Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment15					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	20.0
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	6.8
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	3.8
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	2.8
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	2.7
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	2.6
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	2.4
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)				C54	2.3
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	2.3
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	2.1
LDTP04689	Adenosine kinase (ADK)				C353	2.1
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	2.1
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	2.1
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	2.1
LDTP04424	Galactokinase (GALK1)				C182	2.0
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	2.0
LDTP03159	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)				C374	2.0
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	1.9
LDTP10386	ERO1-like protein alpha (ERO1A)				C37	1.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	1.8
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	1.8
LDTP02502	Thioredoxin (TXN)				C32	1.8
LDTP02733	Pyruvate kinase PKM (PKM)				C423	1.6
LDTP02693	Acylamino-acid-releasing enzyme (APEH)				C641	1.6
LDTP05289	AMP deaminase 2 (AMPD2)				C107	1.6
LDTP01633	Persulfide dioxygenase ETHE1, mitochondrial (ETHE1)				C170	1.6
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	1.6
LDTP09912	DNA repair protein RAD50 (RAD50)				C1302	1.6
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	1.6
LDTP04601	Arginine--tRNA ligase, cytoplasmic (RARS1)				C34	1.6
LDTP03400	Deoxycytidine kinase (DCK)				C9	1.5
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	1.5
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	1.5
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	1.4
LDTP11340	Cyclin-dependent kinase 19 (CDK19)				C349	1.4
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	1.4
LDTP01495	E3 ubiquitin-protein ligase UBR5 (UBR5)				C2267	1.4
LDTP06199	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)				C17	1.4
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.4
LDTP06603	Cyclin-dependent kinase inhibitor 3 (CDKN3)				C39	1.4
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	1.4
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	1.3
LDTP05773	Peroxiredoxin-4 (PRDX4)				C51	1.3
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	1.3
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	1.2
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	1.2
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	1.2
LDTP02672	Elongation factor 2 (EEF2)				C41	1.2
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	1.2
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	1.2
LDTP03400	Deoxycytidine kinase (DCK)				C45	1.2
LDTP09338	NEDD8-activating enzyme E1 catalytic subunit (UBA3)				C237	1.2
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	1.2
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	1.2
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	1.1
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	1.1
LDTP01470	Lysine-specific demethylase 4B (KDM4B)				C694	1.1
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	1.1
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.1
LDTP02329	3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)				C381	1.1
LDTP13663	Dual specificity protein phosphatase 12 (DUSP12)				C265	1.1
LDTP04374	Dynamin-2 (DNM2)				C27	1.1
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	1.1
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	1.1
LDTP01005	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3)				C691	1.1
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C217	1.1
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	1.1
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	1.1
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	1.0
LDTP07098	Probable ATP-dependent RNA helicase DDX59 (DDX59)				C414	1.0
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	1.0
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	1.0
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	1.0
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C322	1.0
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	1.0
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	1.0
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	1.0
LDTP02672	Elongation factor 2 (EEF2)				C136	1.0
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	0.9
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	0.9
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	0.9
LDTP03299	Cyclin-dependent kinase 2 (CDK2)				C177	0.9
LDTP09412	Serine/threonine-protein kinase Nek9 (NEK9)				C623	0.9
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	0.9
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C100	0.9
LDTP00601	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)				C620	0.8
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	0.8
LDTP04306	Adenosine 5'-monophosphoramidase HINT1 (HINT1)				C84	0.8
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	0.8
LDTP03786	Glutaredoxin-1 (GLRX)				C23	0.8
LDTP01333	Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)				C269	0.6
LDTP15306	Transmembrane protease serine 12 (TMPRSS12)				C64	0.5
LDTP04061	26S proteasome regulatory subunit 6B (PSMC4)				C210	0.5

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP04801	Gasdermin-D (GSDMD)				C268	3.0
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	2.1
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	1.3
LDTP00501	Exportin-1 (XPO1)				C34	1.2
LDTP04707	Protein SEC13 homolog (SEC13)				C187	1.2
LDTP13490	Apoptotic chromatin condensation inducer in the nucleus (ACIN1)				C1223	1.1
LDTP01574	Importin-7 (IPO7)				C757	1.1
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	1.1
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	1.1
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	1.0
LDTP00501	Exportin-1 (XPO1)				C528	1.0
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	1.0
LDTP13661	Sorting nexin-6 (SNX6)				C264	0.9
LDTP04662	Exportin-2 (CSE1L)				C842	0.9

