154(0.89)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C389(0.84); C118(0.93); C335(1.12); C154(0.96)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C389(1.00); C118(0.94); C154(1.06)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C389(1.05); C118(1.17); C335(1.04); C154(1.05)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C389(0.97); C118(1.12)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C389(1.05); C118(1.39); C154(0.99)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C389(0.94); C118(1.08); C335(1.06); C154(1.13)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C389(1.03); C118(1.09); C154(1.10)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C389(0.95); C118(1.10); C335(0.98); C154(1.06)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C389(0.93); C118(0.99); C335(1.09); C154(1.09)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C389(0.97); C118(1.11); C154(0.87)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C389(0.96); C118(1.17); C335(0.96); C154(1.07)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C389(1.00); C118(1.07); C335(0.95); C154(1.05)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C389(1.02); C118(1.26)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C389(1.06); C118(0.81); C154(0.95)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C389(1.00); C118(1.26); C335(1.03); C154(0.97)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C389(0.96); C118(1.12); C154(1.03)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C389(0.87); C118(1.01); C335(1.17); C154(1.14)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C389(0.93); C118(1.07); C335(1.10); C154(1.04)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C389(0.97); C118(1.03); C154(0.89)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C389(0.92); C118(1.11); C335(1.17); C154(1.04)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C389(1.00); C118(1.08)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C389(1.07); C118(1.12); C154(0.99)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C389(0.94); C118(0.95); C154(1.04)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C389(0.94); C118(1.14); C335(1.12); C154(1.01)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C389(0.97); C118(0.93); C154(1.01)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C389(0.88); C118(0.90); C335(1.23); C154(1.14)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C389(0.99); C118(1.46); C335(1.07); C154(1.10)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C389(1.02); C118(0.94); C154(1.00)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C389(0.99); C118(1.20); C335(0.90); C154(1.14)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C389(0.90); C118(1.18)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C389(1.04); C118(1.07); C154(1.14)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C389(0.95); C118(1.12); C335(1.20); C154(1.17)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C389(0.93); C118(1.26); C154(1.01)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C389(0.96); C118(0.83); C335(1.11); C154(1.06)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C389(0.90); C118(0.92); C335(1.13); C154(1.11)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C389(0.96); C118(1.08); C335(1.06); C154(1.10)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C389(1.01); C118(0.94); C154(0.92)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C389(0.96); C118(1.15); C335(0.80); C154(1.01)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C389(1.00); C118(1.02)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C389(1.02); C118(1.05); C154(1.14)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C389(0.98); C118(1.05); C335(1.09); C154(1.13)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C389(1.05); C118(1.18); C154(1.03)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C389(0.92); C118(1.14); C335(1.13); C154(1.09)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C389(0.96); C118(1.09); C335(1.02); C154(1.16)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C389(0.95); C118(1.23)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C389(0.93); C118(1.06); C154(0.96)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C389(0.95); C118(1.14); C335(0.95); C154(0.98)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C389(0.98); C118(0.99)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C389(1.00); C118(1.07); C154(1.05)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C389(0.93); C118(1.28); C335(1.16); C154(1.08)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C389(1.01); C118(1.13); C154(1.14)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C389(0.96); C118(1.20); C335(1.05); C154(1.20)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C389(1.00); C118(1.10); C335(0.88); C154(1.16)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C389(0.93); C118(1.30); C154(1.03)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C389(0.93); C118(1.08); C335(1.02); C154(1.02)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 14.20  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C389(1.34)  LDD2214  [18]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C389(0.98)  LDD2227  [11]
