Details of the Target

General Information of Target

Target ID LDTP15306
Target Name Transmembrane protease serine 12 (TMPRSS12)
Gene Name TMPRSS12
Gene ID 283471
Synonyms
Transmembrane protease serine 12; EC 3.4.21.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALEVLMLLAVLIWTGAENLHVKISCSLDWLMVSVIPVAESRNLYIFADELHLGMGCPAN
RIHTYVYEFIYLVRDCGIRTRVVSEETLLFQTELYFTPRNIDHDPQEIHLECSTSRKSVW
LTPVSTENEIKLDPSPFIADFQTTAEELGLLSSSPNLL
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Membrane
Function
Required for male fertility. Plays a critical role in sperm capacitation and acrosome reactions during fertilization, and also plays a role in the regulation of proteins involved in spermatogenesis. Regulates protein pathways that promote chromosomal synapsis formation, double-strand break repair, formation of the inner mitochondrial membrane cristae and apoptosis in developing sperm. Required for normal sperm motility and binding to the zona pellucida, potentially via a role in ADAM3 protein maturation.
Uniprot ID
Q86WS5
Ensemble ID
ENST00000398458.4
HGNC ID
HGNC:28779

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C64(20.00)  LDD1374  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0572  Fragment10 Ramos C64(0.69)  LDD1390  [1]
 LDCM0573  Fragment11 Ramos C64(5.75)  LDD1392  [1]
 LDCM0574  Fragment12 Ramos C64(1.07)  LDD1394  [1]
 LDCM0575  Fragment13 MDA-MB-231 C64(1.25)  LDD1395  [1]
 LDCM0576  Fragment14 MDA-MB-231 C64(0.99)  LDD1397  [1]
 LDCM0577  Fragment15 Ramos C64(0.52)  LDD1400  [1]
 LDCM0580  Fragment21 MDA-MB-231 C64(0.85)  LDD1404  [1]
 LDCM0581  Fragment22 MDA-MB-231 C64(0.87)  LDD1406  [1]
 LDCM0582  Fragment23 MDA-MB-231 C64(0.96)  LDD1408  [1]
 LDCM0578  Fragment27 Ramos C64(1.61)  LDD1414  [1]
 LDCM0586  Fragment28 Ramos C64(1.16)  LDD1416  [1]
 LDCM0587  Fragment29 MDA-MB-231 C64(0.82)  LDD1417  [1]
 LDCM0588  Fragment30 Ramos C64(1.15)  LDD1420  [1]
 LDCM0590  Fragment32 MDA-MB-231 C64(0.87)  LDD1423  [1]
 LDCM0592  Fragment34 Ramos C64(1.26)  LDD1428  [1]
 LDCM0593  Fragment35 Ramos C64(0.76)  LDD1430  [1]
 LDCM0595  Fragment37 Ramos C64(0.77)  LDD1432  [1]
 LDCM0566  Fragment4 MDA-MB-231 C64(1.08)  LDD1378  [1]
 LDCM0598  Fragment40 Ramos C64(0.88)  LDD1437  [1]
 LDCM0599  Fragment41 Ramos C64(0.78)  LDD1439  [1]
 LDCM0600  Fragment42 Ramos C64(0.98)  LDD1440  [1]
 LDCM0604  Fragment46 MDA-MB-231 C64(0.99)  LDD1445  [1]
 LDCM0610  Fragment52 MDA-MB-231 C64(0.74)  LDD1452  [1]
 LDCM0612  Fragment54 MDA-MB-231 C64(1.11)  LDD1456  [1]
 LDCM0613  Fragment55 MDA-MB-231 C64(1.18)  LDD1457  [1]
 LDCM0614  Fragment56 Ramos C64(1.20)  LDD1459  [1]
 LDCM0569  Fragment7 Ramos C64(1.05)  LDD1384  [1]
 LDCM0570  Fragment8 MDA-MB-231 C64(1.00)  LDD1385  [1]
 LDCM0571  Fragment9 MDA-MB-231 C64(2.57)  LDD1387  [1]
 LDCM0022  KB02 MDA-MB-231 C64(20.00)  LDD1374  [1]
 LDCM0023  KB03 Ramos C64(2.25)  LDD1377  [1]
 LDCM0024  KB05 MDA-MB-231 C64(0.98)  LDD1380  [1]

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.