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	1.2
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	1.2
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	1.1
LDTP03969	Signal transducer and activator of transcription 1-alpha/beta (STAT1)				C492	1.0
LDTP02016	Glucocorticoid receptor (NR3C1)				C302	0.9
LDTP05485	Recombining binding protein suppressor of hairless (RBPJ)				C313	0.8

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP12685	Integrator complex subunit 13 (INTS13)				C349	20.0
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	20.0
LDTP13964	MOB-like protein phocein (MOB4)				C134	20.0
LDTP06281	Condensin complex subunit 1 (NCAPD2)				C767	9.9
LDTP04517	Transcription initiation factor IIA subunit 2 (GTF2A2)				C68	4.3
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	3.8
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	3.7
LDTP15730	Ataxin-7-like protein 3B (ATXN7L3B)				C75	3.0
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	2.8
LDTP07755	Dynamin-binding protein (DNMBP)				C691	2.6
LDTP04902	Actin-related protein 3 (ACTR3)				C235	2.6
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	2.5
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	2.4
LDTP02205	Tubulin beta chain (TUBB)				C354	2.3
LDTP05930	SNW domain-containing protein 1 (SNW1)				C250	2.1
LDTP05867	Treacle protein (TCOF1)				C38	2.0
LDTP03395	Large ribosomal subunit protein uL16 (RPL10)				C105	2.0
LDTP00431	Kinetochore protein NDC80 homolog (NDC80)				C449	2.0
LDTP09821	Stalled ribosome sensor GCN1 (GCN1)				C1692	1.8
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	1.8
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	1.8
LDTP10864	Calponin-2 (CNN2)				C164	1.7
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	1.7
LDTP10864	Calponin-2 (CNN2)				C215	1.7
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	1.7
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	1.7
LDTP02205	Tubulin beta chain (TUBB)				C239	1.6
LDTP01567	Structural maintenance of chromosomes protein 2 (SMC2)				C1174	1.6
LDTP05867	Treacle protein (TCOF1)				C1298	1.6
LDTP04117	Ras GTPase-activating-like protein IQGAP1 (IQGAP1)				C781	1.6
LDTP11197	Mini-chromosome maintenance complex-binding protein (MCMBP)				C325	1.5
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)				C553	1.5
LDTP04092	Crk-like protein (CRKL)				C249	1.5
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	1.5
LDTP13580	Coronin-1C (CORO1C)				C420	1.4
LDTP06362	Leucine-rich repeat-containing protein 41 (LRRC41)				C297	1.4
LDTP04997	Small ribosomal subunit protein eS4, X isoform (RPS4X)				C41	1.4
LDTP12737	BRISC and BRCA1-A complex member 1 (BABAM1)				C222	1.4
LDTP12144	GrpE protein homolog 1, mitochondrial (GRPEL1)				C124	1.4
LDTP00202	AH receptor-interacting protein (AIP)				C122	1.4
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	1.4
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C561	1.3
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	1.3
LDTP11890	Protein unc-45 homolog A (UNC45A)				C426	1.3
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	1.3
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	1.3
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	1.3
LDTP18494	Tropomodulin-3 (TMOD3)				C132	1.3
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)				C253	1.2
LDTP02934	T-complex protein 1 subunit alpha (TCP1)				C76	1.2
LDTP06083	Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)				C1999	1.2
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)				C843	1.2
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	1.2
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	1.2
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	1.2
LDTP12914	Hsp70-binding protein 1 (HSPBP1)				C204	1.1
LDTP11239	Protein misato homolog 1 (MSTO1)				C485	1.1
LDTP01011	Protein diaphanous homolog 1 (DIAPH1)				C1227	1.1
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	1.1
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	1.1
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	1.0
LDTP01299	WD repeat and HMG-box DNA-binding protein 1 (WDHD1)				C773	1.0
LDTP13580	Coronin-1C (CORO1C)				C456	1.0
LDTP12443	Anillin (ANLN)				C712	1.0
LDTP03860	Stress-70 protein, mitochondrial (HSPA9)				C317	0.9
LDTP06082	Dynactin subunit 1 (DCTN1)				C1252	0.9
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C280	0.9
LDTP14195	FH1/FH2 domain-containing protein 1 (FHOD1)				C502	0.9
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)				C172	0.9
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C341	0.8
LDTP03244	Cofilin-1 (CFL1)				C80	0.8
LDTP03695	Heat shock 70 kDa protein 4 (HSPA4)				C34	0.8
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C122	0.7

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.