 LDCM0367  CL1 HEK-293T C389(0.90); C118(1.01); C335(0.99)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C389(1.07); C118(1.07)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C389(0.97); C118(0.96); C335(0.90); C154(0.95)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C389(1.04); C118(0.92); C335(0.96)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C389(0.97); C335(0.88); C154(0.92)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C389(1.00); C118(1.08); C154(1.12)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C389(1.02); C118(1.02); C335(1.01); C154(0.91)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C389(1.00); C118(0.83); C335(0.63)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C389(1.04); C335(1.00); C154(0.86)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C389(0.99); C118(1.00); C154(1.07)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C389(0.94); C118(1.15); C335(0.81); C154(1.11)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C389(1.10); C118(0.72); C335(0.79)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C389(1.14); C118(1.22); C154(0.96)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C389(1.22); C335(0.88); C154(0.71)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C389(1.05); C118(0.98); C154(1.10)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C389(0.97); C118(1.01); C335(0.94); C154(0.88)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C389(0.95); C118(0.93); C335(1.01)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C389(1.02); C335(1.05); C154(0.90)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C389(0.98); C118(1.00); C154(1.12)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C389(0.98); C118(1.00); C335(1.03); C154(1.04)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C389(0.98); C118(0.96); C335(1.05)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C389(0.92); C335(0.92); C154(1.04)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C389(1.03); C118(1.03); C154(1.15)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C389(0.98); C118(1.16); C335(1.17); C154(1.06)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C389(0.87); C118(1.00); C335(1.05); C154(1.11)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C389(1.03); C118(0.88); C335(0.76)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C389(0.93); C335(0.90); C154(1.03)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C389(1.21); C118(1.10); C154(0.89)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C389(1.00); C118(0.96); C335(0.94); C154(1.00)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C389(0.99); C118(0.97); C335(0.94)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C389(1.27); C335(0.88); C154(1.20)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C389(1.06); C118(0.88); C154(1.26)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C389(0.97); C118(0.98); C335(1.07); C154(1.03)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C389(0.90); C118(0.87); C335(0.73)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C389(1.03); C335(0.92); C154(1.15)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C389(1.06); C118(0.94); C154(0.90)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C389(0.93); C118(1.05); C335(0.83); C154(1.08)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C389(1.06); C118(0.79); C154(0.75)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C389(0.82); C118(1.15); C335(1.22); C154(1.11)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C389(0.92); C118(0.83); C335(0.97); C154(1.02)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C389(0.95); C335(0.95); C154(1.11)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C389(0.96); C118(1.10); C154(0.98)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C389(1.05); C118(1.25); C335(1.15); C154(0.69)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C389(0.92); C118(1.27)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C389(1.04); C118(0.99); C154(1.33)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C389(0.92); C118(1.19); C335(1.41); C154(0.99)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C389(1.50); C118(0.91); C335(0.94)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C389(0.94); C335(0.93); C154(1.00)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C389(1.00); C118(0.92); C154(1.20)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C389(0.80); C118(0.89); C335(0.85); C154(0.93)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C389(0.88); C118(1.46); C154(0.95)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C389(1.08); C118(0.99); C154(0.96)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C389(0.86); C118(0.90); C335(1.06); C154(1.10)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C389(1.06); C118(1.35); C335(0.96); C154(0.98)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C389(0.98); C118(0.87); C154(0.94)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C389(1.28); C118(0.86); C335(1.25); C154(0.75)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C389(0.97); C118(1.33)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C389(1.00); C118(1.01); C154(1.21)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C389(0.91); C118(1.09); C335(1.12); C154(0.97)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C389(0.95); C118(0.88); C335(0.72)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C389(1.28); C118(0.92); C154(1.37)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C389(0.99); C118(0.92); C335(0.93); C154(0.95)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C389(0.90); C118(1.07); C335(0.98); C154(1.12)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C389(0.98); C118(1.03); C154(1.09)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C389(0.95); C118(0.86); C335(1.15); C154(1.12)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C389(1.00); C118(1.07); C335(1.08); C154(1.07)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C389(1.05); C118(0.92); C154(1.11)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C389(1.14); C118(0.78); C335(1.01); C154(1.09)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C389(1.14); C118(1.31)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C389(1.08); C118(1.16); C154(1.23)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C389(0.99); C118(1.04); C335(1.27); C154(0.91)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C389(0.99); C118(0.85); C335(0.74)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C389(0.97); C118(1.03); C154(0.91)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C389(0.97); C335(1.06); C154(1.05)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C389(1.00); C118(1.06); C335(0.86); C154(1.09)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C389(0.96); C118(0.95); C154(0.74)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C389(1.24); C118(0.90); C335(1.48); C154(0.82)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C389(0.96); C118(1.05); C335(1.00); C154(1.08)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C389(0.97); C118(1.04); C154(1.07)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C389(1.03); C118(1.04); C335(1.00); C154(0.96)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C389(0.95); C118(1.11)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C389(1.13); C118(0.89); C154(1.10)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C389(0.96); C118(0.88); C335(1.06); C154(0.89)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C389(0.92); C118(0.94); C335(1.23); C154(1.08)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C389(0.96); C118(1.23); C335(0.74)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C389(0.93); C335(1.10); C154(1.12)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C389(0.97); C118(1.21); C154(1.05)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C389(1.09); C118(0.71); C335(0.81); C154(0.69)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C389(0.95); C118(1.20); C154(1.20)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C389(0.81); C118(1.06); C335(1.17); C154(0.89)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C389(0.96); C118(1.59); C335(1.05); C154(1.10)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C389(1.11); C118(1.20); C154(0.98)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C389(1.20); C118(1.10); C335(1.16); C154(0.94)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C389(0.89); C118(0.99); C335(0.97); C154(1.14)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C389(0.87); C118(1.33)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C389(1.01); C118(1.07); C154(1.19)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C389(0.90); C118(1.06); C335(1.26); C154(1.04)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C389(1.07); C118(0.95); C335(0.54)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C389(0.93); C335(0.90); C154(1.10)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C389(0.94); C118(0.98); C335(0.93); C154(1.12)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C389(0.90); C118(0.88); C154(0.82)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C389(0.86); C118(1.00); C335(1.06); C154(1.29)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C389(1.06); C118(1.05); C335(1.03); C154(0.96)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C389(1.48); C118(0.73); C154(0.70)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C389(1.02); C118(0.97); C154(0.90)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C389(0.96); C118(1.20); C335(0.96); C154(0.97)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C389(0.91); C118(1.01)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C389(1.08); C118(1.03); C154(1.04)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C389(1.03); C118(1.01); C335(1.25); C154(0.93)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C389(0.96); C118(0.97); C335(0.73)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C389(0.89); C335(0.93); C154(1.20)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C389(1.00); C118(0.89); C154(1.14)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C389(0.94); C118(1.08); C335(0.94); C154(1.20)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C389(0.97); C118(1.12); C154(1.08)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C389(1.06); C118(0.75); C335(0.85); C154(0.76)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C389(1.14); C118(0.79); C335(1.22); C154(0.75)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C389(0.88); C118(0.87); C335(1.02); C154(1.06)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C389(1.15); C118(0.98); C154(0.77)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C389(1.14); C118(1.50); C335(0.83); C154(0.86)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C389(0.99); C118(1.23)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C389(1.17); C118(0.65); C154(0.71)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C389(1.03); C118(0.92); C335(1.46); C154(0.86)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C389(1.15); C118(0.68); C335(0.73)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C389(1.10); C335(1.02); C154(0.91)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C389(0.97); C118(1.08); C154(1.17)  LDD1697  [17]
 LDCM0634  CY-0357 Hep-G2 C389(0.41)  LDD2228  [11]
 LDCM0495  E2913 HEK-293T C389(1.04); C118(0.95); C154(1.33)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C389(1.60)  LDD1702  [19]
 LDCM0625  F8 Ramos C389(1.06)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C389(2.85)  LDD2189  [20]
 LDCM0573  Fragment11 MDA-MB-231 C389(20.00)  LDD1391  [21]
 LDCM0574  Fragment12 MDA-MB-231 C389(20.00)  LDD1393  [21]
 LDCM0575  Fragment13 Ramos C389(0.99)  LDD1396  [21]
 LDCM0576  Fragment14 MDA-MB-231 C389(2.46)  LDD1397  [21]
 LDCM0577  Fragment15 Ramos C389(1.48)  LDD1400  [21]
 LDCM0579  Fragment20 MDA-MB-231 C389(8.55)  LDD1402  [21]
 LDCM0580  Fragment21 Ramos C389(1.36)  LDD2195  [20]
 LDCM0581  Fragment22 Ramos C389(0.98)  LDD1407  [21]
 LDCM0582  Fragment23 MDA-MB-231 C389(1.93)  LDD1408  [21]
 LDCM0583  Fragment24 Ramos C389(2.33)  LDD1410  [21]
 LDCM0584  Fragment25 MDA-MB-231 C389(1.19)  LDD1411  [21]
 LDCM0585  Fragment26 Ramos C389(0.87)  LDD1412  [21]
 LDCM0578  Fragment27 MDA-MB-231 C389(0.85)  LDD1401  [21]
 LDCM0586  Fragment28 MDA-MB-231 C389(1.14)  LDD1415  [21]
 LDCM0587  Fragment29 MDA-MB-231 C389(0.91)  LDD1417  [21]
 LDCM0588  Fragment30 MDA-MB-231 C389(1.40)  LDD1419  [21]
 LDCM0589  Fragment31 MDA-MB-231 C389(1.33)  LDD1421  [21]
 LDCM0590  Fragment32 MDA-MB-231 C389(18.23)  LDD1423  [21]
 LDCM0468  Fragment33 Ramos C389(1.10)  LDD1426  [21]
 LDCM0596  Fragment38 MDA-MB-231 C389(1.16)  LDD1433  [21]
 LDCM0566  Fragment4 MDA-MB-231 C389(4.06)  LDD1378  [21]
 LDCM0598  Fragment40 MDA-MB-231 C389(0.92)  LDD1436  [21]
 LDCM0599  Fragment41 MDA-MB-231 C389(1.02)  LDD1438  [21]
 LDCM0600  Fragment42 Ramos C389(0.94)  LDD1440  [21]
 LDCM0601  Fragment43 MDA-MB-231 C389(16.50)  LDD1441  [21]
 LDCM0602  Fragment44 MDA-MB-231 C389(0.83)  LDD1443  [21]
 LDCM0603  Fragment45 MDA-MB-231 C389(20.00)  LDD1444  [21]
 LDCM0604  Fragment46 MDA-MB-231 C389(1.03)  LDD1445  [21]
 LDCM0606  Fragment48 MDA-MB-231 C389(1.24)  LDD1447  [21]
 LDCM0608  Fragment50 MDA-MB-231 C389(2.39)  LDD1449  [21]
 LDCM0427  Fragment51 Ramos C389(1.34)  LDD1451  [21]
 LDCM0610  Fragment52 MDA-MB-231 C389(2.22)  LDD1452  [21]
 LDCM0611  Fragment53 MDA-MB-231 C389(0.98)  LDD1454  [21]
 LDCM0614  Fragment56 MDA-MB-231 C389(0.93)  LDD1458  [21]
 LDCM0568  Fragment6 MDA-MB-231 C389(1.08)  LDD1382  [21]
 LDCM0569  Fragment7 MDA-MB-231 C389(2.96)  LDD1383  [21]
 LDCM0570  Fragment8 MDA-MB-231 C389(2.77)  LDD1385  [21]
 LDCM0571  Fragment9 MDA-MB-231 C389(7.57)  LDD1387  [21]
 LDCM0022  KB02 MDA-MB-231 C389(20.00)  LDD1374  [21]
 LDCM0023  KB03 Jurkat C389(20.00)  LDD0315  [22]
 LDCM0024  KB05 HMCB C442(2.41)  LDD3312  [4]
 LDCM0109  NEM HeLa N.A.  LDD0224  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C389(0.79)  LDD2206  [23]
 LDCM0628  OTUB2-COV-1 HEK-293T C389(0.73)  LDD2207  [23]
 LDCM0131  RA190 MM1.R C389(1.10)  LDD0304  [24]
 LDCM0112  W16 Hep-G2 C389(0.53)  LDD0239  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mannose-1-phosphate guanyltransferase beta (GMPPB) Transferase hexapeptide repeat family Q9Y5P6
DCN1-like protein 1 (DCUN1D1) . Q96GG9
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Axonemal dynein light intermediate polypeptide 1 (DNALI1) Inner dynein arm light chain family O14645
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
C-reactive protein (CRP) Pentraxin family P02741
General transcription factor 3C polypeptide 3 (GTF3C3) . Q9Y5Q9
Probetacellulin (BTC) . P35070
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
19 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
22 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.